WP_PI3KAKTMTOR_SIGNALING_PATHWAY_AND_THERAPEUTIC_OPPORTUNITIES			Return to index
Order	Gene	Description	ref_hepatocyte	HepG2	HepG2.C3A	HuH.7	SNU475	THLE	liver
1	RHEB	GTP-binding protein Rheb	[1]	-2.11[2]	-1.74[3]	-2.00[4]	-1.28[5]	-1.26[6]	-1.71[7]
2	EIF4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1	[8]	-1.16[9]	-1.68[10]	-1.26[11]	-3.48[12]	-2.02[13]	-2.22[14]
3	AKT1	RAC-alpha serine/threonine-protein kinase	[15]	-0.09[16]	-0.52[17]	-1.79[18]	-0.23[19]	-0.30[20]	-0.87[21]
4	BAD	Bcl2-associated agonist of cell death	[22]	-1.84[23]	-1.91[24]	-3.05[25]	-1.24[26]	-0.93[27]	-2.04[28]
5	NRAS	GTPase NRas	[29]	0.46[30]	0.69[31]	0.91[32]	0.82[33]	0.30[34]	-0.87[35]
6	CDKN1B	Cyclin-dependent kinase inhibitor 1B	[36]	-0.25[37]	-0.01[38]	-0.01[39]	-1.29[40]	-0.91[41]	-1.53[42]
7	HRAS	GTPase HRas	[43]	-1.17[44]	-2.08[45]	-3.06[46]	-1.13[47]	-1.43[48]	-3.28[49]
8	KRAS	GTPase KRas	[50]	-0.68[51]	-0.90[52]	0.50[53]	0.62[54]	0.19[55]	0.05[56]
9	PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha	[57]	-0.64[58]	-0.72[59]	0.18[60]	1.89[61]	1.30[62]	2.38[63]
10	PTEN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN		-0.70[64]	0.49[65]	0.49[66]	-0.74[67]	0.42[68]	1.86[69]
11	PIK3R2	Phosphatidylinositol 3-kinase regulatory subunit beta	[70]	1.71[71]	1.73[72]	2.15[73]	0.53[74]	1.00[75]	-0.91[76]
12	ATG13	Autophagy-related protein 13	[77]	1.88[78]	1.64[79]	1.68[80]	-0.05[81]	0.95[82]	1.22[83]
13	GSK3B	Glycogen synthase kinase-3 beta	[84]	1.10[85]	0.53[86]	0.92[87]	1.64[88]	1.37[89]	0.54[90]
14	GRB10	Growth factor receptor-bound protein 10	[91]	2.34[92]	-0.94[93]	1.24[94]	0.51[95]	1.28[96]	1.32[97]
15	MTOR	Serine/threonine-protein kinase mTOR	[98]	2.37[99]	3.18[100]	2.55[101]	2.51[102]	2.49[103]	2.83[104]
16	RB1CC1	RB1-inducible coiled-coil protein 1	[105]	0.12[106]	2.71[107]	1.53[108]	2.15[109]	1.59[110]	2.24[111]
17	TSC2	Tuberin	[112]	1.65[113]	0.97[114]	1.47[115]	1.02[116]	1.45[117]	1.46[118]
18	ULK1	Serine/threonine-protein kinase ULK1	[119]	1.14[120]	1.22[121]	2.23[122]	1.80[123]	1.05[124]	1.27[125]
19	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform		1.04[126]	1.35[127]	1.32[128]	0.87[129]	0.94[130]	0.53[131]
20	FOXO3	Forkhead box protein O3	[132]	0.29[133]	0.18[134]	0.62[135]	0.22[136]	1.37[137]	1.71[138]
21	RPTOR	Regulatory-associated protein of mTOR	[139]	2.92[140]	1.95[141]	1.86[142]	1.67[143]	1.81[144]	1.71[145]
22	TFEB	Transcription factor EB	[146]	0.21[147]	-0.25[148]	-1.12[149]	0.90[150]	-0.59[151]	-1.23[152]
23	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform		-0.55[153]	0.89[154]	0.89[155]	0.95[156]	1.06[157]	1.29[158]
24	PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial		2.20[159]	2.71[160]	2.14[161]	2.44[162]	0.57[163]	1.44[164]
25	FOXO1	Forkhead box protein O1	[165]	1.53[166]	0.99[167]	0.94[168]	1.00[169]	2.92[170]	2.47[171]
26	RICTOR	Rapamycin-insensitive companion of mTOR	[172]	0.56[173]	2.44[174]	2.92[175]	2.18[176]	2.29[177]	2.89[178]
27	FOXO4	Forkhead box protein O4	[179]	0.56[180]	0.76[181]	0.40[182]	-0.01[183]	0.11[184]	-1.32[185]
28	PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma	[186]	1.56[187]	1.36[188]	2.02[189]	2.99[190]	1.92[191]	2.05[192]
29	NOS3	Nitric oxide synthase, endothelial	[193]	4.60[194]	1.50[195]	0.78[196]	-0.12[197]	1.12[198]	2.15[199]
30	PIK3CG	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform		[200]	[201]	[202]	1.16[203]	-3.81[204]	3.48[205]