WP_PHYSICOCHEMICAL_FEATURES_AND_TOXICITYASSOCIATED_PATHWAYS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PFN1 | Profilin-1 | [1] | -2.23[2] | -2.26[3] | -1.96[4] | -1.91[5] | -2.18[6] | -2.18[7] |
2 | TMSB4X | Thymosin beta-4 | [8] | -5.41[9] | -11.32[10] | -5.08[11] | -1.02[12] | -1.27[13] | -2.28[14] |
3 | SOD1 | Superoxide dismutase [Cu-Zn] | [15] | -3.37[16] | -3.02[17] | -3.96[18] | -3.57[19] | -3.69[20] | -0.86[21] |
4 | RHOA | Transforming protein RhoA | [22] | -0.90[23] | -1.04[24] | -0.77[25] | -1.10[26] | -0.61[27] | -0.67[28] |
5 | GPX1 | Glutathione peroxidase 1 | [29] | -1.49[30] | -1.45[31] | -1.03[32] | -2.15[33] | -1.14[34] | -0.88[35] |
6 | FN1 | Fibronectin | [36] | 3.53[37] | 3.36[38] | 3.30[39] | 3.05[40] | 3.28[41] | 2.95[42] |
7 | ACTR2 | Actin-related protein 2 | [43] | -0.03[44] | 0.53[45] | 0.48[46] | 0.97[47] | 0.42[48] | -0.65[49] |
8 | ACTR3 | Actin-related protein 3 | [50] | -0.25[51] | 0.29[52] | -0.22[53] | 0.98[54] | 0.06[55] | -0.28[56] |
9 | JUN | Transcription factor AP-1 | [57] | -0.45[58] | -1.63[59] | -1.32[60] | -1.58[61] | -0.97[62] | -1.15[63] |
10 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [64] | 0.88[65] | -0.15[66] | -2.80[67] | -1.86[68] | 0.73[69] | -1.18[70] |
11 | AKT1 | RAC-alpha serine/threonine-protein kinase | [71] | 0.12[72] | 0.25[73] | -0.79[74] | 0.08[75] | 0.13[76] | 0.41[77] |
12 | CTNNB1 | Catenin beta-1 | [78] | 1.66[79] | 1.51[80] | 2.45[81] | 0.88[82] | 1.14[83] | 1.76[84] |
13 | MYC | Myc proto-oncogene protein | [85] | 0.47[86] | 0.49[87] | -1.49[88] | -2.66[89] | -0.26[90] | -1.34[91] |
14 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [92] | -0.89[93] | -0.86[94] | -0.23[95] | -0.42[96] | 0.13[97] | -0.54[98] |
15 | PFN2 | Profilin-2 | [99] | 0.19[100] | 0.70[101] | 0.74[102] | 1.50[103] | 0.62[104] | -2.19[105] |
16 | PPP2CA | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | 0.31[106] | 0.76[107] | 0.18[108] | 0.87[109] | 1.02[110] | 0.55[111] | |
17 | GRB2 | Growth factor receptor-bound protein 2 | [112] | 1.23[113] | 1.43[114] | 1.60[115] | 0.68[116] | 0.63[117] | 0.95[118] |
18 | SHC1 | SHC-transforming protein 1 | [119] | 1.20[120] | 1.78[121] | 1.90[122] | 2.78[123] | 2.30[124] | 1.43[125] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [126] | -0.03[127] | 0.74[128] | 2.05[129] | -0.06[130] | 0.84[131] | 1.75[132] |
20 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [133] | -0.05[134] | 0.75[135] | 1.00[136] | -0.98[137] | -0.48[138] | -0.25[139] |
21 | DVL1 | Segment polarity protein dishevelled homolog DVL-1 | [140] | 0.84[141] | 1.66[142] | 0.58[143] | 0.20[144] | 0.27[145] | -0.10[146] |
22 | NCK1 | Cytoplasmic protein NCK1 | [147] | -1.56[148] | -1.09[149] | -0.94[150] | -0.44[151] | -0.29[152] | 0.19[153] |
23 | MAPK1 | Mitogen-activated protein kinase 1 | [154] | 1.75[155] | 2.24[156] | 2.12[157] | 1.98[158] | 1.66[159] | 2.43[160] |
24 | CAMK1 | Calcium/calmodulin-dependent protein kinase type 1 | [161] | -1.21[162] | 0.59[163] | 0.56[164] | -1.34[165] | -0.68[166] | -0.30[167] |
25 | MYLK | Myosin light chain kinase, smooth muscle | [168] | -0.72[169] | 0.00[170] | -0.58[171] | 2.41[172] | 0.05[173] | 3.67[174] |
26 | PTK2 | Focal adhesion kinase 1 | [175] | 0.77[176] | 1.62[177] | 2.05[178] | 2.07[179] | 1.31[180] | 1.42[181] |
27 | WNT11 | Protein Wnt-11 | [182] | -1.38[183] | -6.73[184] | -5.66[185] | -6.41[186] | -6.80[187] | -2.43[188] |
28 | MAPK8 | Mitogen-activated protein kinase 8 | [189] | -1.41[190] | 0.36[191] | -0.72[192] | -0.78[193] | -0.88[194] | 0.14[195] |
29 | SOS1 | Son of sevenless homolog 1 | [196] | -0.06[197] | 1.83[198] | 1.38[199] | 0.97[200] | 0.24[201] | 1.19[202] |
30 | ELK1 | ETS domain-containing protein Elk-1 | [203] | -0.28[204] | -2.05[205] | 0.41[206] | 0.40[207] | 1.02[208] | 0.49[209] |
31 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [210] | 2.41[211] | 1.59[212] | 2.81[213] | 1.38[214] | 1.02[215] | 0.81[216] |
32 | FZD5 | Frizzled-5 | [217] | 1.01[218] | 2.24[219] | 3.27[220] | -1.01[221] | -2.28[222] | 3.24[223] |
33 | EGFR | Epidermal growth factor receptor | [224] | -0.66[225] | -0.67[226] | 2.26[227] | 0.56[228] | 1.21[229] | 3.31[230] |
34 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [231] | 0.74[232] | 1.73[233] | 0.98[234] | 1.33[235] | 0.77[236] | 1.72[237] |
35 | ROCK2 | Rho-associated protein kinase 2 | [238] | 1.51[239] | 3.11[240] | 1.63[241] | 2.76[242] | 0.57[243] | 2.58[244] |
36 | AXIN1 | Axin-1 | [245] | 1.39[246] | 2.07[247] | 0.55[248] | -8.57[249] | 0.31[250] | 0.00[251] |
37 | GSK3B | Glycogen synthase kinase-3 beta | [252] | 1.30[253] | 1.30[254] | 1.92[255] | 1.94[256] | 1.80[257] | 1.82[258] |
38 | SRC | Proto-oncogene tyrosine-protein kinase Src | [259] | 3.06[260] | 3.41[261] | 2.45[262] | 2.52[263] | 1.74[264] | -0.19[265] |
39 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.53[266] | 3.51[267] | 2.89[268] | 2.95[269] | 2.48[270] | 1.00[271] | |
40 | DAAM1 | Disheveled-associated activator of morphogenesis 1 | [272] | 0.40[273] | 1.78[274] | 0.99[275] | 0.94[276] | 1.02[277] | 2.62[278] |
41 | FZD4 | Frizzled-4 | [279] | 4.12[280] | 3.42[281] | 2.51[282] | 0.82[283] | 0.19[284] | 3.60[285] |
42 | STAT5A | Signal transducer and activator of transcription 5A | [286] | -1.91[287] | -0.38[288] | -1.26[289] | -0.72[290] | 0.07[291] | 0.89[292] |
43 | PAK1 | Serine/threonine-protein kinase PAK 1 | [293] | 0.03[294] | -0.37[295] | 2.08[296] | -1.73[297] | 2.09[298] | 0.92[299] |
44 | TGFA | Protransforming growth factor alpha | [300] | 1.83[301] | 3.25[302] | -7.75[303] | -0.84[304] | -2.03[305] | 0.26[306] |
45 | FZD6 | Frizzled-6 | [307] | 1.82[308] | 3.01[309] | 0.55[310] | 4.86[311] | 3.65[312] | 1.77[313] |
46 | APC | Adenomatous polyposis coli protein | [314] | 0.61[315] | 2.64[316] | 2.53[317] | 2.35[318] | 3.02[319] | 4.39[320] |
47 | FZD8 | Frizzled-8 | [321] | -3.09[322] | -8.07[323] | -0.65[324] | -2.84[325] | -1.59[326] | 0.46[327] |
48 | CBL | E3 ubiquitin-protein ligase CBL | [328] | 4.49[329] | 3.79[330] | 4.06[331] | 5.26[332] | 4.78[333] | 4.41[334] |
49 | ACTA1 | Actin, alpha skeletal muscle | [335] | 0.74[336] | 0.00[337] | -2.99[338] | -4.87[339] | -5.24[340] | -2.76[341] |
50 | PFN4 | Profilin-4 | [342] | -5.61[343] | -4.01[344] | -3.54[345] | -1.90[346] | -2.49[347] | -1.75[348] |
51 | FZD7 | Frizzled-7 | [349] | 2.24[350] | -1.44[351] | 4.62[352] | 4.68[353] | 2.13[354] | 0.68[355] |
52 | FZD1 | Frizzled-1 | [356] | 1.59[357] | -0.01[358] | 3.71[359] | 2.54[360] | 3.70[361] | 3.44[362] |
53 | FZD3 | Frizzled-3 | [363] | 2.97[364] | 4.26[365] | 6.01[366] | 3.92[367] | 3.18[368] | 4.30[369] |
54 | NEFH | Neurofilament heavy polypeptide | [370] | 0.54[371] | -3.46[372] | -2.96[373] | 1.81[374] | -1.86[375] | 0.70[376] |
55 | NEFM | Neurofilament medium polypeptide | [377] | [378] | [379] | [380] | 3.76[381] | -1.96[382] | -4.32[383] |
56 | FZD2 | Frizzled-2 | [384] | 1.19[385] | -0.07[386] | 2.69[387] | 7.01[388] | 4.50[389] | 0.30[390] |
57 | FZD9 | Frizzled-9 | [391] | 1.46[392] | 2.01[393] | 1.80[394] | 2.26[395] | 0.00[396] | 0.26[397] |
58 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [398] | [399] | [400] | 1.47[401] | -3.38[402] | 4.75[403] | |
59 | NOS1 | Nitric oxide synthase, brain | [404] | -1.52[405] | 0.81[406] | -0.71[407] | -0.54[408] | -0.61[409] | 1.35[410] |
60 | WNT16 | Protein Wnt-16 | [411] | [412] | [413] | [414] | 1.47[415] | -2.37[416] | 0.81[417] |
61 | NEFL | Neurofilament light polypeptide | [418] | -1.97[419] | [420] | 0.24[421] | 9.79[422] | 2.48[423] | [424] |
62 | MYL1 | Myosin light chain 1/3, skeletal muscle isoform | [425] | [426] | [427] | [428] | -4.57[429] | [430] | -1.16[431] |
63 | GRIA1 | Glutamate receptor 1 | [432] | -2.29[433] | [434] | [435] | -0.53[436] | -0.05[437] | 0.80[438] |
64 | MIR4683 | [439] | [440] | [441] | [442] | [443] | [444] | [445] | |
65 | ERBB4 | Receptor tyrosine-protein kinase erbB-4 | [446] | [447] | [448] | [449] | [450] | [451] | [452] |
66 | MIR6808 | [453] | [454] | [455] | [456] | [457] | [458] | [459] | |
67 | PFN3 | Profilin-3 | [460] | [461] | [462] | [463] | [464] | [465] | [466] |
68 | FZD10 | Frizzled-10 | [467] | [468] | [469] | [470] | [471] | [472] | [473] |