WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CES1 Liver carboxylesterase 1 [1] -2.49[2] -9.10[3] -9.70[4] -3.80[5] -9.26[6] -0.74[7]
2 EPHX1 Epoxide hydrolase 1 [8] -1.97[9] -3.35[10] -3.90[11] -1.21[12] -2.11[13] -0.19[14]
3 SRXN1 Sulfiredoxin-1 [15] 0.62[16] 0.24[17] -1.60[18] 0.91[19] 0.64[20] -0.76[21]
4 HMOX1 Heme oxygenase 1 [22] 0.59[23] -0.23[24] -1.05[25] -1.63[26] 0.53[27] -1.32[28]
5 JUN Transcription factor AP-1 [29] 0.58[30] -0.86[31] -0.29[32] -1.74[33] 1.23[34] -1.05[35]
6 NQO1 NAD(P)H dehydrogenase [quinone] 1 [36] 3.82[37] 3.61[38] 3.52[39] 4.06[40] 2.62[41] -4.48[42]
7 FOS Proto-oncogene c-Fos [43] -4.94[44] -3.57[45] -3.94[46] -6.20[47] -2.73[48] -0.54[49]
8 NQO2 Ribosyldihydronicotinamide dehydrogenase [quinone] [50] -1.58[51] -0.84[52] -0.40[53] -1.64[54] -0.23[55] -0.01[56]
9 ABCC2 Canalicular multispecific organic anion transporter 1 [57] 1.90[58] 3.57[59] 2.29[60] -0.28[61] -4.66[62] 2.71[63]
10 GCLC Glutamate--cysteine ligase catalytic subunit [64] 0.71[65] 1.18[66] 0.26[67] 0.92[68] 0.60[69] 1.18[70]
11 ABCC6 Multidrug resistance-associated protein 6 [71] 0.40[72] 0.96[73] -0.09[74] -4.44[75] -4.76[76] 2.28[77]
12 GCLM Glutamate--cysteine ligase regulatory subunit [78] 0.10[79] -0.57[80] 0.19[81] 0.82[82] 1.39[83] -0.08[84]
13 NFE2L2 Nuclear factor erythroid 2-related factor 2 [85] 1.83[86] 2.88[87] 2.77[88] 0.43[89] 3.07[90] 0.93[91]
14 KEAP1 Kelch-like ECH-associated protein 1 [92] 1.28[93] 1.29[94] 1.32[95] -0.85[96] 2.54[97] 1.31[98]
15 ABCC3 Canalicular multispecific organic anion transporter 2 [99] 2.16[100] 1.58[101] 0.24[102] 0.23[103] 2.04[104] 3.40[105]
16 MAPK14 Mitogen-activated protein kinase 14 [106] 2.54[107] 2.72[108] 2.59[109] 1.65[110] 3.52[111] 2.04[112]
17 MAPK8 Mitogen-activated protein kinase 8 [113] -0.38[114] 1.14[115] 0.31[116] -0.94[117] 1.32[118] 0.25[119]
18 GSTP1 Glutathione S-transferase P [120] -2.90[121] -1.91[122] 6.08[123] 5.68[124] 5.84[125] 0.70[126]
19 MAPK13 Mitogen-activated protein kinase 13 [127] 3.41[128] 3.92[129] 1.54[130] -1.92[131] 2.00[132] -0.96[133]
20 ABCG2 ATP-binding cassette sub-family G member 2 [134] 1.13[135] 1.12[136] 2.55[137] -0.38[138] 0.91[139] 1.03[140]
21 ABCC4 Multidrug resistance-associated protein 4 [141] 2.86[142] 2.05[143] 4.58[144] 2.66[145] 4.57[146] 1.23[147]
22 MAPK12 Mitogen-activated protein kinase 12 [148] 3.89[149] 3.66[150] 5.06[151] 1.45[152] 5.10[153] -0.14[154]
23 MAPK11 Mitogen-activated protein kinase 11 [155] 0.90[156] 0.90[157] 0.31[158] 0.32[159] 4.72[160] 0.93[161]
[1]
ref_hepatocyte CES1
Mean 819
Standard deviation 9e+02
Values 1.5e+02 1.7e+03 1.9e+03 1.5e+02 1.8e+02
[2]
HepG2 CES1
Mean 154
Standard deviation 89
Values 91 2.2e+02
[3]
HepG2.C3A CES1
Mean 1.3
Standard deviation 0.53
Values 0.92 1.7
[4]
HuH.7 CES1
Mean 0.67
Standard deviation 0.32
Values 0.46 1 0.52
[5]
SNU475 CES1
Mean 111
Standard deviation 23
Values 94 1.3e+02
[6]
THLE CES1
Mean 0.535
Standard deviation 0.14
Values 0.63 0.44
[7]
liver CES1
Mean 411
Standard deviation 2.6e+02
Values 1.3e+02 3.2e+02 4.6e+02 7.4e+02
[8]
ref_hepatocyte EPHX1
Mean 300
Standard deviation 3.6e+02
Values 48 6.7e+02 7.2e+02 43 21
[9]
HepG2 EPHX1
Mean 80.5
Standard deviation 9
Values 74 87
[10]
HepG2.C3A EPHX1
Mean 25.6
Standard deviation 6.3
Values 21 30
[11]
HuH.7 EPHX1
Mean 13.6
Standard deviation 1.2
Values 12 14 14
[12]
SNU475 EPHX1
Mean 243
Standard deviation 68
Values 2e+02 2.9e+02
[13]
THLE EPHX1
Mean 27.8
Standard deviation 0.14
Values 28 28
[14]
liver EPHX1
Mean 220
Standard deviation 1.4e+02
Values 61 3.1e+02 1.4e+02 3.7e+02
[15]
ref_hepatocyte SRXN1
Mean 63.4
Standard deviation 58
Values 1e+02 6.5 24 40 1.5e+02
[16]
HepG2 SRXN1
Mean 103
Standard deviation 56
Values 63 1.4e+02
[17]
HepG2.C3A SRXN1
Mean 65.3
Standard deviation 7.7
Values 60 71
[18]
HuH.7 SRXN1
Mean 14.2
Standard deviation 2.5
Values 13 17 13
[19]
SNU475 SRXN1
Mean 224
Standard deviation 8.9
Values 2.3e+02 2.2e+02
[20]
THLE SRXN1
Mean 39.3
Standard deviation 2.3
Values 41 38
[21]
liver SRXN1
Mean 31.4
Standard deviation 19
Values 14 40 18 54
[22]
ref_hepatocyte HMOX1
Mean 45.4
Standard deviation 44
Values 1.2e+02 37 47 19 4.5
[23]
HepG2 HMOX1
Mean 71.8
Standard deviation 29
Values 52 92
[24]
HepG2.C3A HMOX1
Mean 33.6
Standard deviation 4.7
Values 37 30
[25]
HuH.7 HMOX1
Mean 14.9
Standard deviation 6.3
Values 12 22 10
[26]
SNU475 HMOX1
Mean 27.6
Standard deviation 4.6
Values 31 24
[27]
THLE HMOX1
Mean 26.2
Standard deviation 9.7
Values 19 33
[28]
liver HMOX1
Mean 15.2
Standard deviation 2.1
Values 15 13 16 18
[29]
ref_hepatocyte JUN
Mean 42.9
Standard deviation 25
Values 66 20 73 26 30
[30]
HepG2 JUN
Mean 67.5
Standard deviation 36
Values 42 93
[31]
HepG2.C3A JUN
Mean 20.6
Standard deviation 11
Values 13 28
[32]
HuH.7 JUN
Mean 23.9
Standard deviation 19
Values 14 46 11
[33]
SNU475 JUN
Mean 24.2
Standard deviation 4.1
Values 27 21
[34]
THLE JUN
Mean 40.2
Standard deviation 4.7
Values 37 44
[35]
liver JUN
Mean 17.4
Standard deviation 8.4
Values 12 24 25 8.4
[36]
ref_hepatocyte NQO1
Mean 42.1
Standard deviation 85
Values 1.6 0.37 1.4 1.9e+02 13
[37]
HepG2 NQO1
Mean 625
Standard deviation 2.7e+02
Values 4.3e+02 8.1e+02
[38]
HepG2.C3A NQO1
Mean 447
Standard deviation 1.2e+02
Values 5.3e+02 3.6e+02
[39]
HuH.7 NQO1
Mean 329
Standard deviation 90
Values 4e+02 2.3e+02 3.5e+02
[40]
SNU475 NQO1
Mean 1.32e+03
Standard deviation 2.1e+02
Values 1.2e+03 1.5e+03
[41]
THLE NQO1
Mean 103
Standard deviation 3.8
Values 1.1e+02 1e+02
[42]
liver NQO1
Mean 1.58
Standard deviation 1.1
Values 0.97 1.8 0.49 3.1
[43]
ref_hepatocyte FOS
Mean 40
Standard deviation 67
Values 9 27 1.6e+02 4 0.65
[44]
HepG2 FOS
Mean 1.37
Standard deviation 1
Values 0.66 2.1
[45]
HepG2.C3A FOS
Mean 2.92
Standard deviation 1.9
Values 1.6 4.3
[46]
HuH.7 FOS
Mean 1.77
Standard deviation 0.38
Values 2.2 1.6 1.5
[47]
SNU475 FOS
Mean 1.02
Standard deviation 0.13
Values 1.1 0.93
[48]
THLE FOS
Mean 2.4
Standard deviation 0.3
Values 2.2 2.6
[49]
liver FOS
Mean 23
Standard deviation 32
Values 5.7 4.8 71 10
[50]
ref_hepatocyte NQO2
Mean 35.6
Standard deviation 23
Values 26 68 50 12 22
[51]
HepG2 NQO2
Mean 12.5
Standard deviation 1.4
Values 12 14
[52]
HepG2.C3A NQO2
Mean 17.3
Standard deviation 1.9
Values 19 16
[53]
HuH.7 NQO2
Mean 18.4
Standard deviation 6.7
Values 25 11 19
[54]
SNU475 NQO2
Mean 21.5
Standard deviation 5.5
Values 18 25
[55]
THLE NQO2
Mean 12.1
Standard deviation 0.38
Values 12 12
[56]
liver NQO2
Mean 29.7
Standard deviation 19
Values 18 11 51 39
[57]
ref_hepatocyte ABCC2
Mean 31.6
Standard deviation 23
Values 16 17 17 68 40
[58]
HepG2 ABCC2
Mean 125
Standard deviation 1.3
Values 1.3e+02 1.2e+02
[59]
HepG2.C3A ABCC2
Mean 328
Standard deviation 1.2
Values 3.3e+02 3.3e+02
[60]
HuH.7 ABCC2
Mean 105
Standard deviation 48
Values 68 1.6e+02 88
[61]
SNU475 ABCC2
Mean 48.9
Standard deviation 12
Values 41 57
[62]
THLE ABCC2
Mean 0.497
Standard deviation 0.041
Values 0.53 0.47
[63]
liver ABCC2
Mean 174
Standard deviation 96
Values 1.9e+02 3e+02 89 1.1e+02
[64]
ref_hepatocyte GCLC
Mean 23.9
Standard deviation 11
Values 36 37 16 14 17
[65]
HepG2 GCLC
Mean 41.2
Standard deviation 0.21
Values 41 41
[66]
HepG2.C3A GCLC
Mean 47.1
Standard deviation 0.68
Values 47 48
[67]
HuH.7 GCLC
Mean 19.4
Standard deviation 7.4
Values 15 28 15
[68]
SNU475 GCLC
Mean 84.8
Standard deviation 9.1
Values 78 91
[69]
THLE GCLC
Mean 14.4
Standard deviation 0.55
Values 15 14
[70]
liver GCLC
Mean 45.3
Standard deviation 20
Values 64 59 37 22
[71]
ref_hepatocyte ABCC6
Mean 20.8
Standard deviation 21
Values 3.8 55 24 18 3.7
[72]
HepG2 ABCC6
Mean 29
Standard deviation 7.1
Values 34 24
[73]
HepG2.C3A ABCC6
Mean 35.2
Standard deviation 6.7
Values 31 40
[74]
HuH.7 ABCC6
Mean 13.3
Standard deviation 1.3
Values 12 15 13
[75]
SNU475 ABCC6
Mean 1.8
Standard deviation 0.75
Values 1.3 2.3
[76]
THLE ABCC6
Mean 0.308
Standard deviation 0.14
Values 0.41 0.21
[77]
liver ABCC6
Mean 85
Standard deviation 28
Values 1.3e+02 77 71 65
[78]
ref_hepatocyte GCLM
Mean 20.7
Standard deviation 17
Values 32 5.2 8.4 12 45
[79]
HepG2 GCLM
Mean 23.3
Standard deviation 15
Values 13 34
[80]
HepG2.C3A GCLM
Mean 12.1
Standard deviation 3.1
Values 14 9.9
[81]
HuH.7 GCLM
Mean 16.1
Standard deviation 2.7
Values 13 19 16
[82]
SNU475 GCLM
Mean 68.3
Standard deviation 0.053
Values 68 68
[83]
THLE GCLM
Mean 21.6
Standard deviation 2.7
Values 20 24
[84]
liver GCLM
Mean 16.4
Standard deviation 8.1
Values 7 14 18 27
[85]
ref_hepatocyte NFE2L2
Mean 15.6
Standard deviation 4.9
Values 11 19 21 18 9.4
[86]
HepG2 NFE2L2
Mean 58.6
Standard deviation 25
Values 76 41
[87]
HepG2.C3A NFE2L2
Mean 99.8
Standard deviation 19
Values 1.1e+02 86
[88]
HuH.7 NFE2L2
Mean 72.7
Standard deviation 3
Values 74 75 69
[89]
SNU475 NFE2L2
Mean 39.6
Standard deviation 2.1
Values 41 38
[90]
THLE NFE2L2
Mean 52.3
Standard deviation 3.2
Values 55 50
[91]
liver NFE2L2
Mean 25
Standard deviation 9.2
Values 15 21 28 36
[92]
ref_hepatocyte KEAP1
Mean 14.9
Standard deviation 4.1
Values 17 15 20 11 11
[93]
HepG2 KEAP1
Mean 38
Standard deviation 2.6
Values 36 40
[94]
HepG2.C3A KEAP1
Mean 31.6
Standard deviation 0.82
Values 32 31
[95]
HuH.7 KEAP1
Mean 25.2
Standard deviation 5.2
Values 30 20 26
[96]
SNU475 KEAP1
Mean 15.5
Standard deviation 1.8
Values 17 14
[97]
THLE KEAP1
Mean 34.5
Standard deviation 4.9
Values 31 38
[98]
liver KEAP1
Mean 30.9
Standard deviation 7.7
Values 29 23 31 41
[99]
ref_hepatocyte ABCC3
Mean 14.4
Standard deviation 9.9
Values 5 9.7 31 14 12
[100]
HepG2 ABCC3
Mean 67.6
Standard deviation 20
Values 54 81
[101]
HepG2.C3A ABCC3
Mean 37.4
Standard deviation 7.2
Values 32 42
[102]
HuH.7 ABCC3
Mean 11.6
Standard deviation 4.6
Values 10 17 7.9
[103]
SNU475 ABCC3
Mean 31.8
Standard deviation 16
Values 21 43
[104]
THLE ABCC3
Mean 23.7
Standard deviation 5.8
Values 28 20
[105]
liver ABCC3
Mean 128
Standard deviation 23
Values 1.3e+02 1.4e+02 93 1.5e+02
[106]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 7.2 8.3 7.5 12 8.5
[107]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 60 47
[108]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[109]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 34 36 37
[110]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 51 52
[111]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[112]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 37 38 24 22
[113]
ref_hepatocyte MAPK8
Mean 7.1
Standard deviation 4.4
Values 15 4.7 3.8 6.5 5.6
[114]
HepG2 MAPK8
Mean 5.76
Standard deviation 1
Values 6.5 5.1
[115]
HepG2.C3A MAPK8
Mean 13.6
Standard deviation 4
Values 17 11
[116]
HuH.7 MAPK8
Mean 5.99
Standard deviation 0.68
Values 5.2 6.2 6.5
[117]
SNU475 MAPK8
Mean 6.98
Standard deviation 0.5
Values 6.6 7.3
[118]
THLE MAPK8
Mean 7.08
Standard deviation 1
Values 6.4 7.8
[119]
liver MAPK8
Mean 7.08
Standard deviation 1
Values 7.6 7.8 7.3 5.6
[120]
ref_hepatocyte GSTP1
Mean 6.16
Standard deviation 5.2
Values 13 9.9 6 0 2.2
[121]
HepG2 GSTP1
Mean 0.872
Standard deviation 0.24
Values 1 0.7
[122]
HepG2.C3A GSTP1
Mean 1.43
Standard deviation 0.0018
Values 1.4 1.4
[123]
HuH.7 GSTP1
Mean 283
Standard deviation 1e+02
Values 3.8e+02 1.8e+02 2.9e+02
[124]
SNU475 GSTP1
Mean 592
Standard deviation 1.2e+02
Values 5.1e+02 6.7e+02
[125]
THLE GSTP1
Mean 140
Standard deviation 16
Values 1.3e+02 1.5e+02
[126]
liver GSTP1
Mean 8.38
Standard deviation 7.4
Values 2.6 2 17 12
[127]
ref_hepatocyte MAPK13
Mean 5.46
Standard deviation 4.5
Values 9.1 0.39 2.7 11 4
[128]
HepG2 MAPK13
Mean 61.1
Standard deviation 22
Values 46 77
[129]
HepG2.C3A MAPK13
Mean 72
Standard deviation 5.6
Values 68 76
[130]
HuH.7 MAPK13
Mean 10.8
Standard deviation 1.6
Values 9.2 12 11
[131]
SNU475 MAPK13
Mean 2.71
Standard deviation 2.1
Values 4.2 1.2
[132]
THLE MAPK13
Mean 8.71
Standard deviation 2.1
Values 7.2 10
[133]
liver MAPK13
Mean 2.36
Standard deviation 1.5
Values 1.8 1.5 4.6 1.5
[134]
ref_hepatocyte ABCG2
Mean 3
Standard deviation 1.8
Values 2.9 4.4 1.5 1.1 5.2
[135]
HepG2 ABCG2
Mean 6.88
Standard deviation 0.34
Values 6.6 7.1
[136]
HepG2.C3A ABCG2
Mean 5.65
Standard deviation 0.97
Values 6.3 5
[137]
HuH.7 ABCG2
Mean 11.9
Standard deviation 1.2
Values 11 11 13
[138]
SNU475 ABCG2
Mean 4.32
Standard deviation 1
Values 5 3.6
[139]
THLE ABCG2
Mean 2.24
Standard deviation 1.1
Values 1.4 3
[140]
liver ABCG2
Mean 5.14
Standard deviation 1.6
Values 5 7.3 3.4 4.8
[141]
ref_hepatocyte ABCC4
Mean 1.25
Standard deviation 1.2
Values 0.52 0.16 0.41 2.7 2.4
[142]
HepG2 ABCC4
Mean 9.57
Standard deviation 0.89
Values 8.9 10
[143]
HepG2.C3A ABCC4
Mean 4.52
Standard deviation 0.047
Values 4.5 4.5
[144]
HuH.7 ABCC4
Mean 20.4
Standard deviation 3.5
Values 16 23 22
[145]
SNU475 ABCC4
Mean 14.9
Standard deviation 1.9
Values 14 16
[146]
THLE ABCC4
Mean 11.8
Standard deviation 2.1
Values 10 13
[147]
liver ABCC4
Mean 2.46
Standard deviation 0.72
Values 3 3.1 2.2 1.6
[148]
ref_hepatocyte MAPK12
Mean 0.743
Standard deviation 0.94
Values 0.21 0.28 0.41 2.4 0.4
[149]
HepG2 MAPK12
Mean 11.6
Standard deviation 3.6
Values 9 14
[150]
HepG2.C3A MAPK12
Mean 8.16
Standard deviation 0.15
Values 8.3 8.1
[151]
HuH.7 MAPK12
Mean 16.9
Standard deviation 6.7
Values 23 9.7 18
[152]
SNU475 MAPK12
Mean 3.82
Standard deviation 1.9
Values 2.5 5.2
[153]
THLE MAPK12
Mean 10.2
Standard deviation 1.3
Values 9.2 11
[154]
liver MAPK12
Mean 0.564
Standard deviation 0.13
Values 0.69 0.43 0.47 0.67
[155]
ref_hepatocyte MAPK11
Mean 0.382
Standard deviation 0.29
Values 0.22 0.64 0.71 0 0.34
[156]
HepG2 MAPK11
Mean 0.749
Standard deviation 0.18
Values 0.88 0.62
[157]
HepG2.C3A MAPK11
Mean 0.621
Standard deviation 0.12
Values 0.71 0.53
[158]
HuH.7 MAPK11
Mean 0.322
Standard deviation 0.15
Values 0.49 0.2 0.28
[159]
SNU475 MAPK11
Mean 0.898
Standard deviation 0.33
Values 0.66 1.1
[160]
THLE MAPK11
Mean 4.01
Standard deviation 0.7
Values 4.5 3.5
[161]
liver MAPK11
Mean 0.609
Standard deviation 0.32
Values 0.75 0.49 0.96 0.23