WP_PHASE_I_BIOTRANSFORMATIONS_NON_P450 Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CES1 Liver carboxylesterase 1 [1] -0.95[2] -7.32[3] -7.73[4] -0.33[5] -7.22[6] -0.82[7]
2 PON1 Serum paraoxonase/arylesterase 1 [8] -5.91[9] -2.80[10] -0.39[11] -8.79[12] -8.18[13] 1.19[14]
3 PON3 Serum paraoxonase/lactonase 3 [15] -1.55[16] -0.98[17] -1.65[18] -5.03[19] -9.42[20] 0.42[21]
4 PON2 Serum paraoxonase/arylesterase 2 [22] 2.20[23] 2.63[24] 2.82[25] 1.64[26] 2.45[27] 0.45[28]
5 LIPA Lysosomal acid lipase/cholesteryl ester hydrolase [29] 1.92[30] 2.28[31] 1.70[32] 1.52[33] 2.88[34] 0.40[35]
6 CES2 Cocaine esterase [36] 1.60[37] 2.53[38] 0.79[39] 1.04[40] 1.63[41] 1.97[42]
7 ESD S-formylglutathione hydrolase [43] 1.49[44] 2.27[45] 3.10[46] 1.49[47] 2.90[48] -0.02[49]
8 CES5A Carboxylesterase 5A [50] -4.57[51] [52] [53] -3.17[54] -5.10[55] -0.14[56]
[1]
ref_hepatocyte CES1
Mean 819
Standard deviation 9e+02
Values 1.5e+02 1.7e+03 1.9e+03 1.5e+02 1.8e+02
[2]
HepG2 CES1
Mean 154
Standard deviation 89
Values 91 2.2e+02
[3]
HepG2.C3A CES1
Mean 1.3
Standard deviation 0.53
Values 0.92 1.7
[4]
HuH.7 CES1
Mean 0.67
Standard deviation 0.32
Values 0.46 1 0.52
[5]
SNU475 CES1
Mean 111
Standard deviation 23
Values 94 1.3e+02
[6]
THLE CES1
Mean 0.535
Standard deviation 0.14
Values 0.63 0.44
[7]
liver CES1
Mean 411
Standard deviation 2.6e+02
Values 1.3e+02 3.2e+02 4.6e+02 7.4e+02
[8]
ref_hepatocyte PON1
Mean 109
Standard deviation 1.5e+02
Values 2.5 3.3e+02 2.1e+02 0.068 2.6
[9]
HepG2 PON1
Mean 0.654
Standard deviation 0.4
Values 0.94 0.37
[10]
HepG2.C3A PON1
Mean 3.94
Standard deviation 0.73
Values 3.4 4.5
[11]
HuH.7 PON1
Mean 14.4
Standard deviation 7.6
Values 10 23 9.6
[12]
SNU475 PON1
Mean 0.0416
Standard deviation 0.013
Values 0.051 0.032
[13]
THLE PON1
Mean 0.0364
Standard deviation 0.0012
Values 0.035 0.037
[14]
liver PON1
Mean 220
Standard deviation 1.9e+02
Values 76 82 4.8e+02 2.4e+02
[15]
ref_hepatocyte PON3
Mean 101
Standard deviation 1.4e+02
Values 6.8 3e+02 1.8e+02 4.1 3.8
[16]
HepG2 PON3
Mean 12.4
Standard deviation 1.5
Values 14 11
[17]
HepG2.C3A PON3
Mean 12.9
Standard deviation 4.1
Values 16 10
[18]
HuH.7 PON3
Mean 5.57
Standard deviation 1.1
Values 6.8 4.8 5.1
[19]
SNU475 PON3
Mean 0.521
Standard deviation 0.15
Values 0.63 0.41
[20]
THLE PON3
Mean 0.0142
Standard deviation 0.005
Values 0.018 0.011
[21]
liver PON3
Mean 120
Standard deviation 85
Values 40 57 2.2e+02 1.6e+02
[22]
ref_hepatocyte PON2
Mean 68.4
Standard deviation 35
Values 18 66 1e+02 55 99
[23]
HepG2 PON2
Mean 114
Standard deviation 33
Values 1.4e+02 90
[24]
HepG2.C3A PON2
Mean 107
Standard deviation 51
Values 1.4e+02 71
[25]
HuH.7 PON2
Mean 84
Standard deviation 18
Values 1e+02 66 85
[26]
SNU475 PON2
Mean 36.1
Standard deviation 8.6
Values 30 42
[27]
THLE PON2
Mean 36.2
Standard deviation 0.65
Values 36 37
[28]
liver PON2
Mean 83.1
Standard deviation 53
Values 37 42 1.5e+02 1.1e+02
[29]
ref_hepatocyte LIPA
Mean 49.8
Standard deviation 49
Values 9.5 31 23 1.3e+02 52
[30]
HepG2 LIPA
Mean 68.3
Standard deviation 18
Values 81 56
[31]
HepG2.C3A LIPA
Mean 61.2
Standard deviation 4.6
Values 58 64
[32]
HuH.7 LIPA
Mean 28.1
Standard deviation 2.4
Values 27 31 27
[33]
SNU475 LIPA
Mean 24.3
Standard deviation 3
Values 22 26
[34]
THLE LIPA
Mean 35.6
Standard deviation 1.9
Values 34 37
[35]
liver LIPA
Mean 58.5
Standard deviation 24
Values 33 79 43 79
[36]
ref_hepatocyte CES2
Mean 49.3
Standard deviation 49
Values 11 1.1e+02 94 14 17
[37]
HepG2 CES2
Mean 54.1
Standard deviation 2.1
Values 56 53
[38]
HepG2.C3A CES2
Mean 71.8
Standard deviation 6.4
Values 67 76
[39]
HuH.7 CES2
Mean 14.9
Standard deviation 3.2
Values 16 11 17
[40]
SNU475 CES2
Mean 17.1
Standard deviation 1.6
Values 16 18
[41]
THLE CES2
Mean 14.8
Standard deviation 0.53
Values 14 15
[42]
liver CES2
Mean 171
Standard deviation 92
Values 95 89 2.4e+02 2.6e+02
[43]
ref_hepatocyte ESD
Mean 46
Standard deviation 28
Values 18 84 68 26 35
[44]
HepG2 ESD
Mean 46.7
Standard deviation 5
Values 50 43
[45]
HepG2.C3A ESD
Mean 56.1
Standard deviation 4
Values 59 53
[46]
HuH.7 ESD
Mean 68.7
Standard deviation 4.6
Values 70 64 72
[47]
SNU475 ESD
Mean 21.9
Standard deviation 6.3
Values 18 26
[48]
THLE ESD
Mean 33.4
Standard deviation 3.2
Values 31 36
[49]
liver ESD
Mean 40.3
Standard deviation 33
Values 12 13 77 60
[50]
ref_hepatocyte CES5A
Mean 0.943
Standard deviation 1.1
Values 0.49 2.4 1.8 0 0
[51]
HepG2 CES5A
Mean 0.0143
Standard deviation 0.02
Values 0 0.029
[52]
HepG2.C3A CES5A
Mean 0
Standard deviation 0
Values 0 0
[53]
HuH.7 CES5A
Mean 0
Standard deviation 0
Values 0 0 0
[54]
SNU475 CES5A
Mean 0.0177
Standard deviation 0.025
Values 0.035 0
[55]
THLE CES5A
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[56]
liver CES5A
Mean 0.763
Standard deviation 0.35
Values 0.41 0.54 0.92 1.2