WP_PDGF_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -0.85[2] | -1.26[3] | -1.02[4] | -1.33[5] | -0.69[6] | -1.36[7] |
2 | CDC42 | Cell division control protein 42 homolog | [8] | -0.73[9] | 0.07[10] | -0.92[11] | -0.64[12] | -1.17[13] | -2.12[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -0.96[16] | -2.67[17] | -3.03[18] | -3.63[19] | -1.55[20] | -1.17[21] |
4 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [22] | -0.30[23] | -0.54[24] | 0.18[25] | -0.09[26] | 0.08[27] | -1.00[28] |
5 | JUN | Transcription factor AP-1 | [29] | -0.40[30] | -1.85[31] | -1.57[32] | -1.81[33] | -1.05[34] | -1.84[35] |
6 | FOS | Proto-oncogene c-Fos | [36] | -5.92[37] | -4.57[38] | -5.22[39] | -6.27[40] | -5.02[41] | -1.34[42] |
7 | STAT3 | Signal transducer and activator of transcription 3 | [43] | 0.64[44] | -0.77[45] | -0.02[46] | 0.14[47] | -0.40[48] | 2.37[49] |
8 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [50] | -0.84[51] | -1.08[52] | -0.49[53] | -0.65[54] | 0.05[55] | -1.23[56] |
9 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [57] | 0.54[58] | 1.06[59] | 1.02[60] | 0.78[61] | 1.60[62] | 1.22[63] |
10 | GRB2 | Growth factor receptor-bound protein 2 | [64] | 1.29[65] | 1.21[66] | 1.35[67] | 0.45[68] | 0.55[69] | 0.26[70] |
11 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [71] | 0.02[72] | -0.81[73] | 0.31[74] | 2.42[75] | 0.35[76] | 0.92[77] |
12 | SHC1 | SHC-transforming protein 1 | [78] | 1.26[79] | 1.56[80] | 1.65[81] | 2.55[82] | 2.22[83] | 0.75[84] |
13 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [85] | 0.03[86] | 0.52[87] | 1.80[88] | -0.29[89] | 0.76[90] | 1.06[91] |
14 | JAK1 | Tyrosine-protein kinase JAK1 | [92] | 0.60[93] | 0.18[94] | 0.37[95] | 0.52[96] | 1.35[97] | 1.50[98] |
15 | HRAS | GTPase HRas | [99] | -0.92[100] | -1.53[101] | -2.31[102] | -1.05[103] | -1.08[104] | -2.69[105] |
16 | MAPK1 | Mitogen-activated protein kinase 1 | [106] | 1.80[107] | 2.03[108] | 1.87[109] | 1.74[110] | 1.58[111] | 1.74[112] |
17 | WASL | Neural Wiskott-Aldrich syndrome protein | [113] | -0.39[114] | 0.77[115] | 1.18[116] | 1.00[117] | 0.34[118] | 1.10[119] |
18 | VAV2 | Guanine nucleotide exchange factor VAV2 | [120] | 1.39[121] | 1.73[122] | 1.23[123] | -0.64[124] | -0.03[125] | 0.48[126] |
19 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [127] | -0.38[128] | -0.17[129] | 0.93[130] | 1.96[131] | 1.65[132] | 2.97[133] |
20 | ARFIP2 | Arfaptin-2 | [134] | 1.25[135] | 1.41[136] | 1.31[137] | 0.34[138] | 0.11[139] | 0.45[140] |
21 | MAPK8 | Mitogen-activated protein kinase 8 | [141] | -1.35[142] | 0.15[143] | -0.97[144] | -1.01[145] | -0.96[146] | -0.55[147] |
22 | SOS1 | Son of sevenless homolog 1 | [148] | -0.01[149] | 1.61[150] | 1.13[151] | 0.74[152] | 0.16[153] | 0.50[154] |
23 | ELK1 | ETS domain-containing protein Elk-1 | [155] | -0.22[156] | -2.27[157] | 0.16[158] | 0.17[159] | 0.94[160] | -0.20[161] |
24 | SRF | Serum response factor | [162] | 1.55[163] | 1.21[164] | 0.49[165] | 1.43[166] | 0.71[167] | -0.82[168] |
25 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [169] | 0.76[170] | 0.53[171] | 0.33[172] | -0.35[173] | 0.75[174] | 0.42[175] |
26 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [176] | 0.80[177] | 1.51[178] | 0.73[179] | 1.10[180] | 0.69[181] | 1.03[182] |
27 | MAPK3 | Mitogen-activated protein kinase 3 | [183] | 1.94[184] | 2.08[185] | 2.13[186] | 0.32[187] | 0.53[188] | -1.07[189] |
28 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [190] | 0.99[191] | 2.30[192] | 2.28[193] | 0.54[194] | 1.55[195] | 1.48[196] |
29 | SRC | Proto-oncogene tyrosine-protein kinase Src | [197] | 3.12[198] | 3.19[199] | 2.20[200] | 2.29[201] | 1.66[202] | -0.88[203] |
30 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.58[204] | 3.29[205] | 2.63[206] | 2.72[207] | 2.40[208] | 0.31[209] | |
31 | RASA1 | Ras GTPase-activating protein 1 | [210] | 0.47[211] | 1.47[212] | 1.58[213] | 1.81[214] | 1.05[215] | 1.18[216] |
32 | PAK1 | Serine/threonine-protein kinase PAK 1 | [217] | 0.08[218] | -0.59[219] | 1.83[220] | -1.96[221] | 2.01[222] | 0.23[223] |
33 | PDGFA | Platelet-derived growth factor subunit A | [224] | -0.91[225] | -0.61[226] | 1.48[227] | -0.45[228] | -1.17[229] | -0.78[230] |
34 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [231] | 2.74[232] | 2.54[233] | 2.28[234] | 2.22[235] | 1.29[236] | 2.77[237] |
35 | PDGFB | Platelet-derived growth factor subunit B | [238] | 3.15[239] | 3.10[240] | 0.30[241] | -0.04[242] | -0.28[243] | 0.34[244] |
36 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [245] | -4.61[246] | -1.85[247] | -7.02[248] | -1.47[249] | 0.77[250] | 3.31[251] |
37 | PDGFRB | Platelet-derived growth factor receptor beta | [252] | 1.39[253] | 1.88[254] | -0.57[255] | 1.75[256] | 2.50[257] | 3.38[258] |
38 | VAV1 | Proto-oncogene vav | [259] | -8.41[260] | -3.49[261] | -5.19[262] | -6.19[263] | -7.27[264] | 1.15[265] |
39 | PLA2G4A | Cytosolic phospholipase A2 | [266] | 0.36[267] | -2.11[268] | 6.01[269] | 3.40[270] | 7.35[271] | 4.32[272] |
40 | MT-CO2 | Cytochrome c oxidase subunit 2 | [273] | [274] | [275] | [276] | [277] | [278] | [279] |