WP_PDGFRBETA_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | JUN | Transcription factor AP-1 | [1] | -0.80[2] | -2.15[3] | -2.02[4] | -2.51[5] | -1.51[6] | -2.61[7] |
2 | FOS | Proto-oncogene c-Fos | [8] | -6.32[9] | -4.86[10] | -5.67[11] | -6.97[12] | -5.48[13] | -2.11[14] |
3 | STAT3 | Signal transducer and activator of transcription 3 | [15] | 0.24[16] | -1.06[17] | -0.47[18] | -0.56[19] | -0.86[20] | 1.60[21] |
4 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [22] | -1.24[23] | -1.37[24] | -0.94[25] | -1.35[26] | -0.41[27] | -1.99[28] |
5 | GRB2 | Growth factor receptor-bound protein 2 | [29] | 0.89[30] | 0.92[31] | 0.90[32] | -0.25[33] | 0.09[34] | -0.50[35] |
6 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [36] | -0.38[37] | -1.10[38] | -0.14[39] | 1.73[40] | -0.11[41] | 0.15[42] |
7 | SHC1 | SHC-transforming protein 1 | [43] | 0.85[44] | 1.27[45] | 1.20[46] | 1.85[47] | 1.76[48] | -0.02[49] |
8 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [50] | -0.37[51] | 0.23[52] | 1.35[53] | -0.99[54] | 0.30[55] | 0.29[56] |
9 | STAT6 | Signal transducer and activator of transcription 6 | [57] | 0.04[58] | 0.48[59] | -0.75[60] | 0.04[61] | 0.37[62] | -0.10[63] |
10 | JAK1 | Tyrosine-protein kinase JAK1 | [64] | 0.20[65] | -0.11[66] | -0.08[67] | -0.18[68] | 0.90[69] | 0.73[70] |
11 | HRAS | GTPase HRas | [71] | -1.32[72] | -1.83[73] | -2.76[74] | -1.75[75] | -1.54[76] | -3.46[77] |
12 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [78] | -0.78[79] | -0.47[80] | 0.48[81] | 1.26[82] | 1.19[83] | 2.20[84] |
13 | MAPK8 | Mitogen-activated protein kinase 8 | [85] | -1.75[86] | -0.15[87] | -1.42[88] | -1.71[89] | -1.42[90] | -1.31[91] |
14 | SOS1 | Son of sevenless homolog 1 | [92] | -0.41[93] | 1.32[94] | 0.68[95] | 0.04[96] | -0.30[97] | -0.26[98] |
15 | ELK1 | ETS domain-containing protein Elk-1 | [99] | -0.62[100] | -2.56[101] | -0.29[102] | -0.53[103] | 0.49[104] | -0.97[105] |
16 | SRF | Serum response factor | [106] | 1.15[107] | 0.91[108] | 0.04[109] | 0.74[110] | 0.25[111] | -1.59[112] |
17 | EIF2AK2 | Interferon-induced, double-stranded RNA-activated protein kinase | [113] | -0.63[114] | -0.47[115] | -2.59[116] | 0.21[117] | 0.15[118] | -0.01[119] |
18 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [120] | 0.40[121] | 1.22[122] | 0.28[123] | 0.40[124] | 0.23[125] | 0.26[126] |
19 | MAPK3 | Mitogen-activated protein kinase 3 | [127] | 1.54[128] | 1.78[129] | 1.68[130] | -0.38[131] | 0.07[132] | -1.84[133] |
20 | STAT5B | Signal transducer and activator of transcription 5B | [134] | 1.05[135] | 0.87[136] | 1.43[137] | 0.75[138] | 0.32[139] | 0.82[140] |
21 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.18[141] | 3.00[142] | 2.18[143] | 2.02[144] | 1.94[145] | -0.46[146] | |
22 | RASA1 | Ras GTPase-activating protein 1 | [147] | 0.07[148] | 1.18[149] | 1.13[150] | 1.11[151] | 0.60[152] | 0.41[153] |
23 | PRKCA | Protein kinase C alpha type | [154] | 2.53[155] | 2.76[156] | 2.98[157] | 1.35[158] | 2.14[159] | 1.12[160] |
24 | STAT5A | Signal transducer and activator of transcription 5A | [161] | -2.26[162] | -0.89[163] | -1.96[164] | -1.65[165] | -0.46[166] | -0.57[167] |
25 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.69[168] | 1.14[169] | 1.19[170] | 0.33[171] | 0.96[172] | 1.11[173] | |
26 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [174] | 2.34[175] | 2.25[176] | 1.83[177] | 1.52[178] | 0.83[179] | 2.00[180] |
27 | JAK2 | Tyrosine-protein kinase JAK2 | [181] | -0.08[182] | 0.11[183] | -0.48[184] | -0.04[185] | 0.98[186] | 1.90[187] |
28 | PDGFRB | Platelet-derived growth factor receptor beta | [188] | 0.99[189] | 1.58[190] | -1.02[191] | 1.05[192] | 2.04[193] | 2.61[194] |
29 | PRKCB | Protein kinase C beta type | [195] | -7.12[196] | -5.73[197] | [198] | 1.68[199] | -3.20[200] | 2.73[201] |