WP_PATHWAYS_OF_NUCLEIC_ACID_METABOLISM_AND_INNATE_IMMUNE_SENSING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 ADAR Double-stranded RNA-specific adenosine deaminase [1] 0.37[2] 0.29[3] 1.72[4] 1.68[5] 1.35[6] 1.41[7]
2 RNASET2 Ribonuclease T2 [8] 1.11[9] 1.05[10] -3.71[11] -3.28[12] -4.52[13] -2.06[14]
3 OAS1 2'-5'-oligoadenylate synthase 1 [15] -2.01[16] -4.54[17] -10.40[18] -3.85[19] -4.94[20] -1.28[21]
4 IRF3 Interferon regulatory factor 3 [22] -1.08[23] -0.56[24] 0.11[25] -0.75[26] -0.79[27] -2.04[28]
5 RNASEH2C Ribonuclease H2 subunit C [29] -1.47[30] -1.06[31] -2.03[32] -1.53[33] -0.12[34] -0.61[35]
6 RNASEH2A Ribonuclease H2 subunit A [36] -0.99[37] -0.66[38] 0.07[39] -1.35[40] -0.22[41] -3.58[42]
7 IFIH1 Interferon-induced helicase C domain-containing protein 1 [43] -3.35[44] -2.91[45] -7.08[46] -2.33[47] -1.73[48] -0.60[49]
8 RNASEH2B Ribonuclease H2 subunit B [50] -1.46[51] -0.42[52] -0.92[53] -0.65[54] -0.37[55] -1.70[56]
9 DDX58 Probable ATP-dependent RNA helicase DDX58 [57] -2.08[58] -1.74[59] -2.63[60] -1.89[61] -0.96[62] 0.26[63]
10 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [64] 0.10[65] -0.23[66] -1.51[67] 0.50[68] 0.41[69] 1.03[70]
11 TREX1 Three-prime repair exonuclease 1 [71] -4.93[72] -3.29[73] -2.40[74] -2.83[75] -0.03[76] -1.68[77]
12 MAVS Mitochondrial antiviral-signaling protein [78] 2.90[79] 2.86[80] 2.41[81] 2.63[82] 2.59[83] 2.49[84]
13 RNASEL 2-5A-dependent ribonuclease [85] -4.04[86] -5.81[87] -10.21[88] 1.14[89] 1.12[90] 0.77[91]
14 IFNB1 Interferon beta [92] [93] [94] [95] [96] [97] [98]
15 STING1 [99] [100] [101] [102] [103] [104] [105]
16 CGAS [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte ADAR
Mean 13.5
Standard deviation 3.3
Values 18 16 11 12 10
[2]
HepG2 ADAR
Mean 100
Standard deviation 9.1
Values 1.1e+02 94
[3]
HepG2.C3A ADAR
Mean 65.9
Standard deviation 2.9
Values 64 68
[4]
HuH.7 ADAR
Mean 178
Standard deviation 35
Values 1.6e+02 1.6e+02 2.2e+02
[5]
SNU475 ADAR
Mean 170
Standard deviation 30
Values 1.5e+02 1.9e+02
[6]
THLE ADAR
Mean 118
Standard deviation 22
Values 1e+02 1.3e+02
[7]
liver ADAR
Mean 92.2
Standard deviation 6
Values 84 93 99 92
[8]
ref_hepatocyte RNASET2
Mean 12.4
Standard deviation 8.7
Values 4.6 20 8.2 23 5.5
[9]
HepG2 RNASET2
Mean 154
Standard deviation 1.2e+02
Values 66 2.4e+02
[10]
HepG2.C3A RNASET2
Mean 103
Standard deviation 36
Values 77 1.3e+02
[11]
HuH.7 RNASET2
Mean 3.78
Standard deviation 0.37
Values 4.1 3.8 3.4
[12]
SNU475 RNASET2
Mean 5
Standard deviation 0.095
Values 5.1 4.9
[13]
THLE RNASET2
Mean 1.84
Standard deviation 0.26
Values 1.7 2
[14]
liver RNASET2
Mean 7.61
Standard deviation 2.1
Values 5.4 10 8 6.7
[15]
ref_hepatocyte OAS1
Mean 11.6
Standard deviation 7.3
Values 8.4 15 15 0.48 19
[16]
HepG2 OAS1
Mean 16.6
Standard deviation 9.7
Values 9.8 23
[17]
HepG2.C3A OAS1
Mean 2
Standard deviation 1.1
Values 2.8 1.2
[18]
HuH.7 OAS1
Mean 0.0343
Standard deviation 0.028
Values 0.066 0.013 0.025
[19]
SNU475 OAS1
Mean 3.17
Standard deviation 0.99
Values 2.5 3.9
[20]
THLE OAS1
Mean 1.3
Standard deviation 0.34
Values 1.5 1.1
[21]
liver OAS1
Mean 12.3
Standard deviation 6.7
Values 5.3 7.9 17 19
[22]
ref_hepatocyte IRF3
Mean 10
Standard deviation 4.1
Values 13 10 15 7.1 4.7
[23]
HepG2 IRF3
Mean 27.2
Standard deviation 6.6
Values 23 32
[24]
HepG2.C3A IRF3
Mean 27.3
Standard deviation 1.4
Values 26 28
[25]
HuH.7 IRF3
Mean 43.3
Standard deviation 14
Values 54 28 47
[26]
SNU475 IRF3
Mean 23.5
Standard deviation 4.3
Values 27 20
[27]
THLE IRF3
Mean 19.9
Standard deviation 0.46
Values 20 20
[28]
liver IRF3
Mean 6.27
Standard deviation 2.8
Values 4 3.7 8.8 8.7
[29]
ref_hepatocyte RNASEH2C
Mean 6.79
Standard deviation 2.9
Values 3.4 7.5 11 7.1 5
[30]
HepG2 RNASEH2C
Mean 14.1
Standard deviation 1.5
Values 15 13
[31]
HepG2.C3A RNASEH2C
Mean 13
Standard deviation 3.4
Values 15 11
[32]
HuH.7 RNASEH2C
Mean 6.65
Standard deviation 2.6
Values 9.2 3.9 6.9
[33]
SNU475 RNASEH2C
Mean 9.25
Standard deviation 0.2
Values 9.1 9.4
[34]
THLE RNASEH2C
Mean 21.3
Standard deviation 2
Values 20 23
[35]
liver RNASEH2C
Mean 11.4
Standard deviation 9.3
Values 3.6 4.3 23 15
[36]
ref_hepatocyte RNASEH2A
Mean 6.22
Standard deviation 2.3
Values 7 2.9 5.6 9.2 6.3
[37]
HepG2 RNASEH2A
Mean 18
Standard deviation 2.3
Values 16 20
[38]
HepG2.C3A RNASEH2A
Mean 15.8
Standard deviation 6.1
Values 20 11
[39]
HuH.7 RNASEH2A
Mean 26.1
Standard deviation 15
Values 38 9.8 31
[40]
SNU475 RNASEH2A
Mean 9.58
Standard deviation 1.2
Values 10 8.7
[41]
THLE RNASEH2A
Mean 18.3
Standard deviation 3.7
Values 16 21
[42]
liver RNASEH2A
Mean 1.34
Standard deviation 0.99
Values 0.5 1 1.1 2.8
[43]
ref_hepatocyte IFIH1
Mean 4.45
Standard deviation 2
Values 2.9 4.6 2.5 7.6 4.6
[44]
HepG2 IFIH1
Mean 2.51
Standard deviation 0.64
Values 3 2.1
[45]
HepG2.C3A IFIH1
Mean 2.38
Standard deviation 0.31
Values 2.2 2.6
[46]
HuH.7 IFIH1
Mean 0.132
Standard deviation 0.058
Values 0.066 0.17 0.16
[47]
SNU475 IFIH1
Mean 3.48
Standard deviation 0.87
Values 2.9 4.1
[48]
THLE IFIH1
Mean 4.58
Standard deviation 1.1
Values 5.3 3.8
[49]
liver IFIH1
Mean 7.55
Standard deviation 1.8
Values 6.7 7.5 10 5.9
[50]
ref_hepatocyte RNASEH2B
Mean 3.69
Standard deviation 1.9
Values 0.8 5.6 4.8 4.2 3
[51]
HepG2 RNASEH2B
Mean 7.7
Standard deviation 1.8
Values 9 6.4
[52]
HepG2.C3A RNASEH2B
Mean 11.1
Standard deviation 4.3
Values 14 8
[53]
HuH.7 RNASEH2B
Mean 7.84
Standard deviation 1.4
Values 9.4 6.9 7.2
[54]
SNU475 RNASEH2B
Mean 9.25
Standard deviation 0.24
Values 9.1 9.4
[55]
THLE RNASEH2B
Mean 9.8
Standard deviation 1.5
Values 8.8 11
[56]
liver RNASEH2B
Mean 2.92
Standard deviation 0.93
Values 2 2.7 2.8 4.2
[57]
ref_hepatocyte DDX58
Mean 3.45
Standard deviation 3
Values 5.8 1.7 1.2 1.2 7.5
[58]
HepG2 DDX58
Mean 4.68
Standard deviation 1.6
Values 5.8 3.5
[59]
HepG2.C3A DDX58
Mean 4.13
Standard deviation 1.1
Values 4.9 3.4
[60]
HuH.7 DDX58
Mean 2.24
Standard deviation 0.73
Values 1.9 3.1 1.8
[61]
SNU475 DDX58
Mean 3.67
Standard deviation 0.0023
Values 3.7 3.7
[62]
THLE DDX58
Mean 6.07
Standard deviation 0.0034
Values 6.1 6.1
[63]
liver DDX58
Mean 10.6
Standard deviation 2.3
Values 7.7 12 13 10
[64]
ref_hepatocyte SAMHD1
Mean 3.4
Standard deviation 2.2
Values 1.7 4 1.5 6.8 3.1
[65]
HepG2 SAMHD1
Mean 21
Standard deviation 8.3
Values 27 15
[66]
HepG2.C3A SAMHD1
Mean 11.6
Standard deviation 4.4
Values 15 8.5
[67]
HuH.7 SAMHD1
Mean 4.79
Standard deviation 1.3
Values 3.6 4.6 6.2
[68]
SNU475 SAMHD1
Mean 19
Standard deviation 3
Values 17 21
[69]
THLE SAMHD1
Mean 15.5
Standard deviation 1.4
Values 15 17
[70]
liver SAMHD1
Mean 17.8
Standard deviation 6.3
Values 19 26 11 16
[71]
ref_hepatocyte TREX1
Mean 2.46
Standard deviation 2.5
Values 6.1 2.6 3.3 0 0.24
[72]
HepG2 TREX1
Mean 0.463
Standard deviation 0.066
Values 0.42 0.51
[73]
HepG2.C3A TREX1
Mean 1.01
Standard deviation 0.32
Values 0.78 1.2
[74]
HuH.7 TREX1
Mean 1.86
Standard deviation 0.62
Values 2.5 1.2 1.9
[75]
SNU475 TREX1
Mean 1.36
Standard deviation 0.25
Values 1.5 1.2
[76]
THLE TREX1
Mean 8.25
Standard deviation 0.64
Values 8.7 7.8
[77]
liver TREX1
Mean 1.98
Standard deviation 1.2
Values 1.1 0.88 2.6 3.3
[78]
ref_hepatocyte MAVS
Mean 2.3
Standard deviation 1.1
Values 1.7 1.9 1.8 4.3 1.9
[79]
HepG2 MAVS
Mean 98.5
Standard deviation 2.4
Values 1e+02 97
[80]
HepG2.C3A MAVS
Mean 66.9
Standard deviation 0.12
Values 67 67
[81]
HuH.7 MAVS
Mean 48.8
Standard deviation 7.5
Values 41 50 56
[82]
SNU475 MAVS
Mean 56.1
Standard deviation 14
Values 46 66
[83]
THLE MAVS
Mean 47.4
Standard deviation 9.4
Values 41 54
[84]
liver MAVS
Mean 33.3
Standard deviation 8
Values 44 34 26 29
[85]
ref_hepatocyte RNASEL
Mean 0.632
Standard deviation 0.44
Values 1 0.83 0.36 0 0.93
[86]
HepG2 RNASEL
Mean 0.221
Standard deviation 0.15
Values 0.12 0.33
[87]
HepG2.C3A RNASEL
Mean 0.0452
Standard deviation 0.018
Values 0.032 0.058
[88]
HuH.7 RNASEL
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[89]
SNU475 RNASEL
Mean 5.47
Standard deviation 2.5
Values 3.7 7.2
[90]
THLE RNASEL
Mean 4.71
Standard deviation 0.85
Values 4.1 5.3
[91]
liver RNASEL
Mean 2.78
Standard deviation 0.18
Values 2.7 2.9 2.6 3
[92]
ref_hepatocyte IFNB1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[93]
HepG2 IFNB1
Missing
[94]
HepG2.C3A IFNB1
Missing
[95]
HuH.7 IFNB1
Missing
[96]
SNU475 IFNB1
Missing
[97]
THLE IFNB1
Missing
[98]
liver IFNB1
Missing
[99]
ref_hepatocyte STING1
Missing
[100]
HepG2 STING1
Missing
[101]
HepG2.C3A STING1
Missing
[102]
HuH.7 STING1
Missing
[103]
SNU475 STING1
Missing
[104]
THLE STING1
Missing
[105]
liver STING1
Missing
[106]
ref_hepatocyte CGAS
Missing
[107]
HepG2 CGAS
Missing
[108]
HepG2.C3A CGAS
Missing
[109]
HuH.7 CGAS
Missing
[110]
SNU475 CGAS
Missing
[111]
THLE CGAS
Missing
[112]
liver CGAS
Missing