WP_PANCREATIC_ADENOCARCINOMA_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | PEBP1 | Phosphatidylethanolamine-binding protein 1 | [1] | -1.71[2] | -1.26[3] | -2.20[4] | -4.28[5] | -3.77[6] | -0.48[7] |
2 | RHOA | Transforming protein RhoA | [8] | -0.81[9] | -1.21[10] | -0.91[11] | -0.71[12] | -0.32[13] | -1.08[14] |
3 | CDC42 | Cell division control protein 42 homolog | [15] | -0.69[16] | 0.12[17] | -0.81[18] | -0.02[19] | -0.81[20] | -1.84[21] |
4 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [22] | -4.04[23] | -4.70[24] | -3.41[25] | -3.50[26] | -2.59[27] | -1.92[28] |
5 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [29] | -2.33[30] | -3.32[31] | -3.05[32] | -3.47[33] | -1.81[34] | -2.77[35] |
6 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [36] | -0.26[37] | -0.49[38] | 0.29[39] | 0.53[40] | 0.44[41] | -0.72[42] |
7 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [43] | -9.79[44] | [45] | -8.08[46] | -7.32[47] | -7.32[48] | -1.48[49] |
8 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [50] | 0.97[51] | -0.32[52] | -2.93[53] | -1.47[54] | 1.01[55] | -1.59[56] |
9 | AKT1 | RAC-alpha serine/threonine-protein kinase | [57] | 0.22[58] | 0.08[59] | -0.92[60] | 0.46[61] | 0.42[62] | 0.00[63] |
10 | RALB | Ras-related protein Ral-B | [64] | -1.09[65] | -1.03[66] | -1.78[67] | -0.82[68] | -1.22[69] | -1.74[70] |
11 | STAT3 | Signal transducer and activator of transcription 3 | [71] | 0.69[72] | -0.72[73] | 0.10[74] | 0.75[75] | -0.04[76] | 2.65[77] |
12 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [78] | -0.79[79] | -1.03[80] | -0.37[81] | -0.03[82] | 0.41[83] | -0.95[84] |
13 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [85] | 0.19[86] | -0.04[87] | 0.91[88] | -0.33[89] | 0.09[90] | -1.46[91] |
14 | BCL2L1 | Bcl-2-like protein 1 | [92] | 2.27[93] | 1.75[94] | 2.79[95] | -0.10[96] | 0.22[97] | -0.57[98] |
15 | BAX | Apoptosis regulator BAX | [99] | 0.46[100] | -0.24[101] | -0.62[102] | -1.09[103] | -0.77[104] | -3.71[105] |
16 | CCND1 | G1/S-specific cyclin-D1 | [106] | 3.19[107] | 0.78[108] | 1.69[109] | 2.39[110] | 0.85[111] | 1.30[112] |
17 | IKBKG | NF-kappa-B essential modulator | [113] | -0.75[114] | -0.51[115] | -2.68[116] | -0.34[117] | -1.62[118] | -0.36[119] |
18 | RALA | Ras-related protein Ral-A | [120] | -1.06[121] | -0.22[122] | 0.03[123] | -0.06[124] | 0.16[125] | -1.49[126] |
19 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [127] | 0.06[128] | -0.76[129] | 0.42[130] | 3.04[131] | 0.71[132] | 1.20[133] |
20 | CDK4 | Cyclin-dependent kinase 4 | [134] | 1.47[135] | 2.14[136] | 1.85[137] | 0.69[138] | 1.28[139] | -0.59[140] |
21 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [141] | [142] | [143] | [144] | [145] | [146] | [147] |
22 | BAD | Bcl2-associated agonist of cell death | [148] | -1.54[149] | -1.31[150] | -2.18[151] | -0.55[152] | -0.22[153] | -1.18[154] |
23 | RELA | Transcription factor p65 | [155] | 0.27[156] | -0.14[157] | 0.07[158] | 0.46[159] | 0.30[160] | -0.64[161] |
24 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [162] | 0.07[163] | 0.57[164] | 1.92[165] | 0.33[166] | 1.12[167] | 1.34[168] |
25 | VEGFA | Vascular endothelial growth factor A | [169] | 1.35[170] | 2.78[171] | 1.46[172] | 0.95[173] | 1.59[174] | 1.03[175] |
26 | DUSP6 | Dual specificity protein phosphatase 6 | [176] | -0.35[177] | 1.82[178] | 1.18[179] | -3.40[180] | 0.32[181] | 0.50[182] |
27 | JAK1 | Tyrosine-protein kinase JAK1 | [183] | 0.65[184] | 0.23[185] | 0.49[186] | 1.14[187] | 1.72[188] | 1.78[189] |
28 | RALBP1 | RalA-binding protein 1 | [190] | 0.03[191] | 0.55[192] | 1.64[193] | 1.33[194] | 0.67[195] | 0.22[196] |
29 | ARAF | Serine/threonine-protein kinase A-Raf | [197] | -0.32[198] | -0.53[199] | -0.18[200] | 0.42[201] | 0.38[202] | 1.12[203] |
30 | TGFBR2 | TGF-beta receptor type-2 | [204] | 2.95[205] | 2.51[206] | 2.25[207] | 1.58[208] | 3.23[209] | 1.75[210] |
31 | PAK2 | Serine/threonine-protein kinase PAK 2 | [211] | 1.58[212] | 1.42[213] | 1.79[214] | 1.27[215] | 1.74[216] | 1.61[217] |
32 | MAPK1 | Mitogen-activated protein kinase 1 | [218] | 1.84[219] | 2.08[220] | 1.98[221] | 2.36[222] | 1.94[223] | 2.02[224] |
33 | AKT2 | RAC-beta serine/threonine-protein kinase | [225] | 1.09[226] | 1.46[227] | 1.67[228] | 1.37[229] | 1.09[230] | 1.38[231] |
34 | KRAS | GTPase KRas | [232] | -0.38[233] | -0.31[234] | 1.37[235] | 1.31[236] | 0.90[237] | 0.92[238] |
35 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [239] | -0.34[240] | -0.13[241] | 1.04[242] | 2.58[243] | 2.01[244] | 3.25[245] |
36 | MAPK8 | Mitogen-activated protein kinase 8 | [246] | -1.31[247] | 0.19[248] | -0.86[249] | -0.39[250] | -0.60[251] | -0.27[252] |
37 | DDB2 | DNA damage-binding protein 2 | [253] | 1.21[254] | 0.83[255] | -0.40[256] | -1.10[257] | -0.58[258] | -1.28[259] |
38 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [260] | 2.51[261] | 1.42[262] | 2.67[263] | 1.77[264] | 1.30[265] | 0.40[266] |
39 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [267] | 0.80[268] | 0.58[269] | 0.44[270] | 0.27[271] | 1.11[272] | 0.70[273] |
40 | BAK1 | Bcl-2 homologous antagonist/killer | [274] | 1.03[275] | 0.66[276] | 0.71[277] | 1.70[278] | 1.11[279] | -1.54[280] |
41 | SMAD3 | Mothers against decapentaplegic homolog 3 | [281] | 2.06[282] | 1.55[283] | 1.86[284] | 2.31[285] | 3.12[286] | 0.46[287] |
42 | EGFR | Epidermal growth factor receptor | [288] | -0.56[289] | -0.84[290] | 2.12[291] | 0.95[292] | 1.50[293] | 2.90[294] |
43 | TP53 | Cellular tumor antigen p53 | [295] | 1.77[296] | 1.43[297] | 2.27[298] | 1.81[299] | 1.40[300] | 0.20[301] |
44 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [302] | 2.01[303] | 2.33[304] | 3.01[305] | 1.22[306] | 1.71[307] | -0.05[308] |
45 | RAD51 | DNA repair protein RAD51 homolog 1 | [309] | -0.12[310] | -0.21[311] | -0.03[312] | 0.33[313] | 0.23[314] | -3.70[315] |
46 | TGFBR1 | TGF-beta receptor type-1 | [316] | 0.46[317] | 0.78[318] | 0.36[319] | 0.86[320] | 1.90[321] | 1.58[322] |
47 | PAK4 | Serine/threonine-protein kinase PAK 4 | [323] | 1.03[324] | 1.16[325] | 1.94[326] | 1.54[327] | 1.19[328] | -0.09[329] |
48 | MAPK9 | Mitogen-activated protein kinase 9 | [330] | 1.36[331] | 1.68[332] | 1.82[333] | 2.23[334] | 1.62[335] | 0.75[336] |
49 | RIPK4 | Receptor-interacting serine/threonine-protein kinase 4 | [337] | 0.33[338] | 0.04[339] | 0.35[340] | -0.07[341] | -1.62[342] | 1.09[343] |
50 | MAPK3 | Mitogen-activated protein kinase 3 | [344] | 1.98[345] | 2.12[346] | 2.24[347] | 0.94[348] | 0.89[349] | -0.80[350] |
51 | CDK6 | Cyclin-dependent kinase 6 | [351] | 2.18[352] | 2.97[353] | 1.46[354] | 1.43[355] | 2.16[356] | 2.32[357] |
52 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [358] | 1.04[359] | 2.35[360] | 2.39[361] | 1.16[362] | 1.91[363] | 1.76[364] |
53 | RAC2 | Ras-related C3 botulinum toxin substrate 2 | [365] | -1.58[366] | -7.47[367] | -8.00[368] | -0.88[369] | 2.86[370] | -0.99[371] |
54 | PRKCD | Protein kinase C delta type | [372] | 1.23[373] | 1.58[374] | 1.13[375] | 0.01[376] | 1.10[377] | -0.82[378] |
55 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [379] | 0.65[380] | 0.81[381] | 0.99[382] | 0.77[383] | 0.80[384] | 1.43[385] |
56 | MTOR | Serine/threonine-protein kinase mTOR | [386] | 2.67[387] | 3.78[388] | 3.42[389] | 3.20[390] | 3.21[391] | 3.69[392] |
57 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [393] | [394] | [395] | [396] | [397] | [398] | [399] |
58 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1.35[400] | 1.95[401] | 2.19[402] | 1.56[403] | 1.65[404] | 1.40[405] | |
59 | SMAD4 | Mothers against decapentaplegic homolog 4 | [406] | 1.53[407] | 2.25[408] | 2.30[409] | 2.42[410] | 2.72[411] | 3.04[412] |
60 | TGFB2 | Transforming growth factor beta-2 | [413] | -4.16[414] | -6.59[415] | -0.71[416] | 3.97[417] | 2.50[418] | -2.52[419] |
61 | RB1 | Retinoblastoma-associated protein | [420] | 1.35[421] | 1.95[422] | 2.59[423] | 2.79[424] | 3.05[425] | 1.72[426] |
62 | RAC3 | Ras-related C3 botulinum toxin substrate 3 | [427] | -0.23[428] | 2.92[429] | 1.83[430] | 0.62[431] | -0.93[432] | -3.23[433] |
63 | CASP9 | Caspase-9 | [434] | 0.29[435] | 1.34[436] | 0.54[437] | 0.76[438] | 0.01[439] | -0.29[440] |
64 | SMAD2 | Mothers against decapentaplegic homolog 2 | [441] | 2.15[442] | 2.51[443] | 2.08[444] | 2.89[445] | 3.02[446] | 2.81[447] |
65 | E2F1 | Transcription factor E2F1 | [448] | 2.08[449] | 2.03[450] | 2.24[451] | 2.38[452] | 2.75[453] | -3.37[454] |
66 | PAK1 | Serine/threonine-protein kinase PAK 1 | [455] | 0.12[456] | -0.54[457] | 1.94[458] | -1.34[459] | 2.37[460] | 0.51[461] |
67 | TGFB1 | Transforming growth factor beta-1 | [462] | 3.61[463] | 2.66[464] | -0.01[465] | 4.35[466] | 3.51[467] | -0.98[468] |
68 | E2F3 | Transcription factor E2F3 | [469] | 1.85[470] | 1.77[471] | 1.11[472] | 3.14[473] | 2.52[474] | 0.08[475] |
69 | POLK | DNA polymerase kappa | [476] | -0.71[477] | 0.86[478] | 1.19[479] | 2.34[480] | 2.01[481] | 2.34[482] |
70 | PLD1 | Phospholipase D1 | [483] | 2.55[484] | 3.36[485] | 3.93[486] | 1.56[487] | 2.08[488] | 2.30[489] |
71 | TGFA | Protransforming growth factor alpha | [490] | 1.93[491] | 3.08[492] | -7.89[493] | -0.45[494] | -1.74[495] | -0.15[496] |
72 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.25[497] | 1.49[498] | 1.75[499] | 1.64[500] | 1.78[501] | 2.16[502] | |
73 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 2.02[503] | 3.20[504] | -0.53[505] | 0.79[506] | 1.49[507] | 0.54[508] | |
74 | TGFB3 | Transforming growth factor beta-3 | [509] | -1.41[510] | -2.19[511] | -2.35[512] | 0.68[513] | -0.45[514] | 0.70[515] |
75 | BRAF | Serine/threonine-protein kinase B-raf | [516] | 0.38[517] | 0.20[518] | 2.32[519] | 1.25[520] | 0.88[521] | 2.10[522] |
76 | RALGDS | Ral guanine nucleotide dissociation stimulator | [523] | 3.18[524] | 2.93[525] | 1.80[526] | 3.29[527] | 2.79[528] | 1.52[529] |
77 | TIAM1 | T-lymphoma invasion and metastasis-inducing protein 1 | [530] | -4.57[531] | -1.80[532] | -6.91[533] | -0.85[534] | 1.13[535] | 3.59[536] |
78 | ARHGEF6 | Rho guanine nucleotide exchange factor 6 | [537] | -5.88[538] | -3.54[539] | -4.08[540] | 3.74[541] | 2.20[542] | 3.38[543] |
79 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [544] | 1.86[545] | 1.96[546] | 2.88[547] | 3.68[548] | 2.63[549] | 2.92[550] |
80 | AKT3 | RAC-gamma serine/threonine-protein kinase | [551] | -1.71[552] | -4.17[553] | -3.41[554] | 6.35[555] | 5.24[556] | 3.85[557] |
81 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [558] | 4.22[559] | 2.08[560] | 5.56[561] | 5.72[562] | 7.44[563] | -1.91[564] |
82 | E2F2 | Transcription factor E2F2 | [565] | 4.38[566] | 5.37[567] | 4.96[568] | 4.56[569] | 4.82[570] | 1.66[571] |
83 | BRCA2 | Breast cancer type 2 susceptibility protein | [572] | 2.93[573] | 5.52[574] | 5.77[575] | 4.99[576] | 5.07[577] | 3.68[578] |
84 | PAK3 | Serine/threonine-protein kinase PAK 3 | [579] | -6.28[580] | [581] | [582] | -1.09[583] | 0.56[584] | 1.03[585] |
85 | PAK6 | Serine/threonine-protein kinase PAK 6 | [586] | -1.54[587] | [588] | 1.36[589] | 2.72[590] | 1.76[591] | -0.83[592] |
86 | EGF | Pro-epidermal growth factor | [593] | 2.10[594] | 3.98[595] | 7.68[596] | 9.54[597] | 6.89[598] | 1.82[599] |
87 | MAPK10 | Mitogen-activated protein kinase 10 | [600] | -1.35[601] | [602] | [603] | 9.42[604] | 5.09[605] | 7.49[606] |
88 | BUB1B-PA | BUB1B-PAK6 readthrough (Fragment) | [607] | [608] | [609] | [610] | [611] | [612] | [613] |
89 | PAK5 | Serine/threonine-protein kinase PAK 5 | [614] | [615] | [616] | [617] | [618] | [619] | [620] |