WP_P53_TRANSCRIPTIONAL_GENE_NETWORK | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SAT1 | Diamine acetyltransferase 1 | [1] | -2.21[2] | -2.15[3] | -1.53[4] | -3.01[5] | -2.79[6] | -0.98[7] |
2 | GPX1 | Glutathione peroxidase 1 | [8] | -1.66[9] | -1.88[10] | -0.76[11] | -1.22[12] | -1.63[13] | -1.00[14] |
3 | SERPINE1 | Plasminogen activator inhibitor 1 | [15] | 1.00[16] | 1.32[17] | -4.66[18] | -2.75[19] | 2.54[20] | -3.34[21] |
4 | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | [22] | -1.12[23] | 0.70[24] | -2.86[25] | -2.85[26] | -5.22[27] | 1.48[28] |
5 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [29] | -2.61[30] | -3.58[31] | -2.64[32] | -2.93[33] | -2.58[34] | -2.47[35] |
6 | XRCC5 | X-ray repair cross-complementing protein 5 | [36] | 0.93[37] | 1.14[38] | 1.76[39] | 1.87[40] | 0.72[41] | 0.69[42] |
7 | ISG15 | Ubiquitin-like protein ISG15 | [43] | -2.30[44] | -1.94[45] | -2.31[46] | -2.25[47] | -4.77[48] | -1.86[49] |
8 | SIVA1 | Apoptosis regulatory protein Siva | [50] | -1.50[51] | -0.45[52] | -1.66[53] | -1.03[54] | -2.37[55] | -1.15[56] |
9 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [57] | 0.70[58] | -0.58[59] | -2.53[60] | -0.94[61] | 0.24[62] | -1.29[63] |
10 | MGMT | Methylated-DNA--protein-cysteine methyltransferase | [64] | -3.41[65] | -2.95[66] | -1.73[67] | -3.34[68] | -5.01[69] | -0.34[70] |
11 | PERP | p53 apoptosis effector related to PMP-22 | [71] | 0.43[72] | 0.52[73] | 0.69[74] | 0.62[75] | -0.70[76] | 0.75[77] |
12 | BAX | Apoptosis regulator BAX | [78] | 0.19[79] | -0.50[80] | -0.21[81] | -0.55[82] | -1.55[83] | -3.42[84] |
13 | FUCA1 | Tissue alpha-L-fucosidase | [85] | -0.85[86] | -0.09[87] | -1.87[88] | -0.73[89] | -2.48[90] | 0.68[91] |
14 | CCNG1 | Cyclin-G1 | [92] | 0.66[93] | 2.04[94] | 2.85[95] | 0.80[96] | -0.20[97] | 1.05[98] |
15 | GLS2 | Glutaminase liver isoform, mitochondrial | [99] | -2.63[100] | -1.93[101] | -5.52[102] | -6.04[103] | -6.91[104] | 1.02[105] |
16 | TRAF4 | TNF receptor-associated factor 4 | [106] | 0.24[107] | 1.30[108] | 1.47[109] | 0.71[110] | -0.95[111] | -0.21[112] |
17 | ICAM1 | Intercellular adhesion molecule 1 | [113] | 1.76[114] | 1.24[115] | 2.40[116] | 1.24[117] | 2.04[118] | 0.13[119] |
18 | IRF9 | Interferon regulatory factor 9 | [120] | -0.95[121] | -2.67[122] | -1.65[123] | 0.68[124] | -1.73[125] | 0.45[126] |
19 | ACAD11 | Acyl-CoA dehydrogenase family member 11 | [127] | -4.77[128] | -3.75[129] | -2.23[130] | -4.61[131] | -5.32[132] | -1.20[133] |
20 | NCF2 | Neutrophil cytosol factor 2 | [134] | -1.95[135] | -4.55[136] | -7.56[137] | -1.83[138] | -9.83[139] | -1.88[140] |
21 | FAS | Tumor necrosis factor receptor superfamily member 6 | [141] | -1.74[142] | -0.86[143] | -8.11[144] | -0.69[145] | -1.55[146] | -1.18[147] |
22 | CCL2 | C-C motif chemokine 2 | [148] | -13.53[149] | [150] | -12.10[151] | -3.07[152] | -2.28[153] | -3.15[154] |
23 | THBS1 | Thrombospondin-1 | [155] | 2.36[156] | -2.36[157] | -1.61[158] | 3.89[159] | 2.20[160] | 1.65[161] |
24 | TP53I3 | Quinone oxidoreductase PIG3 | [162] | 0.27[163] | -0.35[164] | -1.46[165] | 1.38[166] | -1.11[167] | -1.24[168] |
25 | TP53INP1 | Tumor protein p53-inducible nuclear protein 1 | [169] | 0.22[170] | 0.56[171] | 0.56[172] | 1.26[173] | -1.04[174] | 3.56[175] |
26 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [176] | 0.75[177] | 2.04[178] | 2.90[179] | 2.08[180] | -0.33[181] | 1.95[182] |
27 | SESN2 | Sestrin-2 | [183] | 0.65[184] | 0.12[185] | 1.47[186] | 0.03[187] | -0.57[188] | 0.79[189] |
28 | PTEN | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protei | -0.68[190] | 0.82[191] | 1.77[192] | 0.49[193] | 0.36[194] | 3.02[195] | |
29 | MLH1 | DNA mismatch repair protein Mlh1 | [196] | 0.71[197] | 0.94[198] | 2.44[199] | 1.19[200] | 0.47[201] | 0.97[202] |
30 | DDB2 | DNA damage-binding protein 2 | [203] | 0.94[204] | 0.57[205] | 0.01[206] | -0.56[207] | -1.35[208] | -0.98[209] |
31 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10D | [210] | 1.61[211] | 1.76[212] | 3.06[213] | 1.47[214] | -0.76[215] | 0.56[216] |
32 | ERCC5 | DNA repair protein complementing XP-G cells | [217] | -4.91[218] | -4.02[219] | -3.27[220] | -2.69[221] | -4.26[222] | -1.70[223] |
33 | CX3CL1 | Fractalkine | [224] | 1.69[225] | 2.41[226] | 0.02[227] | -5.83[228] | -9.87[229] | -0.97[230] |
34 | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | [231] | 1.10[232] | 1.37[233] | 0.94[234] | 2.06[235] | 0.47[236] | 0.99[237] |
35 | XPC | DNA repair protein complementing XP-C cells | [238] | 0.77[239] | 0.64[240] | 2.27[241] | 1.49[242] | 0.37[243] | 1.78[244] |
36 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [245] | 0.57[246] | 1.21[247] | 1.11[248] | 0.99[249] | -0.29[250] | 0.54[251] |
37 | BBC3 | Bcl-2-binding component 3 | [252] | 0.60[253] | 0.59[254] | 0.84[255] | -1.75[256] | -2.38[257] | -3.80[258] |
38 | MSH2 | DNA mismatch repair protein Msh2 | [259] | 0.69[260] | 2.08[261] | 2.27[262] | 3.18[263] | 1.17[264] | -0.15[265] |
39 | PML | Protein PML | [266] | 0.10[267] | -0.81[268] | 1.64[269] | 2.94[270] | 1.05[271] | 0.78[272] |
40 | BTG2 | Protein BTG2 | [273] | 1.20[274] | 0.19[275] | 1.20[276] | -0.81[277] | -0.86[278] | -0.25[279] |
41 | ULK1 | Serine/threonine-protein kinase ULK1 | [280] | 1.17[281] | 1.55[282] | 3.51[283] | 3.03[284] | 0.99[285] | 2.43[286] |
42 | SESN1 | Sestrin-1 | [287] | 1.15[288] | 1.58[289] | -0.19[290] | 0.17[291] | 0.01[292] | 1.24[293] |
43 | SLC2A1 | Solute carrier family 2, facilitated glucose transporter member 1 | [294] | 6.51[295] | 3.62[296] | 3.44[297] | 4.50[298] | 2.25[299] | -0.81[300] |
44 | POLK | DNA polymerase kappa | [301] | -0.98[302] | 0.60[303] | 1.60[304] | 2.88[305] | 1.23[306] | 2.63[307] |
45 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [308] | -0.09[309] | -3.35[310] | 0.95[311] | 3.33[312] | 1.17[313] | -3.76[314] |
46 | POLH | DNA polymerase eta | [315] | 1.98[316] | 1.57[317] | 0.89[318] | 3.05[319] | 1.46[320] | 1.87[321] |
47 | DRAM1 | DNA damage-regulated autophagy modulator protein 1 | [322] | 2.48[323] | 1.79[324] | 4.88[325] | 1.66[326] | 0.99[327] | 0.53[328] |
48 | ZMAT3 | Zinc finger matrin-type protein 3 | [329] | 2.64[330] | 2.64[331] | 1.26[332] | 2.66[333] | 2.31[334] | 2.79[335] |
49 | FANCC | Fanconi anemia group C protein | [336] | 0.88[337] | 1.31[338] | 0.45[339] | 2.59[340] | 1.38[341] | 3.47[342] |
50 | LIF | Leukemia inhibitory factor | [343] | 2.14[344] | 2.08[345] | 3.66[346] | 2.67[347] | 2.30[348] | -4.64[349] |
51 | APAF1 | Apoptotic protease-activating factor 1 | [350] | 1.52[351] | 2.05[352] | 3.05[353] | 3.68[354] | 1.40[355] | 2.03[356] |
52 | SLC7A11 | Cystine/glutamate transporter | [357] | 2.53[358] | 3.48[359] | 4.08[360] | 5.93[361] | 3.36[362] | -0.48[363] |
53 | IRF5 | Interferon regulatory factor 5 | [364] | 0.16[365] | 0.05[366] | -0.37[367] | 1.41[368] | -2.24[369] | 1.52[370] |
54 | ULBP2 | UL16-binding protein 2 | [371] | -6.94[372] | -7.23[373] | 0.97[374] | 2.14[375] | 1.13[376] | -3.71[377] |
55 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [378] | 1.77[379] | 0.71[380] | 2.79[381] | 3.63[382] | 2.61[383] | 5.18[384] |
56 | ULK2 | Serine/threonine-protein kinase ULK2 | [385] | -3.24[386] | -2.16[387] | 1.51[388] | 4.34[389] | 2.27[390] | 2.95[391] |
57 | ULBP1 | UL16-binding protein 1 | [392] | -1.03[393] | [394] | 1.71[395] | 0.47[396] | 0.51[397] | -4.33[398] |
58 | NANOG | Homeobox protein NANOG | [399] | 0.28[400] | -0.46[401] | -1.17[402] | -1.22[403] | -3.52[404] | 0.46[405] |
59 | ADORA2B | Adenosine receptor A2b | [406] | 3.97[407] | 3.84[408] | 2.19[409] | 3.58[410] | 3.08[411] | -0.67[412] |
60 | CPT1C | Carnitine O-palmitoyltransferase 1, brain isoform | [413] | -0.41[414] | -1.36[415] | -0.48[416] | 2.60[417] | 5.73[418] | 2.14[419] |
61 | RPRM | Protein reprimo | [420] | -5.32[421] | [422] | -4.25[423] | 6.18[424] | -4.02[425] | [426] |
62 | TP53AIP1 | p53-regulated apoptosis-inducing protein 1 | [427] | -0.21[428] | 0.02[429] | 0.03[430] | 0.52[431] | -1.21[432] | 0.87[433] |
63 | TIGAR | Fructose-2,6-bisphosphatase TIGAR | [434] | [435] | [436] | [437] | [438] | [439] | [440] |
64 | PIDD1 | p53-induced death domain-containing protein 1 | [441] | [442] | [443] | [444] | [445] | [446] | [447] |
65 | SMR3B | Submaxillary gland androgen-regulated protein 3B | [448] | [449] | [450] | [451] | [452] | [453] | [454] |
66 | SERPINB5 | Serpin B5 | [455] | [456] | [457] | [458] | [459] | [460] | [461] |
67 | MIR200C | [462] | [463] | [464] | [465] | [466] | [467] | [468] | |
68 | MIR3191 | [469] | [470] | [471] | [472] | [473] | [474] | [475] | |
69 | ADGRB1 | Adhesion G protein-coupled receptor B1 | [476] | [477] | [478] | [479] | [480] | [481] | [482] |
70 | MIR145 | [483] | [484] | [485] | [486] | [487] | [488] | [489] | |
71 | MIR34B | [490] | [491] | [492] | [493] | [494] | [495] | [496] | |
72 | MIR34C | [497] | [498] | [499] | [500] | [501] | [502] | [503] |