WP_OXYSTEROLS_DERIVED_FROM_CHOLESTEROL | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | LBP | Lipopolysaccharide-binding protein | [1] | -8.14[2] | -12.13[3] | -4.56[4] | -9.10[5] | -14.03[6] | -0.37[7] |
2 | CYP3A4 | Cytochrome P450 3A4 | [8] | -8.22[9] | -9.32[10] | -11.05[11] | -12.48[12] | -10.68[13] | 0.30[14] |
3 | SCP2 | Non-specific lipid-transfer protein | [15] | -0.32[16] | -0.16[17] | 0.09[18] | 0.61[19] | 0.71[20] | -0.10[21] |
4 | EBP | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase | [22] | -0.79[23] | 0.24[24] | 1.03[25] | -0.71[26] | 0.26[27] | -1.83[28] |
5 | CYP27A1 | Sterol 26-hydroxylase, mitochondrial | [29] | 1.44[30] | 1.25[31] | -1.85[32] | -0.52[33] | -1.82[34] | -0.35[35] |
6 | AKR1C4 | Aldo-keto reductase family 1 member C4 | [36] | -5.54[37] | -4.16[38] | -4.75[39] | -6.63[40] | -11.85[41] | -1.31[42] |
7 | SLC27A5 | Bile acyl-CoA synthetase | [43] | -1.92[44] | -1.65[45] | -3.26[46] | -3.45[47] | -5.69[48] | 0.20[49] |
8 | SLC27A2 | Very long-chain acyl-CoA synthetase | [50] | -0.01[51] | -0.83[52] | -1.10[53] | -0.03[54] | -3.69[55] | 0.73[56] |
9 | INSIG1 | Insulin-induced gene 1 protein | [57] | -7.36[58] | -8.11[59] | 1.64[60] | -0.08[61] | -0.71[62] | 0.69[63] |
10 | BAAT | Bile acid-CoA:amino acid N-acyltransferase | [64] | -1.99[65] | -2.35[66] | -4.72[67] | -4.22[68] | -5.27[69] | 1.32[70] |
11 | ACOT2 | Acyl-coenzyme A thioesterase 2, mitochondrial | [71] | 0.90[72] | 0.98[73] | -1.68[74] | -0.14[75] | 0.41[76] | -0.92[77] |
12 | CYP8B1 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase | [78] | -4.70[79] | -3.13[80] | -7.07[81] | -5.94[82] | -7.52[83] | 2.02[84] |
13 | DHCR7 | 7-dehydrocholesterol reductase | [85] | 2.51[86] | 3.27[87] | 3.51[88] | 1.40[89] | 1.90[90] | 0.69[91] |
14 | EPHX2 | Bifunctional epoxide hydrolase 2 | [92] | 0.24[93] | 1.07[94] | 2.50[95] | -1.82[96] | -1.33[97] | 0.51[98] |
15 | HSD3B7 | 3 beta-hydroxysteroid dehydrogenase type 7 | [99] | 2.29[100] | 2.17[101] | -0.97[102] | 0.57[103] | 0.43[104] | -0.10[105] |
16 | AKR1D1 | 3-oxo-5-beta-steroid 4-dehydrogenase | [106] | 0.44[107] | 0.84[108] | -1.88[109] | -6.07[110] | -6.04[111] | -0.71[112] |
17 | ACOX2 | Peroxisomal acyl-coenzyme A oxidase 2 | [113] | 1.11[114] | 1.46[115] | 1.19[116] | -3.83[117] | -1.25[118] | 0.69[119] |
18 | ACOT9 | Acyl-coenzyme A thioesterase 9, mitochondrial | [120] | 2.62[121] | 0.98[122] | 0.25[123] | 3.92[124] | 3.61[125] | -2.13[126] |
19 | ACOT1 | Acyl-coenzyme A thioesterase 1 | [127] | 0.38[128] | 1.24[129] | -2.89[130] | -1.75[131] | -1.36[132] | -1.40[133] |
20 | NR1H2 | Oxysterols receptor LXR-beta | [134] | 2.84[135] | 1.75[136] | 2.10[137] | 3.79[138] | 4.40[139] | -0.42[140] |
21 | AMACR | Alpha-methylacyl-CoA racemase | [141] | -0.34[142] | -1.30[143] | 0.15[144] | -0.54[145] | -0.71[146] | -2.26[147] |
22 | ACOT13 | Acyl-coenzyme A thioesterase 13 | [148] | 3.19[149] | 2.53[150] | 4.06[151] | 4.31[152] | 3.03[153] | 0.66[154] |
23 | ACOT7 | Cytosolic acyl coenzyme A thioester hydrolase | [155] | 4.18[156] | 3.81[157] | 1.77[158] | 4.40[159] | 5.20[160] | -2.16[161] |
24 | NR1I2 | Nuclear receptor subfamily 1 group I member 2 | [162] | 2.14[163] | 0.91[164] | -3.63[165] | -5.98[166] | -4.77[167] | 1.25[168] |
25 | ACOT8 | Acyl-coenzyme A thioesterase 8 | [169] | 2.58[170] | 2.08[171] | 2.11[172] | 3.08[173] | 2.84[174] | -1.30[175] |
26 | ACOT12 | Acyl-coenzyme A thioesterase 12 | [176] | [177] | -8.12[178] | -0.82[179] | -7.16[180] | -6.10[181] | 0.74[182] |
27 | RORC | Nuclear receptor ROR-gamma | [183] | 2.19[184] | 1.91[185] | -8.11[186] | -0.46[187] | -2.21[188] | -0.23[189] |
28 | CYP39A1 | 24-hydroxycholesterol 7-alpha-hydroxylase | [190] | -1.54[191] | -2.70[192] | 1.93[193] | -0.89[194] | 1.31[195] | 0.04[196] |
29 | CYP7A1 | Cholesterol 7-alpha-monooxygenase | [197] | -0.82[198] | -4.13[199] | -7.67[200] | -5.93[201] | [202] | -3.39[203] |
30 | ACOT4 | Acyl-coenzyme A thioesterase 4 | [204] | -5.59[205] | -4.89[206] | -0.58[207] | 2.50[208] | 0.14[209] | 0.31[210] |
31 | ESR1 | Estrogen receptor | [211] | -3.78[212] | [213] | -3.25[214] | -0.13[215] | -2.13[216] | 1.97[217] |
32 | DBP | D site-binding protein | [218] | 2.95[219] | 1.91[220] | 4.75[221] | 5.30[222] | 2.46[223] | -2.17[224] |
33 | CYP7B1 | 25-hydroxycholesterol 7-alpha-hydroxylase | [225] | -4.51[226] | -4.20[227] | [228] | -4.99[229] | -1.01[230] | 1.84[231] |
34 | ACOT6 | Putative acyl-coenzyme A thioesterase 6 | [232] | -1.34[233] | -2.54[234] | -0.51[235] | -3.69[236] | -0.67[237] | -1.04[238] |
35 | ACOT11 | Acyl-coenzyme A thioesterase 11 | [239] | 5.35[240] | 4.77[241] | 1.85[242] | 3.71[243] | 4.66[244] | -1.89[245] |
36 | GPR183 | G-protein coupled receptor 183 | [246] | [247] | -4.48[248] | -3.36[249] | -0.19[250] | [251] | 1.96[252] |
37 | IL17D | Interleukin-17D | [253] | 3.28[254] | 3.74[255] | 1.92[256] | 3.44[257] | 2.41[258] | -2.80[259] |
38 | IL17B | Interleukin-17B | [260] | 2.80[261] | 6.33[262] | -1.69[263] | 4.34[264] | -0.41[265] | -4.78[266] |
39 | THEM5 | Acyl-coenzyme A thioesterase THEM5 | [267] | 0.15[268] | 0.08[269] | -2.10[270] | 3.74[271] | 3.81[272] | 0.36[273] |
40 | CYP46A1 | Cholesterol 24-hydroxylase | [274] | -0.26[275] | 0.10[276] | -0.94[277] | 1.48[278] | 2.93[279] | 1.82[280] |
41 | ESR2 | Estrogen receptor beta | [281] | 2.96[282] | 2.36[283] | 2.37[284] | 4.67[285] | 5.03[286] | 2.10[287] |
42 | IL17A | Interleukin-17A | [288] | [289] | [290] | [291] | [292] | [293] | [294] |
43 | CH25H | Cholesterol 25-hydroxylase | [295] | 0.39[296] | [297] | -0.25[298] | 12.26[299] | 6.01[300] | 2.66[301] |
44 | IL17C | Interleukin-17C | [302] | [303] | [304] | [305] | [306] | [307] | [308] |
45 | IL17F | Interleukin-17F | [309] | [310] | [311] | [312] | [313] | [314] | [315] |
46 | IL25 | Interleukin-25 | [316] | [317] | [318] | [319] | [320] | [321] | [322] |