WP_ONECARBON_METABOLISM | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | MAT1A | S-adenosylmethionine synthase isoform type-1 | [1] | -2.80[2] | -1.43[3] | -3.09[4] | -8.64[5] | -11.54[6] | 0.67[7] |
2 | BHMT | Betaine--homocysteine S-methyltransferase 1 | [8] | -5.47[9] | -6.15[10] | -9.75[11] | -7.74[12] | -14.90[13] | -1.08[14] |
3 | SHMT1 | Serine hydroxymethyltransferase, cytosolic | [15] | -2.28[16] | -2.87[17] | -2.13[18] | -1.05[19] | -1.70[20] | 0.90[21] |
4 | AHCY | Adenosylhomocysteinase | [22] | 1.70[23] | 1.61[24] | 2.11[25] | 1.02[26] | 0.21[27] | -1.28[28] |
5 | GLRX | Glutaredoxin-1 | [29] | -0.80[30] | -0.26[31] | -2.11[32] | -1.10[33] | -1.82[34] | -1.67[35] |
6 | FTCD | Formimidoyltransferase-cyclodeaminase | [36] | -1.81[37] | -1.04[38] | -7.37[39] | -8.05[40] | -10.64[41] | -0.79[42] |
7 | SHMT2 | Serine hydroxymethyltransferase, mitochondrial | [43] | 0.59[44] | 1.16[45] | 0.95[46] | 0.14[47] | 1.03[48] | -0.40[49] |
8 | ALDH1L1 | Cytosolic 10-formyltetrahydrofolate dehydrogenase | [50] | -3.41[51] | -12.53[52] | -13.24[53] | -6.25[54] | -6.44[55] | 0.71[56] |
9 | MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic | [57] | 0.37[58] | -0.69[59] | -0.53[60] | 0.89[61] | 1.18[62] | 0.70[63] |
10 | MTHFS | 5-formyltetrahydrofolate cyclo-ligase | [64] | -3.85[65] | -3.63[66] | -4.03[67] | -3.88[68] | -3.64[69] | -2.78[70] |
11 | ATIC | Bifunctional purine biosynthesis protein PURH | [71] | 1.85[72] | 1.19[73] | 1.41[74] | 1.42[75] | 1.36[76] | -1.53[77] |
12 | TYMS | Thymidylate synthase | [78] | -0.56[79] | -0.66[80] | -0.56[81] | 0.49[82] | 0.16[83] | -6.20[84] |
13 | GART | Trifunctional purine biosynthetic protein adenosine-3 | [85] | 1.52[86] | 0.79[87] | 0.48[88] | 1.96[89] | 1.90[90] | -0.78[91] |
14 | AMT | Aminomethyltransferase, mitochondrial | [92] | 0.20[93] | 0.13[94] | 1.34[95] | -3.88[96] | -3.33[97] | -0.66[98] |
15 | MAT2B | Methionine adenosyltransferase 2 subunit beta | [99] | 0.63[100] | 0.19[101] | 0.66[102] | 2.26[103] | 1.77[104] | -0.25[105] |
16 | CHDH | Choline dehydrogenase, mitochondrial | [106] | 1.55[107] | 2.01[108] | 0.41[109] | -4.21[110] | -4.91[111] | 1.22[112] |
17 | DHFR | Dihydrofolate reductase | [113] | 2.25[114] | 2.45[115] | 3.06[116] | 3.05[117] | 3.53[118] | -0.15[119] |
18 | MTRR | Methionine synthase reductase | [120] | 0.94[121] | 1.10[122] | 2.09[123] | 2.35[124] | 2.64[125] | 0.94[126] |
19 | MTHFD1L | Monofunctional C1-tetrahydrofolate synthase, mitochondrial | [127] | 2.68[128] | 1.80[129] | 1.78[130] | 2.47[131] | 2.02[132] | -2.14[133] |
20 | MTHFD2 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochon | 3.61[134] | 3.93[135] | 2.87[136] | 1.53[137] | 3.88[138] | -2.62[139] | |
21 | FOLH1 | Glutamate carboxypeptidase 2 | [140] | -9.76[141] | -10.53[142] | 1.53[143] | -7.46[144] | -5.91[145] | -0.64[146] |
22 | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | [147] | 3.68[148] | 2.68[149] | 3.84[150] | 4.90[151] | 5.17[152] | 0.81[153] |
23 | MTFMT | Methionyl-tRNA formyltransferase, mitochondrial | [154] | 0.71[155] | 0.24[156] | 0.59[157] | 1.34[158] | 1.47[159] | 0.31[160] |
24 | DNMT3A | DNA (cytosine-5)-methyltransferase 3A | [161] | 2.23[162] | 2.03[163] | 2.20[164] | 1.83[165] | 0.85[166] | 0.25[167] |
25 | DNMT3B | DNA (cytosine-5)-methyltransferase 3B | [168] | 2.43[169] | 1.09[170] | 0.94[171] | 2.31[172] | 0.53[173] | -2.24[174] |
26 | TCN2 | Transcobalamin-2 | [175] | -0.62[176] | -2.90[177] | -0.30[178] | 3.08[179] | 2.00[180] | 1.32[181] |
27 | MTR | Methionine synthase | [182] | 2.98[183] | 3.15[184] | 3.57[185] | 4.94[186] | 3.90[187] | 3.09[188] |
28 | FOLH1B | Putative N-acetylated-alpha-linked acidic dipeptidase | [189] | [190] | -7.02[191] | -2.68[192] | [193] | [194] | 0.32[195] |
29 | AHCYL2 | Adenosylhomocysteinase 3 | [196] | 2.55[197] | 2.17[198] | 2.52[199] | 4.02[200] | 3.66[201] | 1.66[202] |
30 | MTHFR | Methylenetetrahydrofolate reductase | [203] | 2.04[204] | 2.89[205] | 3.41[206] | 4.50[207] | 2.89[208] | 3.54[209] |
31 | MIR6778 | [210] | [211] | [212] | [213] | [214] | [215] | [216] |