WP_ONCOSTATIN_M_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | SERPINE1 | Plasminogen activator inhibitor 1 | [8] | 1.76[9] | 1.85[10] | -4.56[11] | -3.16[12] | 2.62[13] | -3.51[14] |
3 | NFKBIA | NF-kappa-B inhibitor alpha | [15] | -0.43[16] | -2.36[17] | -2.41[18] | -2.88[19] | -1.88[20] | -0.77[21] |
4 | JUND | Transcription factor jun-D | [22] | -0.07[23] | -0.25[24] | -0.12[25] | -2.69[26] | -2.59[27] | -2.50[28] |
5 | FOS | Proto-oncogene c-Fos | [29] | -5.39[30] | -4.26[31] | -4.60[32] | -5.53[33] | -5.34[34] | -0.94[35] |
6 | JUNB | Transcription factor jun-B | [36] | -1.33[37] | -2.33[38] | -1.29[39] | -1.53[40] | -1.57[41] | -1.02[42] |
7 | AKT1 | RAC-alpha serine/threonine-protein kinase | [43] | 0.70[44] | 0.34[45] | -0.41[46] | 0.59[47] | -0.27[48] | 0.12[49] |
8 | CEBPB | CCAAT/enhancer-binding protein beta | [50] | -0.55[51] | -1.32[52] | -0.96[53] | -0.77[54] | -0.72[55] | -1.31[56] |
9 | STAT3 | Signal transducer and activator of transcription 3 | [57] | 1.17[58] | -0.46[59] | 0.61[60] | 0.88[61] | -0.73[62] | 2.77[63] |
10 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [64] | -0.31[65] | -0.77[66] | 0.14[67] | 0.10[68] | -0.28[69] | -0.83[70] |
11 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [71] | 0.68[72] | 0.22[73] | 1.42[74] | -0.20[75] | -0.60[76] | -1.34[77] |
12 | HIF1A | Hypoxia-inducible factor 1-alpha | [78] | 0.47[79] | 0.01[80] | 1.13[81] | 2.93[82] | 2.42[83] | -0.44[84] |
13 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [85] | 1.07[86] | 1.37[87] | 1.65[88] | 1.53[89] | 1.28[90] | 1.62[91] |
14 | GRB2 | Growth factor receptor-bound protein 2 | [92] | 1.82[93] | 1.52[94] | 1.97[95] | 1.19[96] | 0.22[97] | 0.66[98] |
15 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [99] | 0.55[100] | -0.50[101] | 0.93[102] | 3.17[103] | 0.02[104] | 1.32[105] |
16 | SHC1 | SHC-transforming protein 1 | [106] | 1.79[107] | 1.87[108] | 2.27[109] | 3.29[110] | 1.89[111] | 1.15[112] |
17 | IL6ST | Interleukin-6 receptor subunit beta | [113] | 0.88[114] | 2.00[115] | 1.85[116] | 2.37[117] | 2.65[118] | 4.15[119] |
18 | RELA | Transcription factor p65 | [120] | 0.76[121] | 0.12[122] | 0.58[123] | 0.58[124] | -0.39[125] | -0.51[126] |
19 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [127] | 0.56[128] | 0.83[129] | 2.43[130] | 0.46[131] | 0.44[132] | 1.46[133] |
20 | VEGFA | Vascular endothelial growth factor A | [134] | 1.84[135] | 3.05[136] | 1.97[137] | 1.08[138] | 0.91[139] | 1.15[140] |
21 | JAK1 | Tyrosine-protein kinase JAK1 | [141] | 1.14[142] | 0.49[143] | 1.00[144] | 1.27[145] | 1.03[146] | 1.90[147] |
22 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [148] | 0.54[149] | 0.85[150] | 1.37[151] | -0.47[152] | -0.89[153] | -0.54[154] |
23 | LDLR | Low-density lipoprotein receptor | [155] | 0.81[156] | 1.52[157] | 2.85[158] | -0.26[159] | 0.05[160] | 1.60[161] |
24 | EGR1 | Early growth response protein 1 | [162] | -1.18[163] | -0.83[164] | -2.62[165] | -1.69[166] | -0.91[167] | 1.51[168] |
25 | CASP3 | Caspase-3 | [169] | 0.76[170] | 1.30[171] | -0.92[172] | -0.26[173] | -0.14[174] | -0.44[175] |
26 | CDK2 | Cyclin-dependent kinase 2 | [176] | 0.21[177] | 0.24[178] | 0.94[179] | 0.62[180] | 0.33[181] | -1.82[182] |
27 | HRAS | GTPase HRas | [183] | -0.39[184] | -1.22[185] | -1.69[186] | -0.31[187] | -1.41[188] | -2.29[189] |
28 | SOCS3 | Suppressor of cytokine signaling 3 | [190] | -3.52[191] | -4.06[192] | -2.02[193] | -0.16[194] | -2.12[195] | 0.50[196] |
29 | MAPK1 | Mitogen-activated protein kinase 1 | [197] | 2.33[198] | 2.34[199] | 2.49[200] | 2.49[201] | 1.25[202] | 2.14[203] |
30 | CCL2 | C-C motif chemokine 2 | [204] | -12.77[205] | [206] | -12.00[207] | -3.48[208] | -2.20[209] | -3.33[210] |
31 | MMP1 | Interstitial collagenase | [211] | -4.54[212] | -8.45[213] | [214] | -1.11[215] | -2.45[216] | -11.76[217] |
32 | CASP7 | Caspase-7 | [218] | 0.31[219] | -0.18[220] | 0.58[221] | -0.26[222] | -0.94[223] | -0.12[224] |
33 | MMP3 | Stromelysin-1 | [225] | -3.89[226] | -8.94[227] | -10.99[228] | -1.10[229] | -5.04[230] | -7.96[231] |
34 | TIMP3 | Metalloproteinase inhibitor 3 | [232] | 1.40[233] | 1.09[234] | 2.41[235] | -3.54[236] | -3.48[237] | 2.25[238] |
35 | PXN | Paxillin | [239] | 1.62[240] | 1.21[241] | 1.57[242] | 2.76[243] | 1.83[244] | 0.01[245] |
36 | KRAS | GTPase KRas | [246] | 0.11[247] | -0.04[248] | 1.88[249] | 1.44[250] | 0.22[251] | 1.04[252] |
37 | MAPK14 | Mitogen-activated protein kinase 14 | [253] | 2.10[254] | 2.03[255] | 1.94[256] | 2.32[257] | 0.91[258] | 1.65[259] |
38 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [260] | 0.15[261] | 0.14[262] | 1.55[263] | 2.71[264] | 1.32[265] | 3.37[266] |
39 | MAPK8 | Mitogen-activated protein kinase 8 | [267] | -0.82[268] | 0.46[269] | -0.35[270] | -0.26[271] | -1.29[272] | -0.15[273] |
40 | SOS1 | Son of sevenless homolog 1 | [274] | 0.52[275] | 1.92[276] | 1.75[277] | 1.49[278] | -0.17[279] | 0.90[280] |
41 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [281] | 1.29[282] | 0.84[283] | 0.95[284] | 0.39[285] | 0.42[286] | 0.82[287] |
42 | OSMR | Oncostatin-M-specific receptor subunit beta | [288] | 2.64[289] | 2.22[290] | 1.15[291] | 2.36[292] | 2.63[293] | 1.86[294] |
43 | TP53 | Cellular tumor antigen p53 | [295] | 2.26[296] | 1.69[297] | 2.78[298] | 1.93[299] | 0.71[300] | 0.32[301] |
44 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [302] | 1.76[303] | 1.99[304] | 2.44[305] | 1.39[306] | 1.43[307] | 2.36[308] |
45 | MAPK9 | Mitogen-activated protein kinase 9 | [309] | 1.85[310] | 1.94[311] | 2.33[312] | 2.35[313] | 0.93[314] | 0.88[315] |
46 | MAPK3 | Mitogen-activated protein kinase 3 | [316] | 2.47[317] | 2.39[318] | 2.75[319] | 1.06[320] | 0.20[321] | -0.67[322] |
47 | STAT5B | Signal transducer and activator of transcription 5B | [323] | 1.98[324] | 1.47[325] | 2.50[326] | 2.19[327] | 0.45[328] | 1.99[329] |
48 | SRC | Proto-oncogene tyrosine-protein kinase Src | [330] | 3.65[331] | 3.50[332] | 2.82[333] | 3.04[334] | 1.33[335] | -0.48[336] |
49 | PRKCD | Protein kinase C delta type | [337] | 1.72[338] | 1.84[339] | 1.64[340] | 0.14[341] | 0.41[342] | -0.70[343] |
50 | MTOR | Serine/threonine-protein kinase mTOR | [344] | 3.16[345] | 4.04[346] | 3.93[347] | 3.32[348] | 2.52[349] | 3.82[350] |
51 | IRS1 | Insulin receptor substrate 1 | [351] | 2.71[352] | 2.03[353] | 3.78[354] | 2.35[355] | 1.04[356] | 2.48[357] |
52 | PRKCA | Protein kinase C alpha type | [358] | 3.46[359] | 3.37[360] | 4.05[361] | 2.79[362] | 2.27[363] | 2.29[364] |
53 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [365] | 2.34[366] | 3.37[367] | 4.18[368] | 3.18[369] | 2.24[370] | 2.71[371] |
54 | PTK2B | Protein-tyrosine kinase 2-beta | [372] | -0.18[373] | 1.04[374] | 2.33[375] | -1.14[376] | 0.60[377] | 2.14[378] |
55 | RICTOR | Rapamycin-insensitive companion of mTOR | [379] | 1.35[380] | 3.30[381] | 4.30[382] | 3.00[383] | 2.31[384] | 3.88[385] |
56 | PIAS3 | E3 SUMO-protein ligase PIAS3 | [386] | 1.93[387] | 0.98[388] | 2.60[389] | 3.36[390] | 2.17[391] | 1.13[392] |
57 | JAK2 | Tyrosine-protein kinase JAK2 | [393] | 0.85[394] | 0.71[395] | 0.59[396] | 1.40[397] | 1.12[398] | 3.07[399] |
58 | LIFR | Leukemia inhibitory factor receptor | [400] | 1.54[401] | 4.10[402] | 5.00[403] | 4.71[404] | 3.31[405] | 6.89[406] |
59 | PRKCE | Protein kinase C epsilon type | [407] | 1.26[408] | -0.38[409] | 2.44[410] | 1.62[411] | 1.10[412] | 3.93[413] |
60 | PRKCH | Protein kinase C eta type | [414] | 0.26[415] | -3.68[416] | -1.71[417] | 2.92[418] | 3.66[419] | 3.47[420] |
61 | PRKCB | Protein kinase C beta type | [421] | -6.19[422] | -5.13[423] | [424] | 3.12[425] | -3.07[426] | 3.90[427] |
62 | JAK3 | Tyrosine-protein kinase JAK3 | [428] | 2.87[429] | 5.01[430] | -0.67[431] | 0.01[432] | -0.14[433] | 3.46[434] |
63 | OSM | Oncostatin-M | [435] | -4.67[436] | -0.25[437] | -4.67[438] | -4.57[439] | -5.39[440] | -1.37[441] |
64 | CCN1 | [442] | [443] | [444] | [445] | [446] | [447] | [448] | |
65 | MIR6886 | [449] | [450] | [451] | [452] | [453] | [454] | [455] | |
66 | MMP13 | Collagenase 3 | [456] | [457] | [458] | [459] | [460] | [461] | [462] |