WP_NRP1TRIGGERED_SIGNALING_PATHWAYS_IN_PANCREATIC_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [1] | -1.23[2] | -1.64[3] | -0.75[4] | -1.04[5] | -1.30[6] | -1.72[7] |
2 | AKT1 | RAC-alpha serine/threonine-protein kinase | [8] | -0.75[9] | -1.07[10] | -1.97[11] | -1.10[12] | -1.33[13] | -1.00[14] |
3 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [15] | -1.76[16] | -2.17[17] | -1.42[18] | -1.59[19] | -1.33[20] | -1.95[21] |
4 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [22] | -0.78[23] | -1.18[24] | -0.14[25] | -1.89[26] | -1.65[27] | -2.46[28] |
5 | NFKB2 | Nuclear factor NF-kappa-B p100 subunit | [29] | -1.60[30] | -1.38[31] | -0.76[32] | -2.43[33] | -1.83[34] | -3.77[35] |
6 | RELA | Transcription factor p65 | [36] | -0.70[37] | -1.29[38] | -0.97[39] | -1.11[40] | -1.45[41] | -1.63[42] |
7 | VEGFA | Vascular endothelial growth factor A | [43] | 0.39[44] | 1.64[45] | 0.42[46] | -0.61[47] | -0.15[48] | 0.03[49] |
8 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [50] | -0.92[51] | -0.56[52] | -0.18[53] | -2.16[54] | -1.94[55] | -1.66[56] |
9 | MET | Hepatocyte growth factor receptor | [57] | -0.75[58] | -0.80[59] | 0.01[60] | 0.48[61] | -1.04[62] | 0.21[63] |
10 | CDK2 | Cyclin-dependent kinase 2 | [64] | -1.25[65] | -1.16[66] | -0.61[67] | -1.07[68] | -0.73[69] | -2.94[70] |
11 | TGFBR2 | TGF-beta receptor type-2 | [71] | 1.99[72] | 1.37[73] | 1.20[74] | 0.01[75] | 1.48[76] | 0.75[77] |
12 | MAPK1 | Mitogen-activated protein kinase 1 | [78] | 0.88[79] | 0.93[80] | 0.94[81] | 0.80[82] | 0.20[83] | 1.02[84] |
13 | BCAR1 | Breast cancer anti-estrogen resistance protein 1 | [85] | 0.30[86] | 0.09[87] | -0.86[88] | 0.32[89] | -0.20[90] | -0.69[91] |
14 | AKT2 | RAC-beta serine/threonine-protein kinase | [92] | 0.13[93] | 0.32[94] | 0.62[95] | -0.19[96] | -0.65[97] | 0.38[98] |
15 | GSK3A | Glycogen synthase kinase-3 alpha | [99] | -0.21[100] | -0.55[101] | -0.28[102] | -0.97[103] | -0.45[104] | -2.59[105] |
16 | PTK2 | Focal adhesion kinase 1 | [106] | -0.10[107] | 0.31[108] | 0.86[109] | 0.90[110] | -0.15[111] | 0.01[112] |
17 | SLC39A4 | Zinc transporter ZIP4 | [113] | 1.45[114] | 1.83[115] | -6.09[116] | -3.49[117] | -4.13[118] | -2.78[119] |
18 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [120] | -0.16[121] | -0.57[122] | -0.60[123] | -1.30[124] | -0.64[125] | -0.30[126] |
19 | SMAD3 | Mothers against decapentaplegic homolog 3 | [127] | 1.10[128] | 0.41[129] | 0.81[130] | 0.75[131] | 1.38[132] | -0.54[133] |
20 | CHD2 | Chromodomain-helicase-DNA-binding protein 2 | [134] | 0.70[135] | 1.37[136] | 1.69[137] | 0.68[138] | 0.61[139] | 1.62[140] |
21 | EGFR | Epidermal growth factor receptor | [141] | -1.53[142] | -1.99[143] | 1.07[144] | -0.62[145] | -0.25[146] | 1.90[147] |
22 | TGFBR1 | TGF-beta receptor type-1 | [148] | -0.50[149] | -0.36[150] | -0.68[151] | -0.71[152] | 0.15[153] | 0.58[154] |
23 | MAPK3 | Mitogen-activated protein kinase 3 | [155] | 1.02[156] | 0.98[157] | 1.20[158] | -0.63[159] | -0.85[160] | -1.80[161] |
24 | RELB | Transcription factor RelB | [162] | -1.12[163] | -1.62[164] | -1.20[165] | -2.07[166] | -1.09[167] | -3.26[168] |
25 | SRC | Proto-oncogene tyrosine-protein kinase Src | [169] | 2.19[170] | 2.09[171] | 1.27[172] | 1.35[173] | 0.28[174] | -1.60[175] |
26 | NRP1 | Neuropilin-1 | [176] | 0.71[177] | -1.56[178] | 2.55[179] | 2.90[180] | 2.12[181] | 2.45[182] |
27 | CCNE1 | G1/S-specific cyclin-E1 | [183] | 0.41[184] | 0.43[185] | -1.20[186] | -1.46[187] | -1.10[188] | -5.39[189] |
28 | SMAD4 | Mothers against decapentaplegic homolog 4 | [190] | 0.56[191] | 1.11[192] | 1.25[193] | 0.86[194] | 0.98[195] | 2.04[196] |
29 | TGFB2 | Transforming growth factor beta-2 | [197] | -5.12[198] | -7.74[199] | -1.76[200] | 2.41[201] | 0.76[202] | -3.52[203] |
30 | CHD1 | Chromodomain-helicase-DNA-binding protein 1 | [204] | -0.44[205] | 1.32[206] | 1.42[207] | 0.65[208] | 0.54[209] | 1.56[210] |
31 | SNAI2 | Zinc finger protein SNAI2 | [211] | -6.04[212] | -7.09[213] | -8.63[214] | -0.96[215] | 1.82[216] | -1.36[217] |
32 | SMAD2 | Mothers against decapentaplegic homolog 2 | [218] | 1.19[219] | 1.36[220] | 1.04[221] | 1.33[222] | 1.28[223] | 1.81[224] |
33 | TGFB1 | Transforming growth factor beta-1 | [225] | 2.64[226] | 1.52[227] | -1.05[228] | 2.79[229] | 1.77[230] | -1.98[231] |
34 | TGFBR3 | Transforming growth factor beta receptor type 3 | [232] | 1.46[233] | 3.42[234] | 2.17[235] | 0.81[236] | -1.11[237] | 2.22[238] |
35 | TGFB3 | Transforming growth factor beta-3 | [239] | -2.37[240] | -3.33[241] | -3.39[242] | -0.88[243] | -2.19[244] | -0.30[245] |
36 | PLXNA1 | Plexin-A1 | [246] | 3.19[247] | 2.36[248] | 2.30[249] | 2.52[250] | 2.44[251] | 1.51[252] |
37 | CCNE2 | G1/S-specific cyclin-E2 | [253] | -0.41[254] | -0.10[255] | -0.38[256] | 1.99[257] | 1.64[258] | -1.11[259] |
38 | MMP9 | Matrix metalloproteinase-9 | [260] | -3.55[261] | -4.68[262] | -6.90[263] | -2.48[264] | -5.29[265] | -0.90[266] |
39 | PLXNA2 | Plexin-A2 | [267] | 2.54[268] | 1.29[269] | -1.16[270] | 1.71[271] | 2.99[272] | 2.56[273] |
40 | CDH5 | Cadherin-5 | [274] | -2.41[275] | -4.65[276] | [277] | -5.96[278] | -6.76[279] | 3.78[280] |
41 | REL | Proto-oncogene c-Rel | [281] | -1.35[282] | 0.33[283] | 0.44[284] | -0.90[285] | -1.00[286] | 1.59[287] |
42 | COL1A1 | Collagen alpha-1(I) chain | [288] | 3.91[289] | -3.69[290] | -1.69[291] | 5.96[292] | 7.25[293] | 5.60[294] |
43 | AKT3 | RAC-gamma serine/threonine-protein kinase | [295] | -2.67[296] | -5.32[297] | -4.45[298] | 4.79[299] | 3.50[300] | 2.85[301] |
44 | KDR | Vascular endothelial growth factor receptor 2 | [302] | -6.46[303] | -8.20[304] | -7.31[305] | -2.79[306] | 3.43[307] | 5.54[308] |
45 | COL1A2 | Collagen alpha-2(I) chain | [309] | -6.98[310] | -6.99[311] | -4.33[312] | 3.93[313] | 3.72[314] | 5.67[315] |
46 | SNAI1 | Zinc finger protein SNAI1 | [316] | 2.23[317] | 0.47[318] | 2.71[319] | 1.97[320] | 1.01[321] | 0.29[322] |
47 | FLT1 | Vascular endothelial growth factor receptor 1 | [323] | -2.34[324] | -2.06[325] | -2.32[326] | -1.34[327] | -2.53[328] | 5.34[329] |
48 | MMP2 | 72 kDa type IV collagenase | [330] | 2.60[331] | -4.47[332] | -3.01[333] | 6.39[334] | 5.69[335] | 3.18[336] |
49 | PLXNA4 | Plexin-A4 | [337] | -0.28[338] | -2.72[339] | -4.76[340] | 0.17[341] | -2.01[342] | 4.07[343] |
50 | HGF | Hepatocyte growth factor | [344] | [345] | [346] | -2.39[347] | 3.54[348] | 0.33[349] | 8.14[350] |
51 | SEMA3A | Semaphorin-3A | [351] | 5.11[352] | 7.66[353] | 7.96[354] | 6.25[355] | 6.90[356] | 3.40[357] |
52 | EGF | Pro-epidermal growth factor | [358] | 1.14[359] | 2.84[360] | 6.63[361] | 7.97[362] | 5.15[363] | 0.82[364] |
53 | MIR3175 | [365] | [366] | [367] | [368] | [369] | [370] | [371] | |
54 | CCN2 | [372] | [373] | [374] | [375] | [376] | [377] | [378] | |
55 | MIR141 | [379] | [380] | [381] | [382] | [383] | [384] | [385] |