WP_NRF2ARE_REGULATION Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GSTA2 Glutathione S-transferase A2 [1] -6.77[2] -9.24[3] -4.65[4] -10.38[5] -12.16[6] -2.72[7]
2 RBX1 E3 ubiquitin-protein ligase RBX1 [8] -2.08[9] -1.62[10] -1.54[11] -3.64[12] -1.45[13] -1.39[14]
3 HMOX1 Heme oxygenase 1 [15] -0.51[16] -1.41[17] -2.32[18] -2.53[19] -1.00[20] -1.38[21]
4 NQO1 NAD(P)H dehydrogenase [quinone] 1 [22] 2.73[23] 2.44[24] 2.25[25] 3.16[26] 1.09[27] -4.53[28]
5 CEBPB CCAAT/enhancer-binding protein beta [29] -1.20[30] -1.80[31] -1.58[32] -2.35[33] 0.35[34] -0.97[35]
6 GCLC Glutamate--cysteine ligase catalytic subunit [36] -0.38[37] 0.01[38] -1.02[39] 0.02[40] -0.94[41] 1.12[42]
7 GCLM Glutamate--cysteine ligase regulatory subunit [43] -1.00[44] -1.74[45] -1.08[46] -0.08[47] -0.14[48] -0.13[49]
8 YES1 Tyrosine-protein kinase Yes [50] -0.88[51] 0.63[52] 1.05[53] -0.48[54] 0.74[55] 0.83[56]
9 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 -1.09[57] -1.34[58] -1.74[59] -2.69[60] -0.95[61] -0.54[62]
10 NFE2L2 Nuclear factor erythroid 2-related factor 2 [63] 0.74[64] 1.70[65] 1.50[66] -0.47[67] 1.53[68] 0.88[69]
11 KEAP1 Kelch-like ECH-associated protein 1 [70] 0.19[71] 0.12[72] 0.04[73] -1.75[74] 1.01[75] 1.26[76]
12 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial [77] 0.84[78] 0.99[79] 0.64[80] -0.97[81] 0.92[82] 0.46[83]
13 MAPK8 Mitogen-activated protein kinase 8 [84] -1.47[85] -0.03[86] -0.97[87] -1.84[88] -0.21[89] 0.19[90]
14 CUL3 Cullin-3 [91] 0.59[92] 1.53[93] 1.44[94] 0.53[95] 2.38[96] 1.65[97]
15 INSR Insulin receptor [98] 0.44[99] 1.11[100] 2.74[101] -4.01[102] 0.35[103] 4.71[104]
16 GSK3B Glycogen synthase kinase-3 beta [105] 1.24[106] 0.91[107] 1.67[108] 0.88[109] 2.47[110] 1.87[111]
17 SRC Proto-oncogene tyrosine-protein kinase Src [112] 3.00[113] 3.01[114] 2.21[115] 1.47[116] 2.41[117] -0.14[118]
18 MAF Transcription factor Maf [119] -2.91[120] -5.93[121] 1.39[122] -0.78[123] 0.04[124] 3.11[125]
19 PRKCA Protein kinase C alpha type [126] 2.81[127] 2.88[128] 3.43[129] 1.22[130] 3.34[131] 2.62[132]
20 FYN Tyrosine-protein kinase Fyn [133] 0.92[134] -7.65[135] 1.11[136] 0.54[137] 3.83[138] 1.68[139]
21 PIK3CA Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform -0.40[140] 1.26[141] 1.64[142] 0.20[143] 2.16[144] 2.62[145]
22 SLC7A11 Cystine/glutamate transporter [146] 2.64[147] 3.52[148] 3.56[149] 3.95[150] 4.52[151] -0.32[152]
23 EPHB2 Ephrin type-B receptor 2 [153] -0.86[154] -5.89[155] 0.73[156] 1.44[157] 3.94[158] -0.87[159]
[1]
ref_hepatocyte GSTA2
Mean 199
Standard deviation 3.4e+02
Values 1.1 8e+02 1.2e+02 27 48
[2]
HepG2 GSTA2
Mean 4.11
Standard deviation 1.5
Values 5.2 3.1
[3]
HepG2.C3A GSTA2
Mean 0.647
Standard deviation 0.13
Values 0.74 0.55
[4]
HuH.7 GSTA2
Mean 13.1
Standard deviation 7.6
Values 10 22 7.6
[5]
SNU475 GSTA2
Mean 0.525
Standard deviation 0.65
Values 0.066 0.98
[6]
THLE GSTA2
Mean 0.0506
Standard deviation 0.0038
Values 0.053 0.048
[7]
liver GSTA2
Mean 26.3
Standard deviation 39
Values 0.29 20 0.73 84
[8]
ref_hepatocyte RBX1
Mean 54.3
Standard deviation 41
Values 7.4 36 33 88 1.1e+02
[9]
HepG2 RBX1
Mean 28.8
Standard deviation 5.7
Values 33 25
[10]
HepG2.C3A RBX1
Mean 34.6
Standard deviation 13
Values 44 26
[11]
HuH.7 RBX1
Mean 30.6
Standard deviation 15
Values 46 17 29
[12]
SNU475 RBX1
Mean 15.3
Standard deviation 1.3
Values 14 16
[13]
THLE RBX1
Mean 23
Standard deviation 3.5
Values 21 25
[14]
liver RBX1
Mean 18
Standard deviation 18
Values 1.8 2.5 36 32
[15]
ref_hepatocyte HMOX1
Mean 45.4
Standard deviation 44
Values 1.2e+02 37 47 19 4.5
[16]
HepG2 HMOX1
Mean 71.8
Standard deviation 29
Values 52 92
[17]
HepG2.C3A HMOX1
Mean 33.6
Standard deviation 4.7
Values 37 30
[18]
HuH.7 HMOX1
Mean 14.9
Standard deviation 6.3
Values 12 22 10
[19]
SNU475 HMOX1
Mean 27.6
Standard deviation 4.6
Values 31 24
[20]
THLE HMOX1
Mean 26.2
Standard deviation 9.7
Values 19 33
[21]
liver HMOX1
Mean 15.2
Standard deviation 2.1
Values 15 13 16 18
[22]
ref_hepatocyte NQO1
Mean 42.1
Standard deviation 85
Values 1.6 0.37 1.4 1.9e+02 13
[23]
HepG2 NQO1
Mean 625
Standard deviation 2.7e+02
Values 4.3e+02 8.1e+02
[24]
HepG2.C3A NQO1
Mean 447
Standard deviation 1.2e+02
Values 5.3e+02 3.6e+02
[25]
HuH.7 NQO1
Mean 329
Standard deviation 90
Values 4e+02 2.3e+02 3.5e+02
[26]
SNU475 NQO1
Mean 1.32e+03
Standard deviation 2.1e+02
Values 1.2e+03 1.5e+03
[27]
THLE NQO1
Mean 103
Standard deviation 3.8
Values 1.1e+02 1e+02
[28]
liver NQO1
Mean 1.58
Standard deviation 1.1
Values 0.97 1.8 0.49 3.1
[29]
ref_hepatocyte CEBPB
Mean 37.2
Standard deviation 25
Values 24 62 65 9 26
[30]
HepG2 CEBPB
Mean 36.4
Standard deviation 26
Values 18 55
[31]
HepG2.C3A CEBPB
Mean 20.9
Standard deviation 13
Values 12 30
[32]
HuH.7 CEBPB
Mean 20.5
Standard deviation 6.4
Values 23 25 13
[33]
SNU475 CEBPB
Mean 25.6
Standard deviation 11
Values 33 18
[34]
THLE CEBPB
Mean 55
Standard deviation 10
Values 48 62
[35]
liver CEBPB
Mean 16.5
Standard deviation 5.6
Values 22 16 18 9.1
[36]
ref_hepatocyte GCLC
Mean 23.9
Standard deviation 11
Values 36 37 16 14 17
[37]
HepG2 GCLC
Mean 41.2
Standard deviation 0.21
Values 41 41
[38]
HepG2.C3A GCLC
Mean 47.1
Standard deviation 0.68
Values 47 48
[39]
HuH.7 GCLC
Mean 19.4
Standard deviation 7.4
Values 15 28 15
[40]
SNU475 GCLC
Mean 84.8
Standard deviation 9.1
Values 78 91
[41]
THLE GCLC
Mean 14.4
Standard deviation 0.55
Values 15 14
[42]
liver GCLC
Mean 45.3
Standard deviation 20
Values 64 59 37 22
[43]
ref_hepatocyte GCLM
Mean 20.7
Standard deviation 17
Values 32 5.2 8.4 12 45
[44]
HepG2 GCLM
Mean 23.3
Standard deviation 15
Values 13 34
[45]
HepG2.C3A GCLM
Mean 12.1
Standard deviation 3.1
Values 14 9.9
[46]
HuH.7 GCLM
Mean 16.1
Standard deviation 2.7
Values 13 19 16
[47]
SNU475 GCLM
Mean 68.3
Standard deviation 0.053
Values 68 68
[48]
THLE GCLM
Mean 21.6
Standard deviation 2.7
Values 20 24
[49]
liver GCLM
Mean 16.4
Standard deviation 8.1
Values 7 14 18 27
[50]
ref_hepatocyte YES1
Mean 20.5
Standard deviation 18
Values 7.9 7.6 6.7 40 40
[51]
HepG2 YES1
Mean 24.9
Standard deviation 6
Values 29 21
[52]
HepG2.C3A YES1
Mean 62.3
Standard deviation 7.4
Values 68 57
[53]
HuH.7 YES1
Mean 69.8
Standard deviation 10
Values 58 77 74
[54]
SNU475 YES1
Mean 51.4
Standard deviation 2.5
Values 50 53
[55]
THLE YES1
Mean 39.7
Standard deviation 2
Values 41 38
[56]
liver YES1
Mean 31.7
Standard deviation 8
Values 38 39 27 23
[57]
ref_hepatocyte AIMP2
Mean 17.4
Standard deviation 5.5
Values 23 11 16 13 23
[58]
HepG2 AIMP2
Mean 18.3
Standard deviation 2.5
Values 17 20
[59]
HepG2.C3A AIMP2
Mean 13.5
Standard deviation 2.6
Values 15 12
[60]
HuH.7 AIMP2
Mean 8.59
Standard deviation 2.3
Values 10 5.9 9.7
[61]
SNU475 AIMP2
Mean 9.46
Standard deviation 0.75
Values 10 8.9
[62]
THLE AIMP2
Mean 10.4
Standard deviation 1.5
Values 9.3 11
[63]
liver AIMP2
Mean 10.4
Standard deviation 6.3
Values 4.6 5.3 15 17
[64]
ref_hepatocyte NFE2L2
Mean 15.6
Standard deviation 4.9
Values 11 19 21 18 9.4
[65]
HepG2 NFE2L2
Mean 58.6
Standard deviation 25
Values 76 41
[66]
HepG2.C3A NFE2L2
Mean 99.8
Standard deviation 19
Values 1.1e+02 86
[67]
HuH.7 NFE2L2
Mean 72.7
Standard deviation 3
Values 74 75 69
[68]
SNU475 NFE2L2
Mean 39.6
Standard deviation 2.1
Values 41 38
[69]
THLE NFE2L2
Mean 52.3
Standard deviation 3.2
Values 55 50
[70]
liver NFE2L2
Mean 25
Standard deviation 9.2
Values 15 21 28 36
[71]
ref_hepatocyte KEAP1
Mean 14.9
Standard deviation 4.1
Values 17 15 20 11 11
[72]
HepG2 KEAP1
Mean 38
Standard deviation 2.6
Values 36 40
[73]
HepG2.C3A KEAP1
Mean 31.6
Standard deviation 0.82
Values 32 31
[74]
HuH.7 KEAP1
Mean 25.2
Standard deviation 5.2
Values 30 20 26
[75]
SNU475 KEAP1
Mean 15.5
Standard deviation 1.8
Values 17 14
[76]
THLE KEAP1
Mean 34.5
Standard deviation 4.9
Values 31 38
[77]
liver KEAP1
Mean 30.9
Standard deviation 7.7
Values 29 23 31 41
[78]
ref_hepatocyte PGAM5
Mean 9.76
Standard deviation 3
Values 14 7.6 12 6.5 9.3
[79]
HepG2 PGAM5
Mean 39.2
Standard deviation 2.2
Values 38 41
[80]
HepG2.C3A PGAM5
Mean 38
Standard deviation 10
Values 45 31
[81]
HuH.7 PGAM5
Mean 25.1
Standard deviation 9.5
Values 31 14 30
[82]
SNU475 PGAM5
Mean 17.5
Standard deviation 2.3
Values 19 16
[83]
THLE PGAM5
Mean 21.4
Standard deviation 2.4
Values 20 23
[84]
liver PGAM5
Mean 11.7
Standard deviation 2.9
Values 15 13 8.3 10
[85]
ref_hepatocyte MAPK8
Mean 7.1
Standard deviation 4.4
Values 15 4.7 3.8 6.5 5.6
[86]
HepG2 MAPK8
Mean 5.76
Standard deviation 1
Values 6.5 5.1
[87]
HepG2.C3A MAPK8
Mean 13.6
Standard deviation 4
Values 17 11
[88]
HuH.7 MAPK8
Mean 5.99
Standard deviation 0.68
Values 5.2 6.2 6.5
[89]
SNU475 MAPK8
Mean 6.98
Standard deviation 0.5
Values 6.6 7.3
[90]
THLE MAPK8
Mean 7.08
Standard deviation 1
Values 6.4 7.8
[91]
liver MAPK8
Mean 7.08
Standard deviation 1
Values 7.6 7.8 7.3 5.6
[92]
ref_hepatocyte CUL3
Mean 5.91
Standard deviation 1.6
Values 3.5 6 5.4 7.2 7.4
[93]
HepG2 CUL3
Mean 20
Standard deviation 5.9
Values 24 16
[94]
HepG2.C3A CUL3
Mean 33.5
Standard deviation 2.3
Values 35 32
[95]
HuH.7 CUL3
Mean 26.4
Standard deviation 3
Values 27 23 29
[96]
SNU475 CUL3
Mean 29.9
Standard deviation 0.9
Values 31 29
[97]
THLE CUL3
Mean 35.6
Standard deviation 0.55
Values 35 36
[98]
liver CUL3
Mean 16.1
Standard deviation 5.2
Values 20 20 15 9.1
[99]
ref_hepatocyte INSR
Mean 5.73
Standard deviation 1.4
Values 4.1 7.7 5.3 6.5 5
[100]
HepG2 INSR
Mean 17.4
Standard deviation 4.9
Values 14 21
[101]
HepG2.C3A INSR
Mean 24.3
Standard deviation 6.7
Values 20 29
[102]
HuH.7 INSR
Mean 62.9
Standard deviation 26
Values 39 91 58
[103]
SNU475 INSR
Mean 1.24
Standard deviation 0.29
Values 1 1.4
[104]
THLE INSR
Mean 8.45
Standard deviation 0.32
Values 8.2 8.7
[105]
liver INSR
Mean 131
Standard deviation 15
Values 1.3e+02 1.5e+02 1.4e+02 1.1e+02
[106]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 4.9 2.1 2.7 5.2 5.9
[107]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 26 18
[108]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 17 14
[109]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 15 26 24
[110]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 25 29
[111]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[112]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 16 15 14 8.6
[113]
ref_hepatocyte SRC
Mean 3.67
Standard deviation 3.6
Values 2.2 1.2 0.77 9.6 4.7
[114]
HepG2 SRC
Mean 66
Standard deviation 21
Values 51 81
[115]
HepG2.C3A SRC
Mean 58.1
Standard deviation 18
Values 45 71
[116]
HuH.7 SRC
Mean 27.9
Standard deviation 2
Values 26 29 28
[117]
SNU475 SRC
Mean 35.6
Standard deviation 3.5
Values 33 38
[118]
THLE SRC
Mean 22.5
Standard deviation 2.7
Values 21 24
[119]
liver SRC
Mean 2.9
Standard deviation 1
Values 3.2 2.5 4.1 1.7
[120]
ref_hepatocyte MAF
Mean 2.64
Standard deviation 1.4
Values 0.9 4.9 2.4 2.6 2.4
[121]
HepG2 MAF
Mean 0.788
Standard deviation 0.5
Values 1.1 0.44
[122]
HepG2.C3A MAF
Mean 0.0853
Standard deviation 0.11
Values 0.16 0.0097
[123]
HuH.7 MAF
Mean 11.4
Standard deviation 8.2
Values 7.3 21 6.2
[124]
SNU475 MAF
Mean 5.39
Standard deviation 2.7
Values 3.5 7.3
[125]
THLE MAF
Mean 3.15
Standard deviation 0.074
Values 3.2 3.1
[126]
liver MAF
Mean 19.9
Standard deviation 6.7
Values 16 17 30 17
[127]
ref_hepatocyte PRKCA
Mean 2.45
Standard deviation 2.1
Values 1.1 1.2 1.2 2.7 6
[128]
HepG2 PRKCA
Mean 38.7
Standard deviation 5.6
Values 43 35
[129]
HepG2.C3A PRKCA
Mean 35.5
Standard deviation 4.5
Values 39 32
[130]
HuH.7 PRKCA
Mean 43.7
Standard deviation 11
Values 33 44 54
[131]
SNU475 PRKCA
Mean 20
Standard deviation 4.3
Values 23 17
[132]
THLE PRKCA
Mean 28.8
Standard deviation 11
Values 21 36
[133]
liver PRKCA
Mean 13.2
Standard deviation 7.1
Values 21 17 11 4.7
[134]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 0.23 5.5 2.6 2.2 0.039
[135]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 8.4 9.4
[136]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.021 0.019
[137]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.5 4.8 8.9
[138]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 8.9 12
[139]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[140]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 5 4.4 8.9 5.1
[141]
ref_hepatocyte PIK3CA
Mean 1.87
Standard deviation 0.73
Values 2.3 0.94 1.2 2.3 2.6
[142]
HepG2 PIK3CA
Mean 3.17
Standard deviation 1.6
Values 4.3 2.1
[143]
HepG2.C3A PIK3CA
Mean 8.78
Standard deviation 1.1
Values 9.6 8
[144]
HuH.7 PIK3CA
Mean 9.59
Standard deviation 2.4
Values 7 12 10
[145]
SNU475 PIK3CA
Mean 7.49
Standard deviation 0.93
Values 6.8 8.1
[146]
THLE PIK3CA
Mean 9.67
Standard deviation 0.66
Values 10 9.2
[147]
liver PIK3CA
Mean 9.99
Standard deviation 4.7
Values 13 15 6.1 6
[148]
ref_hepatocyte SLC7A11
Mean 1.16
Standard deviation 1.5
Values 1.1 0.081 0.13 0.84 3.6
[149]
HepG2 SLC7A11
Mean 16.2
Standard deviation 8
Values 11 22
[150]
HepG2.C3A SLC7A11
Mean 26.1
Standard deviation 9.4
Values 19 33
[151]
HuH.7 SLC7A11
Mean 22.5
Standard deviation 3.7
Values 18 24 25
[152]
SNU475 SLC7A11
Mean 62.6
Standard deviation 14
Values 72 53
[153]
THLE SLC7A11
Mean 30.6
Standard deviation 10
Values 38 24
[154]
liver SLC7A11
Mean 0.81
Standard deviation 0.61
Values 0.54 0.77 1.7 0.26
[155]
ref_hepatocyte EPHB2
Mean 0.766
Standard deviation 0.96
Values 2 0.065 0.15 0 1.7
[156]
HepG2 EPHB2
Mean 0.949
Standard deviation 0.65
Values 0.49 1.4
[157]
HepG2.C3A EPHB2
Mean 0.0253
Standard deviation 0.0055
Values 0.021 0.029
[158]
HuH.7 EPHB2
Mean 2.09
Standard deviation 1.4
Values 2.5 0.54 3.2
[159]
SNU475 EPHB2
Mean 7.27
Standard deviation 2.9
Values 9.3 5.2
[160]
THLE EPHB2
Mean 13.6
Standard deviation 2
Values 12 15
[161]
liver EPHB2
Mean 0.366
Standard deviation 0.19
Values 0.62 0.37 0.19 0.28