WP_NOTCH_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SKP1 | S-phase kinase-associated protein 1 | [1] | -1.77[2] | -0.97[3] | -1.84[4] | -1.28[5] | -1.03[6] | -1.27[7] |
2 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [8] | 0.05[9] | -0.93[10] | -3.62[11] | -2.76[12] | -0.17[13] | -2.41[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | -0.71[16] | -0.53[17] | -1.61[18] | -0.83[19] | -0.77[20] | -0.82[21] |
4 | APH1A | Gamma-secretase subunit APH-1A | [22] | -0.86[23] | -0.17[24] | 0.05[25] | -1.04[26] | -1.11[27] | -1.59[28] |
5 | STAT3 | Signal transducer and activator of transcription 3 | [29] | -0.24[30] | -1.33[31] | -0.59[32] | -0.53[33] | -1.23[34] | 1.83[35] |
6 | MYC | Myc proto-oncogene protein | [36] | -0.36[37] | -0.29[38] | -2.32[39] | -3.57[40] | -1.16[41] | -2.58[42] |
7 | PSENEN | Gamma-secretase subunit PEN-2 | [43] | -2.86[44] | -2.44[45] | -1.97[46] | -2.66[47] | -3.05[48] | -2.65[49] |
8 | HIF1A | Hypoxia-inducible factor 1-alpha | [50] | -0.95[51] | -0.87[52] | -0.07[53] | 1.51[54] | 1.93[55] | -1.39[56] |
9 | SNW1 | SNW domain-containing protein 1 | [57] | -1.79[58] | -1.21[59] | -1.19[60] | -0.91[61] | -1.12[62] | -2.21[63] |
10 | CCND1 | G1/S-specific cyclin-D1 | [64] | 2.26[65] | 0.16[66] | 1.00[67] | 1.10[68] | -0.34[69] | 0.47[70] |
11 | HDAC1 | Histone deacetylase 1 | [71] | -0.29[72] | 0.14[73] | 0.83[74] | -0.13[75] | -0.31[76] | -1.04[77] |
12 | NCSTN | Nicastrin | [78] | 0.56[79] | 0.12[80] | 0.28[81] | 0.31[82] | 0.23[83] | -0.19[84] |
13 | CUL1 | Cullin-1 | [85] | -1.18[86] | -0.09[87] | -0.54[88] | -0.19[89] | -0.51[90] | 0.17[91] |
14 | NUMB | Protein numb homolog | [92] | -1.23[93] | 0.25[94] | -0.63[95] | -0.50[96] | -0.30[97] | -0.36[98] |
15 | CIR1 | Corepressor interacting with RBPJ 1 | [99] | -3.08[100] | -0.60[101] | -0.08[102] | -1.99[103] | -1.95[104] | -2.42[105] |
16 | RING1 | E3 ubiquitin-protein ligase RING1 | [106] | -0.72[107] | -0.60[108] | -1.35[109] | -0.47[110] | -1.01[111] | -2.76[112] |
17 | ITCH | E3 ubiquitin-protein ligase Itchy homolog | [113] | 0.55[114] | 1.50[115] | 0.75[116] | 0.75[117] | 0.12[118] | 1.59[119] |
18 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [120] | -1.26[121] | -0.74[122] | 0.35[123] | 1.29[124] | 0.83[125] | 2.42[126] |
19 | TLE1 | Transducin-like enhancer protein 1 | [127] | 0.77[128] | 0.57[129] | -0.16[130] | -0.68[131] | -0.84[132] | -0.24[133] |
20 | HES1 | Transcription factor HES-1 | [134] | -1.23[135] | -3.32[136] | -1.06[137] | -2.05[138] | -2.85[139] | -1.98[140] |
21 | NCOR1 | Nuclear receptor corepressor 1 | [141] | 0.29[142] | 1.20[143] | 1.85[144] | 0.79[145] | 0.87[146] | 2.22[147] |
22 | HDAC2 | Histone deacetylase 2 | [148] | 0.93[149] | 2.67[150] | 2.04[151] | 1.38[152] | 1.56[153] | -0.38[154] |
23 | PSEN1 | Presenilin-1 | [155] | 0.27[156] | 0.89[157] | 0.46[158] | 0.48[159] | 0.39[160] | 0.42[161] |
24 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [162] | -0.12[163] | -0.04[164] | -0.25[165] | -1.02[166] | -0.08[167] | -0.13[168] |
25 | NOTCH2 | Neurogenic locus notch homolog protein 2 | [169] | -0.66[170] | -5.98[171] | 1.50[172] | 2.26[173] | 3.08[174] | 2.74[175] |
26 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [176] | 1.08[177] | 1.71[178] | 2.32[179] | -0.07[180] | 0.52[181] | -0.87[182] |
27 | ADAM17 | Disintegrin and metalloproteinase domain-containing protein 17 | [183] | -0.12[184] | 0.18[185] | -0.09[186] | 0.97[187] | 0.13[188] | -0.50[189] |
28 | PSEN2 | Presenilin-2 | [190] | -1.48[191] | -1.93[192] | -5.74[193] | -0.70[194] | -2.03[195] | -0.68[196] |
29 | HES6 | Transcription cofactor HES-6 | [197] | 0.12[198] | 1.34[199] | -0.99[200] | -1.89[201] | -3.93[202] | -3.69[203] |
30 | GSK3B | Glycogen synthase kinase-3 beta | [204] | 0.47[205] | 0.52[206] | 1.09[207] | 1.04[208] | 0.90[209] | 0.58[210] |
31 | SAP30 | Histone deacetylase complex subunit SAP30 | [211] | -1.32[212] | -0.32[213] | 0.28[214] | -1.75[215] | -0.06[216] | -3.03[217] |
32 | SRC | Proto-oncogene tyrosine-protein kinase Src | [218] | 2.23[219] | 2.63[220] | 1.63[221] | 1.62[222] | 0.83[223] | -1.43[224] |
33 | RBPJ | Recombining binding protein suppressor of hairless | [225] | 0.55[226] | 1.53[227] | 2.54[228] | 1.24[229] | 1.21[230] | 1.27[231] |
34 | FBXW7 | F-box/WD repeat-containing protein 7 | [232] | -1.53[233] | -0.44[234] | -0.47[235] | -1.68[236] | -0.63[237] | 0.57[238] |
35 | JAG1 | Protein jagged-1 | [239] | 3.98[240] | 2.98[241] | 2.45[242] | 0.74[243] | -0.58[244] | 0.47[245] |
36 | NCOR2 | Nuclear receptor corepressor 2 | [246] | 2.56[247] | 1.36[248] | 1.46[249] | 3.37[250] | 2.90[251] | 1.31[252] |
37 | DTX1 | E3 ubiquitin-protein ligase DTX1 | [253] | -7.74[254] | -8.27[255] | [256] | -6.59[257] | -8.41[258] | 0.03[259] |
38 | FHL1 | Four and a half LIM domains protein 1 | [260] | -5.65[261] | -8.03[262] | -7.25[263] | 1.76[264] | -1.03[265] | 1.12[266] |
39 | EP300 | Histone acetyltransferase p300 | [267] | 1.93[268] | 1.93[269] | 2.83[270] | 1.80[271] | 1.88[272] | 2.17[273] |
40 | MAML1 | Mastermind-like protein 1 | [274] | 1.32[275] | 1.69[276] | 2.24[277] | 1.47[278] | 1.63[279] | 0.50[280] |
41 | SPEN | Msx2-interacting protein | [281] | 2.09[282] | 3.19[283] | 3.06[284] | 2.77[285] | 2.80[286] | 3.06[287] |
42 | HEY1 | Hairy/enhancer-of-split related with YRPW motif protein 1 | [288] | 0.85[289] | -0.29[290] | -0.22[291] | -1.27[292] | -2.43[293] | -0.53[294] |
43 | JAK2 | Tyrosine-protein kinase JAK2 | [295] | -0.57[296] | -0.16[297] | -0.60[298] | -0.01[299] | 0.62[300] | 2.13[301] |
44 | APH1B | Gamma-secretase subunit APH-1B | [302] | -1.03[303] | 0.19[304] | 3.32[305] | 2.32[306] | 1.39[307] | 0.64[308] |
45 | NUMBL | Numb-like protein | [309] | -1.23[310] | -0.01[311] | 1.45[312] | 2.91[313] | 2.01[314] | -0.06[315] |
46 | NOTCH1 | Neurogenic locus notch homolog protein 1 | [316] | 1.11[317] | 0.36[318] | 1.70[319] | 1.81[320] | 2.20[321] | 4.06[322] |
47 | HEY2 | Hairy/enhancer-of-split related with YRPW motif protein 2 | [323] | -4.51[324] | -5.90[325] | -6.00[326] | -4.64[327] | -7.43[328] | 0.17[329] |
48 | MAML3 | Mastermind-like protein 3 | [330] | -1.17[331] | -0.02[332] | 3.01[333] | 0.63[334] | -0.72[335] | 2.92[336] |
49 | MAPT | Microtubule-associated protein tau | [337] | 1.73[338] | 2.08[339] | 1.38[340] | 0.56[341] | -2.47[342] | -0.25[343] |
50 | LCK | Tyrosine-protein kinase Lck | [344] | 1.98[345] | 2.48[346] | -7.52[347] | -5.86[348] | -6.03[349] | 0.65[350] |
51 | MAML2 | Mastermind-like protein 2 | [351] | 2.70[352] | 3.73[353] | -2.84[354] | 4.00[355] | 2.90[356] | 1.78[357] |
52 | DLL4 | Delta-like protein 4 | [358] | -0.05[359] | 1.07[360] | -0.16[361] | -3.90[362] | -2.58[363] | 2.62[364] |
53 | DLL1 | Delta-like protein 1 | [365] | -5.15[366] | -3.54[367] | -3.48[368] | -7.56[369] | -0.43[370] | 1.93[371] |
54 | NOTCH3 | Neurogenic locus notch homolog protein 3 | [372] | 3.27[373] | -0.67[374] | 5.29[375] | 5.47[376] | 3.35[377] | 3.50[378] |
55 | NOTCH4 | Neurogenic locus notch homolog protein 4 | [379] | -0.22[380] | 0.75[381] | -1.89[382] | -2.78[383] | -0.14[384] | 5.63[385] |
56 | DLL3 | Delta-like protein 3 | [386] | 1.65[387] | -1.51[388] | 2.35[389] | 1.82[390] | 0.10[391] | [392] |
57 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | [393] | -4.98[394] | [395] | 2.33[396] | 0.53[397] | 0.69[398] | 0.63[399] |
58 | JAG2 | Protein jagged-2 | [400] | 2.66[401] | -0.88[402] | 3.16[403] | 5.07[404] | 2.28[405] | 1.32[406] |
59 | PTCRA | Pre T-cell antigen receptor alpha | [407] | [408] | -4.70[409] | [410] | -5.35[411] | [412] | -1.75[413] |
60 | HES5 | Transcription factor HES-5 | [414] | 2.44[415] | -1.38[416] | [417] | [418] | -3.10[419] | -0.20[420] |
61 | MAGEA1 | Melanoma-associated antigen 1 | [421] | [422] | [423] | [424] | [425] | [426] | [427] |
62 | MIR1281 | [428] | [429] | [430] | [431] | [432] | [433] | [434] | |
63 | ENSG00000284930 | [435] | [436] | [437] | [438] | [439] | [440] | [441] |