WP_NONSMALL_CELL_LUNG_CANCER | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [1] | -4.79[2] | -5.38[3] | -4.11[4] | -4.36[5] | -3.25[6] | -2.53[7] |
2 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [8] | -3.09[9] | -4.00[10] | -3.75[11] | -4.33[12] | -2.47[13] | -3.37[14] |
3 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [15] | -10.54[16] | [17] | -8.78[18] | -8.18[19] | -7.98[20] | -2.08[21] |
4 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [22] | 0.22[23] | -1.00[24] | -3.63[25] | -2.33[26] | 0.36[27] | -2.19[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | -0.54[30] | -0.60[31] | -1.62[32] | -0.39[33] | -0.24[34] | -0.61[35] |
6 | STAT3 | Signal transducer and activator of transcription 3 | [36] | -0.07[37] | -1.40[38] | -0.60[39] | -0.10[40] | -0.70[41] | 2.05[42] |
7 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [43] | -1.55[44] | -1.71[45] | -1.07[46] | -0.88[47] | -0.25[48] | -1.55[49] |
8 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [50] | -0.56[51] | -0.72[52] | 0.21[53] | -1.18[54] | -0.57[55] | -2.06[56] |
9 | BAX | Apoptosis regulator BAX | [57] | -0.29[58] | -0.91[59] | -1.32[60] | -1.94[61] | -1.43[62] | -4.32[63] |
10 | CCND1 | G1/S-specific cyclin-D1 | [64] | 2.43[65] | 0.10[66] | 0.99[67] | 1.54[68] | 0.19[69] | 0.69[70] |
11 | GRB2 | Growth factor receptor-bound protein 2 | [71] | 0.58[72] | 0.58[73] | 0.76[74] | 0.21[75] | 0.26[76] | -0.06[77] |
12 | CDK4 | Cyclin-dependent kinase 4 | [78] | 0.71[79] | 1.47[80] | 1.15[81] | -0.16[82] | 0.62[83] | -1.20[84] |
13 | BAD | Bcl2-associated agonist of cell death | [85] | -2.29[86] | -1.99[87] | -2.88[88] | -1.41[89] | -0.88[90] | -1.78[91] |
14 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [92] | -0.68[93] | -0.11[94] | 1.22[95] | -0.53[96] | 0.47[97] | 0.74[98] |
15 | RXRA | Retinoic acid receptor RXR-alpha | [99] | -0.67[100] | -0.70[101] | 0.20[102] | -0.33[103] | -0.53[104] | 1.79[105] |
16 | NRAS | GTPase NRas | [106] | 0.01[107] | 0.61[108] | 1.08[109] | 0.66[110] | 0.36[111] | -0.61[112] |
17 | CYCS | Cytochrome c | [113] | 0.72[114] | 1.08[115] | 1.21[116] | 0.99[117] | 1.52[118] | 0.96[119] |
18 | CASP3 | Caspase-3 | [120] | -0.48[121] | 0.36[122] | -2.13[123] | -1.24[124] | -0.11[125] | -1.17[126] |
19 | ARAF | Serine/threonine-protein kinase A-Raf | [127] | -1.07[128] | -1.21[129] | -0.88[130] | -0.44[131] | -0.27[132] | 0.51[133] |
20 | BID | BH3-interacting domain death agonist | [134] | -0.89[135] | -0.61[136] | -0.94[137] | -0.63[138] | -1.04[139] | -0.19[140] |
21 | HRAS | GTPase HRas | [141] | -1.62[142] | -2.16[143] | -2.90[144] | -1.29[145] | -1.38[146] | -3.02[147] |
22 | RASSF1 | Ras association domain-containing protein 1 | [148] | -1.67[149] | -1.36[150] | -1.68[151] | -1.83[152] | -0.28[153] | -2.27[154] |
23 | MAPK1 | Mitogen-activated protein kinase 1 | [155] | 1.09[156] | 1.40[157] | 1.28[158] | 1.51[159] | 1.29[160] | 1.41[161] |
24 | AKT2 | RAC-beta serine/threonine-protein kinase | [162] | 0.34[163] | 0.79[164] | 0.97[165] | 0.52[166] | 0.44[167] | 0.77[168] |
25 | KRAS | GTPase KRas | [169] | -1.13[170] | -0.98[171] | 0.67[172] | 0.46[173] | 0.25[174] | 0.31[175] |
26 | CASP8 | Caspase-8 | [176] | -0.60[177] | 0.14[178] | -0.63[179] | -0.42[180] | -1.04[181] | -1.78[182] |
27 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [183] | -1.09[184] | -0.80[185] | 0.35[186] | 1.73[187] | 1.36[188] | 2.64[189] |
28 | EML4 | Echinoderm microtubule-associated protein-like 4 | [190] | 2.48[191] | 3.74[192] | 2.34[193] | 1.76[194] | 0.37[195] | 1.77[196] |
29 | SOS1 | Son of sevenless homolog 1 | [197] | -0.72[198] | 0.98[199] | 0.55[200] | 0.50[201] | -0.13[202] | 0.18[203] |
30 | DDB2 | DNA damage-binding protein 2 | [204] | 0.46[205] | 0.16[206] | -1.10[207] | -1.95[208] | -1.24[209] | -1.88[210] |
31 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | [211] | 1.75[212] | 0.74[213] | 1.97[214] | 0.91[215] | 0.65[216] | -0.21[217] |
32 | BAK1 | Bcl-2 homologous antagonist/killer | [218] | 0.28[219] | -0.01[220] | 0.01[221] | 0.85[222] | 0.46[223] | -2.15[224] |
33 | EGFR | Epidermal growth factor receptor | [225] | -1.31[226] | -1.52[227] | 1.42[228] | 0.09[229] | 0.84[230] | 2.29[231] |
34 | TP53 | Cellular tumor antigen p53 | [232] | 1.02[233] | 0.75[234] | 1.57[235] | 0.95[236] | 0.74[237] | -0.40[238] |
35 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [239] | 1.26[240] | 1.65[241] | 2.32[242] | 0.37[243] | 1.05[244] | -0.65[245] |
36 | RXRB | Retinoic acid receptor RXR-beta | [246] | 0.40[247] | 0.89[248] | -0.13[249] | 1.24[250] | 0.25[251] | -0.25[252] |
37 | MAPK3 | Mitogen-activated protein kinase 3 | [253] | 1.23[254] | 1.45[255] | 1.55[256] | 0.08[257] | 0.23[258] | -1.40[259] |
38 | CDK6 | Cyclin-dependent kinase 6 | [260] | 1.43[261] | 2.30[262] | 0.76[263] | 0.58[264] | 1.51[265] | 1.71[266] |
39 | STAT5B | Signal transducer and activator of transcription 5B | [267] | 0.74[268] | 0.54[269] | 1.29[270] | 1.21[271] | 0.48[272] | 1.26[273] |
40 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 2.87[274] | 2.66[275] | 2.05[276] | 2.48[277] | 2.10[278] | -0.02[279] | |
41 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 0.59[280] | 1.27[281] | 1.49[282] | 0.71[283] | 1.00[284] | 0.80[285] | |
42 | RB1 | Retinoblastoma-associated protein | [286] | 0.60[287] | 1.27[288] | 1.89[289] | 1.93[290] | 2.39[291] | 1.12[292] |
43 | FOXO3 | Forkhead box protein O3 | [293] | -0.16[294] | 0.10[295] | 0.79[296] | 0.06[297] | 1.43[298] | 1.97[299] |
44 | CASP9 | Caspase-9 | [300] | -0.46[301] | 0.67[302] | -0.16[303] | -0.10[304] | -0.65[305] | -0.90[306] |
45 | SOS2 | Son of sevenless homolog 2 | [307] | -0.64[308] | 0.65[309] | -0.06[310] | 1.35[311] | 1.34[312] | 1.48[313] |
46 | STK4 | Serine/threonine-protein kinase 4 | [314] | 2.38[315] | 2.43[316] | 2.43[317] | 2.19[318] | 2.37[319] | 1.56[320] |
47 | E2F1 | Transcription factor E2F1 | [321] | 1.33[322] | 1.36[323] | 1.54[324] | 1.52[325] | 2.09[326] | -3.98[327] |
48 | PRKCA | Protein kinase C alpha type | [328] | 2.22[329] | 2.43[330] | 2.85[331] | 1.81[332] | 2.30[333] | 1.56[334] |
49 | STAT5A | Signal transducer and activator of transcription 5A | [335] | -2.57[336] | -1.22[337] | -2.10[338] | -1.19[339] | -0.30[340] | -0.12[341] |
50 | E2F3 | Transcription factor E2F3 | [342] | 1.10[343] | 1.10[344] | 0.41[345] | 2.29[346] | 1.87[347] | -0.53[348] |
51 | POLK | DNA polymerase kappa | [349] | -1.46[350] | 0.18[351] | 0.50[352] | 1.49[353] | 1.35[354] | 1.73[355] |
52 | TGFA | Protransforming growth factor alpha | [356] | 1.17[357] | 2.41[358] | -8.58[359] | -1.30[360] | -2.40[361] | -0.75[362] |
53 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.00[363] | 0.81[364] | 1.05[365] | 0.79[366] | 1.12[367] | 1.55[368] | |
54 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.27[369] | 2.53[370] | -1.23[371] | -0.06[372] | 0.83[373] | -0.06[374] | |
55 | PDK1 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial | 1.75[375] | 2.64[376] | 2.31[377] | 2.27[378] | 0.63[379] | 1.70[380] | |
56 | RASSF5 | Ras association domain-containing protein 5 | [381] | 0.10[382] | -4.39[383] | 0.30[384] | 1.01[385] | 0.26[386] | 0.91[387] |
57 | CRABP2 | Cellular retinoic acid-binding protein 2 | [388] | 0.88[389] | -5.21[390] | -3.17[391] | 5.18[392] | -0.31[393] | -8.97[394] |
58 | FHIT | Bis(5'-adenosyl)-triphosphatase | [395] | -1.72[396] | -1.39[397] | -2.17[398] | -6.91[399] | -2.63[400] | -0.34[401] |
59 | BRAF | Serine/threonine-protein kinase B-raf | [402] | -0.37[403] | -0.47[404] | 1.62[405] | 0.40[406] | 0.22[407] | 1.49[408] |
60 | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | -1.90[409] | -7.47[410] | 0.03[411] | -3.08[412] | -1.79[413] | 2.36[414] | |
61 | CRABP1 | Cellular retinoic acid-binding protein 1 | [415] | [416] | [417] | [418] | -4.48[419] | -6.11[420] | [421] |
62 | PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma | [422] | 1.10[423] | 1.28[424] | 2.19[425] | 2.83[426] | 1.97[427] | 2.32[428] |
63 | AKT3 | RAC-gamma serine/threonine-protein kinase | [429] | -2.46[430] | -4.85[431] | -4.10[432] | 5.50[433] | 4.58[434] | 3.25[435] |
64 | CDKN2A | Cyclin-dependent kinase inhibitor 2A | [436] | 3.47[437] | 1.40[438] | 4.87[439] | 4.87[440] | 6.78[441] | -2.51[442] |
65 | PRKCB | Protein kinase C beta type | [443] | -7.43[444] | -6.06[445] | [446] | 2.14[447] | -3.03[448] | 3.17[449] |
66 | JAK3 | Tyrosine-protein kinase JAK3 | [450] | 1.63[451] | 4.07[452] | -1.88[453] | -0.97[454] | -0.11[455] | 2.74[456] |
67 | E2F2 | Transcription factor E2F2 | [457] | 3.63[458] | 4.69[459] | 4.26[460] | 3.71[461] | 4.17[462] | 1.06[463] |
68 | RARB | Retinoic acid receptor beta | [464] | 0.82[465] | -2.22[466] | 3.67[467] | 5.48[468] | 4.18[469] | 4.41[470] |
69 | PRKCG | Protein kinase C gamma type | [471] | -1.44[472] | -0.60[473] | -2.92[474] | -1.40[475] | -1.36[476] | [477] |
70 | RXRG | Retinoic acid receptor RXR-gamma | [478] | -4.35[479] | [480] | [481] | -2.40[482] | [483] | 2.15[484] |
71 | EGF | Pro-epidermal growth factor | [485] | 1.35[486] | 3.31[487] | 6.98[488] | 8.68[489] | 6.23[490] | 1.22[491] |
72 | ALK | ALK tyrosine kinase receptor | [492] | [493] | [494] | [495] | [496] | [497] | [498] |