WP_NICOTINE_METABOLISM_IN_LIVER_CELLS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP2A6 Cytochrome P450 2A6 [1] -12.25[2] [3] -1.98[4] -6.17[5] -10.08[6] -2.58[7]
2 AOX1 Aldehyde oxidase [8] 1.94[9] 1.87[10] -2.20[11] 1.79[12] 1.95[13] 1.29[14]
3 FMO3 Dimethylaniline monooxygenase [N-oxide-forming] 3 [15] [16] -9.81[17] -0.64[18] -1.67[19] -9.98[20] -2.07[21]
4 UGT1A4 UDP-glucuronosyltransferase 1-4 [22] -8.13[23] [24] -5.32[25] -4.52[26] [27] -0.82[28]
5 CYP2B6 Cytochrome P450 2B6 [29] -4.03[30] -0.49[31] 3.20[32] -3.97[33] -6.44[34] 1.44[35]
6 UGT1A9 UDP-glucuronosyltransferase 1-9 [36] -2.10[37] -6.86[38] -0.73[39] 0.43[40] -6.31[41] -1.60[42]
[1]
ref_hepatocyte CYP2A6
Mean 231
Standard deviation 3e+02
Values 38 5.5e+02 5.6e+02 0 4.6
[2]
HepG2 CYP2A6
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[3]
HepG2.C3A CYP2A6
Mean 0
Standard deviation 0
Values 0 0
[4]
HuH.7 CYP2A6
Mean 0.421
Standard deviation 0.53
Values 0.12 1 0.11
[5]
SNU475 CYP2A6
Mean 0.0428
Standard deviation 0.025
Values 0.025 0.06
[6]
THLE CYP2A6
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[7]
liver CYP2A6
Mean 107
Standard deviation 1e+02
Values 13 1.8e+02 29 2.1e+02
[8]
ref_hepatocyte AOX1
Mean 166
Standard deviation 2e+02
Values 25 4.8e+02 2.5e+02 12 68
[9]
HepG2 AOX1
Mean 28.7
Standard deviation 3.3
Values 31 26
[10]
HepG2.C3A AOX1
Mean 22.6
Standard deviation 2.4
Values 24 21
[11]
HuH.7 AOX1
Mean 0.258
Standard deviation 0.25
Values 0.066 0.55 0.16
[12]
SNU475 AOX1
Mean 7.67
Standard deviation 6.2
Values 12 3.3
[13]
THLE AOX1
Mean 26.7
Standard deviation 2.8
Values 29 25
[14]
liver AOX1
Mean 1.12e+03
Standard deviation 5.3e+02
Values 1.1e+03 1.8e+03 5.6e+02 9.6e+02
[15]
ref_hepatocyte FMO3
Mean 129
Standard deviation 2.2e+02
Values 4.9 5.1e+02 1.2e+02 0 3.5
[16]
HepG2 FMO3
Mean 0
Standard deviation 0
Values 0 0
[17]
HepG2.C3A FMO3
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[18]
HuH.7 FMO3
Mean 0.593
Standard deviation 0.31
Values 0.47 0.95 0.36
[19]
SNU475 FMO3
Mean 0.542
Standard deviation 0.086
Values 0.48 0.6
[20]
THLE FMO3
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[21]
liver FMO3
Mean 85.3
Standard deviation 26
Values 80 64 1.2e+02 75
[22]
ref_hepatocyte UGT1A4
Mean 53.1
Standard deviation 73
Values 2.5 1.6e+02 99 0 4.2
[23]
HepG2 UGT1A4
Mean 0.00858
Standard deviation 0.012
Values 0.017 0
[24]
HepG2.C3A UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[25]
HuH.7 UGT1A4
Mean 0.00954
Standard deviation 0.0096
Values 0.0094 0.019 0
[26]
SNU475 UGT1A4
Mean 0.031
Standard deviation 0.015
Values 0.02 0.042
[27]
THLE UGT1A4
Mean 0
Standard deviation 0
Values 0 0
[28]
liver UGT1A4
Mean 83.1
Standard deviation 65
Values 32 95 36 1.7e+02
[29]
ref_hepatocyte CYP2B6
Mean 49.6
Standard deviation 62
Values 12 1e+02 1.3e+02 0 4.1
[30]
HepG2 CYP2B6
Mean 0.138
Standard deviation 0.15
Values 0.034 0.24
[31]
HepG2.C3A CYP2B6
Mean 1.32
Standard deviation 0.56
Values 0.92 1.7
[32]
HuH.7 CYP2B6
Mean 3.27
Standard deviation 2.3
Values 1.9 5.9 2.1
[33]
SNU475 CYP2B6
Mean 0.0424
Standard deviation 0.04
Values 0.071 0.014
[34]
THLE CYP2B6
Mean 0.0237
Standard deviation 0.033
Values 0.047 0
[35]
liver CYP2B6
Mean 372
Standard deviation 5.3e+02
Values 7.4 3.2e+02 23 1.1e+03
[36]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 2.6 27 26 0 21
[37]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.12 0.2
[38]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[39]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.0094 0.12 0.066
[40]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.03 0.51
[41]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[42]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 3 22 8.7 22