WP_NICOTINE_EFFECT_ON_DOPAMINERGIC_NEURONS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [1] 0.77[2] 0.84[3] 0.03[4] 0.28[5] 0.90[6] -0.84[7]
2 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [8] -0.26[9] -0.49[10] 0.39[11] 0.52[12] -1.04[13] -0.55[14]
3 DDC Aromatic-L-amino-acid decarboxylase [15] -2.32[16] -1.07[17] 0.00[18] -8.21[19] -8.42[20] 0.56[21]
4 PRKACA cAMP-dependent protein kinase catalytic subunit alpha [22] -0.40[23] -0.53[24] -0.86[25] -1.48[26] -0.06[27] -0.38[28]
5 GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-1 [29] -1.89[30] -2.78[31] -0.97[32] 0.21[33] 0.41[34] 1.23[35]
6 CDK5 Cyclin-dependent-like kinase 5 [36] 0.00[37] -0.64[38] -0.93[39] -0.38[40] -0.76[41] -0.48[42]
7 CHRNA4 Neuronal acetylcholine receptor subunit alpha-4 [43] -7.04[44] -7.48[45] -10.01[46] -9.21[47] -8.74[48] 2.31[49]
8 CHRNA5 Neuronal acetylcholine receptor subunit alpha-5 [50] 0.45[51] 0.04[52] -0.47[53] -0.24[54] 1.09[55] -2.23[56]
9 SLC18A2 Synaptic vesicular amine transporter [57] -1.27[58] 1.13[59] 1.16[60] -1.24[61] 0.32[62] 3.69[63]
10 GNG2 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 -6.52[64] -7.34[65] [66] 2.11[67] 2.41[68] 3.18[69]
11 PPP1R1B Protein phosphatase 1 regulatory subunit 1B [70] -1.82[71] -2.64[72] -6.93[73] -4.36[74] 0.34[75] -1.88[76]
12 DRD4 D(4) dopamine receptor [77] -0.81[78] 0.45[79] -0.27[80] -1.12[81] -1.51[82] -1.03[83]
13 TH Tyrosine 3-monooxygenase [84] 1.13[85] [86] [87] [88] -4.13[89] 1.95[90]
14 ADCY2 Adenylate cyclase type 2 [91] -5.62[92] -3.64[93] -5.23[94] -3.74[95] -4.03[96] -3.72[97]
15 KCNK3 Potassium channel subfamily K member 3 [98] 2.37[99] -3.12[100] -6.30[101] 1.29[102] 0.04[103] 5.07[104]
16 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 [105] 0.90[106] 0.04[107] -0.42[108] -0.90[109] 0.99[110] -1.26[111]
17 CHRNB2 Neuronal acetylcholine receptor subunit beta-2 [112] 0.43[113] 1.66[114] 1.67[115] 1.42[116] 0.91[117] 4.28[118]
18 DRD3 D(3) dopamine receptor [119] [120] [121] [122] [123] [124] [125]
19 CHRNA6 Neuronal acetylcholine receptor subunit alpha-6 [126] [127] [128] [129] [130] [131] [132]
20 KCNK9 Potassium channel subfamily K member 9 [133] [134] [135] [136] [137] [138] [139]
21 DRD2 D(2) dopamine receptor [140] [141] [142] [143] [144] [145] [146]
[1]
ref_hepatocyte GNB1
Mean 42.7
Standard deviation 15
Values 53 24 31 44 60
[2]
HepG2 GNB1
Mean 190
Standard deviation 15
Values 1.8e+02 2e+02
[3]
HepG2.C3A GNB1
Mean 171
Standard deviation 4.5
Values 1.7e+02 1.7e+02
[4]
HuH.7 GNB1
Mean 118
Standard deviation 23
Values 1.2e+02 93 1.4e+02
[5]
SNU475 GNB1
Mean 191
Standard deviation 19
Values 1.8e+02 2e+02
[6]
THLE GNB1
Mean 185
Standard deviation 12
Values 1.8e+02 1.9e+02
[7]
liver GNB1
Mean 25.7
Standard deviation 5
Values 27 25 31 19
[8]
ref_hepatocyte PPP1CA
Mean 42.2
Standard deviation 7
Values 39 39 54 36 44
[9]
HepG2 PPP1CA
Mean 92
Standard deviation 5.7
Values 88 96
[10]
HepG2.C3A PPP1CA
Mean 67.5
Standard deviation 3.3
Values 70 65
[11]
HuH.7 PPP1CA
Mean 150
Standard deviation 50
Values 1.9e+02 93 1.7e+02
[12]
SNU475 PPP1CA
Mean 224
Standard deviation 25
Values 2.1e+02 2.4e+02
[13]
THLE PPP1CA
Mean 47.8
Standard deviation 8.9
Values 41 54
[14]
liver PPP1CA
Mean 31
Standard deviation 18
Values 15 17 42 51
[15]
ref_hepatocyte DDC
Mean 16.2
Standard deviation 7.9
Values 3.1 24 19 20 15
[16]
HepG2 DDC
Mean 8.45
Standard deviation 3.2
Values 11 6.2
[17]
HepG2.C3A DDC
Mean 17.3
Standard deviation 4.6
Values 21 14
[18]
HuH.7 DDC
Mean 43.9
Standard deviation 9.4
Values 53 34 45
[19]
SNU475 DDC
Mean 0.201
Standard deviation 0.063
Values 0.16 0.25
[20]
THLE DDC
Mean 0.11
Standard deviation 0.087
Values 0.17 0.048
[21]
liver DDC
Mean 25.7
Standard deviation 11
Values 28 15 41 19
[22]
ref_hepatocyte PRKACA
Mean 15.8
Standard deviation 8.3
Values 11 23 27 7.6 11
[23]
HepG2 PRKACA
Mean 31.2
Standard deviation 2.7
Values 33 29
[24]
HepG2.C3A PRKACA
Mean 24.6
Standard deviation 3.5
Values 22 27
[25]
HuH.7 PRKACA
Mean 23.6
Standard deviation 5.7
Values 27 17 27
[26]
SNU475 PRKACA
Mean 21
Standard deviation 3.3
Values 19 23
[27]
THLE PRKACA
Mean 35.4
Standard deviation 5.3
Values 32 39
[28]
liver PRKACA
Mean 13.1
Standard deviation 4.9
Values 8.9 8.8 18 16
[29]
ref_hepatocyte GNAI1
Mean 6.48
Standard deviation 1.5
Values 6.3 6 4.7 6.5 8.9
[30]
HepG2 GNAI1
Mean 4.56
Standard deviation 1
Values 3.9 5.3
[31]
HepG2.C3A GNAI1
Mean 2.12
Standard deviation 0.54
Values 2.5 1.7
[32]
HuH.7 GNAI1
Mean 8.95
Standard deviation 1.2
Values 10 7.6 9.3
[33]
SNU475 GNAI1
Mean 27.6
Standard deviation 3.4
Values 25 30
[34]
THLE GNAI1
Mean 20
Standard deviation 0.41
Values 20 20
[35]
liver GNAI1
Mean 16.4
Standard deviation 11
Values 9 8.4 32 17
[36]
ref_hepatocyte CDK5
Mean 4.43
Standard deviation 2.1
Values 4.6 4.7 7.2 4.3 1.4
[37]
HepG2 CDK5
Mean 11.6
Standard deviation 2.3
Values 13 9.9
[38]
HepG2.C3A CDK5
Mean 6.36
Standard deviation 1.4
Values 7.4 5.3
[39]
HuH.7 CDK5
Mean 6.32
Standard deviation 1.5
Values 8 4.9 6.1
[40]
SNU475 CDK5
Mean 12.6
Standard deviation 1.1
Values 12 13
[41]
THLE CDK5
Mean 6.09
Standard deviation 0.67
Values 5.6 6.6
[42]
liver CDK5
Mean 3.42
Standard deviation 1.7
Values 2.3 1.8 5.5 4.1
[43]
ref_hepatocyte CHRNA4
Mean 1.63
Standard deviation 2.3
Values 0.24 5.3 2.6 0 0.041
[44]
HepG2 CHRNA4
Mean 0.0322
Standard deviation 0.027
Values 0.013 0.052
[45]
HepG2.C3A CHRNA4
Mean 0.0204
Standard deviation 0.0014
Values 0.021 0.019
[46]
HuH.7 CHRNA4
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[47]
SNU475 CHRNA4
Mean 0.0101
Standard deviation 0.014
Values 0.02 0
[48]
THLE CHRNA4
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[49]
liver CHRNA4
Mean 8.69
Standard deviation 6.8
Values 18 3.4 8.4 4.5
[50]
ref_hepatocyte CHRNA5
Mean 1.01
Standard deviation 0.71
Values 0.52 0.41 0.53 1.9 1.7
[51]
HepG2 CHRNA5
Mean 3.58
Standard deviation 0.27
Values 3.4 3.8
[52]
HepG2.C3A CHRNA5
Mean 2.32
Standard deviation 1.1
Values 3.1 1.5
[53]
HuH.7 CHRNA5
Mean 1.97
Standard deviation 1.2
Values 3 0.7 2.2
[54]
SNU475 CHRNA5
Mean 3.15
Standard deviation 0.92
Values 3.8 2.5
[55]
THLE CHRNA5
Mean 4.98
Standard deviation 1.1
Values 4.2 5.8
[56]
liver CHRNA5
Mean 0.231
Standard deviation 0.046
Values 0.2 0.19 0.28 0.26
[57]
ref_hepatocyte SLC18A2
Mean 0.784
Standard deviation 0.93
Values 0.35 1.7 1.9 0 0
[58]
HepG2 SLC18A2
Mean 0.848
Standard deviation 0.11
Values 0.77 0.93
[59]
HepG2.C3A SLC18A2
Mean 3.83
Standard deviation 2.4
Values 2.2 5.5
[60]
HuH.7 SLC18A2
Mean 4.73
Standard deviation 0.58
Values 5 5.2 4.1
[61]
SNU475 SLC18A2
Mean 1.23
Standard deviation 0.21
Values 1.4 1.1
[62]
THLE SLC18A2
Mean 2.27
Standard deviation 1.1
Values 3 1.5
[63]
liver SLC18A2
Mean 10.9
Standard deviation 2.2
Values 11 9.4 14 9.1
[64]
ref_hepatocyte GNG2
Mean 0.352
Standard deviation 0.41
Values 0.53 0.99 0.18 0 0.06
[65]
HepG2 GNG2
Mean 0.01
Standard deviation 0.002
Values 0.0086 0.011
[66]
HepG2.C3A GNG2
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[67]
HuH.7 GNG2
Mean 0
Standard deviation 0
Values 0 0 0
[68]
SNU475 GNG2
Mean 5.62
Standard deviation 1.4
Values 6.6 4.6
[69]
THLE GNG2
Mean 4.37
Standard deviation 0.87
Values 5 3.8
[70]
liver GNG2
Mean 3.44
Standard deviation 0.91
Values 2.2 3.6 3.5 4.4
[71]
ref_hepatocyte PPP1R1B
Mean 0.0962
Standard deviation 0.22
Values 0.48 0 0 0 0
[72]
HepG2 PPP1R1B
Mean 0.0709
Standard deviation 0.046
Values 0.039 0.1
[73]
HepG2.C3A PPP1R1B
Mean 0.0345
Standard deviation 0.034
Values 0.011 0.058
[74]
HuH.7 PPP1R1B
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[75]
SNU475 PPP1R1B
Mean 0.0173
Standard deviation 0.011
Values 0.025 0.0093
[76]
THLE PPP1R1B
Mean 0.284
Standard deviation 0.11
Values 0.36 0.21
[77]
liver PPP1R1B
Mean 0.0281
Standard deviation 0.021
Values 0.04 0 0.047 0.026
[78]
ref_hepatocyte DRD4
Mean 0.088
Standard deviation 0.12
Values 0 0.18 0 0.26 0
[79]
HepG2 DRD4
Mean 0.131
Standard deviation 0.058
Values 0.09 0.17
[80]
HepG2.C3A DRD4
Mean 0.27
Standard deviation 0.31
Values 0.054 0.49
[81]
HuH.7 DRD4
Mean 0.198
Standard deviation 0.12
Values 0.31 0.21 0.074
[82]
SNU475 DRD4
Mean 0.15
Standard deviation 0.0043
Values 0.15 0.15
[83]
THLE DRD4
Mean 0.0719
Standard deviation 0.049
Values 0.11 0.037
[84]
liver DRD4
Mean 0.0464
Standard deviation 0.045
Values 0.11 0.029 0 0.051
[85]
ref_hepatocyte TH
Mean 0.0869
Standard deviation 0.15
Values 0.35 0.089 0 0 0
[86]
HepG2 TH
Mean 0.495
Standard deviation 0.24
Values 0.33 0.66
[87]
HepG2.C3A TH
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 TH
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 TH
Mean 0
Standard deviation 0
Values 0 0
[90]
THLE TH
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[91]
liver TH
Mean 0.362
Standard deviation 0.4
Values 0.95 0.23 0.16 0.1
[92]
ref_hepatocyte ADCY2
Mean 0.081
Standard deviation 0.073
Values 0.2 0.081 0.043 0.061 0.016
[93]
HepG2 ADCY2
Mean 0.00429
Standard deviation 0.0061
Values 0.0086 0
[94]
HepG2.C3A ADCY2
Mean 0.0146
Standard deviation 0.021
Values 0 0.029
[95]
HuH.7 ADCY2
Mean 0.00586
Standard deviation 0.0051
Values 0.0094 0 0.0082
[96]
SNU475 ADCY2
Mean 0.0224
Standard deviation 0.019
Values 0.035 0.0093
[97]
THLE ADCY2
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[98]
liver ADCY2
Mean 0.00662
Standard deviation 0.013
Values 0.026 0 0 0
[99]
ref_hepatocyte KCNK3
Mean 0.0792
Standard deviation 0.12
Values 0.022 0.081 0.29 0 0
[100]
HepG2 KCNK3
Mean 1.07
Standard deviation 1.1
Values 0.3 1.8
[101]
HepG2.C3A KCNK3
Mean 0.0204
Standard deviation 0.0014
Values 0.021 0.019
[102]
HuH.7 KCNK3
Mean 0.00273
Standard deviation 0.0047
Values 0 0 0.0082
[103]
SNU475 KCNK3
Mean 0.718
Standard deviation 0.41
Values 1 0.43
[104]
THLE KCNK3
Mean 0.189
Standard deviation 0.1
Values 0.12 0.26
[105]
liver KCNK3
Mean 2.86
Standard deviation 2.2
Values 6.2 1.5 1.9 1.8
[106]
ref_hepatocyte CHRNA3
Mean 0.0464
Standard deviation 0.064
Values 0 0 0 0.12 0.12
[107]
HepG2 CHRNA3
Mean 0.226
Standard deviation 0.26
Values 0.039 0.41
[108]
HepG2.C3A CHRNA3
Mean 0.107
Standard deviation 0.014
Values 0.097 0.12
[109]
HuH.7 CHRNA3
Mean 0.094
Standard deviation 0.032
Values 0.13 0.077 0.074
[110]
SNU475 CHRNA3
Mean 0.0916
Standard deviation 0.064
Values 0.14 0.046
[111]
THLE CHRNA3
Mean 0.214
Standard deviation 0.024
Values 0.23 0.2
[112]
liver CHRNA3
Mean 0.0209
Standard deviation 0.027
Values 0.026 0.057 0 0
[113]
ref_hepatocyte CHRNB2
Mean 0.0159
Standard deviation 0.022
Values 0 0.041 0 0 0.039
[114]
HepG2 CHRNB2
Mean 0.0558
Standard deviation 0.006
Values 0.06 0.052
[115]
HepG2.C3A CHRNB2
Mean 0.113
Standard deviation 0.022
Values 0.13 0.097
[116]
HuH.7 CHRNB2
Mean 0.137
Standard deviation 0.043
Values 0.1 0.19 0.12
[117]
SNU475 CHRNB2
Mean 0.157
Standard deviation 0.086
Values 0.096 0.22
[118]
THLE CHRNB2
Mean 0.0698
Standard deviation 0.0066
Values 0.065 0.074
[119]
liver CHRNB2
Mean 0.334
Standard deviation 0.45
Values 0.99 0.27 0.071 0
[120]
ref_hepatocyte DRD3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[121]
HepG2 DRD3
Missing
[122]
HepG2.C3A DRD3
Missing
[123]
HuH.7 DRD3
Missing
[124]
SNU475 DRD3
Missing
[125]
THLE DRD3
Missing
[126]
liver DRD3
Missing
[127]
ref_hepatocyte CHRNA6
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[128]
HepG2 CHRNA6
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A CHRNA6
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 CHRNA6
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 CHRNA6
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[132]
THLE CHRNA6
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[133]
liver CHRNA6
Mean 0.00357
Standard deviation 0.0071
Values 0 0.014 0 0
[134]
ref_hepatocyte KCNK9
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 KCNK9
Mean 0.0143
Standard deviation 0.02
Values 0 0.029
[136]
HepG2.C3A KCNK9
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 KCNK9
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 KCNK9
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE KCNK9
Mean 0
Standard deviation 0
Values 0 0
[140]
liver KCNK9
Mean 0.00331
Standard deviation 0.0066
Values 0.013 0 0 0
[141]
ref_hepatocyte DRD2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 DRD2
Mean 0
Standard deviation 0
Values 0 0
[143]
HepG2.C3A DRD2
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 DRD2
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[145]
SNU475 DRD2
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[146]
THLE DRD2
Mean 0.0346
Standard deviation 0.026
Values 0.053 0.016
[147]
liver DRD2
Mean 0
Standard deviation 0
Values 0 0 0 0