WP_NETRINUNC5B_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.18[2] | -1.45[3] | -1.42[4] | -1.58[5] | -1.35[6] | -1.73[7] |
2 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [8] | -0.63[9] | -0.73[10] | -0.22[11] | -0.34[12] | -0.58[13] | -1.37[14] |
3 | JUN | Transcription factor AP-1 | [15] | -0.73[16] | -2.04[17] | -1.97[18] | -2.06[19] | -1.71[20] | -2.22[21] |
4 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [22] | -0.26[23] | -0.31[24] | 0.71[25] | 1.18[26] | -1.44[27] | -1.36[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | -0.16[30] | -0.16[31] | -1.44[32] | -0.41[33] | -0.61[34] | -0.65[35] |
6 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [36] | -1.17[37] | -1.27[38] | -0.88[39] | -0.90[40] | -0.61[41] | -1.60[42] |
7 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [43] | -0.18[44] | -0.28[45] | 0.40[46] | -1.20[47] | -0.93[48] | -2.11[49] |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [50] | 0.21[51] | 0.87[52] | 0.63[53] | 0.53[54] | 0.94[55] | 0.85[56] |
9 | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | [57] | -0.50[58] | -5.68[59] | -8.76[60] | -4.89[61] | -7.05[62] | 0.39[63] |
10 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [64] | -0.30[65] | 0.33[66] | 1.41[67] | -0.54[68] | 0.10[69] | 0.69[70] |
11 | ICAM1 | Intercellular adhesion molecule 1 | [71] | 1.66[72] | 1.26[73] | 1.48[74] | -0.17[75] | 1.79[76] | -0.82[77] |
12 | NTN4 | Netrin-4 | [78] | -2.25[79] | -1.35[80] | -3.64[81] | -2.10[82] | -1.83[83] | -0.30[84] |
13 | CASP3 | Caspase-3 | [85] | -0.10[86] | 0.80[87] | -1.94[88] | -1.25[89] | -0.48[90] | -1.21[91] |
14 | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform | 0.21[92] | -0.08[93] | 0.14[94] | -0.08[95] | -0.52[96] | 2.52[97] | |
15 | YAP1 | Transcriptional coactivator YAP1 | [98] | 1.73[99] | 1.41[100] | 0.85[101] | 1.93[102] | 1.12[103] | -0.05[104] |
16 | MAPK1 | Mitogen-activated protein kinase 1 | [105] | 1.47[106] | 1.84[107] | 1.47[108] | 1.49[109] | 0.92[110] | 1.37[111] |
17 | CCL2 | C-C motif chemokine 2 | [112] | -13.63[113] | [114] | -13.02[115] | -4.47[116] | -2.53[117] | -4.10[118] |
18 | PTK2 | Focal adhesion kinase 1 | [119] | 0.50[120] | 1.21[121] | 1.40[122] | 1.59[123] | 0.57[124] | 0.35[125] |
19 | MAPK14 | Mitogen-activated protein kinase 14 | [126] | 1.24[127] | 1.53[128] | 0.91[129] | 1.33[130] | 0.58[131] | 0.88[132] |
20 | ARHGEF12 | Rho guanine nucleotide exchange factor 12 | [133] | 1.77[134] | 1.77[135] | 1.21[136] | 2.64[137] | 1.58[138] | 3.76[139] |
21 | TP53 | Cellular tumor antigen p53 | [140] | 1.40[141] | 1.19[142] | 1.75[143] | 0.94[144] | 0.38[145] | -0.45[146] |
22 | MAPK3 | Mitogen-activated protein kinase 3 | [147] | 1.61[148] | 1.88[149] | 1.73[150] | 0.07[151] | -0.13[152] | -1.45[153] |
23 | SRC | Proto-oncogene tyrosine-protein kinase Src | [154] | 2.78[155] | 3.00[156] | 1.80[157] | 2.04[158] | 1.00[159] | -1.26[160] |
24 | DAPK1 | Death-associated protein kinase 1 | [161] | 0.84[162] | 1.05[163] | 1.83[164] | 0.35[165] | 0.28[166] | 2.30[167] |
25 | PRKCA | Protein kinase C alpha type | [168] | 2.60[169] | 2.87[170] | 3.03[171] | 1.79[172] | 1.93[173] | 1.51[174] |
26 | FYN | Tyrosine-protein kinase Fyn | [175] | 0.70[176] | -7.67[177] | 0.70[178] | 1.12[179] | 2.42[180] | 0.56[181] |
27 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -0.62[182] | 1.25[183] | 1.24[184] | 0.77[185] | 0.75[186] | 1.51[187] | |
28 | PTK2B | Protein-tyrosine kinase 2-beta | [188] | -1.04[189] | 0.54[190] | 1.31[191] | -2.13[192] | 0.27[193] | 1.36[194] |
29 | RLF | Zinc finger protein Rlf | [195] | 0.68[196] | 2.36[197] | 2.85[198] | 2.16[199] | 1.60[200] | 1.83[201] |
30 | NEO1 | Neogenin | [202] | 2.41[203] | -0.56[204] | 2.70[205] | 1.30[206] | 3.00[207] | 1.92[208] |
31 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [209] | 3.61[210] | 4.23[211] | -6.15[212] | -6.02[213] | -3.29[214] | 0.87[215] |
32 | VCAM1 | Vascular cell adhesion protein 1 | [216] | -7.26[217] | [218] | -3.99[219] | 0.17[220] | 3.34[221] | 3.12[222] |
33 | SELE | E-selectin | [223] | -5.87[224] | [225] | -5.33[226] | -4.88[227] | [228] | 2.29[229] |
34 | NTN1 | Netrin-1 | [230] | -2.40[231] | -2.85[232] | 0.52[233] | -5.01[234] | -2.94[235] | 2.87[236] |
35 | IL10 | Interleukin-10 | [237] | -2.11[238] | -2.13[239] | -2.15[240] | -2.34[241] | -3.03[242] | -2.00[243] |
36 | CDH5 | Cadherin-5 | [244] | -1.82[245] | -3.74[246] | [247] | -5.26[248] | -6.04[249] | 4.12[250] |
37 | PLEKHH1 | Pleckstrin homology domain-containing family H member 1 | [251] | 2.40[252] | 2.58[253] | 2.87[254] | 0.89[255] | -0.33[256] | 0.81[257] |
38 | COL1A1 | Collagen alpha-1(I) chain | [258] | 4.50[259] | -2.78[260] | -1.16[261] | 6.65[262] | 7.97[263] | 5.95[264] |
39 | KDR | Vascular endothelial growth factor receptor 2 | [265] | -5.87[266] | -7.29[267] | -6.78[268] | -2.10[269] | 4.15[270] | 5.89[271] |
40 | AGAP2 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 | 2.50[272] | 3.76[273] | 1.23[274] | -3.78[275] | 0.34[276] | 0.58[277] | |
41 | ROBO4 | Roundabout homolog 4 | [278] | 0.63[279] | -3.27[280] | [281] | -3.10[282] | -1.64[283] | 4.56[284] |
42 | UNC5B | Netrin receptor UNC5B | [285] | 2.14[286] | -1.00[287] | 1.34[288] | 2.45[289] | 6.53[290] | 2.69[291] |
43 | TNF | Tumor necrosis factor | [292] | 0.86[293] | -1.04[294] | -5.84[295] | -2.58[296] | -6.02[297] | -2.30[298] |
44 | ITGB4 | Integrin beta-4 | [299] | 5.47[300] | 5.77[301] | 2.03[302] | 3.81[303] | 1.44[304] | 2.40[305] |
45 | IL1A | Interleukin-1 alpha | [306] | -0.66[307] | -0.84[308] | -2.21[309] | -1.00[310] | 5.53[311] | -1.99[312] |
46 | NTN3 | Netrin-3 | [313] | 0.47[314] | 1.83[315] | -1.61[316] | 1.34[317] | -0.25[318] | 3.63[319] |
47 | DCSTAMP | Dendritic cell-specific transmembrane protein | [320] | [321] | [322] | [323] | [324] | [325] | [326] |
48 | CCN2 | [327] | [328] | [329] | [330] | [331] | [332] | [333] | |
49 | RGMA | Repulsive guidance molecule A | [334] | [335] | [336] | [337] | [338] | [339] | [340] |
50 | CIP2A | [341] | [342] | [343] | [344] | [345] | [346] | [347] | |
51 | MYF5 | Myogenic factor 5 | [348] | [349] | [350] | [351] | [352] | [353] | [354] |
52 | PTPA | Serine/threonine-protein phosphatase 2A activator | [355] | [356] | [357] | [358] | [359] | [360] | [361] |