WP_NANOPARTICLE_TRIGGERED_AUTOPHAGIC_CELL_DEATH Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 VMP1 Vacuole membrane protein 1 [1] -0.32[2] -0.20[3] -0.40[4] -1.06[5] -1.02[6] -1.16[7]
2 BECN1 Beclin-1 [8] -0.92[9] -1.26[10] -1.66[11] -1.45[12] -1.53[13] -1.83[14]
3 ATG3 Ubiquitin-like-conjugating enzyme ATG3 [15] -2.41[16] -2.00[17] -1.80[18] -1.74[19] -1.10[20] -1.92[21]
4 ATG16L1 Autophagy-related protein 16-1 [22] -0.04[23] -0.13[24] -1.20[25] -0.43[26] -0.99[27] -1.39[28]
5 ATG4A Cysteine protease ATG4A [29] -2.13[30] -1.86[31] -1.82[32] -1.54[33] -1.09[34] -0.66[35]
6 SH3GLB1 Endophilin-B1 [36] 1.79[37] 1.12[38] 0.10[39] 2.32[40] 1.86[41] 0.57[42]
7 MAP1LC3A Microtubule-associated proteins 1A/1B light chain 3A [43] -9.12[44] -10.70[45] -10.41[46] -3.34[47] -1.44[48] -1.71[49]
8 ATG5 Autophagy protein 5 [50] -0.30[51] 0.60[52] -0.09[53] 0.69[54] 0.37[55] 0.07[56]
9 INSR Insulin receptor [57] 0.38[58] 0.90[59] 1.99[60] -3.18[61] -0.63[62] 3.23[63]
10 ATG12 Ubiquitin-like protein ATG12 [64] 0.35[65] 1.12[66] 0.71[67] 1.36[68] 1.09[69] 0.66[70]
11 TSC2 Tuberin [71] 1.73[72] 1.13[73] 1.47[74] 1.11[75] 1.57[76] 1.31[77]
12 ULK1 Serine/threonine-protein kinase ULK1 [78] 1.23[79] 1.38[80] 2.24[81] 1.88[82] 1.17[83] 1.12[84]
13 CHAF1A Chromatin assembly factor 1 subunit A [85] 1.34[86] 1.10[87] 2.09[88] 0.95[89] 2.19[90] -2.01[91]
14 ATG14 Beclin 1-associated autophagy-related key regulator [92] 0.64[93] 1.07[94] 0.84[95] 1.37[96] 1.08[97] -0.03[98]
15 ATG7 Ubiquitin-like modifier-activating enzyme ATG7 [99] 0.91[100] 0.30[101] 0.68[102] 0.59[103] 1.39[104] 0.99[105]
16 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 [106] 2.34[107] 1.81[108] 2.38[109] 0.25[110] 1.06[111] 1.04[112]
17 ATG10 Ubiquitin-like-conjugating enzyme ATG10 [113] -0.61[114] -0.36[115] -0.46[116] 0.16[117] -0.76[118] -0.60[119]
18 TSC1 Hamartin [120] 1.81[121] 2.34[122] 2.14[123] 1.96[124] 2.12[125] 1.99[126]
19 UVRAG UV radiation resistance-associated gene protein [127] 1.43[128] 1.45[129] 0.50[130] 1.16[131] 1.67[132] 1.22[133]
20 ULK2 Serine/threonine-protein kinase ULK2 [134] -3.18[135] -2.33[136] 0.24[137] 3.19[138] 2.45[139] 1.64[140]
21 BCL2 Apoptosis regulator Bcl-2 [141] -2.94[142] 2.34[143] -5.41[144] 1.68[145] 1.34[146] 2.46[147]
22 ATG9B Autophagy-related protein 9B [148] 1.94[149] 1.17[150] 1.99[151] 1.46[152] 0.55[153] 0.12[154]
23 MIR21 [155] [156] [157] [158] [159] [160] [161]
24 INS Insulin [162] [163] [164] [165] [166] [167] [168]
[1]
ref_hepatocyte VMP1
Mean 39
Standard deviation 13
Values 46 21 29 48 51
[2]
HepG2 VMP1
Mean 73.1
Standard deviation 13
Values 82 64
[3]
HepG2.C3A VMP1
Mean 76.8
Standard deviation 3.1
Values 79 75
[4]
HuH.7 VMP1
Mean 82
Standard deviation 6.5
Values 89 80 77
[5]
SNU475 VMP1
Mean 36.7
Standard deviation 5.5
Values 33 41
[6]
THLE VMP1
Mean 43.8
Standard deviation 0.76
Values 43 44
[7]
liver VMP1
Mean 42.4
Standard deviation 11
Values 29 37 52 51
[8]
ref_hepatocyte BECN1
Mean 26.6
Standard deviation 14
Values 21 14 17 47 34
[9]
HepG2 BECN1
Mean 32.9
Standard deviation 2.3
Values 35 31
[10]
HepG2.C3A BECN1
Mean 25.2
Standard deviation 4.8
Values 29 22
[11]
HuH.7 BECN1
Mean 23.3
Standard deviation 2.3
Values 23 21 26
[12]
SNU475 BECN1
Mean 19.1
Standard deviation 2
Values 18 21
[13]
THLE BECN1
Mean 21.1
Standard deviation 3.3
Values 19 23
[14]
liver BECN1
Mean 18.2
Standard deviation 8.1
Values 9.2 14 23 27
[15]
ref_hepatocyte ATG3
Mean 23.7
Standard deviation 8.8
Values 17 22 22 19 39
[16]
HepG2 ATG3
Mean 10.5
Standard deviation 2.5
Values 12 8.7
[17]
HepG2.C3A ATG3
Mean 13.4
Standard deviation 2.5
Values 15 12
[18]
HuH.7 ATG3
Mean 18.8
Standard deviation 4.5
Values 23 14 19
[19]
SNU475 ATG3
Mean 14
Standard deviation 1.3
Values 15 13
[20]
THLE ATG3
Mean 25.3
Standard deviation 2.1
Values 24 27
[21]
liver ATG3
Mean 15.1
Standard deviation 7.5
Values 7.6 10 19 24
[22]
ref_hepatocyte ATG16L1
Mean 12.4
Standard deviation 8.2
Values 14 3.3 4.1 20 20
[23]
HepG2 ATG16L1
Mean 28.1
Standard deviation 1.2
Values 29 27
[24]
HepG2.C3A ATG16L1
Mean 25.7
Standard deviation 3.4
Values 28 23
[25]
HuH.7 ATG16L1
Mean 14.9
Standard deviation 3.4
Values 19 12 14
[26]
SNU475 ATG16L1
Mean 18
Standard deviation 1.7
Values 19 17
[27]
THLE ATG16L1
Mean 14.2
Standard deviation 0.11
Values 14 14
[28]
liver ATG16L1
Mean 11.5
Standard deviation 2.5
Values 10 15 8.6 12
[29]
ref_hepatocyte ATG4A
Mean 7.65
Standard deviation 3.1
Values 8.6 7.2 11 2.7 8.8
[30]
HepG2 ATG4A
Mean 4.1
Standard deviation 1.6
Values 5.2 3
[31]
HepG2.C3A ATG4A
Mean 4.79
Standard deviation 1.3
Values 5.7 3.9
[32]
HuH.7 ATG4A
Mean 6
Standard deviation 0.58
Values 6.5 6.1 5.4
[33]
SNU475 ATG4A
Mean 5.15
Standard deviation 0.14
Values 5.1 5.2
[34]
THLE ATG4A
Mean 8.22
Standard deviation 0.48
Values 8.6 7.9
[35]
liver ATG4A
Mean 11.7
Standard deviation 4.4
Values 7.3 8.8 14 16
[36]
ref_hepatocyte SH3GLB1
Mean 7.55
Standard deviation 3.3
Values 6.8 5 6.1 6.4 13
[37]
HepG2 SH3GLB1
Mean 60.8
Standard deviation 0.26
Values 61 61
[38]
HepG2.C3A SH3GLB1
Mean 37.2
Standard deviation 1.3
Values 38 36
[39]
HuH.7 SH3GLB1
Mean 22.3
Standard deviation 7.5
Values 17 31 20
[40]
SNU475 SH3GLB1
Mean 73.9
Standard deviation 8.8
Values 68 80
[41]
THLE SH3GLB1
Mean 62.7
Standard deviation 6.2
Values 58 67
[42]
liver SH3GLB1
Mean 27.1
Standard deviation 5.1
Values 21 25 31 32
[43]
ref_hepatocyte MAP1LC3A
Mean 7.47
Standard deviation 7.7
Values 6.6 20 6.7 0.12 3.6
[44]
HepG2 MAP1LC3A
Mean 0.0315
Standard deviation 0.004
Values 0.034 0.029
[45]
HepG2.C3A MAP1LC3A
Mean 0.0102
Standard deviation 0.00071
Values 0.011 0.0097
[46]
HuH.7 MAP1LC3A
Mean 0.0152
Standard deviation 0.017
Values 0 0.013 0.033
[47]
SNU475 MAP1LC3A
Mean 1.45
Standard deviation 0.48
Values 1.1 1.8
[48]
THLE MAP1LC3A
Mean 6.29
Standard deviation 0.45
Values 6.6 6
[49]
liver MAP1LC3A
Mean 5.54
Standard deviation 6.3
Values 0.61 0.49 14 7.4
[50]
ref_hepatocyte ATG5
Mean 6.42
Standard deviation 2
Values 6.5 8.3 8.4 4.4 4.5
[51]
HepG2 ATG5
Mean 12.2
Standard deviation 4.5
Values 15 9
[52]
HepG2.C3A ATG5
Mean 22.1
Standard deviation 5.1
Values 26 18
[53]
HuH.7 ATG5
Mean 16.7
Standard deviation 1.4
Values 18 16 16
[54]
SNU475 ATG5
Mean 20.3
Standard deviation 1.9
Values 19 22
[55]
THLE ATG5
Mean 19
Standard deviation 0.43
Values 19 19
[56]
liver ATG5
Mean 16.3
Standard deviation 4.6
Values 11 15 20 20
[57]
ref_hepatocyte INSR
Mean 5.73
Standard deviation 1.4
Values 4.1 7.7 5.3 6.5 5
[58]
HepG2 INSR
Mean 17.4
Standard deviation 4.9
Values 14 21
[59]
HepG2.C3A INSR
Mean 24.3
Standard deviation 6.7
Values 20 29
[60]
HuH.7 INSR
Mean 62.9
Standard deviation 26
Values 39 91 58
[61]
SNU475 INSR
Mean 1.24
Standard deviation 0.29
Values 1 1.4
[62]
THLE INSR
Mean 8.45
Standard deviation 0.32
Values 8.2 8.7
[63]
liver INSR
Mean 131
Standard deviation 15
Values 1.3e+02 1.5e+02 1.4e+02 1.1e+02
[64]
ref_hepatocyte ATG12
Mean 4.73
Standard deviation 0.81
Values 3.6 4.5 4.5 5.6 5.4
[65]
HepG2 ATG12
Mean 14.1
Standard deviation 2.6
Values 16 12
[66]
HepG2.C3A ATG12
Mean 23.3
Standard deviation 1.9
Values 25 22
[67]
HuH.7 ATG12
Mean 21.4
Standard deviation 1.1
Values 23 21 20
[68]
SNU475 ATG12
Mean 23.9
Standard deviation 3.1
Values 22 26
[69]
THLE ATG12
Mean 22.9
Standard deviation 1.3
Values 22 24
[70]
liver ATG12
Mean 18.2
Standard deviation 8
Values 12 11 25 25
[71]
ref_hepatocyte TSC2
Mean 3.2
Standard deviation 0.13
Values 3.2 3.4 3.2 3.1 3.1
[72]
HepG2 TSC2
Mean 24.9
Standard deviation 3.4
Values 22 27
[73]
HepG2.C3A TSC2
Mean 16
Standard deviation 4.7
Values 13 19
[74]
HuH.7 TSC2
Mean 24.6
Standard deviation 4
Values 21 24 29
[75]
SNU475 TSC2
Mean 13.5
Standard deviation 5
Values 10 17
[76]
THLE TSC2
Mean 21.8
Standard deviation 1.7
Values 21 23
[77]
liver TSC2
Mean 19.2
Standard deviation 2.2
Values 22 19 17 18
[78]
ref_hepatocyte ULK1
Mean 3.19
Standard deviation 0.97
Values 3.8 2.7 4.6 2.2 2.6
[79]
HepG2 ULK1
Mean 17.5
Standard deviation 3
Values 15 20
[80]
HepG2.C3A ULK1
Mean 18.9
Standard deviation 12
Values 10 27
[81]
HuH.7 ULK1
Mean 41.8
Standard deviation 6.6
Values 38 49 38
[82]
SNU475 ULK1
Mean 23
Standard deviation 7.3
Values 18 28
[83]
THLE ULK1
Mean 16.5
Standard deviation 0.85
Values 16 17
[84]
liver ULK1
Mean 16.8
Standard deviation 11
Values 22 7.2 29 8.9
[85]
ref_hepatocyte CHAF1A
Mean 2.81
Standard deviation 2.6
Values 1.1 0.81 0.92 6.3 5
[86]
HepG2 CHAF1A
Mean 16.6
Standard deviation 2.1
Values 18 15
[87]
HepG2.C3A CHAF1A
Mean 13.7
Standard deviation 6.3
Values 18 9.3
[88]
HuH.7 CHAF1A
Mean 33.2
Standard deviation 18
Values 41 12 46
[89]
SNU475 CHAF1A
Mean 10.7
Standard deviation 3.6
Values 13 8.1
[90]
THLE CHAF1A
Mean 29.3
Standard deviation 3.9
Values 27 32
[91]
liver CHAF1A
Mean 1.69
Standard deviation 0.17
Values 1.9 1.7 1.5 1.6
[92]
ref_hepatocyte ATG14
Mean 2.38
Standard deviation 1.4
Values 2.3 1.4 0.7 3.6 3.9
[93]
HepG2 ATG14
Mean 8.63
Standard deviation 0.18
Values 8.5 8.8
[94]
HepG2.C3A ATG14
Mean 11.3
Standard deviation 0.19
Values 11 11
[95]
HuH.7 ATG14
Mean 11.8
Standard deviation 3.7
Values 9.6 16 9.7
[96]
SNU475 ATG14
Mean 12
Standard deviation 2.7
Values 10 14
[97]
THLE ATG14
Mean 11.5
Standard deviation 0.21
Values 11 12
[98]
liver ATG14
Mean 5.64
Standard deviation 2
Values 7.1 7.5 4.2 3.7
[99]
ref_hepatocyte ATG7
Mean 1.98
Standard deviation 0.67
Values 2.5 2.4 2.3 0.88 1.8
[100]
HepG2 ATG7
Mean 8.71
Standard deviation 0.27
Values 8.5 8.9
[101]
HepG2.C3A ATG7
Mean 5.51
Standard deviation 0.43
Values 5.8 5.2
[102]
HuH.7 ATG7
Mean 8.79
Standard deviation 1.8
Values 9.1 6.9 10
[103]
SNU475 ATG7
Mean 5.82
Standard deviation 0.2
Values 6 5.7
[104]
THLE ATG7
Mean 11.8
Standard deviation 1.9
Values 10 13
[105]
liver ATG7
Mean 9.51
Standard deviation 2.7
Values 11 12 6.5 8.1
[106]
ref_hepatocyte AMBRA1
Mean 1.9
Standard deviation 0.71
Values 2.9 1.4 1.6 1.2 2.4
[107]
HepG2 AMBRA1
Mean 22.4
Standard deviation 0.5
Values 22 23
[108]
HepG2.C3A AMBRA1
Mean 15.1
Standard deviation 2.3
Values 13 17
[109]
HuH.7 AMBRA1
Mean 27.4
Standard deviation 5.9
Values 21 31 31
[110]
SNU475 AMBRA1
Mean 4.42
Standard deviation 0.15
Values 4.5 4.3
[111]
THLE AMBRA1
Mean 9.06
Standard deviation 2.4
Values 7.3 11
[112]
liver AMBRA1
Mean 9.45
Standard deviation 4.3
Values 14 12 5.7 6
[113]
ref_hepatocyte ATG10
Mean 1.86
Standard deviation 0.78
Values 1.5 1.5 1.9 1.2 3.2
[114]
HepG2 ATG10
Mean 2.85
Standard deviation 0.7
Values 3.3 2.3
[115]
HepG2.C3A ATG10
Mean 3.3
Standard deviation 1.3
Values 4.2 2.4
[116]
HuH.7 ATG10
Mean 3.75
Standard deviation 0.42
Values 4 3.3 4
[117]
SNU475 ATG10
Mean 4.08
Standard deviation 1.2
Values 3.2 4.9
[118]
THLE ATG10
Mean 2.51
Standard deviation 0.4
Values 2.2 2.8
[119]
liver ATG10
Mean 2.98
Standard deviation 1.3
Values 1.9 1.8 4.4 3.8
[120]
ref_hepatocyte TSC1
Mean 1.81
Standard deviation 0.96
Values 2.1 1.1 0.7 3.1 2.1
[121]
HepG2 TSC1
Mean 14.8
Standard deviation 1.6
Values 16 14
[122]
HepG2.C3A TSC1
Mean 20.9
Standard deviation 3.3
Values 19 23
[123]
HuH.7 TSC1
Mean 22.2
Standard deviation 4.3
Values 18 26 22
[124]
SNU475 TSC1
Mean 13.9
Standard deviation 2.8
Values 12 16
[125]
THLE TSC1
Mean 18
Standard deviation 3.2
Values 16 20
[126]
liver TSC1
Mean 17.4
Standard deviation 1.8
Values 17 20 17 16
[127]
ref_hepatocyte UVRAG
Mean 1.58
Standard deviation 0.15
Values 1.8 1.6 1.6 1.4 1.4
[128]
HepG2 UVRAG
Mean 9.92
Standard deviation 1.1
Values 11 9.1
[129]
HepG2.C3A UVRAG
Mean 9.81
Standard deviation 0.79
Values 9.3 10
[130]
HuH.7 UVRAG
Mean 6.16
Standard deviation 1.3
Values 5.6 7.6 5.3
[131]
SNU475 UVRAG
Mean 6.93
Standard deviation 0.45
Values 7.3 6.6
[132]
THLE UVRAG
Mean 11.5
Standard deviation 0.81
Values 11 12
[133]
liver UVRAG
Mean 8.93
Standard deviation 1.3
Values 10 9.6 9.1 7.1
[134]
ref_hepatocyte ULK2
Mean 0.556
Standard deviation 0.3
Values 0.76 0.69 0.65 0.026 0.66
[135]
HepG2 ULK2
Mean 0.143
Standard deviation 0.033
Values 0.12 0.17
[136]
HepG2.C3A ULK2
Mean 0.25
Standard deviation 0.01
Values 0.26 0.24
[137]
HuH.7 ULK2
Mean 1.82
Standard deviation 0.22
Values 1.7 2.1 1.7
[138]
SNU475 ULK2
Mean 9.97
Standard deviation 5.4
Values 6.1 14
[139]
THLE ULK2
Mean 6.93
Standard deviation 0.73
Values 7.4 6.4
[140]
liver ULK2
Mean 4.19
Standard deviation 1.7
Values 5.1 6.1 2.3 3.3
[141]
ref_hepatocyte BCL2
Mean 0.0984
Standard deviation 0.087
Values 0.15 0.2 0.12 0.019 0
[142]
HepG2 BCL2
Mean 0.0301
Standard deviation 0.0061
Values 0.026 0.034
[143]
HepG2.C3A BCL2
Mean 1.13
Standard deviation 0.21
Values 0.99 1.3
[144]
HuH.7 BCL2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[145]
SNU475 BCL2
Mean 0.618
Standard deviation 0.094
Values 0.68 0.55
[146]
THLE BCL2
Mean 0.568
Standard deviation 0.0088
Values 0.56 0.57
[147]
liver BCL2
Mean 1.31
Standard deviation 1
Values 2.5 1.8 0.49 0.49
[148]
ref_hepatocyte ATG9B
Mean 0.0353
Standard deviation 0.055
Values 0.12 0 0.052 0 0
[149]
HepG2 ATG9B
Mean 0.317
Standard deviation 0.03
Values 0.3 0.34
[150]
HepG2.C3A ATG9B
Mean 0.18
Standard deviation 0.088
Values 0.12 0.24
[151]
HuH.7 ATG9B
Mean 0.39
Standard deviation 0.14
Values 0.48 0.22 0.47
[152]
SNU475 ATG9B
Mean 0.191
Standard deviation 0.026
Values 0.17 0.21
[153]
THLE ATG9B
Mean 0.119
Standard deviation 0.025
Values 0.14 0.1
[154]
liver ATG9B
Mean 0.0934
Standard deviation 0.084
Values 0.21 0.014 0.071 0.077
[155]
ref_hepatocyte MIR21
Missing
[156]
HepG2 MIR21
Missing
[157]
HepG2.C3A MIR21
Missing
[158]
HuH.7 MIR21
Missing
[159]
SNU475 MIR21
Missing
[160]
THLE MIR21
Missing
[161]
liver MIR21
Missing
[162]
ref_hepatocyte INS
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 INS
Mean 0.00287
Standard deviation 0.0041
Values 0 0.0057
[164]
HepG2.C3A INS
Mean 0
Standard deviation 0
Values 0 0
[165]
HuH.7 INS
Mean 0
Standard deviation 0
Values 0 0 0
[166]
SNU475 INS
Mean 0
Standard deviation 0
Values 0 0
[167]
THLE INS
Mean 0
Standard deviation 0
Values 0 0
[168]
liver INS
Mean 0.0838
Standard deviation 0.13
Values 0.28 0.057 0 0