WP_NANOMATERIAL_INDUCED_APOPTOSIS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AIFM1 Apoptosis-inducing factor 1, mitochondrial [1] -1.12[2] -1.53[3] -0.17[4] -1.40[5] -1.54[6] 0.02[7]
2 BAX Apoptosis regulator BAX [8] 0.38[9] -0.48[10] -0.71[11] -1.42[12] -0.82[13] -3.77[14]
3 CFLAR CASP8 and FADD-like apoptosis regulator [15] -0.33[16] 0.34[17] 0.13[18] -0.36[19] 0.01[20] 1.74[21]
4 DIABLO Diablo homolog, mitochondrial [22] -0.09[23] 0.09[24] 0.02[25] -0.15[26] -0.18[27] -0.55[28]
5 CYCS Cytochrome c [29] 1.39[30] 1.51[31] 1.82[32] 1.51[33] 2.13[34] 1.50[35]
6 CASP3 Caspase-3 [36] 0.19[37] 0.79[38] -1.52[39] -0.72[40] 0.50[41] -0.62[42]
7 ENDOG Endonuclease G, mitochondrial [43] -2.62[44] -2.44[45] -2.92[46] -3.65[47] -3.29[48] -2.88[49]
8 BID BH3-interacting domain death agonist [50] -0.21[51] -0.18[52] -0.33[53] -0.11[54] -0.43[55] 0.36[56]
9 FAS Tumor necrosis factor receptor superfamily member 6 [57] -1.55[58] -0.84[59] -8.62[60] -1.56[61] -0.83[62] -1.54[63]
10 CASP7 Caspase-7 [64] -0.26[65] -0.69[66] -0.02[67] -0.72[68] -0.30[69] -0.30[70]
11 FADD FAS-associated death domain protein [71] 0.09[72] -0.69[73] 0.27[74] 2.11[75] 0.14[76] -1.59[77]
12 CASP8 Caspase-8 [78] 0.07[79] 0.57[80] -0.02[81] 0.10[82] -0.43[83] -1.24[84]
13 CASP6 Caspase-6 [85] -1.21[86] -1.08[87] -0.48[88] -0.77[89] -0.88[90] -0.70[91]
14 HTRA2 Serine protease HTRA2, mitochondrial [92] 0.10[93] 0.94[94] -0.29[95] 0.01[96] -0.11[97] -0.67[98]
15 BAK1 Bcl-2 homologous antagonist/killer [99] 0.95[100] 0.42[101] 0.62[102] 1.37[103] 1.06[104] -1.61[105]
16 CASP9 Caspase-9 [106] 0.21[107] 1.10[108] 0.45[109] 0.43[110] -0.04[111] -0.36[112]
17 APAF1 Apoptotic protease-activating factor 1 [113] 1.71[114] 2.07[115] 2.55[116] 2.81[117] 2.12[118] 1.67[119]
18 PRF1 Perforin-1 [120] 4.01[121] -3.28[122] -6.75[123] -7.53[124] -5.96[125] 1.63[126]
19 BCL2 Apoptosis regulator Bcl-2 [127] -2.80[128] 2.53[129] -4.64[130] 1.96[131] 1.88[132] 3.41[133]
20 FASLG Tumor necrosis factor ligand superfamily member 6 [134] -3.76[135] -1.96[136] -5.70[137] [138] [139] 0.77[140]
[1]
ref_hepatocyte AIFM1
Mean 38.8
Standard deviation 20
Values 11 58 57 42 26
[2]
HepG2 AIFM1
Mean 37.9
Standard deviation 11
Values 46 30
[3]
HepG2.C3A AIFM1
Mean 26.8
Standard deviation 3.1
Values 29 25
[4]
HuH.7 AIFM1
Mean 56.2
Standard deviation 19
Values 71 35 63
[5]
SNU475 AIFM1
Mean 23.8
Standard deviation 2.3
Values 22 25
[6]
THLE AIFM1
Mean 20.8
Standard deviation 3.6
Values 18 23
[7]
liver AIFM1
Mean 49.2
Standard deviation 27
Values 24 29 65 79
[8]
ref_hepatocyte BAX
Mean 24.8
Standard deviation 9.1
Values 34 11 27 30 21
[9]
HepG2 BAX
Mean 68.8
Standard deviation 16
Values 58 80
[10]
HepG2.C3A BAX
Mean 35.4
Standard deviation 3
Values 33 38
[11]
HuH.7 BAX
Mean 24.6
Standard deviation 9.8
Values 34 14 26
[12]
SNU475 BAX
Mean 15
Standard deviation 0.87
Values 16 14
[13]
THLE BAX
Mean 21.9
Standard deviation 0.028
Values 22 22
[14]
liver BAX
Mean 2.27
Standard deviation 0.64
Values 1.4 2.5 2.3 2.9
[15]
ref_hepatocyte CFLAR
Mean 16.4
Standard deviation 8.4
Values 22 11 11 9.6 29
[16]
HepG2 CFLAR
Mean 27.8
Standard deviation 7.9
Values 33 22
[17]
HepG2.C3A CFLAR
Mean 41.4
Standard deviation 1.1
Values 41 42
[18]
HuH.7 CFLAR
Mean 29.2
Standard deviation 4.7
Values 26 35 27
[19]
SNU475 CFLAR
Mean 20.7
Standard deviation 4
Values 18 24
[20]
THLE CFLAR
Mean 25.9
Standard deviation 3.2
Values 28 24
[21]
liver CFLAR
Mean 68.9
Standard deviation 22
Values 97 73 63 44
[22]
ref_hepatocyte DIABLO
Mean 16.2
Standard deviation 5.1
Values 24 17 15 11 14
[23]
HepG2 DIABLO
Mean 32.4
Standard deviation 1.1
Values 33 32
[24]
HepG2.C3A DIABLO
Mean 34.5
Standard deviation 2.7
Values 36 33
[25]
HuH.7 DIABLO
Mean 26.8
Standard deviation 4.5
Values 32 23 26
[26]
SNU475 DIABLO
Mean 23.7
Standard deviation 0.05
Values 24 24
[27]
THLE DIABLO
Mean 22.5
Standard deviation 0.81
Values 22 23
[28]
liver DIABLO
Mean 13.9
Standard deviation 8.5
Values 5.8 7.3 22 21
[29]
ref_hepatocyte CYCS
Mean 14.3
Standard deviation 4.3
Values 7.5 14 15 16 19
[30]
HepG2 CYCS
Mean 79.8
Standard deviation 18
Values 93 67
[31]
HepG2.C3A CYCS
Mean 81.4
Standard deviation 39
Values 1.1e+02 54
[32]
HuH.7 CYCS
Mean 82.3
Standard deviation 19
Values 94 60 93
[33]
SNU475 CYCS
Mean 66.3
Standard deviation 0.99
Values 67 66
[34]
THLE CYCS
Mean 98.4
Standard deviation 7.6
Values 93 1e+02
[35]
liver CYCS
Mean 50.8
Standard deviation 34
Values 19 30 59 95
[36]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 6.8 5.1 4.9 33 13
[37]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 36 25
[38]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 59 27
[39]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 7.8 7.5 5.9
[40]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 12 13
[41]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[42]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 6.1 9 9.5 16
[43]
ref_hepatocyte ENDOG
Mean 12.3
Standard deviation 8.8
Values 4 22 22 6.8 7
[44]
HepG2 ENDOG
Mean 4.26
Standard deviation 0.48
Values 3.9 4.6
[45]
HepG2.C3A ENDOG
Mean 4.53
Standard deviation 0.49
Values 4.2 4.9
[46]
HuH.7 ENDOG
Mean 2.66
Standard deviation 1.1
Values 3.9 1.8 2.3
[47]
SNU475 ENDOG
Mean 1.59
Standard deviation 0.02
Values 1.6 1.6
[48]
THLE ENDOG
Mean 1.97
Standard deviation 0.37
Values 1.7 2.2
[49]
liver ENDOG
Mean 2.1
Standard deviation 0.52
Values 2 2.8 2 1.6
[50]
ref_hepatocyte BID
Mean 12.3
Standard deviation 4.8
Values 17 12 15 4.5 12
[51]
HepG2 BID
Mean 22.5
Standard deviation 0.74
Values 23 22
[52]
HepG2.C3A BID
Mean 21.5
Standard deviation 4.7
Values 25 18
[53]
HuH.7 BID
Mean 15.9
Standard deviation 4.6
Values 21 12 15
[54]
SNU475 BID
Mean 18.5
Standard deviation 1.4
Values 17 19
[55]
THLE BID
Mean 14.3
Standard deviation 1.7
Values 13 15
[56]
liver BID
Mean 19.7
Standard deviation 11
Values 10 9.4 30 29
[57]
ref_hepatocyte FAS
Mean 10.9
Standard deviation 10
Values 13 3.1 5 5.6 28
[58]
HepG2 FAS
Mean 7.93
Standard deviation 5
Values 11 4.4
[59]
HepG2.C3A FAS
Mean 12.1
Standard deviation 8.5
Values 18 6.1
[60]
HuH.7 FAS
Mean 0.0451
Standard deviation 0.028
Values 0.075 0.019 0.041
[61]
SNU475 FAS
Mean 5.96
Standard deviation 1.8
Values 7.2 4.7
[62]
THLE FAS
Mean 9.58
Standard deviation 1.5
Values 11 8.5
[63]
liver FAS
Mean 4.68
Standard deviation 1.2
Values 3.7 4.1 6.4 4.5
[64]
ref_hepatocyte CASP7
Mean 10
Standard deviation 4.1
Values 15 6 7.6 7.8 14
[65]
HepG2 CASP7
Mean 17.9
Standard deviation 4
Values 21 15
[66]
HepG2.C3A CASP7
Mean 12.4
Standard deviation 4
Values 15 9.5
[67]
HuH.7 CASP7
Mean 16.1
Standard deviation 1.8
Values 18 15 15
[68]
SNU475 CASP7
Mean 9.89
Standard deviation 0.26
Values 9.7 10
[69]
THLE CASP7
Mean 12.8
Standard deviation 0.29
Values 13 13
[70]
liver CASP7
Mean 10.2
Standard deviation 3.1
Values 10 6.6 14 9.7
[71]
ref_hepatocyte FADD
Mean 9.28
Standard deviation 6.6
Values 20 5.1 6.3 3.8 12
[72]
HepG2 FADD
Mean 21.1
Standard deviation 4.6
Values 18 24
[73]
HepG2.C3A FADD
Mean 11.5
Standard deviation 1.6
Values 13 10
[74]
HuH.7 FADD
Mean 18.2
Standard deviation 3.2
Values 22 16 16
[75]
SNU475 FADD
Mean 65.1
Standard deviation 11
Values 58 73
[76]
THLE FADD
Mean 16
Standard deviation 3.5
Values 14 19
[77]
liver FADD
Mean 3.86
Standard deviation 1.3
Values 5.1 4.9 2.5 3
[78]
ref_hepatocyte CASP8
Mean 8.88
Standard deviation 6.8
Values 8.9 2.8 1.9 18 13
[79]
HepG2 CASP8
Mean 19.9
Standard deviation 3.1
Values 18 22
[80]
HepG2.C3A CASP8
Mean 26.3
Standard deviation 13
Values 35 17
[81]
HuH.7 CASP8
Mean 14.2
Standard deviation 3.6
Values 18 11 14
[82]
SNU475 CASP8
Mean 15.4
Standard deviation 0.7
Values 15 16
[83]
THLE CASP8
Mean 10.3
Standard deviation 0.97
Values 9.6 11
[84]
liver CASP8
Mean 4.72
Standard deviation 0.87
Values 5 5.2 3.4 5.3
[85]
ref_hepatocyte CASP6
Mean 8.44
Standard deviation 1.3
Values 7.9 8.2 7 8.6 10
[86]
HepG2 CASP6
Mean 7.74
Standard deviation 2.2
Values 9.3 6.2
[87]
HepG2.C3A CASP6
Mean 7.97
Standard deviation 4.4
Values 11 4.9
[88]
HuH.7 CASP6
Mean 9.83
Standard deviation 3.2
Values 13 6.4 10
[89]
SNU475 CASP6
Mean 8.02
Standard deviation 2.2
Values 6.5 9.5
[90]
THLE CASP6
Mean 7.17
Standard deviation 0.61
Values 6.7 7.6
[91]
liver CASP6
Mean 6.51
Standard deviation 3
Values 3.8 4 9.1 9.2
[92]
ref_hepatocyte HTRA2
Mean 6.31
Standard deviation 1.6
Values 7.4 4.8 8.5 5.3 5.5
[93]
HepG2 HTRA2
Mean 14.4
Standard deviation 3.3
Values 12 17
[94]
HepG2.C3A HTRA2
Mean 24.1
Standard deviation 6.2
Values 20 28
[95]
HuH.7 HTRA2
Mean 8.42
Standard deviation 1.9
Values 10 6.5 8.5
[96]
SNU475 HTRA2
Mean 10.3
Standard deviation 1.6
Values 11 9.1
[97]
THLE HTRA2
Mean 9.14
Standard deviation 0.36
Values 8.9 9.4
[98]
liver HTRA2
Mean 4.96
Standard deviation 1.1
Values 3.9 4.1 6.1 5.7
[99]
ref_hepatocyte BAK1
Mean 6.08
Standard deviation 5.2
Values 14 2.6 2.7 2.6 8.3
[100]
HepG2 BAK1
Mean 24.9
Standard deviation 3.2
Values 23 27
[101]
HepG2.C3A BAK1
Mean 16.2
Standard deviation 1.2
Values 17 15
[102]
HuH.7 BAK1
Mean 15.2
Standard deviation 1.3
Values 16 14 16
[103]
SNU475 BAK1
Mean 25.4
Standard deviation 4.7
Values 22 29
[104]
THLE BAK1
Mean 19.9
Standard deviation 2.1
Values 18 21
[105]
liver BAK1
Mean 2.5
Standard deviation 0.66
Values 1.7 2.5 2.5 3.3
[106]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 2 4.4 2.7 1.9 1.9
[107]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 7 5.8
[108]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[109]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.6 4.1 6.7
[110]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 5 6.3
[111]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[112]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 1.6 1.9 2.4 4.2
[113]
ref_hepatocyte APAF1
Mean 1.36
Standard deviation 0.48
Values 1.2 1.1 0.79 1.9 1.8
[114]
HepG2 APAF1
Mean 9.46
Standard deviation 4.9
Values 13 6
[115]
HepG2.C3A APAF1
Mean 11.3
Standard deviation 2.5
Values 13 9.5
[116]
HuH.7 APAF1
Mean 12.9
Standard deviation 2.1
Values 12 12 15
[117]
SNU475 APAF1
Mean 15.4
Standard deviation 1.9
Values 14 17
[118]
THLE APAF1
Mean 9.25
Standard deviation 1.4
Values 8.2 10
[119]
liver APAF1
Mean 5.4
Standard deviation 3.4
Values 8.2 8.5 2.4 2.5
[120]
ref_hepatocyte PRF1
Mean 0.528
Standard deviation 0.78
Values 0 1.8 0.72 0.094 0
[121]
HepG2 PRF1
Mean 18.1
Standard deviation 0.67
Values 19 18
[122]
HepG2.C3A PRF1
Mean 0.108
Standard deviation 0.029
Values 0.13 0.087
[123]
HuH.7 PRF1
Mean 0.008
Standard deviation 0.0015
Values 0.0094 0.0064 0.0082
[124]
SNU475 PRF1
Mean 0.00464
Standard deviation 0.0066
Values 0 0.0093
[125]
THLE PRF1
Mean 0.0133
Standard deviation 0.019
Values 0 0.027
[126]
liver PRF1
Mean 2.05
Standard deviation 1.2
Values 1.2 1.2 2 3.8
[127]
ref_hepatocyte BCL2
Mean 0.0984
Standard deviation 0.087
Values 0.15 0.2 0.12 0.019 0
[128]
HepG2 BCL2
Mean 0.0301
Standard deviation 0.0061
Values 0.026 0.034
[129]
HepG2.C3A BCL2
Mean 1.13
Standard deviation 0.21
Values 0.99 1.3
[130]
HuH.7 BCL2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[131]
SNU475 BCL2
Mean 0.618
Standard deviation 0.094
Values 0.68 0.55
[132]
THLE BCL2
Mean 0.568
Standard deviation 0.0088
Values 0.56 0.57
[133]
liver BCL2
Mean 1.31
Standard deviation 1
Values 2.5 1.8 0.49 0.49
[134]
ref_hepatocyte FASLG
Mean 0.0683
Standard deviation 0.15
Values 0 0.34 0 0 0
[135]
HepG2 FASLG
Mean 0.0107
Standard deviation 0.0091
Values 0.0043 0.017
[136]
HepG2.C3A FASLG
Mean 0.035
Standard deviation 0.019
Values 0.021 0.049
[137]
HuH.7 FASLG
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[138]
SNU475 FASLG
Mean 0
Standard deviation 0
Values 0 0
[139]
THLE FASLG
Mean 0
Standard deviation 0
Values 0 0
[140]
liver FASLG
Mean 0.145
Standard deviation 0.073
Values 0.15 0.043 0.19 0.21