WP_NAD_METABOLISM_SIRTUINS_AND_AGING Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NAMPT Nicotinamide phosphoribosyltransferase [1] -2.15[2] -1.76[3] -1.57[4] -1.50[5] 0.00[6] 0.44[7]
2 PARP1 Poly [ADP-ribose] polymerase 1 [8] 0.70[9] 0.23[10] 0.59[11] -0.09[12] -1.44[13] -0.95[14]
3 HIF1A Hypoxia-inducible factor 1-alpha [15] 0.41[16] -0.13[17] 0.28[18] 1.67[19] 1.19[20] -1.35[21]
4 TFAM Transcription factor A, mitochondrial [22] 0.44[23] 1.40[24] 0.41[25] -0.42[26] -1.57[27] -0.79[28]
5 NFKB1 Nuclear factor NF-kappa-B p105 subunit [29] 1.24[30] 0.70[31] 0.11[32] -0.87[33] -0.82[34] -0.09[35]
6 SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial [36] -0.09[37] 0.23[38] -0.11[39] -1.71[40] -3.48[41] -0.51[42]
7 PPARG Peroxisome proliferator-activated receptor gamma [43] 0.48[44] 1.88[45] 2.01[46] 0.23[47] -0.67[48] -0.92[49]
8 FOXO3 Forkhead box protein O3 [50] 1.02[51] 0.90[52] 1.15[53] -0.22[54] 0.16[55] 1.79[56]
9 SIRT1 NAD-dependent protein deacetylase sirtuin-1 [57] 1.07[58] 1.95[59] 1.12[60] 0.94[61] 0.33[62] 0.80[63]
10 FOXO1 Forkhead box protein O1 [64] 2.26[65] 1.71[66] 1.47[67] 0.56[68] 1.71[69] 2.55[70]
11 ROS1 Proto-oncogene tyrosine-protein kinase ROS [71] 3.24[72] 2.96[73] 7.55[74] 5.09[75] 9.23[76] 0.41[77]
[1]
ref_hepatocyte NAMPT
Mean 74.5
Standard deviation 39
Values 57 89 95 16 1.2e+02
[2]
HepG2 NAMPT
Mean 25.1
Standard deviation 8.5
Values 31 19
[3]
HepG2.C3A NAMPT
Mean 33.9
Standard deviation 3.2
Values 36 32
[4]
HuH.7 NAMPT
Mean 48.4
Standard deviation 12
Values 38 62 44
[5]
SNU475 NAMPT
Mean 74.1
Standard deviation 15
Values 85 63
[6]
THLE NAMPT
Mean 427
Standard deviation 55
Values 4.7e+02 3.9e+02
[7]
liver NAMPT
Mean 209
Standard deviation 33
Values 1.9e+02 2.5e+02 1.8e+02 2.2e+02
[8]
ref_hepatocyte PARP1
Mean 36.6
Standard deviation 31
Values 33 16 17 26 91
[9]
HepG2 PARP1
Mean 88.3
Standard deviation 6.6
Values 93 84
[10]
HepG2.C3A PARP1
Mean 66.3
Standard deviation 14
Values 76 56
[11]
HuH.7 PARP1
Mean 106
Standard deviation 38
Values 1.3e+02 62 1.3e+02
[12]
SNU475 PARP1
Mean 96.8
Standard deviation 5.2
Values 93 1e+02
[13]
THLE PARP1
Mean 77.5
Standard deviation 13
Values 68 87
[14]
liver PARP1
Mean 39.1
Standard deviation 10
Values 31 44 31 51
[15]
ref_hepatocyte HIF1A
Mean 26.5
Standard deviation 22
Values 30 5.8 8.1 27 61
[16]
HepG2 HIF1A
Mean 52.5
Standard deviation 22
Values 68 37
[17]
HepG2.C3A HIF1A
Mean 37.2
Standard deviation 10
Values 44 30
[18]
HuH.7 HIF1A
Mean 62
Standard deviation 17
Values 49 55 81
[19]
SNU475 HIF1A
Mean 237
Standard deviation 65
Values 1.9e+02 2.8e+02
[20]
THLE HIF1A
Mean 346
Standard deviation 60
Values 3.9e+02 3e+02
[21]
liver HIF1A
Mean 21.5
Standard deviation 8.5
Values 31 25 12 18
[22]
ref_hepatocyte TFAM
Mean 13.5
Standard deviation 8.1
Values 6.4 9 7.8 24 20
[23]
HepG2 TFAM
Mean 27.2
Standard deviation 8.8
Values 33 21
[24]
HepG2.C3A TFAM
Mean 54.7
Standard deviation 24
Values 72 38
[25]
HuH.7 TFAM
Mean 34.5
Standard deviation 12
Values 35 22 46
[26]
SNU475 TFAM
Mean 28.4
Standard deviation 3.3
Values 31 26
[27]
THLE TFAM
Mean 26.1
Standard deviation 2
Values 25 27
[28]
liver TFAM
Mean 16.1
Standard deviation 3.4
Values 11 16 19 19
[29]
ref_hepatocyte NFKB1
Mean 6.35
Standard deviation 3.5
Values 12 4.7 5.3 3 6.7
[30]
HepG2 NFKB1
Mean 22.3
Standard deviation 5.4
Values 26 18
[31]
HepG2.C3A NFKB1
Mean 15.9
Standard deviation 1
Values 17 15
[32]
HuH.7 NFKB1
Mean 13.2
Standard deviation 0.86
Values 13 12 14
[33]
SNU475 NFKB1
Mean 9.83
Standard deviation 0.38
Values 10 9.6
[34]
THLE NFKB1
Mean 20.7
Standard deviation 5.3
Values 17 24
[35]
liver NFKB1
Mean 12.3
Standard deviation 4.6
Values 17 15 9.7 7.2
[36]
ref_hepatocyte SIRT3
Mean 5.6
Standard deviation 2.3
Values 3.2 9.1 6.5 5.2 4
[37]
HepG2 SIRT3
Mean 7.83
Standard deviation 0.8
Values 8.4 7.3
[38]
HepG2.C3A SIRT3
Mean 10.1
Standard deviation 1.9
Values 8.7 11
[39]
HuH.7 SIRT3
Mean 9.98
Standard deviation 2.5
Values 12 7.4 10
[40]
SNU475 SIRT3
Mean 4.84
Standard deviation 1.7
Values 3.7 6
[41]
THLE SIRT3
Mean 2.87
Standard deviation 0.022
Values 2.9 2.9
[42]
liver SIRT3
Mean 8.11
Standard deviation 5.1
Values 4.1 3.7 14 11
[43]
ref_hepatocyte PPARG
Mean 3.66
Standard deviation 0.37
Values 3.1 3.9 3.6 3.6 4.1
[44]
HepG2 PPARG
Mean 7.61
Standard deviation 0.54
Values 7.2 8
[45]
HepG2.C3A PPARG
Mean 20.7
Standard deviation 6.8
Values 16 26
[46]
HuH.7 PPARG
Mean 28.4
Standard deviation 6.2
Values 26 35 24
[47]
SNU475 PPARG
Mean 12.1
Standard deviation 2.4
Values 14 10
[48]
THLE PPARG
Mean 13.2
Standard deviation 1.2
Values 12 14
[49]
liver PPARG
Mean 4
Standard deviation 1.3
Values 2.5 4 3.8 5.7
[50]
ref_hepatocyte FOXO3
Mean 2.79
Standard deviation 0.38
Values 2.3 2.9 2.8 3.3 2.7
[51]
HepG2 FOXO3
Mean 8.44
Standard deviation 1
Values 9.2 7.7
[52]
HepG2.C3A FOXO3
Mean 8
Standard deviation 2.4
Values 6.3 9.7
[53]
HuH.7 FOXO3
Mean 11.9
Standard deviation 3.6
Values 7.9 15 13
[54]
SNU475 FOXO3
Mean 6.76
Standard deviation 0.76
Values 6.2 7.3
[55]
THLE FOXO3
Mean 17.9
Standard deviation 3.1
Values 16 20
[56]
liver FOXO3
Mean 20
Standard deviation 5.5
Values 23 21 24 12
[57]
ref_hepatocyte SIRT1
Mean 1.83
Standard deviation 0.67
Values 1.2 2 1.4 2.9 1.6
[58]
HepG2 SIRT1
Mean 5.71
Standard deviation 1.4
Values 6.7 4.7
[59]
HepG2.C3A SIRT1
Mean 10.9
Standard deviation 1
Values 12 10
[60]
HuH.7 SIRT1
Mean 7.67
Standard deviation 1.5
Values 6.3 9.3 7.5
[61]
SNU475 SIRT1
Mean 9.92
Standard deviation 1.6
Values 11 8.8
[62]
THLE SIRT1
Mean 13.2
Standard deviation 0.39
Values 13 13
[63]
liver SIRT1
Mean 6.57
Standard deviation 1.6
Values 7.7 6.2 7.9 4.4
[64]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 2 2.6 1.9 0.71 1.7
[65]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 14 11
[66]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 7.9 10
[67]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 7.6 10 10
[68]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 6 8.6
[69]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[70]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 29 19 25 13
[71]
ref_hepatocyte ROS1
Mean 0.00473
Standard deviation 0.007
Values 0 0.0081 0 0 0.016
[72]
HepG2 ROS1
Mean 0.0666
Standard deviation 0.076
Values 0.013 0.12
[73]
HepG2.C3A ROS1
Mean 0.057
Standard deviation 0.026
Values 0.075 0.039
[74]
HuH.7 ROS1
Mean 1.71
Standard deviation 1.6
Values 0.56 3.5 1.1
[75]
SNU475 ROS1
Mean 0.453
Standard deviation 0.074
Values 0.4 0.51
[76]
THLE ROS1
Mean 16.3
Standard deviation 5.4
Values 20 12
[77]
liver ROS1
Mean 0.013
Standard deviation 0.015
Values 0 0.029 0.024 0