WP_NAD_METABOLISM_IN_ONCOGENEINDUCED_SENESCENCE_AND_MITOCHONDRIAL_DYSFUNCTIONASSOCIATED_SENESCENCE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 MDH2 Malate dehydrogenase, mitochondrial [1] -1.39[2] -1.33[3] -0.92[4] -1.43[5] -2.20[6] -0.49[7]
2 HMGA1 High mobility group protein HMG-I/HMG-Y [8] 0.44[9] -0.06[10] 0.34[11] -0.64[12] 0.30[13] -4.90[14]
3 GOT1 Aspartate aminotransferase, cytoplasmic [15] -1.59[16] 0.60[17] -1.02[18] -3.70[19] -2.98[20] 0.37[21]
4 NAMPT Nicotinamide phosphoribosyltransferase [22] -3.01[23] -1.86[24] -1.36[25] -0.76[26] 1.40[27] 0.95[28]
5 MDH1 Malate dehydrogenase, cytoplasmic [29] -0.93[30] 0.23[31] -0.41[32] -0.38[33] -0.96[34] -0.61[35]
6 GOT2 Aspartate aminotransferase, mitochondrial [36] -0.71[37] -0.60[38] -0.49[39] -1.61[40] -0.76[41] 0.69[42]
7 PARP1 Poly [ADP-ribose] polymerase 1 [43] -0.16[44] 0.14[45] 0.80[46] 0.66[47] -0.04[48] -0.44[49]
8 RELA Transcription factor p65 [50] -0.16[51] -0.11[52] -0.05[53] 0.07[54] -0.23[55] -0.91[56]
9 SCO2 Protein SCO2 homolog, mitochondrial [57] -4.50[58] -3.78[59] -3.23[60] -5.06[61] -5.91[62] -4.42[63]
10 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [64] -0.38[65] 1.46[66] 2.89[67] 1.59[68] 1.66[69] 2.03[70]
11 SIRT2 NAD-dependent protein deacetylase sirtuin-2 [71] -0.55[72] 0.27[73] 0.56[74] -0.60[75] -0.03[76] 0.51[77]
12 G6PD Glucose-6-phosphate 1-dehydrogenase [78] 2.39[79] 0.97[80] 0.63[81] 4.64[82] 1.39[83] -2.56[84]
13 SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial [85] -0.95[86] 0.13[87] 0.10[88] -0.96[89] -2.08[90] 0.00[91]
14 TP53 Cellular tumor antigen p53 [92] 1.34[93] 1.46[94] 2.14[95] 1.42[96] 0.88[97] -0.07[98]
15 ELAVL1 ELAV-like protein 1 [99] 1.87[100] 2.04[101] 2.39[102] 1.95[103] 2.02[104] 1.06[105]
16 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial [106] 0.31[107] 1.49[108] 0.88[109] 0.19[110] -1.05[111] 1.13[112]
17 IL1B Interleukin-1 beta [113] -8.99[114] -8.31[115] -4.06[116] -3.46[117] 1.92[118] -5.23[119]
18 RB1 Retinoblastoma-associated protein [120] 0.93[121] 1.98[122] 2.46[123] 2.41[124] 2.52[125] 1.45[126]
19 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 [127] 6.35[128] 3.91[129] 2.91[130] 3.58[131] 2.50[132] -1.38[133]
20 SIRT1 NAD-dependent protein deacetylase sirtuin-1 [134] 0.21[135] 1.86[136] 1.33[137] 1.69[138] 1.73[139] 1.31[140]
21 IL6 Interleukin-6 [141] -8.74[142] [143] -4.65[144] -0.73[145] 1.58[146] [147]
22 SLC2A4 Solute carrier family 2, facilitated glucose transporter member 4 [148] 1.53[149] 2.33[150] 2.87[151] -2.00[152] -2.94[153] 1.41[154]
23 CCL27 C-C motif chemokine 27 [155] -5.67[156] -4.14[157] -4.19[158] -6.74[159] -5.36[160] -3.16[161]
24 NMNAT2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [162] -3.14[163] -2.66[164] -3.50[165] 5.10[166] 4.93[167] 0.77[168]
[1]
ref_hepatocyte MDH2
Mean 104
Standard deviation 75
Values 77 1.3e+02 2.2e+02 38 53
[2]
HepG2 MDH2
Mean 107
Standard deviation 16
Values 96 1.2e+02
[3]
HepG2.C3A MDH2
Mean 67.7
Standard deviation 5.8
Values 64 72
[4]
HuH.7 MDH2
Mean 91.1
Standard deviation 31
Values 98 57 1.2e+02
[5]
SNU475 MDH2
Mean 64.7
Standard deviation 14
Values 55 74
[6]
THLE MDH2
Mean 49
Standard deviation 8.8
Values 43 55
[7]
liver MDH2
Mean 107
Standard deviation 92
Values 29 26 1.7e+02 2e+02
[8]
ref_hepatocyte HMGA1
Mean 79
Standard deviation 95
Values 2.3e+02 10 6.2 27 1.3e+02
[9]
HepG2 HMGA1
Mean 291
Standard deviation 1.5e+02
Values 1.9e+02 3.9e+02
[10]
HepG2.C3A HMGA1
Mean 124
Standard deviation 23
Values 1.4e+02 1.1e+02
[11]
HuH.7 HMGA1
Mean 167
Standard deviation 39
Values 1.8e+02 1.2e+02 2e+02
[12]
SNU475 HMGA1
Mean 84.9
Standard deviation 63
Values 1.3e+02 41
[13]
THLE HMGA1
Mean 212
Standard deviation 88
Values 1.5e+02 2.7e+02
[14]
liver HMGA1
Mean 3.84
Standard deviation 3.2
Values 1.4 0.86 7.1 6
[15]
ref_hepatocyte GOT1
Mean 75.1
Standard deviation 57
Values 62 1.1e+02 1.5e+02 6.4 44
[16]
HepG2 GOT1
Mean 67.6
Standard deviation 26
Values 49 86
[17]
HepG2.C3A GOT1
Mean 188
Standard deviation 68
Values 1.4e+02 2.4e+02
[18]
HuH.7 GOT1
Mean 61.7
Standard deviation 15
Values 75 45 65
[19]
SNU475 GOT1
Mean 9.68
Standard deviation 0.11
Values 9.8 9.6
[20]
THLE GOT1
Mean 20.6
Standard deviation 1.6
Values 20 22
[21]
liver GOT1
Mean 140
Standard deviation 1e+02
Values 51 1.1e+02 1.1e+02 2.8e+02
[22]
ref_hepatocyte NAMPT
Mean 74.5
Standard deviation 39
Values 57 89 95 16 1.2e+02
[23]
HepG2 NAMPT
Mean 25.1
Standard deviation 8.5
Values 31 19
[24]
HepG2.C3A NAMPT
Mean 33.9
Standard deviation 3.2
Values 36 32
[25]
HuH.7 NAMPT
Mean 48.4
Standard deviation 12
Values 38 62 44
[26]
SNU475 NAMPT
Mean 74.1
Standard deviation 15
Values 85 63
[27]
THLE NAMPT
Mean 427
Standard deviation 55
Values 4.7e+02 3.9e+02
[28]
liver NAMPT
Mean 209
Standard deviation 33
Values 1.9e+02 2.5e+02 1.8e+02 2.2e+02
[29]
ref_hepatocyte MDH1
Mean 74.5
Standard deviation 43
Values 9.2 1.1e+02 1e+02 99 52
[30]
HepG2 MDH1
Mean 106
Standard deviation 36
Values 1.3e+02 80
[31]
HepG2.C3A MDH1
Mean 144
Standard deviation 49
Values 1.8e+02 1.1e+02
[32]
HuH.7 MDH1
Mean 93.1
Standard deviation 25
Values 1.2e+02 67 96
[33]
SNU475 MDH1
Mean 95.9
Standard deviation 44
Values 65 1.3e+02
[34]
THLE MDH1
Mean 83.2
Standard deviation 9.4
Values 77 90
[35]
liver MDH1
Mean 70.6
Standard deviation 50
Values 22 34 1.2e+02 1.1e+02
[36]
ref_hepatocyte GOT2
Mean 58.1
Standard deviation 35
Values 29 1e+02 86 32 39
[37]
HepG2 GOT2
Mean 96.4
Standard deviation 0.81
Values 97 96
[38]
HepG2.C3A GOT2
Mean 63.2
Standard deviation 7.6
Values 69 58
[39]
HuH.7 GOT2
Mean 69
Standard deviation 13
Values 72 55 80
[40]
SNU475 GOT2
Mean 31.9
Standard deviation 2.4
Values 30 34
[41]
THLE GOT2
Mean 74.4
Standard deviation 6.4
Values 70 79
[42]
liver GOT2
Mean 136
Standard deviation 87
Values 50 77 1.8e+02 2.4e+02
[43]
ref_hepatocyte PARP1
Mean 36.6
Standard deviation 31
Values 33 16 17 26 91
[44]
HepG2 PARP1
Mean 88.3
Standard deviation 6.6
Values 93 84
[45]
HepG2.C3A PARP1
Mean 66.3
Standard deviation 14
Values 76 56
[46]
HuH.7 PARP1
Mean 106
Standard deviation 38
Values 1.3e+02 62 1.3e+02
[47]
SNU475 PARP1
Mean 96.8
Standard deviation 5.2
Values 93 1e+02
[48]
THLE PARP1
Mean 77.5
Standard deviation 13
Values 68 87
[49]
liver PARP1
Mean 39.1
Standard deviation 10
Values 31 44 31 51
[50]
ref_hepatocyte RELA
Mean 16
Standard deviation 11
Values 35 8.1 15 9.8 12
[51]
HepG2 RELA
Mean 38.7
Standard deviation 4.7
Values 35 42
[52]
HepG2.C3A RELA
Mean 24.3
Standard deviation 6.4
Values 20 29
[53]
HuH.7 RELA
Mean 25.6
Standard deviation 2.6
Values 23 25 29
[54]
SNU475 RELA
Mean 28.2
Standard deviation 0.33
Values 28 28
[55]
THLE RELA
Mean 29.7
Standard deviation 4
Values 27 32
[56]
liver RELA
Mean 12.3
Standard deviation 8.7
Values 5.7 4.1 19 20
[57]
ref_hepatocyte SCO2
Mean 13
Standard deviation 8.9
Values 22 14 22 2.3 5.8
[58]
HepG2 SCO2
Mean 1.56
Standard deviation 0.044
Values 1.6 1.5
[59]
HepG2.C3A SCO2
Mean 1.56
Standard deviation 0.15
Values 1.7 1.4
[60]
HuH.7 SCO2
Mean 2.3
Standard deviation 0.8
Values 3 1.4 2.5
[61]
SNU475 SCO2
Mean 0.655
Standard deviation 0.11
Values 0.58 0.73
[62]
THLE SCO2
Mean 0.47
Standard deviation 0.16
Values 0.35 0.59
[63]
liver SCO2
Mean 0.882
Standard deviation 0.89
Values 0.17 0.057 1.6 1.7
[64]
ref_hepatocyte PRKAA1
Mean 8.04
Standard deviation 3.4
Values 6.1 14 7.2 5.4 7.6
[65]
HepG2 PRKAA1
Mean 16.8
Standard deviation 2.1
Values 18 15
[66]
HepG2.C3A PRKAA1
Mean 36.3
Standard deviation 5.5
Values 40 32
[67]
HuH.7 PRKAA1
Mean 99.5
Standard deviation 14
Values 84 1e+02 1.1e+02
[68]
SNU475 PRKAA1
Mean 40.7
Standard deviation 4.8
Values 37 44
[69]
THLE PRKAA1
Mean 55.1
Standard deviation 6.9
Values 60 50
[70]
liver PRKAA1
Mean 47.6
Standard deviation 7.3
Values 47 58 40 45
[71]
ref_hepatocyte SIRT2
Mean 7.87
Standard deviation 6.1
Values 3.2 11 17 4 4
[72]
HepG2 SIRT2
Mean 14.6
Standard deviation 0.6
Values 15 14
[73]
HepG2.C3A SIRT2
Mean 15.6
Standard deviation 3.5
Values 13 18
[74]
HuH.7 SIRT2
Mean 19.2
Standard deviation 2.3
Values 18 22 18
[75]
SNU475 SIRT2
Mean 8.73
Standard deviation 3.4
Values 6.3 11
[76]
THLE SIRT2
Mean 16.8
Standard deviation 0.97
Values 16 17
[77]
liver SIRT2
Mean 16.3
Standard deviation 8.6
Values 9.1 8.6 23 24
[78]
ref_hepatocyte G6PD
Mean 7
Standard deviation 9.9
Values 1.2 1.1 1.1 24 7.7
[79]
HepG2 G6PD
Mean 99.6
Standard deviation 38
Values 73 1.3e+02
[80]
HepG2.C3A G6PD
Mean 22.6
Standard deviation 2
Values 21 24
[81]
HuH.7 G6PD
Mean 18.1
Standard deviation 6.7
Values 19 11 24
[82]
SNU475 G6PD
Mean 293
Standard deviation 1.9e+02
Values 1.6e+02 4.3e+02
[83]
THLE G6PD
Mean 39.9
Standard deviation 6.1
Values 36 44
[84]
liver G6PD
Mean 1.72
Standard deviation 0.72
Values 1.6 1 1.6 2.7
[85]
ref_hepatocyte SIRT3
Mean 5.6
Standard deviation 2.3
Values 3.2 9.1 6.5 5.2 4
[86]
HepG2 SIRT3
Mean 7.83
Standard deviation 0.8
Values 8.4 7.3
[87]
HepG2.C3A SIRT3
Mean 10.1
Standard deviation 1.9
Values 8.7 11
[88]
HuH.7 SIRT3
Mean 9.98
Standard deviation 2.5
Values 12 7.4 10
[89]
SNU475 SIRT3
Mean 4.84
Standard deviation 1.7
Values 3.7 6
[90]
THLE SIRT3
Mean 2.87
Standard deviation 0.022
Values 2.9 2.9
[91]
liver SIRT3
Mean 8.11
Standard deviation 5.1
Values 4.1 3.7 14 11
[92]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 6.2 5.5 5.5 5.5 3.7
[93]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[94]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 25 23
[95]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 46 20 50
[96]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 19 28
[97]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[98]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 5.6 5 9 9.5
[99]
ref_hepatocyte ELAVL1
Mean 4.7
Standard deviation 1.1
Values 5.8 5.7 5 3.5 3.6
[100]
HepG2 ELAVL1
Mean 46.6
Standard deviation 1.2
Values 46 47
[101]
HepG2.C3A ELAVL1
Mean 31.9
Standard deviation 2.6
Values 34 30
[102]
HuH.7 ELAVL1
Mean 41.1
Standard deviation 9.5
Values 47 30 46
[103]
SNU475 ELAVL1
Mean 30.4
Standard deviation 3
Values 28 33
[104]
THLE ELAVL1
Mean 41.4
Standard deviation 7.9
Values 36 47
[105]
liver ELAVL1
Mean 14.2
Standard deviation 5.5
Values 10 8.6 20 18
[106]
ref_hepatocyte SIRT5
Mean 3.85
Standard deviation 2.9
Values 1.4 7.7 6.2 2.5 1.4
[107]
HepG2 SIRT5
Mean 12.9
Standard deviation 1.2
Values 12 14
[108]
HepG2.C3A SIRT5
Mean 17.8
Standard deviation 1.8
Values 16 19
[109]
HuH.7 SIRT5
Mean 11.8
Standard deviation 1.9
Values 13 9.7 12
[110]
SNU475 SIRT5
Mean 7.39
Standard deviation 2.7
Values 5.5 9.3
[111]
THLE SIRT5
Mean 4.04
Standard deviation 0.26
Values 3.9 4.2
[112]
liver SIRT5
Mean 12.2
Standard deviation 3
Values 9.4 11 12 16
[113]
ref_hepatocyte IL1B
Mean 3.09
Standard deviation 5.4
Values 13 0.76 2 0 0.08
[114]
HepG2 IL1B
Mean 0.0165
Standard deviation 0.017
Values 0.0043 0.029
[115]
HepG2.C3A IL1B
Mean 0.0161
Standard deviation 0.023
Values 0.032 0
[116]
HuH.7 IL1B
Mean 0.309
Standard deviation 0.06
Values 0.3 0.37 0.25
[117]
SNU475 IL1B
Mean 0.472
Standard deviation 0.21
Values 0.62 0.32
[118]
THLE IL1B
Mean 25.4
Standard deviation 8.5
Values 31 19
[119]
liver IL1B
Mean 0.12
Standard deviation 0.051
Values 0.17 0.11 0.14 0.051
[120]
ref_hepatocyte RB1
Mean 3.07
Standard deviation 1.4
Values 3 2.2 1.4 5 3.8
[121]
HepG2 RB1
Mean 15.8
Standard deviation 7.9
Values 21 10
[122]
HepG2.C3A RB1
Mean 19.9
Standard deviation 6.1
Values 24 16
[123]
HuH.7 RB1
Mean 28.2
Standard deviation 3.3
Values 28 25 32
[124]
SNU475 RB1
Mean 27.3
Standard deviation 0.91
Values 27 28
[125]
THLE RB1
Mean 38.3
Standard deviation 1.7
Values 37 40
[126]
liver RB1
Mean 12.1
Standard deviation 2.2
Values 9 14 12 13
[127]
ref_hepatocyte SLC2A1
Mean 2.27
Standard deviation 1.4
Values 2.3 1 0.99 4.2 2.9
[128]
HepG2 SLC2A1
Mean 502
Standard deviation 1.7e+02
Values 3.8e+02 6.3e+02
[129]
HepG2.C3A SLC2A1
Mean 56.3
Standard deviation 15
Values 67 46
[130]
HuH.7 SLC2A1
Mean 28.3
Standard deviation 3.1
Values 26 27 32
[131]
SNU475 SLC2A1
Mean 45.4
Standard deviation 2.9
Values 43 47
[132]
THLE SLC2A1
Mean 27.9
Standard deviation 3.1
Values 26 30
[133]
liver SLC2A1
Mean 1.26
Standard deviation 0.55
Values 0.77 1.2 1.1 2.1
[134]
ref_hepatocyte SIRT1
Mean 1.83
Standard deviation 0.67
Values 1.2 2 1.4 2.9 1.6
[135]
HepG2 SIRT1
Mean 5.71
Standard deviation 1.4
Values 6.7 4.7
[136]
HepG2.C3A SIRT1
Mean 10.9
Standard deviation 1
Values 12 10
[137]
HuH.7 SIRT1
Mean 7.67
Standard deviation 1.5
Values 6.3 9.3 7.5
[138]
SNU475 SIRT1
Mean 9.92
Standard deviation 1.6
Values 11 8.8
[139]
THLE SIRT1
Mean 13.2
Standard deviation 0.39
Values 13 13
[140]
liver SIRT1
Mean 6.57
Standard deviation 1.6
Values 7.7 6.2 7.9 4.4
[141]
ref_hepatocyte IL6
Mean 1.35
Standard deviation 2.5
Values 5.9 0.28 0.6 0 0
[142]
HepG2 IL6
Mean 0.0086
Standard deviation 0.012
Values 0 0.017
[143]
HepG2.C3A IL6
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 IL6
Mean 0.0895
Standard deviation 0.012
Values 0.1 0.083 0.082
[145]
SNU475 IL6
Mean 1.37
Standard deviation 1.7
Values 2.6 0.15
[146]
THLE IL6
Mean 8.81
Standard deviation 1.5
Values 7.7 9.9
[147]
liver IL6
Mean 0
Standard deviation 0
Values 0 0 0 0
[148]
ref_hepatocyte SLC2A4
Mean 0.539
Standard deviation 0.49
Values 0.027 1.1 0.48 1 0.1
[149]
HepG2 SLC2A4
Mean 4.23
Standard deviation 1.9
Values 2.9 5.5
[150]
HepG2.C3A SLC2A4
Mean 4.46
Standard deviation 1.2
Values 3.6 5.3
[151]
HuH.7 SLC2A4
Mean 6.56
Standard deviation 1.3
Values 7.1 5.1 7.5
[152]
SNU475 SLC2A4
Mean 0.226
Standard deviation 0.054
Values 0.19 0.26
[153]
THLE SLC2A4
Mean 0.153
Standard deviation 0.043
Values 0.18 0.12
[154]
liver SLC2A4
Mean 2.08
Standard deviation 1.4
Values 1.3 1 4 2
[155]
ref_hepatocyte CCL27
Mean 0.162
Standard deviation 0.27
Values 0.62 0.19 0 0 0
[156]
HepG2 CCL27
Mean 0.0086
Standard deviation 0.012
Values 0 0.017
[157]
HepG2.C3A CCL27
Mean 0.0151
Standard deviation 0.0062
Values 0.011 0.019
[158]
HuH.7 CCL27
Mean 0.0148
Standard deviation 0.013
Values 0.019 0.026 0
[159]
SNU475 CCL27
Mean 0.00253
Standard deviation 0.0036
Values 0.0051 0
[160]
THLE CCL27
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[161]
liver CCL27
Mean 0.0263
Standard deviation 0.037
Values 0.079 0 0 0.026
[162]
ref_hepatocyte NMNAT2
Mean 0.0372
Standard deviation 0.07
Values 0.16 0 0.026 0 0
[163]
HepG2 NMNAT2
Mean 0.0114
Standard deviation 0.0081
Values 0.017 0.0057
[164]
HepG2.C3A NMNAT2
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[165]
HuH.7 NMNAT2
Mean 0.00547
Standard deviation 0.0095
Values 0 0 0.016
[166]
SNU475 NMNAT2
Mean 2.15
Standard deviation 1.4
Values 3.2 1.1
[167]
THLE NMNAT2
Mean 2.47
Standard deviation 0.39
Values 2.2 2.8
[168]
liver NMNAT2
Mean 0.092
Standard deviation 0.085
Values 0.12 0.2 0.024 0.026