WP_NAD_METABOLISM Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 NAMPT Nicotinamide phosphoribosyltransferase [1] -2.03[2] -1.93[3] -1.36[4] -0.56[5] 0.73[6] 0.35[7]
2 PARP1 Poly [ADP-ribose] polymerase 1 [8] 0.81[9] 0.06[10] 0.80[11] 0.85[12] -0.70[13] -1.04[14]
3 NADK NAD kinase [15] 0.62[16] 0.56[17] -0.59[18] -0.20[19] -1.67[20] 0.32[21]
4 SIRT2 NAD-dependent protein deacetylase sirtuin-2 [22] 0.43[23] 0.20[24] 0.55[25] -0.41[26] -0.70[27] -0.09[28]
5 SIRT7 NAD-dependent protein deacetylase sirtuin-7 [29] 0.67[30] 0.04[31] -0.79[32] -0.50[33] -2.12[34] -2.39[35]
6 SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial [36] 0.02[37] 0.06[38] 0.10[39] -0.77[40] -2.75[41] -0.60[42]
7 NT5E 5'-nucleotidase [43] -0.62[44] 2.35[45] 2.36[46] -0.35[47] 0.57[48] 0.75[49]
8 SIRT6 NAD-dependent protein deacetylase sirtuin-6 [50] -0.01[51] -0.80[52] -0.09[53] -0.85[54] -1.41[55] -2.29[56]
9 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial [57] 1.29[58] 1.41[59] 0.87[60] 0.39[61] -1.72[62] 0.53[63]
10 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 [64] 0.97[65] 2.04[66] -0.07[67] 0.90[68] -0.68[69] -0.33[70]
11 SIRT1 NAD-dependent protein deacetylase sirtuin-1 [71] 1.18[72] 1.78[73] 1.33[74] 1.88[75] 1.06[76] 0.71[77]
12 SIRT4 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial [78] -1.58[79] -1.85[80] -1.03[81] -2.04[82] -3.10[83] -1.78[84]
13 NMNAT3 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 [85] 0.90[86] 0.92[87] -7.02[88] -1.84[89] -5.72[90] -1.56[91]
14 CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [92] -7.78[93] [94] -4.82[95] -3.32[96] -3.29[97] 0.28[98]
15 NMNAT2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 [99] -2.16[100] -2.73[101] -3.50[102] 5.30[103] 4.26[104] 0.17[105]
16 NRK Nik-related protein kinase [106] -2.33[107] -0.88[108] 2.58[109] 4.73[110] 4.59[111] 3.54[112]
[1]
ref_hepatocyte NAMPT
Mean 74.5
Standard deviation 39
Values 57 89 95 16 1.2e+02
[2]
HepG2 NAMPT
Mean 25.1
Standard deviation 8.5
Values 31 19
[3]
HepG2.C3A NAMPT
Mean 33.9
Standard deviation 3.2
Values 36 32
[4]
HuH.7 NAMPT
Mean 48.4
Standard deviation 12
Values 38 62 44
[5]
SNU475 NAMPT
Mean 74.1
Standard deviation 15
Values 85 63
[6]
THLE NAMPT
Mean 427
Standard deviation 55
Values 4.7e+02 3.9e+02
[7]
liver NAMPT
Mean 209
Standard deviation 33
Values 1.9e+02 2.5e+02 1.8e+02 2.2e+02
[8]
ref_hepatocyte PARP1
Mean 36.6
Standard deviation 31
Values 33 16 17 26 91
[9]
HepG2 PARP1
Mean 88.3
Standard deviation 6.6
Values 93 84
[10]
HepG2.C3A PARP1
Mean 66.3
Standard deviation 14
Values 76 56
[11]
HuH.7 PARP1
Mean 106
Standard deviation 38
Values 1.3e+02 62 1.3e+02
[12]
SNU475 PARP1
Mean 96.8
Standard deviation 5.2
Values 93 1e+02
[13]
THLE PARP1
Mean 77.5
Standard deviation 13
Values 68 87
[14]
liver PARP1
Mean 39.1
Standard deviation 10
Values 31 44 31 51
[15]
ref_hepatocyte NADK
Mean 25.5
Standard deviation 12
Values 13 38 37 16 24
[16]
HepG2 NADK
Mean 54.2
Standard deviation 7.3
Values 49 59
[17]
HepG2.C3A NADK
Mean 65.3
Standard deviation 11
Values 58 73
[18]
HuH.7 NADK
Mean 28.3
Standard deviation 4.5
Values 33 24 28
[19]
SNU475 NADK
Mean 32.6
Standard deviation 7.7
Values 27 38
[20]
THLE NADK
Mean 27.6
Standard deviation 0.52
Values 27 28
[21]
liver NADK
Mean 70.2
Standard deviation 28
Values 45 47 95 94
[22]
ref_hepatocyte SIRT2
Mean 7.87
Standard deviation 6.1
Values 3.2 11 17 4 4
[23]
HepG2 SIRT2
Mean 14.6
Standard deviation 0.6
Values 15 14
[24]
HepG2.C3A SIRT2
Mean 15.6
Standard deviation 3.5
Values 13 18
[25]
HuH.7 SIRT2
Mean 19.2
Standard deviation 2.3
Values 18 22 18
[26]
SNU475 SIRT2
Mean 8.73
Standard deviation 3.4
Values 6.3 11
[27]
THLE SIRT2
Mean 16.8
Standard deviation 0.97
Values 16 17
[28]
liver SIRT2
Mean 16.3
Standard deviation 8.6
Values 9.1 8.6 23 24
[29]
ref_hepatocyte SIRT7
Mean 7.21
Standard deviation 1.5
Values 9.8 6.2 6.6 6.7 6.8
[30]
HepG2 SIRT7
Mean 15.8
Standard deviation 0.88
Values 15 16
[31]
HepG2.C3A SIRT7
Mean 12.9
Standard deviation 0.33
Values 13 13
[32]
HuH.7 SIRT7
Mean 6.97
Standard deviation 2
Values 9.1 5.3 6.4
[33]
SNU475 SIRT7
Mean 7.48
Standard deviation 1.1
Values 6.7 8.2
[34]
THLE SIRT7
Mean 5.72
Standard deviation 0.24
Values 5.9 5.5
[35]
liver SIRT7
Mean 3.04
Standard deviation 1.1
Values 2.5 1.9 4.4 3.3
[36]
ref_hepatocyte SIRT3
Mean 5.6
Standard deviation 2.3
Values 3.2 9.1 6.5 5.2 4
[37]
HepG2 SIRT3
Mean 7.83
Standard deviation 0.8
Values 8.4 7.3
[38]
HepG2.C3A SIRT3
Mean 10.1
Standard deviation 1.9
Values 8.7 11
[39]
HuH.7 SIRT3
Mean 9.98
Standard deviation 2.5
Values 12 7.4 10
[40]
SNU475 SIRT3
Mean 4.84
Standard deviation 1.7
Values 3.7 6
[41]
THLE SIRT3
Mean 2.87
Standard deviation 0.022
Values 2.9 2.9
[42]
liver SIRT3
Mean 8.11
Standard deviation 5.1
Values 4.1 3.7 14 11
[43]
ref_hepatocyte NT5E
Mean 5.59
Standard deviation 3.2
Values 8.3 8 5.6 0.3 5.8
[44]
HepG2 NT5E
Mean 5.01
Standard deviation 1.5
Values 6 4
[45]
HepG2.C3A NT5E
Mean 49.3
Standard deviation 7.9
Values 44 55
[46]
HuH.7 NT5E
Mean 47.8
Standard deviation 5.7
Values 49 42 53
[47]
SNU475 NT5E
Mean 6.43
Standard deviation 1.3
Values 7.4 5.5
[48]
THLE NT5E
Mean 28.7
Standard deviation 11
Values 21 36
[49]
liver NT5E
Mean 20.8
Standard deviation 5.2
Values 26 19 23 14
[50]
ref_hepatocyte SIRT6
Mean 5.25
Standard deviation 1.6
Values 6.5 4.9 6 2.6 6.4
[51]
HepG2 SIRT6
Mean 7.17
Standard deviation 1.1
Values 6.4 8
[52]
HepG2.C3A SIRT6
Mean 5.21
Standard deviation 0.34
Values 5 5.5
[53]
HuH.7 SIRT6
Mean 8.24
Standard deviation 2.7
Values 11 5.8 7.7
[54]
SNU475 SIRT6
Mean 4.28
Standard deviation 0.79
Values 4.8 3.7
[55]
THLE SIRT6
Mean 6.83
Standard deviation 0.32
Values 7.1 6.6
[56]
liver SIRT6
Mean 2.37
Standard deviation 1.6
Values 1.1 0.86 4 3.5
[57]
ref_hepatocyte SIRT5
Mean 3.85
Standard deviation 2.9
Values 1.4 7.7 6.2 2.5 1.4
[58]
HepG2 SIRT5
Mean 12.9
Standard deviation 1.2
Values 12 14
[59]
HepG2.C3A SIRT5
Mean 17.8
Standard deviation 1.8
Values 16 19
[60]
HuH.7 SIRT5
Mean 11.8
Standard deviation 1.9
Values 13 9.7 12
[61]
SNU475 SIRT5
Mean 7.39
Standard deviation 2.7
Values 5.5 9.3
[62]
THLE SIRT5
Mean 4.04
Standard deviation 0.26
Values 3.9 4.2
[63]
liver SIRT5
Mean 12.2
Standard deviation 3
Values 9.4 11 12 16
[64]
ref_hepatocyte NMNAT1
Mean 2.87
Standard deviation 1.2
Values 1.6 2 2.6 4.6 3.6
[65]
HepG2 NMNAT1
Mean 7.76
Standard deviation 0.7
Values 8.2 7.3
[66]
HepG2.C3A NMNAT1
Mean 20.4
Standard deviation 2.1
Values 22 19
[67]
HuH.7 NMNAT1
Mean 4.53
Standard deviation 0.81
Values 5.1 3.6 4.9
[68]
SNU475 NMNAT1
Mean 7.88
Standard deviation 1.8
Values 6.6 9.2
[69]
THLE NMNAT1
Mean 6.18
Standard deviation 0.82
Values 5.6 6.8
[70]
liver NMNAT1
Mean 5.02
Standard deviation 0.66
Values 4.2 5.3 4.9 5.8
[71]
ref_hepatocyte SIRT1
Mean 1.83
Standard deviation 0.67
Values 1.2 2 1.4 2.9 1.6
[72]
HepG2 SIRT1
Mean 5.71
Standard deviation 1.4
Values 6.7 4.7
[73]
HepG2.C3A SIRT1
Mean 10.9
Standard deviation 1
Values 12 10
[74]
HuH.7 SIRT1
Mean 7.67
Standard deviation 1.5
Values 6.3 9.3 7.5
[75]
SNU475 SIRT1
Mean 9.92
Standard deviation 1.6
Values 11 8.8
[76]
THLE SIRT1
Mean 13.2
Standard deviation 0.39
Values 13 13
[77]
liver SIRT1
Mean 6.57
Standard deviation 1.6
Values 7.7 6.2 7.9 4.4
[78]
ref_hepatocyte SIRT4
Mean 1.48
Standard deviation 0.96
Values 0.57 1.5 3.1 1.3 0.98
[79]
HepG2 SIRT4
Mean 0.682
Standard deviation 0.19
Values 0.54 0.82
[80]
HepG2.C3A SIRT4
Mean 0.712
Standard deviation 0.19
Values 0.58 0.85
[81]
HuH.7 SIRT4
Mean 1.21
Standard deviation 0.54
Values 0.99 1.8 0.81
[82]
SNU475 SIRT4
Mean 0.527
Standard deviation 0.12
Values 0.61 0.45
[83]
THLE SIRT4
Mean 0.593
Standard deviation 0.13
Values 0.69 0.5
[84]
liver SIRT4
Mean 0.945
Standard deviation 0.73
Values 0.54 0.47 2 0.74
[85]
ref_hepatocyte NMNAT3
Mean 1.31
Standard deviation 1.8
Values 0 0.87 1.1 4.5 0.13
[86]
HepG2 NMNAT3
Mean 3.36
Standard deviation 0.041
Values 3.4 3.3
[87]
HepG2.C3A NMNAT3
Mean 4.31
Standard deviation 0.33
Values 4.1 4.5
[88]
HuH.7 NMNAT3
Mean 0.0168
Standard deviation 0.015
Values 0 0.026 0.025
[89]
SNU475 NMNAT3
Mean 0.536
Standard deviation 0.28
Values 0.34 0.73
[90]
THLE NMNAT3
Mean 0.0855
Standard deviation 0.038
Values 0.11 0.059
[91]
liver NMNAT3
Mean 0.977
Standard deviation 0.36
Values 0.87 0.91 1.5 0.64
[92]
ref_hepatocyte CD38
Mean 0.801
Standard deviation 1.1
Values 0 2.4 1.5 0 0.08
[93]
HepG2 CD38
Mean 0.00501
Standard deviation 0.001
Values 0.0043 0.0057
[94]
HepG2.C3A CD38
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 CD38
Mean 0.0471
Standard deviation 0.038
Values 0.019 0.09 0.033
[96]
SNU475 CD38
Mean 0.118
Standard deviation 0.1
Values 0.046 0.19
[97]
THLE CD38
Mean 0.283
Standard deviation 0.15
Values 0.39 0.18
[98]
liver CD38
Mean 2.14
Standard deviation 0.61
Values 1.6 2.2 1.8 3
[99]
ref_hepatocyte NMNAT2
Mean 0.0372
Standard deviation 0.07
Values 0.16 0 0.026 0 0
[100]
HepG2 NMNAT2
Mean 0.0114
Standard deviation 0.0081
Values 0.017 0.0057
[101]
HepG2.C3A NMNAT2
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[102]
HuH.7 NMNAT2
Mean 0.00547
Standard deviation 0.0095
Values 0 0 0.016
[103]
SNU475 NMNAT2
Mean 2.15
Standard deviation 1.4
Values 3.2 1.1
[104]
THLE NMNAT2
Mean 2.47
Standard deviation 0.39
Values 2.2 2.8
[105]
liver NMNAT2
Mean 0.092
Standard deviation 0.085
Values 0.12 0.2 0.024 0.026
[106]
ref_hepatocyte NRK
Mean 0.0315
Standard deviation 0.043
Values 0.076 0.081 0 0 0
[107]
HepG2 NRK
Mean 0.0086
Standard deviation 0.012
Values 0 0.017
[108]
HepG2.C3A NRK
Mean 0.0297
Standard deviation 0.027
Values 0.011 0.049
[109]
HuH.7 NRK
Mean 0.314
Standard deviation 0.24
Values 0.094 0.58 0.27
[110]
SNU475 NRK
Mean 1.23
Standard deviation 0.81
Values 1.8 0.66
[111]
THLE NRK
Mean 2.61
Standard deviation 0.026
Values 2.6 2.6
[112]
liver NRK
Mean 0.806
Standard deviation 0.76
Values 1.4 1.5 0.12 0.18