WP_NAD_BIOSYNTHETIC_PATHWAYS Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TDO2 Tryptophan 2,3-dioxygenase [1] -13.86[2] -12.12[3] -8.59[4] -6.97[5] -10.18[6] 0.45[7]
2 NAMPT Nicotinamide phosphoribosyltransferase [8] -1.87[9] -1.48[10] -0.99[11] 0.03[12] 1.66[13] 0.32[14]
3 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] [15] 1.31[16] 1.16[17] 0.85[18] -0.44[19] -2.88[20] -1.12[21]
4 PARP1 Poly [ADP-ribose] polymerase 1 [22] 0.97[23] 0.51[24] 1.17[25] 1.45[26] 0.22[27] -1.07[28]
5 ACMSD 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [29] -13.09[30] -10.52[31] -3.77[32] -11.21[33] -11.50[34] -1.28[35]
6 PARP2 Poly [ADP-ribose] polymerase 2 [36] 0.77[37] 0.19[38] 0.87[39] 0.64[40] 0.68[41] -2.13[42]
7 SIRT2 NAD-dependent protein deacetylase sirtuin-2 [43] 0.59[44] 0.65[45] 0.93[46] 0.19[47] 0.23[48] -0.12[49]
8 SIRT7 NAD-dependent protein deacetylase sirtuin-7 [50] 0.83[51] 0.50[52] -0.41[53] 0.09[54] -1.19[55] -2.41[56]
9 NADSYN1 Glutamine-dependent NAD(+) synthetase [57] 1.98[58] 1.64[59] 0.21[60] 0.80[61] -0.18[62] -0.17[63]
10 PARP4 Poly [ADP-ribose] polymerase 4 [64] 2.18[65] 2.38[66] 0.84[67] 3.22[68] 2.13[69] 1.15[70]
11 SIRT3 NAD-dependent protein deacetylase sirtuin-3, mitochondrial [71] 0.19[72] 0.51[73] 0.47[74] -0.17[75] -1.82[76] -0.63[77]
12 SIRT6 NAD-dependent protein deacetylase sirtuin-6 [78] 0.15[79] -0.35[80] 0.29[81] -0.25[82] -0.48[83] -2.31[84]
13 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial [85] 1.45[86] 1.86[87] 1.25[88] 0.98[89] -0.79[90] 0.50[91]
14 TNKS2 Tankyrase-2 [92] 2.56[93] 3.42[94] 3.81[95] 3.05[96] 2.49[97] 1.76[98]
15 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 [99] 1.14[100] 2.49[101] 0.30[102] 1.50[103] 0.25[104] -0.36[105]
16 SIRT1 NAD-dependent protein deacetylase sirtuin-1 [106] 1.35[107] 2.23[108] 1.71[109] 2.48[110] 1.99[111] 0.68[112]
17 TNKS Tankyrase-1 [113] 3.58[114] 3.69[115] 4.58[116] 2.53[117] 2.82[118] 2.55[119]
18 SIRT4 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial [120] -1.41[121] -1.40[122] -0.65[123] -1.45[124] -2.18[125] -1.81[126]
19 BST1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 [127] -4.87[128] -4.70[129] -1.43[130] -3.30[131] 0.10[132] 0.45[133]
20 CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [134] -7.62[135] [136] -4.45[137] -2.72[138] -2.36[139] 0.25[140]
21 IDO1 Indoleamine 2,3-dioxygenase 1 [141] -0.52[142] 0.07[143] -0.94[144] 2.65[145] -1.45[146] -0.29[147]
22 NAPRT Nicotinate phosphoribosyltransferase [148] [149] [150] [151] [152] [153] [154]
[1]
ref_hepatocyte TDO2
Mean 130
Standard deviation 1.9e+02
Values 5.3 4.3e+02 2e+02 0 18
[2]
HepG2 TDO2
Mean 0.0107
Standard deviation 0.0091
Values 0.0043 0.017
[3]
HepG2.C3A TDO2
Mean 0.037
Standard deviation 0.039
Values 0.064 0.0097
[4]
HuH.7 TDO2
Mean 0.435
Standard deviation 0.39
Values 0.26 0.89 0.16
[5]
SNU475 TDO2
Mean 1.01
Standard deviation 0.68
Values 1.5 0.53
[6]
THLE TDO2
Mean 0.203
Standard deviation 0.19
Values 0.34 0.069
[7]
liver TDO2
Mean 397
Standard deviation 2.8e+02
Values 1.8e+02 1.8e+02 7.8e+02 4.4e+02
[8]
ref_hepatocyte NAMPT
Mean 74.5
Standard deviation 39
Values 57 89 95 16 1.2e+02
[9]
HepG2 NAMPT
Mean 25.1
Standard deviation 8.5
Values 31 19
[10]
HepG2.C3A NAMPT
Mean 33.9
Standard deviation 3.2
Values 36 32
[11]
HuH.7 NAMPT
Mean 48.4
Standard deviation 12
Values 38 62 44
[12]
SNU475 NAMPT
Mean 74.1
Standard deviation 15
Values 85 63
[13]
THLE NAMPT
Mean 427
Standard deviation 55
Values 4.7e+02 3.9e+02
[14]
liver NAMPT
Mean 209
Standard deviation 33
Values 1.9e+02 2.5e+02 1.8e+02 2.2e+02
[15]
ref_hepatocyte QPRT
Mean 54.6
Standard deviation 24
Values 18 83 60 66 46
[16]
HepG2 QPRT
Mean 166
Standard deviation 13
Values 1.8e+02 1.6e+02
[17]
HepG2.C3A QPRT
Mean 155
Standard deviation 28
Values 1.4e+02 1.7e+02
[18]
HuH.7 QPRT
Mean 127
Standard deviation 6.4
Values 1.2e+02 1.3e+02 1.2e+02
[19]
SNU475 QPRT
Mean 39.2
Standard deviation 20
Values 25 54
[20]
THLE QPRT
Mean 13.5
Standard deviation 0.43
Values 13 14
[21]
liver QPRT
Mean 56.2
Standard deviation 29
Values 34 31 92 68
[22]
ref_hepatocyte PARP1
Mean 36.6
Standard deviation 31
Values 33 16 17 26 91
[23]
HepG2 PARP1
Mean 88.3
Standard deviation 6.6
Values 93 84
[24]
HepG2.C3A PARP1
Mean 66.3
Standard deviation 14
Values 76 56
[25]
HuH.7 PARP1
Mean 106
Standard deviation 38
Values 1.3e+02 62 1.3e+02
[26]
SNU475 PARP1
Mean 96.8
Standard deviation 5.2
Values 93 1e+02
[27]
THLE PARP1
Mean 77.5
Standard deviation 13
Values 68 87
[28]
liver PARP1
Mean 39.1
Standard deviation 10
Values 31 44 31 51
[29]
ref_hepatocyte ACMSD
Mean 35.4
Standard deviation 47
Values 3 81 91 0 1.6
[30]
HepG2 ACMSD
Mean 0.00501
Standard deviation 0.001
Values 0.0043 0.0057
[31]
HepG2.C3A ACMSD
Mean 0.0307
Standard deviation 0.0021
Values 0.032 0.029
[32]
HuH.7 ACMSD
Mean 3.33
Standard deviation 0.47
Values 3.9 3.2 3
[33]
SNU475 ACMSD
Mean 0.0146
Standard deviation 0.00091
Values 0.015 0.014
[34]
THLE ACMSD
Mean 0.0222
Standard deviation 0.0063
Values 0.018 0.027
[35]
liver ACMSD
Mean 32.8
Standard deviation 10
Values 19 32 35 44
[36]
ref_hepatocyte PARP2
Mean 9.38
Standard deviation 6.1
Values 5.5 4.6 4.8 15 17
[37]
HepG2 PARP2
Mean 19.7
Standard deviation 5.2
Values 23 16
[38]
HepG2.C3A PARP2
Mean 13.6
Standard deviation 4
Values 16 11
[39]
HuH.7 PARP2
Mean 22
Standard deviation 9.2
Values 30 12 24
[40]
SNU475 PARP2
Mean 14.2
Standard deviation 3.8
Values 17 12
[41]
THLE PARP2
Mean 27.3
Standard deviation 2.1
Values 29 26
[42]
liver PARP2
Mean 4.8
Standard deviation 3.1
Values 2.2 2.1 8 6.9
[43]
ref_hepatocyte SIRT2
Mean 7.87
Standard deviation 6.1
Values 3.2 11 17 4 4
[44]
HepG2 SIRT2
Mean 14.6
Standard deviation 0.6
Values 15 14
[45]
HepG2.C3A SIRT2
Mean 15.6
Standard deviation 3.5
Values 13 18
[46]
HuH.7 SIRT2
Mean 19.2
Standard deviation 2.3
Values 18 22 18
[47]
SNU475 SIRT2
Mean 8.73
Standard deviation 3.4
Values 6.3 11
[48]
THLE SIRT2
Mean 16.8
Standard deviation 0.97
Values 16 17
[49]
liver SIRT2
Mean 16.3
Standard deviation 8.6
Values 9.1 8.6 23 24
[50]
ref_hepatocyte SIRT7
Mean 7.21
Standard deviation 1.5
Values 9.8 6.2 6.6 6.7 6.8
[51]
HepG2 SIRT7
Mean 15.8
Standard deviation 0.88
Values 15 16
[52]
HepG2.C3A SIRT7
Mean 12.9
Standard deviation 0.33
Values 13 13
[53]
HuH.7 SIRT7
Mean 6.97
Standard deviation 2
Values 9.1 5.3 6.4
[54]
SNU475 SIRT7
Mean 7.48
Standard deviation 1.1
Values 6.7 8.2
[55]
THLE SIRT7
Mean 5.72
Standard deviation 0.24
Values 5.9 5.5
[56]
liver SIRT7
Mean 3.04
Standard deviation 1.1
Values 2.5 1.9 4.4 3.3
[57]
ref_hepatocyte NADSYN1
Mean 6.84
Standard deviation 2.5
Values 3.2 6.5 9.5 8.9 6.1
[58]
HepG2 NADSYN1
Mean 33.2
Standard deviation 0.013
Values 33 33
[59]
HepG2.C3A NADSYN1
Mean 27
Standard deviation 8
Values 21 33
[60]
HuH.7 NADSYN1
Mean 10.2
Standard deviation 0.43
Values 10 9.8 11
[61]
SNU475 NADSYN1
Mean 11.5
Standard deviation 5
Values 8 15
[62]
THLE NADSYN1
Mean 11
Standard deviation 0.13
Values 11 11
[63]
liver NADSYN1
Mean 13.7
Standard deviation 3.8
Values 10 12 19 14
[64]
ref_hepatocyte PARP4
Mean 6.45
Standard deviation 2.5
Values 5.2 5.1 4.4 10 7
[65]
HepG2 PARP4
Mean 36.1
Standard deviation 9.6
Values 43 29
[66]
HepG2.C3A PARP4
Mean 42.5
Standard deviation 3.2
Values 45 40
[67]
HuH.7 PARP4
Mean 14.8
Standard deviation 1.9
Values 13 17 15
[68]
SNU475 PARP4
Mean 58.5
Standard deviation 13
Values 50 67
[69]
THLE PARP4
Mean 51.2
Standard deviation 16
Values 40 63
[70]
liver PARP4
Mean 32.1
Standard deviation 7.6
Values 28 43 26 31
[71]
ref_hepatocyte SIRT3
Mean 5.6
Standard deviation 2.3
Values 3.2 9.1 6.5 5.2 4
[72]
HepG2 SIRT3
Mean 7.83
Standard deviation 0.8
Values 8.4 7.3
[73]
HepG2.C3A SIRT3
Mean 10.1
Standard deviation 1.9
Values 8.7 11
[74]
HuH.7 SIRT3
Mean 9.98
Standard deviation 2.5
Values 12 7.4 10
[75]
SNU475 SIRT3
Mean 4.84
Standard deviation 1.7
Values 3.7 6
[76]
THLE SIRT3
Mean 2.87
Standard deviation 0.022
Values 2.9 2.9
[77]
liver SIRT3
Mean 8.11
Standard deviation 5.1
Values 4.1 3.7 14 11
[78]
ref_hepatocyte SIRT6
Mean 5.25
Standard deviation 1.6
Values 6.5 4.9 6 2.6 6.4
[79]
HepG2 SIRT6
Mean 7.17
Standard deviation 1.1
Values 6.4 8
[80]
HepG2.C3A SIRT6
Mean 5.21
Standard deviation 0.34
Values 5 5.5
[81]
HuH.7 SIRT6
Mean 8.24
Standard deviation 2.7
Values 11 5.8 7.7
[82]
SNU475 SIRT6
Mean 4.28
Standard deviation 0.79
Values 4.8 3.7
[83]
THLE SIRT6
Mean 6.83
Standard deviation 0.32
Values 7.1 6.6
[84]
liver SIRT6
Mean 2.37
Standard deviation 1.6
Values 1.1 0.86 4 3.5
[85]
ref_hepatocyte SIRT5
Mean 3.85
Standard deviation 2.9
Values 1.4 7.7 6.2 2.5 1.4
[86]
HepG2 SIRT5
Mean 12.9
Standard deviation 1.2
Values 12 14
[87]
HepG2.C3A SIRT5
Mean 17.8
Standard deviation 1.8
Values 16 19
[88]
HuH.7 SIRT5
Mean 11.8
Standard deviation 1.9
Values 13 9.7 12
[89]
SNU475 SIRT5
Mean 7.39
Standard deviation 2.7
Values 5.5 9.3
[90]
THLE SIRT5
Mean 4.04
Standard deviation 0.26
Values 3.9 4.2
[91]
liver SIRT5
Mean 12.2
Standard deviation 3
Values 9.4 11 12 16
[92]
ref_hepatocyte TNKS2
Mean 3.45
Standard deviation 1.4
Values 3.3 3.4 1.4 5.1 4.1
[93]
HepG2 TNKS2
Mean 25
Standard deviation 11
Values 33 17
[94]
HepG2.C3A TNKS2
Mean 46.8
Standard deviation 4.2
Values 50 44
[95]
HuH.7 TNKS2
Mean 62
Standard deviation 13
Values 48 73 65
[96]
SNU475 TNKS2
Mean 27.7
Standard deviation 4
Values 25 31
[97]
THLE TNKS2
Mean 35.3
Standard deviation 2.6
Values 33 37
[98]
liver TNKS2
Mean 26.1
Standard deviation 16
Values 39 40 15 9.9
[99]
ref_hepatocyte NMNAT1
Mean 2.87
Standard deviation 1.2
Values 1.6 2 2.6 4.6 3.6
[100]
HepG2 NMNAT1
Mean 7.76
Standard deviation 0.7
Values 8.2 7.3
[101]
HepG2.C3A NMNAT1
Mean 20.4
Standard deviation 2.1
Values 22 19
[102]
HuH.7 NMNAT1
Mean 4.53
Standard deviation 0.81
Values 5.1 3.6 4.9
[103]
SNU475 NMNAT1
Mean 7.88
Standard deviation 1.8
Values 6.6 9.2
[104]
THLE NMNAT1
Mean 6.18
Standard deviation 0.82
Values 5.6 6.8
[105]
liver NMNAT1
Mean 5.02
Standard deviation 0.66
Values 4.2 5.3 4.9 5.8
[106]
ref_hepatocyte SIRT1
Mean 1.83
Standard deviation 0.67
Values 1.2 2 1.4 2.9 1.6
[107]
HepG2 SIRT1
Mean 5.71
Standard deviation 1.4
Values 6.7 4.7
[108]
HepG2.C3A SIRT1
Mean 10.9
Standard deviation 1
Values 12 10
[109]
HuH.7 SIRT1
Mean 7.67
Standard deviation 1.5
Values 6.3 9.3 7.5
[110]
SNU475 SIRT1
Mean 9.92
Standard deviation 1.6
Values 11 8.8
[111]
THLE SIRT1
Mean 13.2
Standard deviation 0.39
Values 13 13
[112]
liver SIRT1
Mean 6.57
Standard deviation 1.6
Values 7.7 6.2 7.9 4.4
[113]
ref_hepatocyte TNKS
Mean 1.48
Standard deviation 0.41
Values 1.4 1.6 0.85 2 1.6
[114]
HepG2 TNKS
Mean 21.7
Standard deviation 1.5
Values 23 21
[115]
HepG2.C3A TNKS
Mean 24.2
Standard deviation 6
Values 20 28
[116]
HuH.7 TNKS
Mean 45.6
Standard deviation 18
Values 29 65 44
[117]
SNU475 TNKS
Mean 8.29
Standard deviation 0.84
Values 7.7 8.9
[118]
THLE TNKS
Mean 19
Standard deviation 1.5
Values 20 18
[119]
liver TNKS
Mean 19.4
Standard deviation 8.9
Values 25 29 13 11
[120]
ref_hepatocyte SIRT4
Mean 1.48
Standard deviation 0.96
Values 0.57 1.5 3.1 1.3 0.98
[121]
HepG2 SIRT4
Mean 0.682
Standard deviation 0.19
Values 0.54 0.82
[122]
HepG2.C3A SIRT4
Mean 0.712
Standard deviation 0.19
Values 0.58 0.85
[123]
HuH.7 SIRT4
Mean 1.21
Standard deviation 0.54
Values 0.99 1.8 0.81
[124]
SNU475 SIRT4
Mean 0.527
Standard deviation 0.12
Values 0.61 0.45
[125]
THLE SIRT4
Mean 0.593
Standard deviation 0.13
Values 0.69 0.5
[126]
liver SIRT4
Mean 0.945
Standard deviation 0.73
Values 0.54 0.47 2 0.74
[127]
ref_hepatocyte BST1
Mean 0.849
Standard deviation 0.79
Values 0 1.6 1.2 0 1.4
[128]
HepG2 BST1
Mean 0.0358
Standard deviation 0.034
Values 0.06 0.011
[129]
HepG2.C3A BST1
Mean 0.0414
Standard deviation 0.017
Values 0.054 0.029
[130]
HuH.7 BST1
Mean 0.407
Standard deviation 0.086
Values 0.47 0.31 0.44
[131]
SNU475 BST1
Mean 0.0836
Standard deviation 0.039
Values 0.11 0.056
[132]
THLE BST1
Mean 1.66
Standard deviation 0.7
Values 1.2 2.1
[133]
liver BST1
Mean 2.6
Standard deviation 2.4
Values 1.9 0.88 6.2 1.4
[134]
ref_hepatocyte CD38
Mean 0.801
Standard deviation 1.1
Values 0 2.4 1.5 0 0.08
[135]
HepG2 CD38
Mean 0.00501
Standard deviation 0.001
Values 0.0043 0.0057
[136]
HepG2.C3A CD38
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 CD38
Mean 0.0471
Standard deviation 0.038
Values 0.019 0.09 0.033
[138]
SNU475 CD38
Mean 0.118
Standard deviation 0.1
Values 0.046 0.19
[139]
THLE CD38
Mean 0.283
Standard deviation 0.15
Values 0.39 0.18
[140]
liver CD38
Mean 2.14
Standard deviation 0.61
Values 1.6 2.2 1.8 3
[141]
ref_hepatocyte IDO1
Mean 0.512
Standard deviation 0.3
Values 0.35 0.33 0.22 0.8 0.86
[142]
HepG2 IDO1
Mean 0.438
Standard deviation 0.012
Values 0.45 0.43
[143]
HepG2.C3A IDO1
Mean 0.68
Standard deviation 0.23
Values 0.51 0.85
[144]
HuH.7 IDO1
Mean 0.343
Standard deviation 0.071
Values 0.26 0.4 0.37
[145]
SNU475 IDO1
Mean 3.13
Standard deviation 1.9
Values 1.8 4.4
[146]
THLE IDO1
Mean 0.339
Standard deviation 0.014
Values 0.35 0.33
[147]
liver IDO1
Mean 0.937
Standard deviation 0.19
Values 1.1 1.1 0.85 0.72
[148]
ref_hepatocyte NAPRT
Missing
[149]
HepG2 NAPRT
Missing
[150]
HepG2.C3A NAPRT
Missing
[151]
HuH.7 NAPRT
Missing
[152]
SNU475 NAPRT
Missing
[153]
THLE NAPRT
Missing
[154]
liver NAPRT
Missing