WP_MTHFR_DEFICIENCY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 BHMT Betaine--homocysteine S-methyltransferase 1 [1] -5.75[2] -6.48[3] -9.82[4] -8.66[5] -15.43[6] -0.76[7]
2 CHPT1 Cholinephosphotransferase 1 [8] -0.64[9] -0.36[10] -0.98[11] -2.76[12] -1.91[13] -1.44[14]
3 COMT Catechol O-methyltransferase [15] -0.21[16] -0.16[17] -1.80[18] -0.86[19] -0.81[20] 0.42[21]
4 PEMT Phosphatidylethanolamine N-methyltransferase [22] -2.49[23] -2.24[24] -3.45[25] -2.56[26] -3.32[27] 0.08[28]
5 HNMT Histamine N-methyltransferase [29] -0.99[30] 1.61[31] 0.97[32] -0.24[33] -1.50[34] -0.02[35]
6 ALDH7A1 Alpha-aminoadipic semialdehyde dehydrogenase [36] 1.08[37] 0.46[38] 0.79[39] 0.81[40] 1.18[41] 0.34[42]
7 PCYT1A Choline-phosphate cytidylyltransferase A [43] -1.06[44] -1.53[45] -0.99[46] -0.46[47] -0.42[48] -1.32[49]
8 CYCS Cytochrome c [50] 1.76[51] 1.40[52] 2.01[53] 2.21[54] 2.62[55] 1.37[56]
9 CASP3 Caspase-3 [57] 0.56[58] 0.68[59] -1.34[60] -0.02[61] 0.98[62] -0.75[63]
10 CHDH Choline dehydrogenase, mitochondrial [64] 1.27[65] 1.68[66] 0.34[67] -5.13[68] -5.44[69] 1.54[70]
11 CHKA Choline kinase alpha [71] 2.10[72] 1.49[73] 2.72[74] 1.79[75] -0.06[76] 0.06[77]
12 SGMS1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 [78] -0.14[79] 0.29[80] -0.21[81] 1.91[82] 1.85[83] 1.14[84]
13 EHMT2 Histone-lysine N-methyltransferase EHMT2 [85] 2.90[86] 1.96[87] 2.56[88] 3.54[89] 2.26[90] 0.31[91]
14 DNMT1 DNA (cytosine-5)-methyltransferase 1 [92] 3.39[93] 2.35[94] 3.77[95] 3.98[96] 4.64[97] 1.14[98]
15 EHMT1 Histone-lysine N-methyltransferase EHMT1 [99] 2.07[100] 1.31[101] 2.17[102] 2.57[103] 2.18[104] 1.96[105]
16 DNMT3A DNA (cytosine-5)-methyltransferase 3A [106] 1.94[107] 1.71[108] 2.13[109] 0.91[110] 0.32[111] 0.57[112]
17 CASP9 Caspase-9 [113] 0.58[114] 0.99[115] 0.64[116] 1.12[117] 0.44[118] -0.48[119]
18 DNMT3B DNA (cytosine-5)-methyltransferase 3B [120] 2.14[121] 0.77[122] 0.88[123] 1.40[124] 0.00[125] -1.92[126]
19 MTHFR Methylenetetrahydrofolate reductase [127] 1.76[128] 2.57[129] 3.34[130] 3.58[131] 2.36[132] 3.86[133]
20 ASMT Acetylserotonin O-methyltransferase [134] [135] [136] [137] [138] [139] [140]
21 GRIN2D Glutamate receptor ionotropic, NMDA 2D [141] 4.91[142] 4.25[143] 5.10[144] 3.66[145] 2.62[146] 0.00[147]
22 GRIN2A Glutamate receptor ionotropic, NMDA 2A [148] [149] [150] -0.20[151] 9.93[152] 2.47[153] 8.09[154]
23 NDUFAF7 Protein arginine methyltransferase NDUFAF7, mitochondrial [155] [156] [157] [158] [159] [160] [161]
24 MARS1 [162] [163] [164] [165] [166] [167] [168]
25 GRIN1 Glutamate receptor ionotropic, NMDA 1 [169] [170] [171] [172] [173] [174] [175]
26 MIR4761 [176] [177] [178] [179] [180] [181] [182]
27 MIR6758 [183] [184] [185] [186] [187] [188] [189]
[1]
ref_hepatocyte BHMT
Mean 117
Standard deviation 1.9e+02
Values 6.9 4.5e+02 1.1e+02 8.1 4.9
[2]
HepG2 BHMT
Mean 3.57
Standard deviation 0.19
Values 3.4 3.7
[3]
HepG2.C3A BHMT
Mean 2.82
Standard deviation 2.3
Values 4.4 1.2
[4]
HuH.7 BHMT
Mean 0.184
Standard deviation 0.018
Values 0.2 0.19 0.16
[5]
SNU475 BHMT
Mean 0.29
Standard deviation 0.11
Values 0.21 0.37
[6]
THLE BHMT
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[7]
liver BHMT
Mean 94.8
Standard deviation 50
Values 39 69 1.5e+02 1.2e+02
[8]
ref_hepatocyte CHPT1
Mean 51.9
Standard deviation 41
Values 9.9 50 47 1.2e+02 34
[9]
HepG2 CHPT1
Mean 54.8
Standard deviation 22
Values 70 39
[10]
HepG2.C3A CHPT1
Mean 86.8
Standard deviation 20
Values 1e+02 73
[11]
HuH.7 CHPT1
Mean 37.6
Standard deviation 2.3
Values 40 38 35
[12]
SNU475 CHPT1
Mean 7.64
Standard deviation 0.99
Values 6.9 8.3
[13]
THLE CHPT1
Mean 15.4
Standard deviation 1.6
Values 14 17
[14]
liver CHPT1
Mean 26.3
Standard deviation 11
Values 16 20 39 30
[15]
ref_hepatocyte COMT
Mean 41.6
Standard deviation 29
Values 14 83 61 24 25
[16]
HepG2 COMT
Mean 59.3
Standard deviation 6.8
Values 55 64
[17]
HepG2.C3A COMT
Mean 80
Standard deviation 0.37
Values 80 80
[18]
HuH.7 COMT
Mean 17.1
Standard deviation 2.6
Values 19 18 14
[19]
SNU475 COMT
Mean 22.9
Standard deviation 4.5
Values 20 26
[20]
THLE COMT
Mean 26.6
Standard deviation 0.81
Values 26 27
[21]
liver COMT
Mean 76.3
Standard deviation 82
Values 20 20 1.9e+02 71
[22]
ref_hepatocyte PEMT
Mean 36.5
Standard deviation 41
Values 13 93 66 5.5 4.4
[23]
HepG2 PEMT
Mean 10.7
Standard deviation 1.2
Values 9.8 12
[24]
HepG2.C3A PEMT
Mean 16.7
Standard deviation 7.9
Values 11 22
[25]
HuH.7 PEMT
Mean 4.78
Standard deviation 0.99
Values 4.9 3.7 5.7
[26]
SNU475 PEMT
Mean 6.17
Standard deviation 0.66
Values 5.7 6.6
[27]
THLE PEMT
Mean 4.09
Standard deviation 0.51
Values 4.4 3.7
[28]
liver PEMT
Mean 52.7
Standard deviation 35
Values 28 17 82 84
[29]
ref_hepatocyte HNMT
Mean 23.7
Standard deviation 12
Values 15 40 26 28 9.1
[30]
HepG2 HNMT
Mean 19.5
Standard deviation 6.3
Values 24 15
[31]
HepG2.C3A HNMT
Mean 155
Standard deviation 0.43
Values 1.6e+02 1.5e+02
[32]
HuH.7 HNMT
Mean 66.1
Standard deviation 6.9
Values 71 58 69
[33]
SNU475 HNMT
Mean 20
Standard deviation 5
Values 17 24
[34]
THLE HNMT
Mean 9.34
Standard deviation 1.5
Values 8.3 10
[35]
liver HNMT
Mean 32
Standard deviation 14
Values 21 22 52 34
[36]
ref_hepatocyte ALDH7A1
Mean 17.3
Standard deviation 15
Values 1 39 16 24 6.2
[37]
HepG2 ALDH7A1
Mean 60.1
Standard deviation 16
Values 72 49
[38]
HepG2.C3A ALDH7A1
Mean 51.1
Standard deviation 14
Values 61 41
[39]
HuH.7 ALDH7A1
Mean 42.6
Standard deviation 10
Values 49 31 48
[40]
SNU475 ALDH7A1
Mean 30.3
Standard deviation 10
Values 23 38
[41]
THLE ALDH7A1
Mean 43.7
Standard deviation 3.2
Values 41 46
[42]
liver ALDH7A1
Mean 30
Standard deviation 18
Values 14 17 50 40
[43]
ref_hepatocyte PCYT1A
Mean 15.9
Standard deviation 12
Values 32 5.9 6.6 9.8 25
[44]
HepG2 PCYT1A
Mean 12.5
Standard deviation 3.2
Values 15 10
[45]
HepG2.C3A PCYT1A
Mean 11.9
Standard deviation 3.3
Values 14 9.5
[46]
HuH.7 PCYT1A
Mean 11.5
Standard deviation 1.6
Values 10 11 13
[47]
SNU475 PCYT1A
Mean 11.6
Standard deviation 2.1
Values 10 13
[48]
THLE PCYT1A
Mean 13.3
Standard deviation 2.7
Values 11 15
[49]
liver PCYT1A
Mean 8.76
Standard deviation 2.6
Values 9.8 12 5.6 7.9
[50]
ref_hepatocyte CYCS
Mean 14.3
Standard deviation 4.3
Values 7.5 14 15 16 19
[51]
HepG2 CYCS
Mean 79.8
Standard deviation 18
Values 93 67
[52]
HepG2.C3A CYCS
Mean 81.4
Standard deviation 39
Values 1.1e+02 54
[53]
HuH.7 CYCS
Mean 82.3
Standard deviation 19
Values 94 60 93
[54]
SNU475 CYCS
Mean 66.3
Standard deviation 0.99
Values 67 66
[55]
THLE CYCS
Mean 98.4
Standard deviation 7.6
Values 93 1e+02
[56]
liver CYCS
Mean 50.8
Standard deviation 34
Values 19 30 59 95
[57]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 6.8 5.1 4.9 33 13
[58]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 36 25
[59]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 59 27
[60]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 7.8 7.5 5.9
[61]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 12 13
[62]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[63]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 6.1 9 9.5 16
[64]
ref_hepatocyte CHDH
Mean 8.63
Standard deviation 5.4
Values 3.1 14 11 13 2.5
[65]
HepG2 CHDH
Mean 34.2
Standard deviation 8.2
Values 40 28
[66]
HepG2.C3A CHDH
Mean 59.6
Standard deviation 4.1
Values 57 63
[67]
HuH.7 CHDH
Mean 15.6
Standard deviation 0.26
Values 15 16 16
[68]
SNU475 CHDH
Mean 0.247
Standard deviation 0.005
Values 0.24 0.25
[69]
THLE CHDH
Mean 0.222
Standard deviation 0.1
Values 0.3 0.15
[70]
liver CHDH
Mean 34.4
Standard deviation 9.9
Values 21 44 34 39
[71]
ref_hepatocyte CHKA
Mean 7.34
Standard deviation 5.6
Values 3.8 6.9 5 17 4
[72]
HepG2 CHKA
Mean 51.9
Standard deviation 3.7
Values 54 49
[73]
HepG2.C3A CHKA
Mean 44.3
Standard deviation 5.6
Values 40 48
[74]
HuH.7 CHKA
Mean 69.1
Standard deviation 18
Values 63 89 55
[75]
SNU475 CHKA
Mean 25.4
Standard deviation 0.82
Values 25 26
[76]
THLE CHKA
Mean 7.89
Standard deviation 0.21
Values 7.7 8
[77]
liver CHKA
Mean 10.5
Standard deviation 0.71
Values 10 11 11 9.6
[78]
ref_hepatocyte SGMS1
Mean 4.43
Standard deviation 2
Values 4.1 3.9 2.2 4.2 7.7
[79]
HepG2 SGMS1
Mean 6.6
Standard deviation 2.6
Values 8.4 4.8
[80]
HepG2.C3A SGMS1
Mean 11.6
Standard deviation 2.4
Values 10 13
[81]
HuH.7 SGMS1
Mean 5.45
Standard deviation 1.4
Values 4.6 7.1 4.7
[82]
SNU475 SGMS1
Mean 16.7
Standard deviation 3.8
Values 14 19
[83]
THLE SGMS1
Mean 17.9
Standard deviation 2
Values 16 19
[84]
liver SGMS1
Mean 13.4
Standard deviation 1.8
Values 13 14 15 11
[85]
ref_hepatocyte EHMT2
Mean 3.9
Standard deviation 2.8
Values 2.2 2.9 2.7 8.9 2.8
[86]
HepG2 EHMT2
Mean 47.9
Standard deviation 1.4
Values 47 49
[87]
HepG2.C3A EHMT2
Mean 32.7
Standard deviation 3.5
Values 30 35
[88]
HuH.7 EHMT2
Mean 32.9
Standard deviation 6.7
Values 34 26 39
[89]
SNU475 EHMT2
Mean 45.3
Standard deviation 4.2
Values 42 48
[90]
THLE EHMT2
Mean 20.9
Standard deviation 2.3
Values 19 23
[91]
liver EHMT2
Mean 6.65
Standard deviation 1.5
Values 6.1 5 8.4 7.1
[92]
ref_hepatocyte DNMT1
Mean 3.28
Standard deviation 1.4
Values 3.3 1.6 2.4 5.2 3.9
[93]
HepG2 DNMT1
Mean 56.5
Standard deviation 6.2
Values 61 52
[94]
HepG2.C3A DNMT1
Mean 36.1
Standard deviation 9.3
Values 43 30
[95]
HuH.7 DNMT1
Mean 63.9
Standard deviation 30
Values 76 30 86
[96]
SNU475 DNMT1
Mean 51.7
Standard deviation 9.8
Values 59 45
[97]
THLE DNMT1
Mean 91.2
Standard deviation 13
Values 82 1e+02
[98]
liver DNMT1
Mean 9.87
Standard deviation 1
Values 9.5 11 8.6 11
[99]
ref_hepatocyte EHMT1
Mean 3.27
Standard deviation 0.31
Values 3.7 3.5 3.1 2.9 3.1
[100]
HepG2 EHMT1
Mean 22.5
Standard deviation 1.6
Values 21 24
[101]
HepG2.C3A EHMT1
Mean 17.5
Standard deviation 2.6
Values 16 19
[102]
HuH.7 EHMT1
Mean 20.9
Standard deviation 4.1
Values 23 16 24
[103]
SNU475 EHMT1
Mean 19.4
Standard deviation 3.5
Values 17 22
[104]
THLE EHMT1
Mean 16.6
Standard deviation 5
Values 13 20
[105]
liver EHMT1
Mean 17.4
Standard deviation 6.4
Values 24 21 13 11
[106]
ref_hepatocyte DNMT3A
Mean 2.8
Standard deviation 3.3
Values 1.1 1.3 1.2 8.7 1.7
[107]
HepG2 DNMT3A
Mean 17.7
Standard deviation 0.61
Values 17 18
[108]
HepG2.C3A DNMT3A
Mean 19.7
Standard deviation 0.75
Values 20 19
[109]
HuH.7 DNMT3A
Mean 17.6
Standard deviation 2.3
Values 16 16 20
[110]
SNU475 DNMT3A
Mean 5.28
Standard deviation 2.5
Values 3.5 7
[111]
THLE DNMT3A
Mean 3.91
Standard deviation 0.33
Values 3.7 4.1
[112]
liver DNMT3A
Mean 5.72
Standard deviation 1.9
Values 7.1 6.3 6.5 3
[113]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 2 4.4 2.7 1.9 1.9
[114]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 7 5.8
[115]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[116]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.6 4.1 6.7
[117]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 5 6.3
[118]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[119]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 1.6 1.9 2.4 4.2
[120]
ref_hepatocyte DNMT3B
Mean 2.35
Standard deviation 2
Values 5 2 0.1 3.6 1.1
[121]
HepG2 DNMT3B
Mean 17.1
Standard deviation 1.1
Values 16 18
[122]
HepG2.C3A DNMT3B
Mean 8.62
Standard deviation 2.8
Values 11 6.6
[123]
HuH.7 DNMT3B
Mean 6.18
Standard deviation 2.5
Values 7.4 3.3 7.8
[124]
SNU475 DNMT3B
Mean 6.2
Standard deviation 1.4
Values 5.2 7.2
[125]
THLE DNMT3B
Mean 2.63
Standard deviation 0.35
Values 2.4 2.9
[126]
liver DNMT3B
Mean 0.855
Standard deviation 0.27
Values 0.93 0.77 0.54 1.2
[127]
ref_hepatocyte MTHFR
Mean 0.857
Standard deviation 0.14
Values 0.91 0.6 0.95 0.9 0.92
[128]
HepG2 MTHFR
Mean 4.76
Standard deviation 0.36
Values 5 4.5
[129]
HepG2.C3A MTHFR
Mean 10.9
Standard deviation 2
Values 9.5 12
[130]
HuH.7 MTHFR
Mean 12.4
Standard deviation 3.7
Values 9.7 17 11
[131]
SNU475 MTHFR
Mean 10.2
Standard deviation 3.7
Values 7.6 13
[132]
THLE MTHFR
Mean 4.9
Standard deviation 0.19
Values 5 4.8
[133]
liver MTHFR
Mean 17.1
Standard deviation 4.4
Values 19 21 17 11
[134]
ref_hepatocyte ASMT
Mean 0.657
Standard deviation 0.74
Values 0 0.88 1.8 0.29 0.27
[135]
HepG2 ASMT
Missing
[136]
HepG2.C3A ASMT
Missing
[137]
HuH.7 ASMT
Missing
[138]
SNU475 ASMT
Missing
[139]
THLE ASMT
Missing
[140]
liver ASMT
Missing
[141]
ref_hepatocyte GRIN2D
Mean 0.0598
Standard deviation 0.13
Values 0 0 0 0.3 0
[142]
HepG2 GRIN2D
Mean 2.96
Standard deviation 2.4
Values 1.3 4.6
[143]
HepG2.C3A GRIN2D
Mean 2.45
Standard deviation 0.75
Values 1.9 3
[144]
HuH.7 GRIN2D
Mean 2.93
Standard deviation 0.45
Values 2.6 2.7 3.5
[145]
SNU475 GRIN2D
Mean 0.755
Standard deviation 0.44
Values 1.1 0.44
[146]
THLE GRIN2D
Mean 0.41
Standard deviation 0.031
Values 0.43 0.39
[147]
liver GRIN2D
Mean 0.0818
Standard deviation 0.083
Values 0.13 0.17 0.024 0
[148]
ref_hepatocyte GRIN2A
Mean 0.00172
Standard deviation 0.0039
Values 0 0 0.0086 0 0
[149]
HepG2 GRIN2A
Mean 0
Standard deviation 0
Values 0 0
[150]
HepG2.C3A GRIN2A
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 GRIN2A
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[152]
SNU475 GRIN2A
Mean 1.69
Standard deviation 0.46
Values 2 1.4
[153]
THLE GRIN2A
Mean 0.0106
Standard deviation 0.015
Values 0 0.021
[154]
liver GRIN2A
Mean 0.641
Standard deviation 0.48
Values 1.3 0.74 0.28 0.26
[155]
ref_hepatocyte NDUFAF7
Missing
[156]
HepG2 NDUFAF7
Mean 9.56
Standard deviation 1.2
Values 10 8.7
[157]
HepG2.C3A NDUFAF7
Mean 14.4
Standard deviation 2.8
Values 16 12
[158]
HuH.7 NDUFAF7
Mean 7.64
Standard deviation 2.1
Values 9.7 5.5 7.8
[159]
SNU475 NDUFAF7
Mean 4.52
Standard deviation 0.0033
Values 4.5 4.5
[160]
THLE NDUFAF7
Mean 5.43
Standard deviation 0.024
Values 5.4 5.4
[161]
liver NDUFAF7
Mean 6.86
Standard deviation 1.8
Values 4.6 6.3 7.8 8.7
[162]
ref_hepatocyte MARS1
Missing
[163]
HepG2 MARS1
Missing
[164]
HepG2.C3A MARS1
Missing
[165]
HuH.7 MARS1
Missing
[166]
SNU475 MARS1
Missing
[167]
THLE MARS1
Missing
[168]
liver MARS1
Missing
[169]
ref_hepatocyte GRIN1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 GRIN1
Mean 0.68
Standard deviation 0.6
Values 0.25 1.1
[171]
HepG2.C3A GRIN1
Mean 0.154
Standard deviation 0.11
Values 0.075 0.23
[172]
HuH.7 GRIN1
Mean 0.0602
Standard deviation 0.028
Values 0.028 0.071 0.082
[173]
SNU475 GRIN1
Mean 0.0414
Standard deviation 0.006
Values 0.046 0.037
[174]
THLE GRIN1
Mean 0.00858
Standard deviation 0.0046
Values 0.012 0.0053
[175]
liver GRIN1
Mean 0
Standard deviation 0
Values 0 0 0 0
[176]
ref_hepatocyte MIR4761
Missing
[177]
HepG2 MIR4761
Missing
[178]
HepG2.C3A MIR4761
Missing
[179]
HuH.7 MIR4761
Missing
[180]
SNU475 MIR4761
Missing
[181]
THLE MIR4761
Missing
[182]
liver MIR4761
Missing
[183]
ref_hepatocyte MIR6758
Missing
[184]
HepG2 MIR6758
Missing
[185]
HepG2.C3A MIR6758
Missing
[186]
HuH.7 MIR6758
Missing
[187]
SNU475 MIR6758
Missing
[188]
THLE MIR6758
Missing
[189]
liver MIR6758
Missing