WP_MODULATORS_OF_TCR_SIGNALING_AND_T_CELL_ACTIVATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NFKBIA | NF-kappa-B inhibitor alpha | [1] | -1.14[2] | -2.94[3] | -3.26[4] | -3.35[5] | -1.53[6] | -1.04[7] |
2 | PCBP2 | Poly(rC)-binding protein 2 | [8] | 0.21[9] | 0.33[10] | 0.74[11] | 0.03[12] | 0.09[13] | -1.06[14] |
3 | NDUFB10 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | [15] | -2.79[16] | -2.84[17] | -2.60[18] | -3.45[19] | -2.44[20] | -1.80[21] |
4 | ZFP36L1 | mRNA decay activator protein ZFP36L1 | [22] | -1.16[23] | -2.21[24] | -1.81[25] | -0.01[26] | -0.52[27] | 0.34[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | 0.00[30] | -0.24[31] | -1.27[32] | 0.12[33] | 0.08[34] | -0.15[35] |
6 | IKBKG | NF-kappa-B essential modulator | [36] | -0.97[37] | -0.83[38] | -3.02[39] | -0.68[40] | -1.96[41] | -0.51[42] |
7 | GRB2 | Growth factor receptor-bound protein 2 | [43] | 1.11[44] | 0.94[45] | 1.12[46] | 0.72[47] | 0.57[48] | 0.39[49] |
8 | RNF7 | RING-box protein 2 | [50] | -0.27[51] | -0.05[52] | -0.97[53] | -0.64[54] | -0.64[55] | -0.64[56] |
9 | RELA | Transcription factor p65 | [57] | 0.05[58] | -0.46[59] | -0.27[60] | 0.11[61] | -0.04[62] | -0.79[63] |
10 | FIBP | Acidic fibroblast growth factor intracellular-binding protein | [64] | -0.88[65] | -1.02[66] | -1.07[67] | -0.61[68] | -0.09[69] | -1.09[70] |
11 | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfa | 0.30[71] | 0.48[72] | 0.53[73] | 0.18[74] | -0.66[75] | -1.19[76] | |
12 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [77] | -0.17[78] | 0.27[79] | 0.52[80] | -0.94[81] | -0.54[82] | -0.81[83] |
13 | RPRD1B | Regulation of nuclear pre-mRNA domain-containing protein 1B | [84] | 0.16[85] | 0.48[86] | -0.26[87] | 0.26[88] | -0.28[89] | 0.36[90] |
14 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | [91] | 0.03[92] | 0.20[93] | 0.73[94] | 1.36[95] | 0.13[96] | 0.63[97] |
15 | TNFAIP3 | Tumor necrosis factor alpha-induced protein 3 | [98] | 0.55[99] | 1.24[100] | -1.96[101] | -1.05[102] | 0.86[103] | -0.93[104] |
16 | TMEM222 | Transmembrane protein 222 | [105] | -0.71[106] | -0.84[107] | -1.26[108] | -0.65[109] | -0.54[110] | -0.36[111] |
17 | ARIH2 | E3 ubiquitin-protein ligase ARIH2 | [112] | 1.03[113] | 0.84[114] | 2.10[115] | 0.56[116] | 1.37[117] | 1.00[118] |
18 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [119] | -0.56[120] | -0.44[121] | 0.70[122] | 2.23[123] | 1.67[124] | 3.10[125] |
19 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [126] | 0.58[127] | 0.26[128] | 0.10[129] | -0.08[130] | 0.77[131] | 0.55[132] |
20 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [133] | -0.55[134] | -0.36[135] | 0.27[136] | -6.97[137] | -2.01[138] | -0.08[139] |
21 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [140] | 1.79[141] | 2.01[142] | 2.67[143] | 0.88[144] | 1.37[145] | -0.20[146] |
22 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [147] | 0.82[148] | 2.03[149] | 2.05[150] | 0.82[151] | 1.57[152] | 1.61[153] |
23 | CUL5 | Cullin-5 | [154] | 0.49[155] | 1.97[156] | 1.51[157] | 2.69[158] | 1.77[159] | 2.42[160] |
24 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [161] | 2.25[162] | 3.43[163] | 2.20[164] | 1.60[165] | 1.94[166] | 2.60[167] |
25 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.41[168] | 3.02[169] | 2.41[170] | 2.99[171] | 2.42[172] | 0.44[173] | |
26 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [174] | 0.44[175] | 0.49[176] | 0.65[177] | 0.43[178] | 0.46[179] | 1.28[180] |
27 | DGKZ | Diacylglycerol kinase zeta | [181] | 1.98[182] | 1.23[183] | 1.23[184] | -0.11[185] | 1.13[186] | 0.50[187] |
28 | BCL10 | B-cell lymphoma/leukemia 10 | [188] | 0.00[189] | -0.50[190] | 0.54[191] | 0.71[192] | 0.68[193] | 0.63[194] |
29 | SH2B3 | SH2B adapter protein 3 | [195] | 1.03[196] | 0.62[197] | 0.89[198] | 1.72[199] | 2.49[200] | 1.50[201] |
30 | MEF2D | Myocyte-specific enhancer factor 2D | [202] | 0.66[203] | 0.52[204] | 1.29[205] | 2.74[206] | 2.27[207] | 0.95[208] |
31 | SOCS1 | Suppressor of cytokine signaling 1 | [209] | -1.53[210] | -0.67[211] | -0.35[212] | -1.63[213] | -3.07[214] | -1.37[215] |
32 | CBLB | E3 ubiquitin-protein ligase CBL-B | [216] | -0.73[217] | 0.51[218] | 0.99[219] | 0.94[220] | 1.75[221] | 1.47[222] |
33 | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | 2.77[223] | 2.61[224] | 2.09[225] | 2.21[226] | 1.43[227] | 2.36[228] | |
34 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [229] | -0.48[230] | -0.03[231] | -1.14[232] | 2.24[233] | 1.16[234] | 0.97[235] |
35 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | [236] | 1.66[237] | 1.66[238] | 0.90[239] | 0.27[240] | 1.53[241] | 0.58[242] |
36 | RASA2 | Ras GTPase-activating protein 2 | [243] | -1.38[244] | -0.36[245] | -0.42[246] | 0.15[247] | 0.05[248] | 0.83[249] |
37 | TRAF6 | TNF receptor-associated factor 6 | [250] | 1.01[251] | 0.89[252] | 1.51[253] | 1.83[254] | 1.22[255] | 3.00[256] |
38 | LCP2 | Lymphocyte cytosolic protein 2 | [257] | [258] | [259] | [260] | -3.55[261] | [262] | 1.24[263] |
39 | LAT | Linker for activation of T-cells family member 1 | [264] | -1.53[265] | 0.00[266] | -1.54[267] | -1.20[268] | -0.68[269] | -0.33[270] |
40 | CD3E | T-cell surface glycoprotein CD3 epsilon chain | [271] | -8.95[272] | [273] | -5.42[274] | [275] | [276] | -0.51[277] |
41 | DGKA | Diacylglycerol kinase alpha | [278] | 2.43[279] | 1.75[280] | 1.55[281] | 2.10[282] | 3.67[283] | 0.64[284] |
42 | REL | Proto-oncogene c-Rel | [285] | -0.60[286] | 1.16[287] | 1.15[288] | 0.31[289] | 0.41[290] | 2.44[291] |
43 | VAV1 | Proto-oncogene vav | [292] | -8.58[293] | -3.76[294] | -5.41[295] | -5.92[296] | -7.24[297] | 1.28[298] |
44 | CD247 | T-cell surface glycoprotein CD3 zeta chain | [299] | -4.95[300] | -5.63[301] | -7.08[302] | -3.34[303] | -4.79[304] | 0.08[305] |
45 | CD3D | T-cell surface glycoprotein CD3 delta chain | [306] | 1.31[307] | -0.70[308] | -3.02[309] | -6.33[310] | -4.40[311] | -0.23[312] |
46 | LCK | Tyrosine-protein kinase Lck | [313] | 2.69[314] | 2.77[315] | -7.17[316] | -4.92[317] | -5.18[318] | 1.33[319] |
47 | CD8A | T-cell surface glycoprotein CD8 alpha chain | [320] | -0.71[321] | -4.47[322] | 0.72[323] | -4.51[324] | -3.21[325] | 0.93[326] |
48 | CD3G | T-cell surface glycoprotein CD3 gamma chain | [327] | -3.68[328] | -2.93[329] | -3.93[330] | -4.45[331] | -3.92[332] | -0.25[333] |
49 | MAP4K1 | Mitogen-activated protein kinase kinase kinase kinase 1 | [334] | -2.48[335] | -0.77[336] | -1.35[337] | 0.02[338] | -1.44[339] | 1.43[340] |
50 | ZAP70 | Tyrosine-protein kinase ZAP-70 | [341] | 0.92[342] | 1.13[343] | -5.04[344] | -5.38[345] | -4.09[346] | 2.25[347] |
51 | SH2D1A | SH2 domain-containing protein 1A | [348] | [349] | [350] | -6.82[351] | [352] | [353] | 0.95[354] |
52 | ITK | Tyrosine-protein kinase ITK/TSK | [355] | -6.98[356] | -4.01[357] | [358] | 0.00[359] | -4.80[360] | 2.29[361] |
53 | RHOH | Rho-related GTP-binding protein RhoH | [362] | -3.17[363] | -3.97[364] | 2.03[365] | -3.62[366] | -3.49[367] | 1.63[368] |
54 | CARD11 | Caspase recruitment domain-containing protein 11 | [369] | 1.05[370] | -5.47[371] | -6.18[372] | 1.41[373] | 5.86[374] | 2.37[375] |
55 | CD28 | T-cell-specific surface glycoprotein CD28 | [376] | -4.09[377] | -3.22[378] | -3.14[379] | -2.18[380] | -2.29[381] | 1.21[382] |
56 | GRAP2 | GRB2-related adapter protein 2 | [383] | -5.93[384] | [385] | -2.27[386] | -1.81[387] | -0.83[388] | 0.93[389] |
57 | PRKCQ | Protein kinase C theta type | [390] | 0.82[391] | -2.75[392] | [393] | 2.29[394] | 3.73[395] | 2.18[396] |
58 | CD5 | T-cell surface glycoprotein CD5 | [397] | -1.05[398] | [399] | -2.23[400] | -3.21[401] | -3.72[402] | 2.11[403] |
59 | UBASH3A | Ubiquitin-associated and SH3 domain-containing protein A | [404] | -1.41[405] | [406] | [407] | [408] | [409] | 3.64[410] |
60 | AGO1 | Protein argonaute-1 | [411] | [412] | [413] | [414] | [415] | [416] | [417] |
61 | ELOB | Elongin-B | [418] | [419] | [420] | [421] | [422] | [423] | [424] |