WP_MIRNA_REGULATION_OF_DNA_DAMAGE_RESPONSE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | GADD45B | Growth arrest and DNA damage-inducible protein GADD45 beta | [1] | -4.79[2] | -5.59[3] | -4.42[4] | -4.29[5] | -3.62[6] | -1.94[7] |
2 | GADD45A | Growth arrest and DNA damage-inducible protein GADD45 alpha | [8] | -3.09[9] | -4.20[10] | -4.06[11] | -4.26[12] | -2.84[13] | -2.78[14] |
3 | SFN | 14-3-3 protein sigma | [15] | -2.98[16] | -3.37[17] | -3.03[18] | -8.10[19] | -9.34[20] | -9.87[21] |
4 | GADD45G | Growth arrest and DNA damage-inducible protein GADD45 gamma | [22] | -10.54[23] | [24] | -9.09[25] | -8.10[26] | -8.35[27] | -1.49[28] |
5 | CDKN1A | Cyclin-dependent kinase inhibitor 1 | [29] | 0.22[30] | -1.20[31] | -3.94[32] | -2.26[33] | -0.01[34] | -1.61[35] |
6 | MYC | Myc proto-oncogene protein | [36] | -0.19[37] | -0.56[38] | -2.64[39] | -3.06[40] | -1.00[41] | -1.77[42] |
7 | BAX | Apoptosis regulator BAX | [43] | -0.29[44] | -1.12[45] | -1.63[46] | -1.87[47] | -1.80[48] | -3.73[49] |
8 | RPA2 | Replication protein A 32 kDa subunit | [50] | -2.08[51] | -2.04[52] | -1.52[53] | -1.02[54] | -1.25[55] | -2.17[56] |
9 | CCND1 | G1/S-specific cyclin-D1 | [57] | 2.43[58] | -0.11[59] | 0.68[60] | 1.61[61] | -0.18[62] | 1.28[63] |
10 | CDK4 | Cyclin-dependent kinase 4 | [64] | 0.71[65] | 1.26[66] | 0.84[67] | -0.09[68] | 0.25[69] | -0.61[70] |
11 | CCNG1 | Cyclin-G1 | [71] | 0.18[72] | 1.42[73] | 1.43[74] | -0.52[75] | -0.45[76] | 0.73[77] |
12 | TNFRSF10 | Tumor necrosis factor receptor superfamily member 10B | [78] | 1.37[79] | 1.21[80] | 0.96[81] | -0.60[82] | 0.70[83] | 0.26[84] |
13 | CYCS | Cytochrome c | [85] | 0.72[86] | 0.88[87] | 0.90[88] | 1.06[89] | 1.15[90] | 1.55[91] |
14 | CDKN1B | Cyclin-dependent kinase inhibitor 1B | [92] | -0.70[93] | -0.30[94] | -0.15[95] | -1.38[96] | -1.23[97] | -0.68[98] |
15 | MCM7 | DNA replication licensing factor MCM7 | [99] | 1.30[100] | 1.05[101] | 2.23[102] | 1.02[103] | 1.26[104] | -0.57[105] |
16 | CASP3 | Caspase-3 | [106] | -0.48[107] | 0.16[108] | -2.44[109] | -1.17[110] | -0.48[111] | -0.58[112] |
17 | BID | BH3-interacting domain death agonist | [113] | -0.89[114] | -0.82[115] | -1.25[116] | -0.56[117] | -1.41[118] | 0.40[119] |
18 | CDK2 | Cyclin-dependent kinase 2 | [120] | -1.03[121] | -0.90[122] | -0.57[123] | -0.29[124] | -0.01[125] | -1.96[126] |
19 | FAS | Tumor necrosis factor receptor superfamily member 6 | [127] | -2.22[128] | -1.48[129] | -9.53[130] | -2.01[131] | -1.81[132] | -1.50[133] |
20 | RFC1 | Replication factor C subunit 1 | [134] | -0.48[135] | 0.78[136] | 1.11[137] | 0.05[138] | 0.58[139] | 1.01[140] |
21 | CASP8 | Caspase-8 | [141] | -0.60[142] | -0.06[143] | -0.94[144] | -0.35[145] | -1.41[146] | -1.19[147] |
22 | CCNB1 | G2/mitotic-specific cyclin-B1 | [148] | 1.23[149] | 1.43[150] | 1.56[151] | 1.34[152] | 2.00[153] | -2.12[154] |
23 | TLK1 | Serine/threonine-protein kinase tousled-like 1 | [155] | -0.86[156] | 0.70[157] | -0.03[158] | 0.51[159] | -0.49[160] | 1.51[161] |
24 | RAD17 | Cell cycle checkpoint protein RAD17 | [162] | -1.47[163] | -0.41[164] | -0.41[165] | -0.61[166] | -0.57[167] | -0.20[168] |
25 | DDB2 | DNA damage-binding protein 2 | [169] | 0.46[170] | -0.05[171] | -1.41[172] | -1.88[173] | -1.61[174] | -1.29[175] |
26 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | [176] | 1.49[177] | 2.88[178] | 0.06[179] | 0.24[180] | 0.80[181] | 2.39[182] |
27 | NBN | Nibrin | [183] | -1.04[184] | 0.11[185] | -0.18[186] | 1.23[187] | 0.04[188] | 1.50[189] |
28 | CDK1 | Cyclin-dependent kinase 1 | [190] | 0.63[191] | 2.66[192] | 1.35[193] | 2.00[194] | 2.50[195] | -2.24[196] |
29 | CHEK2 | Serine/threonine-protein kinase Chk2 | [197] | -0.52[198] | -0.11[199] | 0.24[200] | -0.52[201] | -1.20[202] | -3.05[203] |
30 | TP53 | Cellular tumor antigen p53 | [204] | 1.02[205] | 0.55[206] | 1.26[207] | 1.02[208] | 0.37[209] | 0.19[210] |
31 | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B | [211] | 0.62[212] | 0.75[213] | -0.48[214] | 0.74[215] | 0.22[216] | 0.68[217] |
32 | RAD51 | DNA repair protein RAD51 homolog 1 | [218] | -0.87[219] | -1.09[220] | -1.04[221] | -0.45[222] | -0.80[223] | -3.72[224] |
33 | CDK5 | Cyclin-dependent-like kinase 5 | [225] | -0.38[226] | -1.11[227] | -1.11[228] | 0.36[229] | -1.17[230] | -0.65[231] |
34 | SMC1A | Structural maintenance of chromosomes protein 1A | [232] | 1.48[233] | 1.31[234] | 2.27[235] | 2.74[236] | 3.27[237] | 2.67[238] |
35 | BBC3 | Bcl-2-binding component 3 | [239] | 0.12[240] | -0.03[241] | -0.58[242] | -3.07[243] | -2.63[244] | -4.11[245] |
36 | CDK6 | Cyclin-dependent kinase 6 | [246] | 1.43[247] | 2.09[248] | 0.45[249] | 0.65[250] | 1.14[251] | 2.30[252] |
37 | ABL1 | Tyrosine-protein kinase ABL1 | [253] | 1.61[254] | 0.97[255] | 1.72[256] | 1.80[257] | 2.17[258] | 1.17[259] |
38 | RAD50 | DNA repair protein RAD50 | [260] | -0.47[261] | 1.63[262] | 0.73[263] | 1.00[264] | 1.17[265] | 2.43[266] |
39 | PML | Protein PML | [267] | -0.38[268] | -1.43[269] | 0.22[270] | 1.62[271] | 0.80[272] | 0.47[273] |
40 | CCND3 | G1/S-specific cyclin-D3 | [274] | 0.33[275] | -0.76[276] | -2.44[277] | 3.39[278] | 2.26[279] | 0.88[280] |
41 | CCNE1 | G1/S-specific cyclin-E1 | [281] | 0.62[282] | 0.70[283] | -1.17[284] | -0.68[285] | -0.39[286] | -4.40[287] |
42 | PRKDC | DNA-dependent protein kinase catalytic subunit | [288] | 3.60[289] | 3.03[290] | 4.87[291] | 4.62[292] | 4.39[293] | 4.47[294] |
43 | SESN1 | Sestrin-1 | [295] | 0.67[296] | 0.96[297] | -1.60[298] | -1.15[299] | -0.25[300] | 0.93[301] |
44 | RB1 | Retinoblastoma-associated protein | [302] | 0.60[303] | 1.06[304] | 1.58[305] | 2.01[306] | 2.02[307] | 1.70[308] |
45 | TLK2 | Serine/threonine-protein kinase tousled-like 2 | [309] | 1.19[310] | 1.44[311] | 0.89[312] | 1.71[313] | 1.16[314] | 1.67[315] |
46 | CASP9 | Caspase-9 | [316] | -0.46[317] | 0.46[318] | -0.47[319] | -0.02[320] | -1.02[321] | -0.31[322] |
47 | E2F1 | Transcription factor E2F1 | [323] | 1.33[324] | 1.15[325] | 1.23[326] | 1.59[327] | 1.72[328] | -3.39[329] |
48 | CHEK1 | Serine/threonine-protein kinase Chk1 | [330] | 0.92[331] | 1.24[332] | 0.76[333] | 1.88[334] | 1.80[335] | -1.80[336] |
49 | PMAIP1 | Phorbol-12-myristate-13-acetate-induced protein 1 | [337] | -0.57[338] | -3.97[339] | -0.47[340] | 2.01[341] | 0.92[342] | -4.07[343] |
50 | CDC25A | M-phase inducer phosphatase 1 | [344] | 0.81[345] | 1.41[346] | 1.71[347] | 0.07[348] | 1.22[349] | -2.43[350] |
51 | CCNB2 | G2/mitotic-specific cyclin-B2 | [351] | 1.47[352] | 2.20[353] | 2.53[354] | 2.25[355] | 2.92[356] | -1.37[357] |
52 | RAD1 | Cell cycle checkpoint protein RAD1 | [358] | 0.75[359] | 1.39[360] | 1.88[361] | 1.53[362] | 2.11[363] | 1.13[364] |
53 | RAD9A | Cell cycle checkpoint control protein RAD9A | [365] | -0.55[366] | -0.30[367] | 1.46[368] | 2.06[369] | -0.43[370] | 0.06[371] |
54 | BRCA1 | Breast cancer type 1 susceptibility protein | [372] | 1.05[373] | 2.26[374] | 2.61[375] | 1.87[376] | 2.09[377] | 1.90[378] |
55 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [379] | 1.10[380] | 2.23[381] | 2.67[382] | 2.27[383] | 1.90[384] | 2.57[385] |
56 | ATRIP | ATR-interacting protein | [386] | -0.37[387] | -0.17[388] | 0.66[389] | -0.62[390] | 0.15[391] | 0.06[392] |
57 | ATR | Serine/threonine-protein kinase ATR | [393] | 0.48[394] | 1.44[395] | 1.47[396] | 2.26[397] | 1.91[398] | 3.78[399] |
58 | APAF1 | Apoptotic protease-activating factor 1 | [400] | 1.04[401] | 1.43[402] | 1.63[403] | 2.36[404] | 1.14[405] | 1.72[406] |
59 | RAD52 | DNA repair protein RAD52 homolog | [407] | -0.24[408] | 0.49[409] | 0.55[410] | -0.69[411] | -0.54[412] | 0.98[413] |
60 | FANCD2 | Fanconi anemia group D2 protein | [414] | 1.81[415] | 1.92[416] | 2.94[417] | 2.15[418] | 2.52[419] | 0.25[420] |
61 | ATM | Serine-protein kinase ATM | [421] | 2.41[422] | 3.98[423] | 3.66[424] | 3.89[425] | 3.06[426] | 5.22[427] |
62 | CCNE2 | G1/S-specific cyclin-E2 | [428] | -0.20[429] | 0.17[430] | -0.35[431] | 2.77[432] | 2.36[433] | -0.13[434] |
63 | CDC25C | M-phase inducer phosphatase 3 | [435] | 1.31[436] | 2.43[437] | 2.41[438] | 1.66[439] | 2.19[440] | -1.19[441] |
64 | CCND2 | G1/S-specific cyclin-D2 | [442] | 2.52[443] | 1.07[444] | -5.18[445] | -4.72[446] | -2.12[447] | 2.08[448] |
65 | CCNB3 | G2/mitotic-specific cyclin-B3 | [449] | -2.28[450] | -3.06[451] | -3.37[452] | -2.17[453] | 0.37[454] | 2.07[455] |
66 | HUS1B | Checkpoint protein HUS1B | [456] | -1.43[457] | -2.45[458] | -2.09[459] | 0.80[460] | -0.92[461] | 1.44[462] |
67 | TP53AIP1 | p53-regulated apoptosis-inducing protein 1 | [463] | -0.69[464] | -0.60[465] | -1.39[466] | -0.80[467] | -1.46[468] | 0.56[469] |
68 | CDC20B | Cell division cycle protein 20 homolog B | [470] | [471] | [472] | [473] | 0.86[474] | 0.52[475] | [476] |
69 | MIR373 | [477] | [478] | [479] | [480] | [481] | [482] | [483] | |
70 | MIR17 | [484] | [485] | [486] | [487] | [488] | [489] | [490] | |
71 | MIR18A | [491] | [492] | [493] | [494] | [495] | [496] | [497] | |
72 | PIDD1 | p53-induced death domain-containing protein 1 | [498] | [499] | [500] | [501] | [502] | [503] | [504] |
73 | MIR221 | [505] | [506] | [507] | [508] | [509] | [510] | [511] | |
74 | MIR449A | [512] | [513] | [514] | [515] | [516] | [517] | [518] | |
75 | MIR16-1 | [519] | [520] | [521] | [522] | [523] | [524] | [525] | |
76 | MIR106B | [526] | [527] | [528] | [529] | [530] | [531] | [532] | |
77 | MIR19B1 | [533] | [534] | [535] | [536] | [537] | [538] | [539] | |
78 | MIR181A1 | [540] | [541] | [542] | [543] | [544] | [545] | [546] | |
79 | MIR203A | [547] | [548] | [549] | [550] | [551] | [552] | [553] | |
80 | MIR92A1 | [554] | [555] | [556] | [557] | [558] | [559] | [560] | |
81 | MIR222 | [561] | [562] | [563] | [564] | [565] | [566] | [567] | |
82 | MIR421 | [568] | [569] | [570] | [571] | [572] | [573] | [574] | |
83 | H2AX | [575] | [576] | [577] | [578] | [579] | [580] | [581] | |
84 | MIR3591 | [582] | [583] | [584] | [585] | [586] | [587] | [588] | |
85 | MIR20A | [589] | [590] | [591] | [592] | [593] | [594] | [595] | |
86 | MIR17HG | Putative microRNA 17 host gene protein | [596] | [597] | [598] | [599] | [600] | [601] | [602] |
87 | MIR210 | [603] | [604] | [605] | [606] | [607] | [608] | [609] | |
88 | MIR34B | [610] | [611] | [612] | [613] | [614] | [615] | [616] | |
89 | MIR145 | [617] | [618] | [619] | [620] | [621] | [622] | [623] | |
90 | MIR3191 | [624] | [625] | [626] | [627] | [628] | [629] | [630] | |
91 | MIR449B | [631] | [632] | [633] | [634] | [635] | [636] | [637] | |
92 | MRE11 | Double-strand break repair protein MRE11 | [638] | [639] | [640] | [641] | [642] | [643] | [644] |
93 | MIR19A | [645] | [646] | [647] | [648] | [649] | [650] | [651] |