WP_MEVALONATE_ARM_OF_CHOLESTEROL_BIOSYNTHESIS_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 FDPS Farnesyl pyrophosphate synthase [1] -0.51[2] -0.88[3] -0.67[4] -0.21[5] 0.06[6] -1.38[7]
2 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial [8] -0.02[9] -2.14[10] -3.39[11] -0.17[12] -0.88[13] 0.80[14]
3 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic [15] -1.34[16] -0.11[17] 1.21[18] -1.55[19] -1.41[20] -0.03[21]
4 FDFT1 Squalene synthase [22] 0.70[23] 0.65[24] 0.13[25] -1.03[26] 0.41[27] -0.74[28]
5 HMGCL Hydroxymethylglutaryl-CoA lyase, mitochondrial [29] -0.45[30] -0.90[31] -1.68[32] -0.49[33] -0.60[34] -0.04[35]
6 ACAT2 Acetyl-CoA acetyltransferase, cytosolic [36] 0.31[37] 0.33[38] -0.23[39] -0.87[40] 0.04[41] -0.51[42]
7 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 [43] -0.39[44] 1.10[45] -0.39[46] 1.17[47] 0.34[48] 0.53[49]
8 PMVK Phosphomevalonate kinase [50] -0.08[51] -2.01[52] -0.85[53] 0.68[54] 0.82[55] -1.95[56]
9 MVD Diphosphomevalonate decarboxylase [57] 1.21[58] 1.69[59] 0.81[60] 0.33[61] 0.74[62] -0.22[63]
10 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase [64] 1.90[65] 2.65[66] 2.85[67] 2.42[68] 2.50[69] 1.59[70]
11 MVK Mevalonate kinase [71] 0.15[72] 0.51[73] -0.11[74] -0.49[75] -0.31[76] 0.46[77]
12 GGPS1 Geranylgeranyl pyrophosphate synthase [78] 2.67[79] 1.93[80] 1.82[81] 4.34[82] 3.09[83] 0.57[84]
13 IDI2 Isopentenyl-diphosphate delta-isomerase 2 [85] 3.22[86] 2.10[87] 1.99[88] 5.50[89] 4.42[90] 0.73[91]
[1]
ref_hepatocyte FDPS
Mean 168
Standard deviation 1.2e+02
Values 65 1.3e+02 1e+02 1.8e+02 3.6e+02
[2]
HepG2 FDPS
Mean 47.3
Standard deviation 9.8
Values 54 40
[3]
HepG2.C3A FDPS
Mean 130
Standard deviation 36
Values 1e+02 1.5e+02
[4]
HuH.7 FDPS
Mean 153
Standard deviation 26
Values 1.8e+02 1.3e+02 1.4e+02
[5]
SNU475 FDPS
Mean 40
Standard deviation 13
Values 31 49
[6]
THLE FDPS
Mean 41.3
Standard deviation 7.5
Values 36 47
[7]
liver FDPS
Mean 78.7
Standard deviation 39
Values 50 54 76 1.3e+02
[8]
ref_hepatocyte ACAT1
Mean 166
Standard deviation 1.7e+02
Values 23 3.9e+02 3.2e+02 49 47
[9]
HepG2 ACAT1
Mean 65.7
Standard deviation 6.9
Values 71 61
[10]
HepG2.C3A ACAT1
Mean 53.7
Standard deviation 16
Values 65 43
[11]
HuH.7 ACAT1
Mean 22.9
Standard deviation 6
Values 29 17 22
[12]
SNU475 ACAT1
Mean 40.9
Standard deviation 14
Values 31 51
[13]
THLE ACAT1
Mean 21.3
Standard deviation 4.8
Values 18 25
[14]
liver ACAT1
Mean 353
Standard deviation 1.8e+02
Values 1.6e+02 2.4e+02 4.7e+02 5.4e+02
[15]
ref_hepatocyte HMGCS1
Mean 128
Standard deviation 1e+02
Values 58 72 32 2.5e+02 2.3e+02
[16]
HepG2 HMGCS1
Mean 20.3
Standard deviation 12
Values 28 12
[17]
HepG2.C3A HMGCS1
Mean 170
Standard deviation 81
Values 1.1e+02 2.3e+02
[18]
HuH.7 HMGCS1
Mean 427
Standard deviation 1.7e+02
Values 3.3e+02 6.2e+02 3.3e+02
[19]
SNU475 HMGCS1
Mean 12.1
Standard deviation 4.1
Values 9.2 15
[20]
THLE HMGCS1
Mean 11.4
Standard deviation 0.78
Values 11 12
[21]
liver HMGCS1
Mean 154
Standard deviation 63
Values 2.2e+02 1.9e+02 79 1.3e+02
[22]
ref_hepatocyte FDFT1
Mean 87.4
Standard deviation 77
Values 41 38 48 2.2e+02 91
[23]
HepG2 FDFT1
Mean 56.9
Standard deviation 24
Values 74 40
[24]
HepG2.C3A FDFT1
Mean 196
Standard deviation 63
Values 1.5e+02 2.4e+02
[25]
HuH.7 FDFT1
Mean 138
Standard deviation 16
Values 1.6e+02 1.3e+02 1.3e+02
[26]
SNU475 FDFT1
Mean 11.8
Standard deviation 4
Values 9 15
[27]
THLE FDFT1
Mean 27.4
Standard deviation 0.93
Values 27 28
[28]
liver FDFT1
Mean 64.1
Standard deviation 23
Values 52 45 62 98
[29]
ref_hepatocyte HMGCL
Mean 70.8
Standard deviation 75
Values 16 1.7e+02 1.3e+02 13 21
[30]
HepG2 HMGCL
Mean 20.8
Standard deviation 4.9
Values 17 24
[31]
HepG2.C3A HMGCL
Mean 54.2
Standard deviation 20
Values 40 68
[32]
HuH.7 HMGCL
Mean 31.8
Standard deviation 4.4
Values 37 30 29
[33]
SNU475 HMGCL
Mean 13.9
Standard deviation 6.4
Values 9.4 18
[34]
THLE HMGCL
Mean 11
Standard deviation 0.25
Values 11 11
[35]
liver HMGCL
Mean 84.2
Standard deviation 57
Values 29 42 1.3e+02 1.3e+02
[36]
ref_hepatocyte ACAT2
Mean 68.2
Standard deviation 50
Values 17 76 49 1.5e+02 51
[37]
HepG2 ACAT2
Mean 33.9
Standard deviation 23
Values 50 18
[38]
HepG2.C3A ACAT2
Mean 123
Standard deviation 6.4
Values 1.2e+02 1.3e+02
[39]
HuH.7 ACAT2
Mean 84.1
Standard deviation 10
Values 95 76 82
[40]
SNU475 ACAT2
Mean 10.3
Standard deviation 0.34
Values 10 11
[41]
THLE ACAT2
Mean 16.6
Standard deviation 3.1
Values 14 19
[42]
liver ACAT2
Mean 58.5
Standard deviation 28
Values 39 47 48 1e+02
[43]
ref_hepatocyte IDI1
Mean 49.3
Standard deviation 26
Values 14 62 33 79 59
[44]
HepG2 IDI1
Mean 15.1
Standard deviation 12
Values 23 6.9
[45]
HepG2.C3A IDI1
Mean 151
Standard deviation 3.5
Values 1.5e+02 1.5e+02
[46]
HuH.7 IDI1
Mean 54.3
Standard deviation 7.2
Values 59 58 46
[47]
SNU475 IDI1
Mean 30.7
Standard deviation 8.7
Values 24 37
[48]
THLE IDI1
Mean 14.8
Standard deviation 3.6
Values 12 17
[49]
liver IDI1
Mean 87.2
Standard deviation 46
Values 55 57 84 1.5e+02
[50]
ref_hepatocyte PMVK
Mean 22.4
Standard deviation 12
Values 20 34 33 3.4 22
[51]
HepG2 PMVK
Mean 8.49
Standard deviation 1
Values 7.8 9.2
[52]
HepG2.C3A PMVK
Mean 7.97
Standard deviation 0.74
Values 7.4 8.5
[53]
HuH.7 PMVK
Mean 17.9
Standard deviation 3.9
Values 22 14 18
[54]
SNU475 PMVK
Mean 9.92
Standard deviation 2.1
Values 8.5 11
[55]
THLE PMVK
Mean 9.34
Standard deviation 1.8
Values 8 11
[56]
liver PMVK
Mean 7.06
Standard deviation 5.2
Values 3.4 2.4 13 9
[57]
ref_hepatocyte MVD
Mean 20.1
Standard deviation 9.1
Values 15 24 17 34 10
[58]
HepG2 MVD
Mean 18.7
Standard deviation 5.5
Values 23 15
[59]
HepG2.C3A MVD
Mean 92.8
Standard deviation 59
Values 51 1.3e+02
[60]
HuH.7 MVD
Mean 50.8
Standard deviation 5.1
Values 56 45 51
[61]
SNU475 MVD
Mean 7
Standard deviation 2.5
Values 5.2 8.8
[62]
THLE MVD
Mean 7.96
Standard deviation 0.012
Values 8 8
[63]
liver MVD
Mean 21.1
Standard deviation 12
Values 19 14 12 39
[64]
ref_hepatocyte HMGCR
Mean 14.8
Standard deviation 13
Values 9.1 9.8 5.9 37 12
[65]
HepG2 HMGCR
Mean 22.2
Standard deviation 14
Values 32 12
[66]
HepG2.C3A HMGCR
Mean 133
Standard deviation 31
Values 1.1e+02 1.5e+02
[67]
HuH.7 HMGCR
Mean 154
Standard deviation 61
Values 1.1e+02 2.2e+02 1.3e+02
[68]
SNU475 HMGCR
Mean 22
Standard deviation 2.5
Values 20 24
[69]
THLE HMGCR
Mean 19.8
Standard deviation 3.5
Values 17 22
[70]
liver HMGCR
Mean 54.5
Standard deviation 28
Values 81 71 20 46
[71]
ref_hepatocyte MVK
Mean 14.5
Standard deviation 7.2
Values 7.9 24 20 12 8.7
[72]
HepG2 MVK
Mean 6.45
Standard deviation 1.7
Values 7.6 5.3
[73]
HepG2.C3A MVK
Mean 29.6
Standard deviation 8.4
Values 24 36
[74]
HuH.7 MVK
Mean 19.4
Standard deviation 2
Values 22 18 19
[75]
SNU475 MVK
Mean 2.86
Standard deviation 0.47
Values 2.5 3.2
[76]
THLE MVK
Mean 2.76
Standard deviation 0.64
Values 2.3 3.2
[77]
liver MVK
Mean 24.4
Standard deviation 13
Values 16 11 36 35
[78]
ref_hepatocyte GGPS1
Mean 3.62
Standard deviation 1.6
Values 2.9 3.2 3.1 6.4 2.5
[79]
HepG2 GGPS1
Mean 9.28
Standard deviation 2.3
Values 11 7.6
[80]
HepG2.C3A GGPS1
Mean 19.7
Standard deviation 0.38
Values 19 20
[81]
HuH.7 GGPS1
Mean 18.5
Standard deviation 0.7
Values 19 18 18
[82]
SNU475 GGPS1
Mean 20.3
Standard deviation 4.3
Values 17 23
[83]
THLE GGPS1
Mean 7.32
Standard deviation 0.42
Values 7.6 7
[84]
liver GGPS1
Mean 6.56
Standard deviation 3.2
Values 3.3 4.6 10 8.2
[85]
ref_hepatocyte IDI2
Mean 0.262
Standard deviation 0.32
Values 0.079 0.6 0.63 0 0
[86]
HepG2 IDI2
Mean 0.98
Standard deviation 0.15
Values 0.87 1.1
[87]
HepG2.C3A IDI2
Mean 1.6
Standard deviation 0.39
Values 1.3 1.9
[88]
HuH.7 IDI2
Mean 1.5
Standard deviation 0.45
Values 1.9 1 1.5
[89]
SNU475 IDI2
Mean 3.28
Standard deviation 1.1
Values 4.1 2.5
[90]
THLE IDI2
Mean 1.33
Standard deviation 0.055
Values 1.3 1.4
[91]
liver IDI2
Mean 0.531
Standard deviation 0.12
Values 0.49 0.41 0.71 0.51