WP_METHIONINE_DE_NOVO_AND_SALVAGE_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TXN Thioredoxin [1] -1.36[2] -1.79[3] -1.90[4] -0.36[5] -0.85[6] -3.06[7]
2 MAT1A S-adenosylmethionine synthase isoform type-1 [8] -1.96[9] -0.56[10] -2.12[11] -8.33[12] -10.89[13] 1.14[14]
3 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [15] -1.20[16] -1.66[17] -1.91[18] -1.38[19] -0.94[20] 0.19[21]
4 BHMT Betaine--homocysteine S-methyltransferase 1 [22] -4.62[23] -5.28[24] -8.79[25] -7.43[26] -14.24[27] -0.61[28]
5 TAT Tyrosine aminotransferase [29] -5.77[30] -3.56[31] -5.68[32] -8.51[33] -9.15[34] 2.06[35]
6 ODC1 Ornithine decarboxylase [36] 1.33[37] 1.50[38] 0.67[39] 0.03[40] 0.90[41] -1.75[42]
7 AHCY Adenosylhomocysteinase [43] 2.54[44] 2.48[45] 3.08[46] 1.33[47] 0.86[48] -0.81[49]
8 SMS Spermine synthase [50] 0.72[51] 0.00[52] 0.67[53] 1.36[54] 1.34[55] -2.40[56]
9 SRM Spermidine synthase [57] 1.02[58] 1.21[59] 0.12[60] 1.08[61] 1.36[62] -2.07[63]
10 AMD1 S-adenosylmethionine decarboxylase proenzyme [64] 1.80[65] 1.83[66] 1.67[67] 1.67[68] 2.44[69] -0.21[70]
11 MAT2A S-adenosylmethionine synthase isoform type-2 [71] 2.07[72] 1.92[73] 2.08[74] 2.93[75] 3.12[76] 1.08[77]
12 MSRA Mitochondrial peptide methionine sulfoxide reductase [78] -2.56[79] -2.53[80] -3.18[81] -3.44[82] -2.51[83] -0.12[84]
13 APIP Methylthioribulose-1-phosphate dehydratase [85] -0.11[86] 0.12[87] 0.70[88] 0.56[89] 0.01[90] -1.02[91]
14 MSRB2 Methionine-R-sulfoxide reductase B2, mitochondrial [92] -1.16[93] -0.85[94] -0.75[95] 1.15[96] 0.92[97] -0.15[98]
15 MAT2B Methionine adenosyltransferase 2 subunit beta [99] 1.47[100] 1.07[101] 1.63[102] 2.57[103] 2.43[104] 0.23[105]
16 ENOPH1 Enolase-phosphatase E1 [106] 1.85[107] 1.98[108] 2.02[109] 1.44[110] 1.89[111] -0.70[112]
17 CHDH Choline dehydrogenase, mitochondrial [113] 2.40[114] 2.88[115] 1.37[116] -3.90[117] -4.25[118] 1.69[119]
18 MTAP S-methyl-5'-thioadenosine phosphorylase [120] 2.32[121] 1.51[122] 2.07[123] 2.75[124] 3.06[125] 0.75[126]
19 MRI1 Methylthioribose-1-phosphate isomerase [127] 2.04[128] 1.69[129] 3.22[130] 1.97[131] 2.53[132] 1.32[133]
20 MTR Methionine synthase [134] 3.82[135] 4.02[136] 4.54[137] 5.25[138] 4.55[139] 3.56[140]
21 IL4I1 L-amino-acid oxidase [141] -3.20[142] -4.59[143] -1.09[144] 2.01[145] -0.11[146] -1.11[147]
22 MSRB3 Methionine-R-sulfoxide reductase B3 [148] 3.76[149] 0.57[150] 3.96[151] 7.82[152] 7.68[153] 3.80[154]
[1]
ref_hepatocyte TXN
Mean 524
Standard deviation 4.3e+02
Values 2.7e+02 2e+02 2.4e+02 6.9e+02 1.2e+03
[2]
HepG2 TXN
Mean 153
Standard deviation 27
Values 1.3e+02 1.7e+02
[3]
HepG2.C3A TXN
Mean 142
Standard deviation 55
Values 1.8e+02 1e+02
[4]
HuH.7 TXN
Mean 98.2
Standard deviation 36
Values 1.4e+02 67 91
[5]
SNU475 TXN
Mean 174
Standard deviation 25
Values 1.6e+02 1.9e+02
[6]
THLE TXN
Mean 143
Standard deviation 0.49
Values 1.4e+02 1.4e+02
[7]
liver TXN
Mean 77.5
Standard deviation 77
Values 7.5 16 1.5e+02 1.3e+02
[8]
ref_hepatocyte MAT1A
Mean 212
Standard deviation 2.8e+02
Values 7.2 6.3e+02 3.6e+02 46 12
[9]
HepG2 MAT1A
Mean 41.1
Standard deviation 3.9
Values 44 38
[10]
HepG2.C3A MAT1A
Mean 135
Standard deviation 10
Values 1.3e+02 1.4e+02
[11]
HuH.7 MAT1A
Mean 34.1
Standard deviation 22
Values 22 60 20
[12]
SNU475 MAT1A
Mean 0.281
Standard deviation 0.061
Values 0.24 0.32
[13]
THLE MAT1A
Mean 0.055
Standard deviation 0.048
Values 0.089 0.021
[14]
liver MAT1A
Mean 578
Standard deviation 1.7e+02
Values 4.1e+02 6.1e+02 4.8e+02 8.1e+02
[15]
ref_hepatocyte ADI1
Mean 179
Standard deviation 1.9e+02
Values 25 4.9e+02 2.1e+02 69 1e+02
[16]
HepG2 ADI1
Mean 58.5
Standard deviation 28
Values 78 39
[17]
HepG2.C3A ADI1
Mean 53.1
Standard deviation 27
Values 72 34
[18]
HuH.7 ADI1
Mean 33.4
Standard deviation 6.3
Values 39 27 35
[19]
SNU475 ADI1
Mean 29.4
Standard deviation 6.5
Values 25 34
[20]
THLE ADI1
Mean 45.8
Standard deviation 4.9
Values 42 49
[21]
liver ADI1
Mean 252
Standard deviation 2.2e+02
Values 64 80 5.4e+02 3.3e+02
[22]
ref_hepatocyte BHMT
Mean 117
Standard deviation 1.9e+02
Values 6.9 4.5e+02 1.1e+02 8.1 4.9
[23]
HepG2 BHMT
Mean 3.57
Standard deviation 0.19
Values 3.4 3.7
[24]
HepG2.C3A BHMT
Mean 2.82
Standard deviation 2.3
Values 4.4 1.2
[25]
HuH.7 BHMT
Mean 0.184
Standard deviation 0.018
Values 0.2 0.19 0.16
[26]
SNU475 BHMT
Mean 0.29
Standard deviation 0.11
Values 0.21 0.37
[27]
THLE BHMT
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[28]
liver BHMT
Mean 94.8
Standard deviation 50
Values 39 69 1.5e+02 1.2e+02
[29]
ref_hepatocyte TAT
Mean 98.7
Standard deviation 1.4e+02
Values 8.6 1.8e+02 3e+02 1.5 2
[30]
HepG2 TAT
Mean 1.36
Standard deviation 0.56
Values 0.97 1.8
[31]
HepG2.C3A TAT
Mean 7.84
Standard deviation 2.3
Values 6.2 9.4
[32]
HuH.7 TAT
Mean 1.34
Standard deviation 0.97
Values 0.8 2.5 0.76
[33]
SNU475 TAT
Mean 0.116
Standard deviation 0.013
Values 0.11 0.13
[34]
THLE TAT
Mean 0.0852
Standard deviation 0.03
Values 0.11 0.064
[35]
liver TAT
Mean 507
Standard deviation 1.5e+02
Values 3.2e+02 4.6e+02 6.4e+02 6.1e+02
[36]
ref_hepatocyte ODC1
Mean 80.4
Standard deviation 64
Values 1.3e+02 20 54 34 1.7e+02
[37]
HepG2 ODC1
Mean 152
Standard deviation 16
Values 1.6e+02 1.4e+02
[38]
HepG2.C3A ODC1
Mean 213
Standard deviation 1.3e+02
Values 3e+02 1.2e+02
[39]
HuH.7 ODC1
Mean 89.1
Standard deviation 41
Values 1.2e+02 42 1e+02
[40]
SNU475 ODC1
Mean 35.1
Standard deviation 2.2
Values 34 37
[41]
THLE ODC1
Mean 73.4
Standard deviation 18
Values 60 87
[42]
liver ODC1
Mean 29.6
Standard deviation 18
Values 20 50 10 39
[43]
ref_hepatocyte AHCY
Mean 72
Standard deviation 24
Values 38 67 80 1e+02 71
[44]
HepG2 AHCY
Mean 316
Standard deviation 75
Values 2.6e+02 3.7e+02
[45]
HepG2.C3A AHCY
Mean 377
Standard deviation 69
Values 3.3e+02 4.3e+02
[46]
HuH.7 AHCY
Mean 425
Standard deviation 39
Values 4e+02 4e+02 4.7e+02
[47]
SNU475 AHCY
Mean 77.3
Standard deviation 9.8
Values 70 84
[48]
THLE AHCY
Mean 64.2
Standard deviation 8.6
Values 58 70
[49]
liver AHCY
Mean 50.8
Standard deviation 11
Values 40 45 55 64
[50]
ref_hepatocyte SMS
Mean 48.6
Standard deviation 41
Values 65 18 12 35 1.1e+02
[51]
HepG2 SMS
Mean 60
Standard deviation 5.2
Values 56 64
[52]
HepG2.C3A SMS
Mean 45.7
Standard deviation 8.7
Values 52 40
[53]
HuH.7 SMS
Mean 54.1
Standard deviation 17
Values 69 35 59
[54]
SNU475 SMS
Mean 53.5
Standard deviation 0.37
Values 54 53
[55]
THLE SMS
Mean 60.3
Standard deviation 9.2
Values 54 67
[56]
liver SMS
Mean 11.4
Standard deviation 7.2
Values 4.4 6 16 19
[57]
ref_hepatocyte SRM
Mean 28.1
Standard deviation 25
Values 70 16 33 6.5 15
[58]
HepG2 SRM
Mean 42.7
Standard deviation 0.29
Values 43 43
[59]
HepG2.C3A SRM
Mean 60.7
Standard deviation 5.5
Values 65 57
[60]
HuH.7 SRM
Mean 21.2
Standard deviation 10
Values 27 9.7 27
[61]
SNU475 SRM
Mean 25.5
Standard deviation 6.7
Values 30 21
[62]
THLE SRM
Mean 35.3
Standard deviation 5.7
Values 31 39
[63]
liver SRM
Mean 8.26
Standard deviation 6.7
Values 2.5 2.4 14 14
[64]
ref_hepatocyte AMD1
Mean 24.4
Standard deviation 20
Values 14 6.2 8.6 42 51
[65]
HepG2 AMD1
Mean 63.6
Standard deviation 14
Values 74 53
[66]
HepG2.C3A AMD1
Mean 81.5
Standard deviation 16
Values 93 70
[67]
HuH.7 AMD1
Mean 54.3
Standard deviation 9.8
Values 58 43 61
[68]
SNU475 AMD1
Mean 33.1
Standard deviation 11
Values 41 25
[69]
THLE AMD1
Mean 65.1
Standard deviation 0.15
Values 65 65
[70]
liver AMD1
Mean 26.1
Standard deviation 4.4
Values 27 29 20 29
[71]
ref_hepatocyte MAT2A
Mean 23.3
Standard deviation 13
Values 14 16 44 15 27
[72]
HepG2 MAT2A
Mean 73.6
Standard deviation 11
Values 81 66
[73]
HepG2.C3A MAT2A
Mean 82.6
Standard deviation 22
Values 98 67
[74]
HuH.7 MAT2A
Mean 68.8
Standard deviation 31
Values 93 34 79
[75]
SNU475 MAT2A
Mean 75.8
Standard deviation 6
Values 80 72
[76]
THLE MAT2A
Mean 99.7
Standard deviation 1.6
Values 1e+02 99
[77]
liver MAT2A
Mean 61
Standard deviation 25
Values 34 46 78 86
[78]
ref_hepatocyte MSRA
Mean 14
Standard deviation 13
Values 7.8 30 28 2.4 2.9
[79]
HepG2 MSRA
Mean 1.79
Standard deviation 0.64
Values 2.2 1.3
[80]
HepG2.C3A MSRA
Mean 2.28
Standard deviation 0.7
Values 2.8 1.8
[81]
HuH.7 MSRA
Mean 1.08
Standard deviation 0.11
Values 1 1 1.2
[82]
SNU475 MSRA
Mean 0.551
Standard deviation 0.027
Values 0.53 0.57
[83]
THLE MSRA
Mean 1.21
Standard deviation 0.12
Values 1.1 1.3
[84]
liver MSRA
Mean 16
Standard deviation 13
Values 5.1 4.7 31 23
[85]
ref_hepatocyte APIP
Mean 13.7
Standard deviation 4.9
Values 7.6 14 11 21 15
[86]
HepG2 APIP
Mean 9.53
Standard deviation 0.68
Values 10 9
[87]
HepG2.C3A APIP
Mean 14
Standard deviation 2.8
Values 16 12
[88]
HuH.7 APIP
Mean 15.6
Standard deviation 6.5
Values 22 8.8 16
[89]
SNU475 APIP
Mean 8.67
Standard deviation 2.2
Values 7.1 10
[90]
THLE APIP
Mean 6.76
Standard deviation 0.32
Values 6.5 7
[91]
liver APIP
Mean 8.35
Standard deviation 5.9
Values 2.9 4.2 16 11
[92]
ref_hepatocyte MSRB2
Mean 13
Standard deviation 12
Values 4.2 29 24 2.5 6
[93]
HepG2 MSRB2
Mean 4.37
Standard deviation 0.21
Values 4.5 4.2
[94]
HepG2.C3A MSRB2
Mean 6.78
Standard deviation 0.92
Values 6.1 7.4
[95]
HuH.7 MSRB2
Mean 5.41
Standard deviation 1.3
Values 6.9 4.8 4.6
[96]
SNU475 MSRB2
Mean 12.4
Standard deviation 3.6
Values 9.8 15
[97]
THLE MSRB2
Mean 12
Standard deviation 0.84
Values 13 11
[98]
liver MSRB2
Mean 14.5
Standard deviation 13
Values 2.8 3.3 27 24
[99]
ref_hepatocyte MAT2B
Mean 12.1
Standard deviation 5.7
Values 6.8 21 9.4 13 9.7
[100]
HepG2 MAT2B
Mean 25.3
Standard deviation 2.8
Values 27 23
[101]
HepG2.C3A MAT2B
Mean 23.8
Standard deviation 7.6
Values 29 18
[102]
HuH.7 MAT2B
Mean 26.2
Standard deviation 6.2
Values 32 20 27
[103]
SNU475 MAT2B
Mean 30.8
Standard deviation 4.2
Values 28 34
[104]
THLE MAT2B
Mean 32
Standard deviation 4.5
Values 29 35
[105]
liver MAT2B
Mean 17.5
Standard deviation 7.4
Values 10 12 22 26
[106]
ref_hepatocyte ENOPH1
Mean 11.4
Standard deviation 6.4
Values 10 5.6 5.3 17 19
[107]
HepG2 ENOPH1
Mean 31
Standard deviation 2.5
Values 33 29
[108]
HepG2.C3A ENOPH1
Mean 42.3
Standard deviation 11
Values 50 34
[109]
HuH.7 ENOPH1
Mean 32.3
Standard deviation 11
Values 42 21 35
[110]
SNU475 ENOPH1
Mean 13.3
Standard deviation 0.42
Values 14 13
[111]
THLE ENOPH1
Mean 20.8
Standard deviation 4.1
Values 18 24
[112]
liver ENOPH1
Mean 8.65
Standard deviation 3.6
Values 4.8 6.7 10 13
[113]
ref_hepatocyte CHDH
Mean 8.63
Standard deviation 5.4
Values 3.1 14 11 13 2.5
[114]
HepG2 CHDH
Mean 34.2
Standard deviation 8.2
Values 40 28
[115]
HepG2.C3A CHDH
Mean 59.6
Standard deviation 4.1
Values 57 63
[116]
HuH.7 CHDH
Mean 15.6
Standard deviation 0.26
Values 15 16 16
[117]
SNU475 CHDH
Mean 0.247
Standard deviation 0.005
Values 0.24 0.25
[118]
THLE CHDH
Mean 0.222
Standard deviation 0.1
Values 0.3 0.15
[119]
liver CHDH
Mean 34.4
Standard deviation 9.9
Values 21 44 34 39
[120]
ref_hepatocyte MTAP
Mean 5.62
Standard deviation 4
Values 5.1 2.8 2.5 5.2 13
[121]
HepG2 MTAP
Mean 21.2
Standard deviation 0.73
Values 22 21
[122]
HepG2.C3A MTAP
Mean 15
Standard deviation 2.2
Values 17 13
[123]
HuH.7 MTAP
Mean 16.5
Standard deviation 5.3
Values 19 10 20
[124]
SNU475 MTAP
Mean 16.2
Standard deviation 2.2
Values 18 15
[125]
THLE MTAP
Mean 23
Standard deviation 2.5
Values 21 25
[126]
liver MTAP
Mean 11.7
Standard deviation 2.6
Values 10 14 8.6 13
[127]
ref_hepatocyte MRI1
Mean 3.64
Standard deviation 1.3
Values 5.2 4.4 3.8 1.7 3.1
[128]
HepG2 MRI1
Mean 11.2
Standard deviation 0.37
Values 11 11
[129]
HepG2.C3A MRI1
Mean 11
Standard deviation 0.74
Values 12 10
[130]
HuH.7 MRI1
Mean 23.7
Standard deviation 7.2
Values 28 15 28
[131]
SNU475 MRI1
Mean 6.12
Standard deviation 0.42
Values 5.8 6.4
[132]
THLE MRI1
Mean 10.3
Standard deviation 0.76
Values 11 9.8
[133]
liver MRI1
Mean 11.2
Standard deviation 0.87
Values 12 10 12 11
[134]
ref_hepatocyte MTR
Mean 1.43
Standard deviation 1
Values 1.2 0.48 0.53 2.9 2.1
[135]
HepG2 MTR
Mean 15.2
Standard deviation 4.2
Values 18 12
[136]
HepG2.C3A MTR
Mean 21.8
Standard deviation 0.68
Values 21 22
[137]
HuH.7 MTR
Mean 23.2
Standard deviation 4.8
Values 20 21 29
[138]
SNU475 MTR
Mean 23.4
Standard deviation 7.7
Values 18 29
[139]
THLE MTR
Mean 16.5
Standard deviation 1
Values 17 16
[140]
liver MTR
Mean 20.9
Standard deviation 9.9
Values 24 34 12 14
[141]
ref_hepatocyte IL4I1
Mean 0.263
Standard deviation 0.43
Values 1 0.22 0.078 0 0
[142]
HepG2 IL4I1
Mean 0.0215
Standard deviation 0.018
Values 0.0086 0.034
[143]
HepG2.C3A IL4I1
Mean 0.0102
Standard deviation 0.00071
Values 0.011 0.0097
[144]
HuH.7 IL4I1
Mean 0.086
Standard deviation 0.025
Values 0.094 0.058 0.11
[145]
SNU475 IL4I1
Mean 0.452
Standard deviation 0.29
Values 0.66 0.25
[146]
THLE IL4I1
Mean 0.12
Standard deviation 0.011
Values 0.11 0.13
[147]
liver IL4I1
Mean 0.15
Standard deviation 0.14
Values 0.053 0.071 0.12 0.36
[148]
ref_hepatocyte MSRB3
Mean 0.223
Standard deviation 0.37
Values 0.035 0 0.1 0.094 0.88
[149]
HepG2 MSRB3
Mean 2.27
Standard deviation 0.76
Values 2.8 1.7
[150]
HepG2.C3A MSRB3
Mean 0.311
Standard deviation 2.4e-05
Values 0.31 0.31
[151]
HuH.7 MSRB3
Mean 2.43
Standard deviation 0.13
Values 2.3 2.5 2.5
[152]
SNU475 MSRB3
Mean 21.6
Standard deviation 0.023
Values 22 22
[153]
THLE MSRB3
Mean 22.5
Standard deviation 4
Values 20 25
[154]
liver MSRB3
Mean 3.83
Standard deviation 1.9
Values 3.8 4.3 1.4 5.9