WP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 JUN Transcription factor AP-1 [1] -0.33[2] -1.76[3] -1.79[4] -1.65[5] -1.18[6] -1.32[7]
2 FOS Proto-oncogene c-Fos [8] -5.86[9] -4.48[10] -5.44[11] -6.12[12] -5.14[13] -0.81[14]
3 MYC Myc proto-oncogene protein [15] 0.59[16] 0.36[17] -1.96[18] -2.74[19] -0.46[20] -1.50[21]
4 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [22] -0.77[23] -0.99[24] -0.71[25] -0.49[26] -0.08[27] -0.70[28]
5 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [29] 0.21[30] 0.00[31] 0.57[32] -0.79[33] -0.40[34] -1.21[35]
6 SHC1 SHC-transforming protein 1 [36] 1.32[37] 1.65[38] 1.43[39] 2.70[40] 2.09[41] 1.27[42]
7 RAF1 RAF proto-oncogene serine/threonine-protein kinase [43] 0.09[44] 0.61[45] 1.58[46] -0.14[47] 0.63[48] 1.59[49]
8 KRAS GTPase KRas [50] -0.36[51] -0.27[52] 1.04[53] 0.85[54] 0.42[55] 1.17[56]
9 SOS1 Son of sevenless homolog 1 [57] 0.06[58] 1.70[59] 0.91[60] 0.89[61] 0.03[62] 1.03[63]
10 ELK1 ETS domain-containing protein Elk-1 [64] -0.16[65] -2.18[66] -0.06[67] 0.32[68] 0.82[69] 0.33[70]
11 MAPK3 Mitogen-activated protein kinase 3 [71] 2.01[72] 2.16[73] 1.91[74] 0.47[75] 0.40[76] -0.55[77]
12 SOS2 Son of sevenless homolog 2 [78] 0.13[79] 1.37[80] 0.30[81] 1.74[82] 1.51[83] 2.33[84]
13 BRAF Serine/threonine-protein kinase B-raf [85] 0.40[86] 0.24[87] 1.98[88] 0.79[89] 0.39[90] 2.35[91]
14 KSR1 Kinase suppressor of Ras 1 [92] 3.42[93] 3.23[94] -0.15[95] 2.09[96] 2.50[97] 1.22[98]
15 GAREM2 GRB2-associated and regulator of MAPK protein 2 [99] [100] [101] [102] [103] [104] [105]
16 ALK ALK tyrosine kinase receptor [106] [107] [108] [109] [110] [111] [112]
[1]
ref_hepatocyte JUN
Mean 42.9
Standard deviation 25
Values 66 20 73 26 30
[2]
HepG2 JUN
Mean 67.5
Standard deviation 36
Values 42 93
[3]
HepG2.C3A JUN
Mean 20.6
Standard deviation 11
Values 13 28
[4]
HuH.7 JUN
Mean 23.9
Standard deviation 19
Values 14 46 11
[5]
SNU475 JUN
Mean 24.2
Standard deviation 4.1
Values 27 21
[6]
THLE JUN
Mean 40.2
Standard deviation 4.7
Values 37 44
[7]
liver JUN
Mean 17.4
Standard deviation 8.4
Values 12 24 25 8.4
[8]
ref_hepatocyte FOS
Mean 40
Standard deviation 67
Values 9 27 1.6e+02 4 0.65
[9]
HepG2 FOS
Mean 1.37
Standard deviation 1
Values 0.66 2.1
[10]
HepG2.C3A FOS
Mean 2.92
Standard deviation 1.9
Values 1.6 4.3
[11]
HuH.7 FOS
Mean 1.77
Standard deviation 0.38
Values 2.2 1.6 1.5
[12]
SNU475 FOS
Mean 1.02
Standard deviation 0.13
Values 1.1 0.93
[13]
THLE FOS
Mean 2.4
Standard deviation 0.3
Values 2.2 2.6
[14]
liver FOS
Mean 23
Standard deviation 32
Values 5.7 4.8 71 10
[15]
ref_hepatocyte MYC
Mean 29.9
Standard deviation 34
Values 89 1.4 23 15 20
[16]
HepG2 MYC
Mean 88.8
Standard deviation 53
Values 52 1.3e+02
[17]
HepG2.C3A MYC
Mean 62.6
Standard deviation 15
Values 52 73
[18]
HuH.7 MYC
Mean 14.7
Standard deviation 2.6
Values 14 18 13
[19]
SNU475 MYC
Mean 7.93
Standard deviation 1.4
Values 8.9 6.9
[20]
THLE MYC
Mean 46
Standard deviation 10
Values 39 53
[21]
liver MYC
Mean 10.6
Standard deviation 6
Values 5.5 5.9 18 13
[22]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 32 27 15 27 39
[23]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 30 35
[24]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[25]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 40 27 33
[26]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 39 32
[27]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[28]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 12 11 28 18
[29]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 28 26 42 22 20
[30]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 48 79
[31]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 36 55
[32]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 69 82 87
[33]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[34]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[35]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 11 11 17 9.8
[36]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 19 16 26 5.8 17
[37]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[38]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 93 77
[39]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 85 84 89
[40]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 1.7e+02 2.2e+02
[41]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[42]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 37 56
[43]
ref_hepatocyte RAF1
Mean 15.5
Standard deviation 5.7
Values 20 17 20 6 14
[44]
HepG2 RAF1
Mean 32.7
Standard deviation 5.2
Values 36 29
[45]
HepG2.C3A RAF1
Mean 38.6
Standard deviation 2.8
Values 37 41
[46]
HuH.7 RAF1
Mean 89
Standard deviation 4.2
Values 89 93 85
[47]
SNU475 RAF1
Mean 25
Standard deviation 4.6
Values 28 22
[48]
THLE RAF1
Mean 50.9
Standard deviation 5.2
Values 47 55
[49]
liver RAF1
Mean 47
Standard deviation 3.6
Values 46 42 51 49
[50]
ref_hepatocyte KRAS
Mean 8.97
Standard deviation 7.9
Values 5.4 2.7 1.7 18 17
[51]
HepG2 KRAS
Mean 13.9
Standard deviation 3.1
Values 16 12
[52]
HepG2.C3A KRAS
Mean 12.2
Standard deviation 2.3
Values 14 11
[53]
HuH.7 KRAS
Mean 35.4
Standard deviation 4.8
Values 36 30 40
[54]
SNU475 KRAS
Mean 28.7
Standard deviation 5.5
Values 25 33
[55]
THLE KRAS
Mean 25.4
Standard deviation 1.5
Values 24 26
[56]
liver KRAS
Mean 20.4
Standard deviation 8.7
Values 14 16 33 19
[57]
ref_hepatocyte SOS1
Mean 6.81
Standard deviation 11
Values 2.2 1.5 1.3 27 1.9
[58]
HepG2 SOS1
Mean 14
Standard deviation 6.5
Values 19 9.4
[59]
HepG2.C3A SOS1
Mean 36.1
Standard deviation 3.7
Values 33 39
[60]
HuH.7 SOS1
Mean 24.6
Standard deviation 11
Values 15 37 22
[61]
SNU475 SOS1
Mean 22.5
Standard deviation 3.3
Values 20 25
[62]
THLE SOS1
Mean 14.8
Standard deviation 1.4
Values 16 14
[63]
liver SOS1
Mean 14.1
Standard deviation 3.8
Values 16 18 13 9.3
[64]
ref_hepatocyte ELK1
Mean 6.81
Standard deviation 3.9
Values 7.5 4.4 8.5 1.7 12
[65]
HepG2 ELK1
Mean 12.1
Standard deviation 1.5
Values 11 13
[66]
HepG2.C3A ELK1
Mean 2.45
Standard deviation 0.82
Values 1.9 3
[67]
HuH.7 ELK1
Mean 12.6
Standard deviation 1.8
Values 13 11 14
[68]
SNU475 ELK1
Mean 15.1
Standard deviation 0.2
Values 15 15
[69]
THLE ELK1
Mean 25.4
Standard deviation 3.5
Values 23 28
[70]
liver ELK1
Mean 8.61
Standard deviation 2.4
Values 7.1 6 10 11
[71]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[72]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[73]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[74]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[75]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[76]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[77]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[78]
ref_hepatocyte SOS2
Mean 2.58
Standard deviation 0.97
Values 2.8 1.9 1.5 4 2.6
[79]
HepG2 SOS2
Mean 5.6
Standard deviation 3
Values 7.7 3.5
[80]
HepG2.C3A SOS2
Mean 10.9
Standard deviation 0.059
Values 11 11
[81]
HuH.7 SOS2
Mean 6.11
Standard deviation 1.7
Values 4.3 7.5 6.5
[82]
SNU475 SOS2
Mean 15.3
Standard deviation 6
Values 11 19
[83]
THLE SOS2
Mean 15.6
Standard deviation 2.6
Values 17 14
[84]
liver SOS2
Mean 13.1
Standard deviation 7.3
Values 20 19 7.4 6.2
[85]
ref_hepatocyte BRAF
Mean 1.07
Standard deviation 0.72
Values 2.3 0.67 0.67 0.56 1.2
[86]
HepG2 BRAF
Mean 2.8
Standard deviation 0.62
Values 3.2 2.4
[87]
HepG2.C3A BRAF
Mean 2.07
Standard deviation 0.66
Values 2.5 1.6
[88]
HuH.7 BRAF
Mean 8.12
Standard deviation 5.8
Values 3.4 15 6.4
[89]
SNU475 BRAF
Mean 3.28
Standard deviation 0.16
Values 3.4 3.2
[90]
THLE BRAF
Mean 2.97
Standard deviation 0.38
Values 2.7 3.2
[91]
liver BRAF
Mean 5.48
Standard deviation 2.9
Values 7.9 8 3.1 2.9
[92]
ref_hepatocyte KSR1
Mean 0.387
Standard deviation 0.39
Values 0.38 0.11 0.06 1 0.34
[93]
HepG2 KSR1
Mean 8.21
Standard deviation 0.63
Values 7.8 8.7
[94]
HepG2.C3A KSR1
Mean 5.95
Standard deviation 0.11
Values 5.9 6
[95]
HuH.7 KSR1
Mean 0.672
Standard deviation 0.25
Values 0.47 0.95 0.6
[96]
SNU475 KSR1
Mean 2.94
Standard deviation 0.81
Values 3.5 2.4
[97]
THLE KSR1
Mean 4.65
Standard deviation 0.57
Values 4.2 5
[98]
liver KSR1
Mean 0.913
Standard deviation 0.48
Values 1.2 1.4 0.49 0.51
[99]
ref_hepatocyte GAREM2
Missing
[100]
HepG2 GAREM2
Missing
[101]
HepG2.C3A GAREM2
Missing
[102]
HuH.7 GAREM2
Missing
[103]
SNU475 GAREM2
Missing
[104]
THLE GAREM2
Missing
[105]
liver GAREM2
Missing
[106]
ref_hepatocyte ALK
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[107]
HepG2 ALK
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A ALK
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 ALK
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[110]
SNU475 ALK
Mean 0.0319
Standard deviation 0.012
Values 0.041 0.023
[111]
THLE ALK
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[112]
liver ALK
Mean 0.137
Standard deviation 0.12
Values 0.29 0.19 0.047 0.026