WP_MAPK_CASCADE | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | JUN | Transcription factor AP-1 | [1] | -0.72[2] | -2.28[3] | -2.23[4] | -2.05[5] | -1.44[6] | -1.99[7] |
2 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [8] | -1.45[9] | -1.17[10] | -2.49[11] | -2.17[12] | -2.27[13] | -1.62[14] |
3 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [15] | -1.16[16] | -1.51[17] | -1.15[18] | -0.89[19] | -0.34[20] | -1.37[21] |
4 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [22] | -0.17[23] | -0.52[24] | 0.13[25] | -1.19[26] | -0.66[27] | -1.88[28] |
5 | GRB2 | Growth factor receptor-bound protein 2 | [29] | 0.97[30] | 0.78[31] | 0.68[32] | 0.21[33] | 0.16[34] | 0.12[35] |
6 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [36] | -0.29[37] | 0.09[38] | 1.14[39] | -0.53[40] | 0.37[41] | 0.92[42] |
7 | NRAS | GTPase NRas | [43] | 0.40[44] | 0.81[45] | 1.00[46] | 0.65[47] | 0.26[48] | -0.43[49] |
8 | RRAS | Ras-related protein R-Ras | [50] | -1.72[51] | -2.72[52] | -2.36[53] | -0.63[54] | -0.58[55] | -2.36[56] |
9 | ARAF | Serine/threonine-protein kinase A-Raf | [57] | -0.68[58] | -1.01[59] | -0.96[60] | -0.44[61] | -0.37[62] | 0.70[63] |
10 | HRAS | GTPase HRas | [64] | -1.23[65] | -1.96[66] | -2.98[67] | -1.30[68] | -1.47[69] | -2.84[70] |
11 | MAPK1 | Mitogen-activated protein kinase 1 | [71] | 1.48[72] | 1.60[73] | 1.20[74] | 1.50[75] | 1.19[76] | 1.60[77] |
12 | KRAS | GTPase KRas | [78] | -0.74[79] | -0.79[80] | 0.59[81] | 0.45[82] | 0.15[83] | 0.50[84] |
13 | MAPK14 | Mitogen-activated protein kinase 14 | [85] | 1.25[86] | 1.29[87] | 0.65[88] | 1.34[89] | 0.85[90] | 1.10[91] |
14 | SOS1 | Son of sevenless homolog 1 | [92] | -0.33[93] | 1.18[94] | 0.47[95] | 0.50[96] | -0.23[97] | 0.36[98] |
15 | ELK1 | ETS domain-containing protein Elk-1 | [99] | -0.54[100] | -2.70[101] | -0.50[102] | -0.07[103] | 0.55[104] | -0.35[105] |
16 | MBP | Myelin basic protein | [106] | -1.80[107] | -0.06[108] | -2.28[109] | -1.13[110] | -0.91[111] | 0.73[112] |
17 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [113] | 0.48[114] | 1.08[115] | 0.07[116] | 0.86[117] | 0.30[118] | 0.89[119] |
18 | LAMTOR3 | Ragulator complex protein LAMTOR3 | [120] | 0.76[121] | 1.32[122] | 0.21[123] | 0.13[124] | 0.68[125] | 0.71[126] |
19 | MAPK3 | Mitogen-activated protein kinase 3 | [127] | 1.62[128] | 1.65[129] | 1.46[130] | 0.08[131] | 0.14[132] | -1.22[133] |
20 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [134] | 0.73[135] | 0.86[136] | 1.21[137] | -0.06[138] | 0.53[139] | -0.94[140] |
21 | SOS2 | Son of sevenless homolog 2 | [141] | -0.25[142] | 0.85[143] | -0.14[144] | 1.34[145] | 1.25[146] | 1.66[147] |
22 | SIPA1 | Signal-induced proliferation-associated protein 1 | [148] | 0.97[149] | -0.38[150] | 0.20[151] | 1.11[152] | 1.61[153] | 1.10[154] |
23 | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 | [155] | 1.21[156] | 2.39[157] | 1.90[158] | 2.73[159] | 2.04[160] | 3.64[161] |
24 | MAP2 | Microtubule-associated protein 2 | [162] | -4.72[163] | -7.36[164] | -3.79[165] | 2.68[166] | 2.34[167] | 0.47[168] |
25 | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | [169] | 1.78[170] | 1.24[171] | 1.48[172] | 2.36[173] | 2.05[174] | 0.55[175] |
26 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [176] | 0.06[177] | -3.17[178] | 1.46[179] | 0.66[180] | -3.33[181] | -1.80[182] |
27 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | [183] | 1.39[184] | 1.86[185] | 0.92[186] | 1.73[187] | 2.03[188] | 1.96[189] |
28 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [190] | 2.42[191] | 2.12[192] | 1.62[193] | 1.98[194] | 0.90[195] | 2.62[196] |
29 | BRAF | Serine/threonine-protein kinase B-raf | [197] | 0.02[198] | -0.27[199] | 1.54[200] | 0.39[201] | 0.13[202] | 1.67[203] |
30 | MAPK12 | Mitogen-activated protein kinase 12 | [204] | 2.59[205] | 2.23[206] | 3.12[207] | 1.14[208] | 2.43[209] | -1.08[210] |
31 | RASA3 | Ras GTPase-activating protein 3 | [211] | -0.04[212] | -7.07[213] | -6.55[214] | 3.32[215] | 2.90[216] | 1.42[217] |
32 | MAP3K12 | Mitogen-activated protein kinase kinase kinase 12 | [218] | 1.52[219] | 1.14[220] | 2.54[221] | 4.34[222] | 5.94[223] | 2.65[224] |
33 | MAPK10 | Mitogen-activated protein kinase 10 | [225] | -1.71[226] | [227] | [228] | 8.56[229] | 4.34[230] | 7.07[231] |