WP_MAMMALIAN_DISORDER_OF_SEXUAL_DEVELOPMENT Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CTNNB1 Catenin beta-1 [1] 0.08[2] -0.24[3] 0.07[4] -0.23[5] -0.01[6] 0.02[7]
2 SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1 [8] -3.55[9] -3.26[10] -2.82[11] -2.05[12] -1.59[13] 0.10[14]
3 SOX9 Transcription factor SOX-9 [15] 0.82[16] 1.14[17] 0.41[18] -1.91[19] -2.67[20] -4.22[21]
4 GATA4 Transcription factor GATA-4 [22] -0.75[23] -0.63[24] 0.22[25] -2.20[26] 0.72[27] -0.50[28]
5 RBFOX2 RNA binding protein fox-1 homolog 2 [29] 0.27[30] 0.41[31] 1.07[32] 1.64[33] 1.25[34] 1.09[35]
6 FST Follistatin [36] -1.58[37] 0.26[38] -4.02[39] -5.73[40] -4.47[41] -1.05[42]
7 NR5A1 Steroidogenic factor 1 [43] 2.23[44] 2.26[45] -4.13[46] -7.77[47] -7.85[48] -10.46[49]
8 FGFR2 Fibroblast growth factor receptor 2 [50] -4.05[51] -2.66[52] 0.71[53] 0.48[54] -4.38[55] 2.33[56]
9 CBX2 Chromobox protein homolog 2 [57] 1.80[58] 1.91[59] 2.30[60] 1.73[61] 0.69[62] -1.96[63]
10 PBX1 Pre-B-cell leukemia transcription factor 1 [64] -4.44[65] -6.14[66] 1.72[67] 4.80[68] 4.02[69] 1.08[70]
11 PTGDS Prostaglandin-H2 D-isomerase [71] -1.05[72] -0.68[73] -10.13[74] -1.16[75] -1.06[76] -0.20[77]
12 MAPK11 Mitogen-activated protein kinase 11 [78] -1.71[79] -1.63[80] -3.10[81] -0.63[82] 1.35[83] -0.92[84]
13 WNT4 Protein Wnt-4 [85] -5.23[86] -4.18[87] -5.87[88] -2.34[89] -3.68[90] -0.88[91]
14 AMHR2 Anti-Muellerian hormone type-2 receptor [92] 0.41[93] -0.93[94] -3.23[95] -4.48[96] -3.70[97] 0.89[98]
15 EMX2 Homeobox protein EMX2 [99] [100] -4.27[101] [102] -2.59[103] -5.69[104] -1.59[105]
16 SRY Sex-determining region Y protein [106] -0.28[107] -0.13[108] [109] [110] [111] [112]
17 SOX8 Transcription factor SOX-8 [113] 1.10[114] -0.90[115] -1.58[116] [117] -5.02[118] -0.86[119]
18 AMH Muellerian-inhibiting factor [120] -2.66[121] 2.05[122] 4.23[123] 0.90[124] 4.20[125] 0.42[126]
19 FGF9 Fibroblast growth factor 9 [127] 0.72[128] -2.75[129] [130] 1.80[131] -3.33[132] -0.99[133]
20 DHH Desert hedgehog protein [134] [135] [136] [137] [138] [139] [140]
21 DMRT1 Doublesex- and mab-3-related transcription factor 1 [141] [142] [143] [144] [145] [146] [147]
22 RSPO1 R-spondin-1 [148] [149] [150] [151] [152] [153] [154]
23 MIR4321 [155] [156] [157] [158] [159] [160] [161]
24 WT1 Wilms tumor protein [162] [163] [164] [165] [166] [167] [168]
25 FOXL2 Forkhead box protein L2 [169] [170] [171] [172] [173] [174] [175]
26 INSL3 Insulin-like 3 [176] [177] [178] [179] [180] [181] [182]
[1]
ref_hepatocyte CTNNB1
Mean 37.2
Standard deviation 16
Values 22 31 23 57 53
[2]
HepG2 CTNNB1
Mean 252
Standard deviation 27
Values 2.7e+02 2.3e+02
[3]
HepG2.C3A CTNNB1
Mean 158
Standard deviation 34
Values 1.8e+02 1.3e+02
[4]
HuH.7 CTNNB1
Mean 282
Standard deviation 64
Values 3.1e+02 2.1e+02 3.3e+02
[5]
SNU475 CTNNB1
Mean 115
Standard deviation 10
Values 1.1e+02 1.2e+02
[6]
THLE CTNNB1
Mean 151
Standard deviation 19
Values 1.4e+02 1.6e+02
[7]
liver CTNNB1
Mean 114
Standard deviation 15
Values 1.1e+02 1.3e+02 98 1.2e+02
[8]
ref_hepatocyte SRD5A1
Mean 9.94
Standard deviation 8.7
Values 1.9 24 11 6.1 6.5
[9]
HepG2 SRD5A1
Mean 5.45
Standard deviation 0.84
Values 6 4.9
[10]
HepG2.C3A SRD5A1
Mean 5.22
Standard deviation 0.13
Values 5.1 5.3
[11]
HuH.7 SRD5A1
Mean 10.1
Standard deviation 0.77
Values 11 9.3 10
[12]
SNU475 SRD5A1
Mean 8.73
Standard deviation 0.84
Values 8.1 9.3
[13]
THLE SRD5A1
Mean 13.5
Standard deviation 3.6
Values 16 11
[14]
liver SRD5A1
Mean 32.2
Standard deviation 11
Values 31 26 48 24
[15]
ref_hepatocyte SOX9
Mean 6.44
Standard deviation 14
Values 0.63 0.27 0.17 31 0.028
[16]
HepG2 SOX9
Mean 73.1
Standard deviation 8
Values 67 79
[17]
HepG2.C3A SOX9
Mean 71.7
Standard deviation 24
Values 55 89
[18]
HuH.7 SOX9
Mean 61.6
Standard deviation 13
Values 60 50 75
[19]
SNU475 SOX9
Mean 6.21
Standard deviation 0.59
Values 5.8 6.6
[20]
THLE SOX9
Mean 4.14
Standard deviation 0.56
Values 4.5 3.7
[21]
liver SOX9
Mean 1.05
Standard deviation 0.26
Values 1.4 0.96 0.78 1.1
[22]
ref_hepatocyte GATA4
Mean 3.97
Standard deviation 2.3
Values 2.3 4.3 6 6.3 1
[23]
HepG2 GATA4
Mean 15.1
Standard deviation 1.5
Values 16 14
[24]
HepG2.C3A GATA4
Mean 12.9
Standard deviation 0.72
Values 12 13
[25]
HuH.7 GATA4
Mean 33.3
Standard deviation 6.5
Values 29 41 30
[26]
SNU475 GATA4
Mean 3.13
Standard deviation 0.12
Values 3 3.2
[27]
THLE GATA4
Mean 26.9
Standard deviation 1.1
Values 26 28
[28]
liver GATA4
Mean 8.47
Standard deviation 2.5
Values 6.2 6.8 12 9.2
[29]
ref_hepatocyte RBFOX2
Mean 3.81
Standard deviation 1.1
Values 3.2 3.1 3.2 3.8 5.8
[30]
HepG2 RBFOX2
Mean 29.4
Standard deviation 0.19
Values 30 29
[31]
HepG2.C3A RBFOX2
Mean 25.4
Standard deviation 3.3
Values 23 28
[32]
HuH.7 RBFOX2
Mean 57.8
Standard deviation 13
Values 43 68 62
[33]
SNU475 RBFOX2
Mean 43
Standard deviation 5.5
Values 39 47
[34]
THLE RBFOX2
Mean 37.3
Standard deviation 7.3
Values 32 42
[35]
liver RBFOX2
Mean 24.5
Standard deviation 9.5
Values 31 31 24 11
[36]
ref_hepatocyte FST
Mean 3.43
Standard deviation 3.2
Values 4.6 0.66 8.4 0.64 2.9
[37]
HepG2 FST
Mean 7.39
Standard deviation 1
Values 6.7 8.1
[38]
HepG2.C3A FST
Mean 20.7
Standard deviation 4.4
Values 18 24
[39]
HuH.7 FST
Mean 1.53
Standard deviation 0.3
Values 1.9 1.3 1.4
[40]
SNU475 FST
Mean 0.234
Standard deviation 0.042
Values 0.26 0.2
[41]
THLE FST
Mean 0.634
Standard deviation 0.091
Values 0.7 0.57
[42]
liver FST
Mean 5.01
Standard deviation 4.3
Values 2.1 2.9 11 3.6
[43]
ref_hepatocyte NR5A1
Mean 1.54
Standard deviation 3.4
Values 0 0.024 0 7.7 0
[44]
HepG2 NR5A1
Mean 46.3
Standard deviation 3.3
Values 44 49
[45]
HepG2.C3A NR5A1
Mean 37.1
Standard deviation 14
Values 27 47
[46]
HuH.7 NR5A1
Mean 0.634
Standard deviation 0.33
Values 0.49 1 0.4
[47]
SNU475 NR5A1
Mean 0.0257
Standard deviation 0.029
Values 0.0051 0.046
[48]
THLE NR5A1
Mean 0.0275
Standard deviation 0.014
Values 0.018 0.037
[49]
liver NR5A1
Mean 0.00331
Standard deviation 0.0066
Values 0.013 0 0 0
[50]
ref_hepatocyte FGFR2
Mean 1.34
Standard deviation 1.4
Values 0.084 3.2 2.4 0.47 0.46
[51]
HepG2 FGFR2
Mean 0.519
Standard deviation 0.3
Values 0.73 0.3
[52]
HepG2.C3A FGFR2
Mean 1.07
Standard deviation 0.3
Values 1.3 0.86
[53]
HuH.7 FGFR2
Mean 15.7
Standard deviation 0.71
Values 16 15 16
[54]
SNU475 FGFR2
Mean 6.74
Standard deviation 6.4
Values 2.2 11
[55]
THLE FGFR2
Mean 0.263
Standard deviation 0.0039
Values 0.27 0.26
[56]
liver FGFR2
Mean 20.4
Standard deviation 8
Values 32 19 18 13
[57]
ref_hepatocyte CBX2
Mean 0.789
Standard deviation 1.1
Values 0.91 0.27 0 2.7 0.054
[58]
HepG2 CBX2
Mean 17.6
Standard deviation 3.1
Values 15 20
[59]
HepG2.C3A CBX2
Mean 14.9
Standard deviation 0.24
Values 15 15
[60]
HuH.7 CBX2
Mean 28
Standard deviation 11
Values 31 15 37
[61]
SNU475 CBX2
Mean 9.46
Standard deviation 0.74
Values 8.9 10
[62]
THLE CBX2
Mean 5.2
Standard deviation 0.14
Values 5.1 5.3
[63]
liver CBX2
Mean 0.615
Standard deviation 0.18
Values 0.37 0.61 0.71 0.77
[64]
ref_hepatocyte PBX1
Mean 0.566
Standard deviation 0.5
Values 0.61 0.54 0.34 0 1.3
[65]
HepG2 PBX1
Mean 0.167
Standard deviation 0.042
Values 0.2 0.14
[66]
HepG2.C3A PBX1
Mean 0.0404
Standard deviation 0.012
Values 0.032 0.049
[67]
HuH.7 PBX1
Mean 13.5
Standard deviation 3.6
Values 9.3 16 15
[68]
SNU475 PBX1
Mean 57.2
Standard deviation 7
Values 52 62
[69]
THLE PBX1
Mean 37.8
Standard deviation 14
Values 28 47
[70]
liver PBX1
Mean 3.62
Standard deviation 0.95
Values 3.9 3.4 4.7 2.5
[71]
ref_hepatocyte PTGDS
Mean 0.485
Standard deviation 0.7
Values 0 1.5 0.9 0 0
[72]
HepG2 PTGDS
Mean 1.51
Standard deviation 1.9
Values 0.19 2.8
[73]
HepG2.C3A PTGDS
Mean 1.52
Standard deviation 1
Values 0.78 2.3
[74]
HuH.7 PTGDS
Mean 0.00312
Standard deviation 0.0054
Values 0.0094 0 0
[75]
SNU475 PTGDS
Mean 0.785
Standard deviation 0.16
Values 0.9 0.67
[76]
THLE PTGDS
Mean 0.956
Standard deviation 0.028
Values 0.98 0.94
[77]
liver PTGDS
Mean 1.28
Standard deviation 1.1
Values 0.46 0.23 2.4 2.1
[78]
ref_hepatocyte MAPK11
Mean 0.382
Standard deviation 0.29
Values 0.22 0.64 0.71 0 0.34
[79]
HepG2 MAPK11
Mean 0.749
Standard deviation 0.18
Values 0.88 0.62
[80]
HepG2.C3A MAPK11
Mean 0.621
Standard deviation 0.12
Values 0.71 0.53
[81]
HuH.7 MAPK11
Mean 0.322
Standard deviation 0.15
Values 0.49 0.2 0.28
[82]
SNU475 MAPK11
Mean 0.898
Standard deviation 0.33
Values 0.66 1.1
[83]
THLE MAPK11
Mean 4.01
Standard deviation 0.7
Values 4.5 3.5
[84]
liver MAPK11
Mean 0.609
Standard deviation 0.32
Values 0.75 0.49 0.96 0.23
[85]
ref_hepatocyte WNT4
Mean 0.276
Standard deviation 0.47
Values 0.3 0 1.1 0 0
[86]
HepG2 WNT4
Mean 0.0472
Standard deviation 0.0061
Values 0.043 0.052
[87]
HepG2.C3A WNT4
Mean 0.0764
Standard deviation 0.0019
Values 0.075 0.078
[88]
HuH.7 WNT4
Mean 0.034
Standard deviation 0.022
Values 0.056 0.013 0.033
[89]
SNU475 WNT4
Mean 0.197
Standard deviation 0.1
Values 0.27 0.13
[90]
THLE WNT4
Mean 0.0881
Standard deviation 0.034
Values 0.11 0.064
[91]
liver WNT4
Mean 0.454
Standard deviation 0.67
Values 1.4 0.3 0.024 0.051
[92]
ref_hepatocyte AMHR2
Mean 0.0598
Standard deviation 0.13
Values 0 0 0 0.3 0
[93]
HepG2 AMHR2
Mean 0.51
Standard deviation 0.097
Values 0.58 0.44
[94]
HepG2.C3A AMHR2
Mean 0.158
Standard deviation 0.011
Values 0.15 0.17
[95]
HuH.7 AMHR2
Mean 0.0459
Standard deviation 0.072
Values 0.0094 0.13 0
[96]
SNU475 AMHR2
Mean 0.00971
Standard deviation 0.00061
Values 0.01 0.0093
[97]
THLE AMHR2
Mean 0.0189
Standard deviation 0.018
Values 0.0059 0.032
[98]
liver AMHR2
Mean 0.335
Standard deviation 0.26
Values 0.16 0.086 0.66 0.44
[99]
ref_hepatocyte EMX2
Mean 0.0372
Standard deviation 0.051
Values 0.095 0 0 0 0.091
[100]
HepG2 EMX2
Mean 0
Standard deviation 0
Values 0 0
[101]
HepG2.C3A EMX2
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[102]
HuH.7 EMX2
Mean 0
Standard deviation 0
Values 0 0 0
[103]
SNU475 EMX2
Mean 0.0224
Standard deviation 0.019
Values 0.035 0.0093
[104]
THLE EMX2
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[105]
liver EMX2
Mean 0.0372
Standard deviation 0.05
Values 0.11 0.043 0 0
[106]
ref_hepatocyte SRY
Mean 0.0268
Standard deviation 0.06
Values 0 0 0 0.13 0
[107]
HepG2 SRY
Mean 0.142
Standard deviation 0.13
Values 0.23 0.052
[108]
HepG2.C3A SRY
Mean 0.124
Standard deviation 0.037
Values 0.15 0.097
[109]
HuH.7 SRY
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 SRY
Mean 0
Standard deviation 0
Values 0 0
[111]
THLE SRY
Mean 0
Standard deviation 0
Values 0 0
[112]
liver SRY
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte SOX8
Mean 0.0234
Standard deviation 0.052
Values 0.12 0 0 0 0
[114]
HepG2 SOX8
Mean 0.321
Standard deviation 0.19
Values 0.19 0.45
[115]
HepG2.C3A SOX8
Mean 0.0632
Standard deviation 0.089
Values 0 0.13
[116]
HuH.7 SOX8
Mean 0.0561
Standard deviation 0.029
Values 0.037 0.09 0.041
[117]
SNU475 SOX8
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE SOX8
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[119]
liver SOX8
Mean 0.039
Standard deviation 0.036
Values 0.093 0.014 0.024 0.026
[120]
ref_hepatocyte AMH
Mean 0.0163
Standard deviation 0.036
Values 0 0.081 0 0 0
[121]
HepG2 AMH
Mean 0.0165
Standard deviation 0.0071
Values 0.021 0.011
[122]
HepG2.C3A AMH
Mean 0.338
Standard deviation 0.099
Values 0.27 0.41
[123]
HuH.7 AMH
Mean 2.21
Standard deviation 0.66
Values 2.7 2.4 1.5
[124]
SNU475 AMH
Mean 0.11
Standard deviation 0.038
Values 0.14 0.083
[125]
THLE AMH
Mean 1.23
Standard deviation 0.41
Values 1.5 0.94
[126]
liver AMH
Mean 0.0658
Standard deviation 0.08
Values 0.19 0.029 0.024 0.026
[127]
ref_hepatocyte FGF9
Mean 0.0065
Standard deviation 0.015
Values 0 0.033 0 0 0
[128]
HepG2 FGF9
Mean 0.0687
Standard deviation 9.1e-05
Values 0.069 0.069
[129]
HepG2.C3A FGF9
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[130]
HuH.7 FGF9
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 FGF9
Mean 0.0822
Standard deviation 0.08
Values 0.025 0.14
[132]
THLE FGF9
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[133]
liver FGF9
Mean 0.00993
Standard deviation 0.02
Values 0.04 0 0 0
[134]
ref_hepatocyte DHH
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 DHH
Mean 0.00716
Standard deviation 0.002
Values 0.0086 0.0057
[136]
HepG2.C3A DHH
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[137]
HuH.7 DHH
Mean 0.00214
Standard deviation 0.0037
Values 0 0.0064 0
[138]
SNU475 DHH
Mean 0.00696
Standard deviation 0.0098
Values 0 0.014
[139]
THLE DHH
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[140]
liver DHH
Mean 0.03
Standard deviation 0.051
Values 0.11 0.014 0 0
[141]
ref_hepatocyte DMRT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[142]
HepG2 DMRT1
Mean 0.00501
Standard deviation 0.001
Values 0.0043 0.0057
[143]
HepG2.C3A DMRT1
Mean 0
Standard deviation 0
Values 0 0
[144]
HuH.7 DMRT1
Mean 0
Standard deviation 0
Values 0 0 0
[145]
SNU475 DMRT1
Mean 0
Standard deviation 0
Values 0 0
[146]
THLE DMRT1
Mean 0.00828
Standard deviation 0.0033
Values 0.0059 0.011
[147]
liver DMRT1
Mean 0.00662
Standard deviation 0.013
Values 0.026 0 0 0
[148]
ref_hepatocyte RSPO1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[149]
HepG2 RSPO1
Mean 0.00287
Standard deviation 0.0041
Values 0 0.0057
[150]
HepG2.C3A RSPO1
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 RSPO1
Mean 0
Standard deviation 0
Values 0 0 0
[152]
SNU475 RSPO1
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[153]
THLE RSPO1
Mean 0.0461
Standard deviation 0.035
Values 0.071 0.021
[154]
liver RSPO1
Mean 0.0135
Standard deviation 0.019
Values 0.04 0.014 0 0
[155]
ref_hepatocyte MIR4321
Missing
[156]
HepG2 MIR4321
Mean 0
Standard deviation 0
Values 0 0
[157]
HepG2.C3A MIR4321
Mean 0
Standard deviation 0
Values 0 0
[158]
HuH.7 MIR4321
Mean 0.0201
Standard deviation 0.017
Values 0.028 0.032 0
[159]
SNU475 MIR4321
Mean 0
Standard deviation 0
Values 0 0
[160]
THLE MIR4321
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[161]
liver MIR4321
Mean 0
Standard deviation 0
Values 0 0 0 0
[162]
ref_hepatocyte WT1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[163]
HepG2 WT1
Mean 0.593
Standard deviation 0.28
Values 0.39 0.79
[164]
HepG2.C3A WT1
Mean 3.91
Standard deviation 0.87
Values 4.5 3.3
[165]
HuH.7 WT1
Mean 0.00273
Standard deviation 0.0047
Values 0 0 0.0082
[166]
SNU475 WT1
Mean 0.247
Standard deviation 0.23
Values 0.41 0.083
[167]
THLE WT1
Mean 3.5
Standard deviation 1
Values 2.8 4.2
[168]
liver WT1
Mean 0.0592
Standard deviation 0.062
Values 0 0.014 0.094 0.13
[169]
ref_hepatocyte FOXL2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[170]
HepG2 FOXL2
Mean 0.0558
Standard deviation 0.055
Values 0.094 0.017
[171]
HepG2.C3A FOXL2
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[172]
HuH.7 FOXL2
Mean 0.136
Standard deviation 0.033
Values 0.15 0.16 0.098
[173]
SNU475 FOXL2
Mean 2.71
Standard deviation 0.15
Values 2.8 2.6
[174]
THLE FOXL2
Mean 1.6
Standard deviation 0.29
Values 1.4 1.8
[175]
liver FOXL2
Mean 0
Standard deviation 0
Values 0 0 0 0
[176]
ref_hepatocyte INSL3
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[177]
HepG2 INSL3
Mean 0.0193
Standard deviation 0.021
Values 0.0043 0.034
[178]
HepG2.C3A INSL3
Mean 0.0696
Standard deviation 0.053
Values 0.032 0.11
[179]
HuH.7 INSL3
Mean 0
Standard deviation 0
Values 0 0 0
[180]
SNU475 INSL3
Mean 0
Standard deviation 0
Values 0 0
[181]
THLE INSL3
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[182]
liver INSL3
Mean 0.0242
Standard deviation 0.033
Values 0.026 0 0.071 0