WP_LIVER_X_RECEPTOR_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CYP3A4 Cytochrome P450 3A4 [1] -10.50[2] -11.94[3] -14.36[4] -13.60[5] -11.79[6] -0.32[7]
2 SCD Acyl-CoA desaturase [8] 0.62[9] 1.13[10] 1.20[11] -0.07[12] -0.71[13] -0.56[14]
3 CYP2B6 Cytochrome P450 2B6 [15] -8.40[16] -6.29[17] -5.61[18] -8.16[19] -8.89[20] 1.35[21]
4 SREBF1 Sterol regulatory element-binding protein 1 [22] 0.47[23] -0.56[24] -0.71[25] 1.37[26] 1.83[27] -0.56[28]
5 FASN Fatty acid synthase [29] 3.64[30] 2.97[31] 2.83[32] 3.64[33] 3.95[34] 1.45[35]
6 NR1H3 Oxysterols receptor LXR-alpha [36] -0.43[37] -0.72[38] -0.49[39] 0.18[40] -0.89[41] -1.36[42]
7 RXRA Retinoic acid receptor RXR-alpha [43] 1.19[44] -0.33[45] -0.18[46] 2.93[47] 2.87[48] 1.09[49]
8 ABCG8 ATP-binding cassette sub-family G member 8 [50] -0.74[51] -1.10[52] -7.35[53] -9.77[54] -8.38[55] 0.73[56]
9 ABCG5 ATP-binding cassette sub-family G member 5 [57] -0.74[58] 0.10[59] -7.71[60] -9.36[61] -7.06[62] 0.77[63]
10 CYP7A1 Cholesterol 7-alpha-monooxygenase [64] -3.10[65] -6.75[66] -10.98[67] -7.05[68] [69] -4.01[70]
[1]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[2]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[3]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[4]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[5]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[6]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[7]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[8]
ref_hepatocyte SCD
Mean 184
Standard deviation 1.7e+02
Values 35 3.1e+02 1.3e+02 4.1e+02 33
[9]
HepG2 SCD
Mean 263
Standard deviation 44
Values 2.9e+02 2.3e+02
[10]
HepG2.C3A SCD
Mean 832
Standard deviation 2.9e+02
Values 6.3e+02 1e+03
[11]
HuH.7 SCD
Mean 1.37e+03
Standard deviation 3.6e+02
Values 1e+03 1.7e+03 1.4e+03
[12]
SNU475 SCD
Mean 42.8
Standard deviation 2.4
Values 41 45
[13]
THLE SCD
Mean 25.4
Standard deviation 2.3
Values 24 27
[14]
liver SCD
Mean 369
Standard deviation 2.8e+02
Values 1.4e+02 5.6e+02 1.1e+02 6.7e+02
[15]
ref_hepatocyte CYP2B6
Mean 49.6
Standard deviation 62
Values 12 1e+02 1.3e+02 0 4.1
[16]
HepG2 CYP2B6
Mean 0.138
Standard deviation 0.15
Values 0.034 0.24
[17]
HepG2.C3A CYP2B6
Mean 1.32
Standard deviation 0.56
Values 0.92 1.7
[18]
HuH.7 CYP2B6
Mean 3.27
Standard deviation 2.3
Values 1.9 5.9 2.1
[19]
SNU475 CYP2B6
Mean 0.0424
Standard deviation 0.04
Values 0.071 0.014
[20]
THLE CYP2B6
Mean 0.0237
Standard deviation 0.033
Values 0.047 0
[21]
liver CYP2B6
Mean 372
Standard deviation 5.3e+02
Values 7.4 3.2e+02 23 1.1e+03
[22]
ref_hepatocyte SREBF1
Mean 27.4
Standard deviation 36
Values 6.5 85 42 1.8 1.2
[23]
HepG2 SREBF1
Mean 35.4
Standard deviation 8.8
Values 29 42
[24]
HepG2.C3A SREBF1
Mean 38.3
Standard deviation 21
Values 24 53
[25]
HuH.7 SREBF1
Mean 53.8
Standard deviation 3.4
Values 56 55 50
[26]
SNU475 SREBF1
Mean 17.3
Standard deviation 4.1
Values 14 20
[27]
THLE SREBF1
Mean 21.9
Standard deviation 0.74
Values 21 22
[28]
liver SREBF1
Mean 54.7
Standard deviation 14
Values 35 59 58 67
[29]
ref_hepatocyte FASN
Mean 16.9
Standard deviation 11
Values 11 22 17 31 3.5
[30]
HepG2 FASN
Mean 197
Standard deviation 11
Values 2e+02 1.9e+02
[31]
HepG2.C3A FASN
Mean 273
Standard deviation 1.4e+02
Values 1.7e+02 3.7e+02
[32]
HuH.7 FASN
Mean 387
Standard deviation 1.1e+02
Values 2.9e+02 3.8e+02 5e+02
[33]
SNU475 FASN
Mean 51.5
Standard deviation 12
Values 43 60
[34]
THLE FASN
Mean 59
Standard deviation 19
Values 46 72
[35]
liver FASN
Mean 136
Standard deviation 1e+02
Values 2.8e+02 1.2e+02 92 54
[36]
ref_hepatocyte NR1H3
Mean 14.8
Standard deviation 10
Values 6.4 29 22 6.4 9.6
[37]
HepG2 NR1H3
Mean 10.3
Standard deviation 0.1
Values 10 10
[38]
HepG2.C3A NR1H3
Mean 18.6
Standard deviation 4.7
Values 15 22
[39]
HuH.7 NR1H3
Mean 33.8
Standard deviation 2.7
Values 35 36 31
[40]
SNU475 NR1H3
Mean 4.08
Standard deviation 1.1
Values 4.8 3.3
[41]
THLE NR1H3
Mean 1.8
Standard deviation 0.21
Values 1.7 1.9
[42]
liver NR1H3
Mean 16.9
Standard deviation 7.5
Values 9.7 12 25 21
[43]
ref_hepatocyte RXRA
Mean 14.5
Standard deviation 6.1
Values 9.4 18 22 15 7.5
[44]
HepG2 RXRA
Mean 30.9
Standard deviation 2.8
Values 29 33
[45]
HepG2.C3A RXRA
Mean 23.9
Standard deviation 6.1
Values 20 28
[46]
HuH.7 RXRA
Mean 41.2
Standard deviation 10
Values 30 51 42
[47]
SNU475 RXRA
Mean 26.9
Standard deviation 8.3
Values 21 33
[48]
THLE RXRA
Mean 23.9
Standard deviation 7.5
Values 19 29
[49]
liver RXRA
Mean 91.4
Standard deviation 37
Values 1.2e+02 72 1.3e+02 49
[50]
ref_hepatocyte ABCG8
Mean 8.3
Standard deviation 8.1
Values 1.2 17 17 5.6 0.83
[51]
HepG2 ABCG8
Mean 4.64
Standard deviation 1.2
Values 5.5 3.8
[52]
HepG2.C3A ABCG8
Mean 8.02
Standard deviation 1.9
Values 6.7 9.4
[53]
HuH.7 ABCG8
Mean 0.164
Standard deviation 0.19
Values 0.056 0.38 0.057
[54]
SNU475 ABCG8
Mean 0.00232
Standard deviation 0.0033
Values 0 0.0046
[55]
THLE ABCG8
Mean 0.00562
Standard deviation 0.00042
Values 0.0059 0.0053
[56]
liver ABCG8
Mean 40.7
Standard deviation 8.7
Values 51 40 30 42
[57]
ref_hepatocyte ABCG5
Mean 6.81
Standard deviation 7.7
Values 0.43 18 12 3.9 0.22
[58]
HepG2 ABCG5
Mean 3.81
Standard deviation 0.63
Values 4.3 3.4
[59]
HepG2.C3A ABCG5
Mean 15.1
Standard deviation 4
Values 12 18
[60]
HuH.7 ABCG5
Mean 0.105
Standard deviation 0.098
Values 0.056 0.22 0.041
[61]
SNU475 ABCG5
Mean 0.00253
Standard deviation 0.0036
Values 0.0051 0
[62]
THLE ABCG5
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[63]
liver ABCG5
Mean 34.4
Standard deviation 19
Values 24 18 61 34
[64]
ref_hepatocyte CYP7A1
Mean 4.03
Standard deviation 5.2
Values 0 9.7 0.69 9.8 0
[65]
HepG2 CYP7A1
Mean 0.438
Standard deviation 0.47
Values 0.77 0.11
[66]
HepG2.C3A CYP7A1
Mean 0.0774
Standard deviation 0.027
Values 0.097 0.058
[67]
HuH.7 CYP7A1
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[68]
SNU475 CYP7A1
Mean 0.00739
Standard deviation 0.0039
Values 0.01 0.0046
[69]
THLE CYP7A1
Mean 0
Standard deviation 0
Values 0 0
[70]
liver CYP7A1
Mean 0.737
Standard deviation 0.45
Values 0.079 0.94 1.1 0.82