WP_LEPTININSULIN_SIGNALING_OVERLAP Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -0.29[2] -0.35[3] -1.59[4] -0.14[5] -0.13[6] -2.38[7]
2 STAT3 Signal transducer and activator of transcription 3 [8] 0.18[9] -1.14[10] -0.57[11] 0.16[12] -0.59[13] 0.27[14]
3 SOCS3 Suppressor of cytokine signaling 3 [15] -4.52[16] -4.75[17] -3.19[18] -0.89[19] -1.98[20] -2.00[21]
4 LEPR Leptin receptor [22] -4.96[23] -2.12[24] 0.39[25] -1.39[26] -1.35[27] 2.10[28]
5 INSR Insulin receptor [29] 0.08[30] 0.91[31] 2.18[32] -3.17[33] -0.58[34] 1.87[35]
6 SOCS2 Suppressor of cytokine signaling 2 [36] -1.18[37] -3.54[38] -5.46[39] 0.57[40] -5.17[41] -0.48[42]
7 PDPK1 3-phosphoinositide-dependent protein kinase 1 [43] 1.96[44] 3.33[45] 1.87[46] 1.35[47] 1.73[48] 0.37[49]
8 DGKZ Diacylglycerol kinase zeta [50] 1.69[51] 1.13[52] 0.90[53] -0.36[54] 0.92[55] -1.73[56]
9 IRS1 Insulin receptor substrate 1 [57] 1.71[58] 1.34[59] 2.60[60] 1.62[61] 1.18[62] -0.02[63]
10 IRS2 Insulin receptor substrate 2 [64] -6.03[65] [66] -3.15[67] -0.75[68] 3.06[69] 0.25[70]
11 SOCS1 Suppressor of cytokine signaling 1 [71] -1.83[72] -0.78[73] -0.67[74] -1.88[75] -3.28[76] -3.60[77]
12 JAK2 Tyrosine-protein kinase JAK2 [78] -0.15[79] 0.03[80] -0.58[81] 0.68[82] 1.25[83] 0.57[84]
13 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma [85] 1.35[86] 1.54[87] 2.22[88] 3.08[89] 2.08[90] 0.54[91]
14 PIK3CG Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [92] [93] [94] 1.25[95] -3.65[96] 1.97[97]
15 LEP Leptin [98] -1.70[99] -0.54[100] -1.25[101] -0.94[102] -2.28[103] 0.17[104]
16 IRS4 Insulin receptor substrate 4 [105] [106] [107] [108] -1.64[109] -2.76[110] [111]
17 INS Insulin [112] [113] [114] [115] [116] [117] [118]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[8]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 18 36 46 26 25
[9]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 1e+02 90
[10]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 27 34
[11]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 35 65 47
[12]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 57 74
[13]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[14]
liver STAT3
Mean 227
Standard deviation 42
Values 2e+02 2.3e+02 1.9e+02 2.8e+02
[15]
ref_hepatocyte SOCS3
Mean 11.2
Standard deviation 10
Values 19 10 24 1 1.5
[16]
HepG2 SOCS3
Mean 1.4
Standard deviation 0.4
Values 1.1 1.7
[17]
HepG2.C3A SOCS3
Mean 0.939
Standard deviation 0.87
Values 0.32 1.6
[18]
HuH.7 SOCS3
Mean 2.97
Standard deviation 2.7
Values 1.4 6.1 1.4
[19]
SNU475 SOCS3
Mean 11.8
Standard deviation 0.67
Values 11 12
[20]
THLE SOCS3
Mean 6.29
Standard deviation 1.1
Values 7.1 5.5
[21]
liver SOCS3
Mean 17.4
Standard deviation 5.5
Values 26 14 15 15
[22]
ref_hepatocyte LEPR
Mean 6.17
Standard deviation 5.3
Values 2.2 11 12 0.18 5.1
[23]
HepG2 LEPR
Mean 0.566
Standard deviation 0.13
Values 0.66 0.48
[24]
HepG2.C3A LEPR
Mean 3.19
Standard deviation 0.049
Values 3.2 3.2
[25]
HuH.7 LEPR
Mean 19.5
Standard deviation 12
Values 11 33 14
[26]
SNU475 LEPR
Mean 4.59
Standard deviation 0.66
Values 4.1 5.1
[27]
THLE LEPR
Mean 5.37
Standard deviation 0.72
Values 4.9 5.9
[28]
liver LEPR
Mean 165
Standard deviation 89
Values 96 2.7e+02 86 2.1e+02
[29]
ref_hepatocyte INSR
Mean 5.73
Standard deviation 1.4
Values 4.1 7.7 5.3 6.5 5
[30]
HepG2 INSR
Mean 17.4
Standard deviation 4.9
Values 14 21
[31]
HepG2.C3A INSR
Mean 24.3
Standard deviation 6.7
Values 20 29
[32]
HuH.7 INSR
Mean 62.9
Standard deviation 26
Values 39 91 58
[33]
SNU475 INSR
Mean 1.24
Standard deviation 0.29
Values 1 1.4
[34]
THLE INSR
Mean 8.45
Standard deviation 0.32
Values 8.2 8.7
[35]
liver INSR
Mean 131
Standard deviation 15
Values 1.3e+02 1.5e+02 1.4e+02 1.1e+02
[36]
ref_hepatocyte SOCS2
Mean 3.66
Standard deviation 2
Values 2.3 1.5 4.2 3.6 6.7
[37]
HepG2 SOCS2
Mean 4.62
Standard deviation 2.2
Values 6.2 3.1
[38]
HepG2.C3A SOCS2
Mean 0.708
Standard deviation 0.27
Values 0.9 0.52
[39]
HuH.7 SOCS2
Mean 0.201
Standard deviation 0.17
Values 0.066 0.4 0.14
[40]
SNU475 SOCS2
Mean 10.6
Standard deviation 6.9
Values 5.7 15
[41]
THLE SOCS2
Mean 0.224
Standard deviation 0.00099
Values 0.22 0.22
[42]
liver SOCS2
Mean 16.3
Standard deviation 15
Values 19 4.4 36 5.7
[43]
ref_hepatocyte PDPK1
Mean 3.54
Standard deviation 2
Values 3.6 2 1.8 6.9 3.4
[44]
HepG2 PDPK1
Mean 39.4
Standard deviation 5.6
Values 43 35
[45]
HepG2.C3A PDPK1
Mean 80.1
Standard deviation 13
Values 71 89
[46]
HuH.7 PDPK1
Mean 31.4
Standard deviation 4.5
Values 26 33 35
[47]
SNU475 PDPK1
Mean 17.6
Standard deviation 0.21
Values 18 17
[48]
THLE PDPK1
Mean 25.9
Standard deviation 4.6
Values 23 29
[49]
liver PDPK1
Mean 28.5
Standard deviation 5.1
Values 31 27 34 22
[50]
ref_hepatocyte DGKZ
Mean 3.31
Standard deviation 1.9
Values 6.1 2.4 3 0.95 4.1
[51]
HepG2 DGKZ
Mean 30.7
Standard deviation 1.8
Values 29 32
[52]
HepG2.C3A DGKZ
Mean 16.3
Standard deviation 1.5
Values 15 17
[53]
HuH.7 DGKZ
Mean 15
Standard deviation 4
Values 16 10 18
[54]
SNU475 DGKZ
Mean 5.03
Standard deviation 0.13
Values 4.9 5.1
[55]
THLE DGKZ
Mean 13.9
Standard deviation 3
Values 12 16
[56]
liver DGKZ
Mean 6.23
Standard deviation 1.3
Values 7.7 6.9 4.8 5.5
[57]
ref_hepatocyte IRS1
Mean 3.05
Standard deviation 1.4
Values 2.7 4.7 2.1 4.3 1.5
[58]
HepG2 IRS1
Mean 28.7
Standard deviation 8.6
Values 23 35
[59]
HepG2.C3A IRS1
Mean 17.4
Standard deviation 6
Values 13 22
[60]
HuH.7 IRS1
Mean 44.8
Standard deviation 6.6
Values 37 48 49
[61]
SNU475 IRS1
Mean 18.3
Standard deviation 5.2
Values 22 15
[62]
THLE IRS1
Mean 15.3
Standard deviation 0.24
Values 15 15
[63]
liver IRS1
Mean 18.8
Standard deviation 4.8
Values 22 18 23 12
[64]
ref_hepatocyte IRS2
Mean 2.12
Standard deviation 2.3
Values 1.4 2.9 5.7 0.019 0.61
[65]
HepG2 IRS2
Mean 0.0931
Standard deviation 0.071
Values 0.043 0.14
[66]
HepG2.C3A IRS2
Mean 0
Standard deviation 0
Values 0 0
[67]
HuH.7 IRS2
Mean 0.575
Standard deviation 0.68
Values 0.17 1.4 0.2
[68]
SNU475 IRS2
Mean 2.45
Standard deviation 0.45
Values 2.8 2.1
[69]
THLE IRS2
Mean 39
Standard deviation 5.9
Values 35 43
[70]
liver IRS2
Mean 15.7
Standard deviation 9.9
Values 17 11 29 6.3
[71]
ref_hepatocyte SOCS1
Mean 2.1
Standard deviation 1.9
Values 1.3 3.4 4.7 1.1 0
[72]
HepG2 SOCS1
Mean 1.7
Standard deviation 0.19
Values 1.6 1.8
[73]
HepG2.C3A SOCS1
Mean 2.76
Standard deviation 1.3
Values 1.9 3.7
[74]
HuH.7 SOCS1
Mean 3.19
Standard deviation 2.1
Values 5.3 1 3.3
[75]
SNU475 SOCS1
Mean 1.11
Standard deviation 0.23
Values 0.95 1.3
[76]
THLE SOCS1
Mean 0.479
Standard deviation 0.076
Values 0.53 0.43
[77]
liver SOCS1
Mean 1.08
Standard deviation 0.8
Values 2.2 0.27 1.1 0.8
[78]
ref_hepatocyte JAK2
Mean 0.762
Standard deviation 0.48
Values 0.62 0.5 0.18 1.3 1.3
[79]
HepG2 JAK2
Mean 1.97
Standard deviation 1.3
Values 2.9 1
[80]
HepG2.C3A JAK2
Mean 1.75
Standard deviation 0.67
Values 2.2 1.3
[81]
HuH.7 JAK2
Mean 1.23
Standard deviation 0.34
Values 0.9 1.6 1.2
[82]
SNU475 JAK2
Mean 2.37
Standard deviation 0.1
Values 2.4 2.3
[83]
THLE JAK2
Mean 4.02
Standard deviation 0.77
Values 4.6 3.5
[84]
liver JAK2
Mean 7.06
Standard deviation 3.8
Values 9.8 11 4.7 2.9
[85]
ref_hepatocyte PIK3R3
Mean 0.405
Standard deviation 0.3
Values 0.47 0.15 0.078 0.52 0.81
[86]
HepG2 PIK3R3
Mean 2.95
Standard deviation 2.5
Values 4.7 1.2
[87]
HepG2.C3A PIK3R3
Mean 2.65
Standard deviation 1.6
Values 3.8 1.5
[88]
HuH.7 PIK3R3
Mean 4.56
Standard deviation 1.3
Values 5 3.1 5.7
[89]
SNU475 PIK3R3
Mean 6.68
Standard deviation 0.22
Values 6.8 6.5
[90]
THLE PIK3R3
Mean 3.8
Standard deviation 0.9
Values 3.2 4.4
[91]
liver PIK3R3
Mean 3.68
Standard deviation 0.27
Values 4 3.8 3.7 3.3
[92]
ref_hepatocyte PIK3CG
Mean 0.0637
Standard deviation 0.13
Values 0 0.29 0.026 0 0
[93]
HepG2 PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[94]
HepG2.C3A PIK3CG
Mean 0
Standard deviation 0
Values 0 0
[95]
HuH.7 PIK3CG
Mean 0
Standard deviation 0
Values 0 0 0
[96]
SNU475 PIK3CG
Mean 0.296
Standard deviation 0.1
Values 0.37 0.22
[97]
THLE PIK3CG
Mean 0.0112
Standard deviation 0.00084
Values 0.012 0.011
[98]
liver PIK3CG
Mean 1.55
Standard deviation 0.43
Values 1.6 1.9 0.94 1.7
[99]
ref_hepatocyte LEP
Mean 0.0195
Standard deviation 0.035
Values 0.016 0.081 0 0 0
[100]
HepG2 LEP
Mean 0.0172
Standard deviation 2.3e-05
Values 0.017 0.017
[101]
HepG2.C3A LEP
Mean 0.0302
Standard deviation 0.012
Values 0.021 0.039
[102]
HuH.7 LEP
Mean 0.0199
Standard deviation 0.0091
Values 0.0094 0.026 0.025
[103]
SNU475 LEP
Mean 0.0198
Standard deviation 0.015
Values 0.03 0.0093
[104]
THLE LEP
Mean 0.00887
Standard deviation 0.013
Values 0.018 0
[105]
liver LEP
Mean 0.137
Standard deviation 0.14
Values 0.25 0.27 0 0.026
[106]
ref_hepatocyte IRS4
Mean 0.00813
Standard deviation 0.018
Values 0 0.041 0 0 0
[107]
HepG2 IRS4
Mean 0
Standard deviation 0
Values 0 0
[108]
HepG2.C3A IRS4
Mean 0
Standard deviation 0
Values 0 0
[109]
HuH.7 IRS4
Mean 0
Standard deviation 0
Values 0 0 0
[110]
SNU475 IRS4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[111]
THLE IRS4
Mean 0.00266
Standard deviation 0.0038
Values 0 0.0053
[112]
liver IRS4
Mean 0
Standard deviation 0
Values 0 0 0 0
[113]
ref_hepatocyte INS
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[114]
HepG2 INS
Mean 0.00287
Standard deviation 0.0041
Values 0 0.0057
[115]
HepG2.C3A INS
Mean 0
Standard deviation 0
Values 0 0
[116]
HuH.7 INS
Mean 0
Standard deviation 0
Values 0 0 0
[117]
SNU475 INS
Mean 0
Standard deviation 0
Values 0 0
[118]
THLE INS
Mean 0
Standard deviation 0
Values 0 0
[119]
liver INS
Mean 0.0838
Standard deviation 0.13
Values 0.28 0.057 0 0