WP_KYNURENINE_PATHWAY_AND_LINKS_TO_CELL_SENESCENCE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 TDO2 Tryptophan 2,3-dioxygenase [1] -13.99[2] -12.05[3] -8.06[4] -5.84[5] -8.98[6] 0.87[7]
2 KYNU Kynureninase [8] -2.14[9] -1.57[10] -4.09[11] -2.29[12] -3.76[13] -2.80[14]
3 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] [15] 1.18[16] 1.24[17] 1.38[18] 0.69[19] -1.68[20] -0.70[21]
4 HAAO 3-hydroxyanthranilate 3,4-dioxygenase [22] -2.78[23] -1.73[24] -3.35[25] -9.08[26] -11.73[27] -0.92[28]
5 CDKN1A Cyclin-dependent kinase inhibitor 1 [29] 1.56[30] 0.16[31] -2.16[32] 0.06[33] 1.95[34] -2.07[35]
6 ACMSD 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase [36] -13.21[37] -10.44[38] -3.24[39] -10.08[40] -10.30[41] -0.85[42]
7 AFMID Kynurenine formamidase [43] 0.07[44] 1.30[45] -0.01[46] -2.09[47] -2.22[48] 0.23[49]
8 EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 [50] 2.08[51] 2.30[52] 2.65[53] 2.46[54] 1.92[55] 0.47[56]
9 AADAT Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [57] -1.15[58] -0.94[59] -2.29[60] -0.97[61] -1.23[62] -0.01[63]
10 EIF2AK4 eIF-2-alpha kinase GCN2 [64] 2.39[65] 2.74[66] 0.91[67] 3.89[68] 2.98[69] 1.09[70]
11 TP53 Cellular tumor antigen p53 [71] 2.36[72] 1.91[73] 3.04[74] 3.34[75] 2.34[76] -0.28[77]
12 IL1R2 Interleukin-1 receptor type 2 [78] -1.71[79] -1.77[80] -5.36[81] -3.54[82] -2.11[83] -1.07[84]
13 AHR Aryl hydrocarbon receptor [85] 1.84[86] 2.13[87] 3.52[88] 2.59[89] 2.84[90] 2.36[91]
14 KMO Kynurenine 3-monooxygenase [92] -8.21[93] -6.59[94] -3.93[95] -1.36[96] -6.99[97] 1.42[98]
15 FOXO1 Forkhead box protein O1 [99] 2.41[100] 2.07[101] 2.58[102] 3.22[103] 4.57[104] 2.85[105]
16 KLF5 Krueppel-like factor 5 [106] 2.34[107] -0.29[108] 4.94[109] 3.09[110] 2.87[111] -3.34[112]
17 TLR4 Toll-like receptor 4 [113] 0.99[114] -4.17[115] -4.69[116] -3.05[117] 6.70[118] 4.23[119]
18 IDO1 Indoleamine 2,3-dioxygenase 1 [120] -0.65[121] 0.14[122] -0.41[123] 3.78[124] -0.26[125] 0.13[126]
19 IDO2 Indoleamine 2,3-dioxygenase 2 [127] [128] [129] [130] -5.14[131] [132] -0.33[133]
20 IFNG Interferon gamma [134] [135] [136] [137] 1.36[138] [139] -2.53[140]
21 TNF Tumor necrosis factor [141] 1.82[142] -0.33[143] -4.55[144] -0.17[145] -4.06[146] -2.13[147]
22 NOS1 Nitric oxide synthase, brain [148] -0.83[149] 1.12[150] -0.08[151] 1.38[152] 0.60[153] 0.45[154]
23 IFNB1 Interferon beta [155] [156] [157] [158] [159] [160] [161]
[1]
ref_hepatocyte TDO2
Mean 130
Standard deviation 1.9e+02
Values 5.3 4.3e+02 2e+02 0 18
[2]
HepG2 TDO2
Mean 0.0107
Standard deviation 0.0091
Values 0.0043 0.017
[3]
HepG2.C3A TDO2
Mean 0.037
Standard deviation 0.039
Values 0.064 0.0097
[4]
HuH.7 TDO2
Mean 0.435
Standard deviation 0.39
Values 0.26 0.89 0.16
[5]
SNU475 TDO2
Mean 1.01
Standard deviation 0.68
Values 1.5 0.53
[6]
THLE TDO2
Mean 0.203
Standard deviation 0.19
Values 0.34 0.069
[7]
liver TDO2
Mean 397
Standard deviation 2.8e+02
Values 1.8e+02 1.8e+02 7.8e+02 4.4e+02
[8]
ref_hepatocyte KYNU
Mean 90.5
Standard deviation 1.2e+02
Values 70 24 31 22 3.1e+02
[9]
HepG2 KYNU
Mean 27.4
Standard deviation 17
Values 16 39
[10]
HepG2.C3A KYNU
Mean 36.6
Standard deviation 14
Values 47 26
[11]
HuH.7 KYNU
Mean 4.72
Standard deviation 2.1
Values 3.2 7.1 3.9
[12]
SNU475 KYNU
Mean 8.24
Standard deviation 5.2
Values 12 4.6
[13]
THLE KYNU
Mean 5.29
Standard deviation 2.8
Values 7.2 3.3
[14]
liver KYNU
Mean 21.7
Standard deviation 3.4
Values 21 18 26 22
[15]
ref_hepatocyte QPRT
Mean 54.6
Standard deviation 24
Values 18 83 60 66 46
[16]
HepG2 QPRT
Mean 166
Standard deviation 13
Values 1.8e+02 1.6e+02
[17]
HepG2.C3A QPRT
Mean 155
Standard deviation 28
Values 1.4e+02 1.7e+02
[18]
HuH.7 QPRT
Mean 127
Standard deviation 6.4
Values 1.2e+02 1.3e+02 1.2e+02
[19]
SNU475 QPRT
Mean 39.2
Standard deviation 20
Values 25 54
[20]
THLE QPRT
Mean 13.5
Standard deviation 0.43
Values 13 14
[21]
liver QPRT
Mean 56.2
Standard deviation 29
Values 34 31 92 68
[22]
ref_hepatocyte HAAO
Mean 49.4
Standard deviation 65
Values 9.1 1.5e+02 72 8.2 3.8
[23]
HepG2 HAAO
Mean 9.61
Standard deviation 2.4
Values 11 7.9
[24]
HepG2.C3A HAAO
Mean 18
Standard deviation 2.2
Values 16 20
[25]
HuH.7 HAAO
Mean 4.33
Standard deviation 0.95
Values 4.9 3.2 4.8
[26]
SNU475 HAAO
Mean 0.0405
Standard deviation 0.021
Values 0.025 0.056
[27]
THLE HAAO
Mean 0.0115
Standard deviation 0.0088
Values 0.018 0.0053
[28]
liver HAAO
Mean 43.7
Standard deviation 25
Values 23 21 64 67
[29]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 76 5.7 52 19 48
[30]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.2e+02 1.9e+02
[31]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 57 51
[32]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 7.3 10 6.5
[33]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 24 13
[34]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[35]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 16 26
[36]
ref_hepatocyte ACMSD
Mean 35.4
Standard deviation 47
Values 3 81 91 0 1.6
[37]
HepG2 ACMSD
Mean 0.00501
Standard deviation 0.001
Values 0.0043 0.0057
[38]
HepG2.C3A ACMSD
Mean 0.0307
Standard deviation 0.0021
Values 0.032 0.029
[39]
HuH.7 ACMSD
Mean 3.33
Standard deviation 0.47
Values 3.9 3.2 3
[40]
SNU475 ACMSD
Mean 0.0146
Standard deviation 0.00091
Values 0.015 0.014
[41]
THLE ACMSD
Mean 0.0222
Standard deviation 0.0063
Values 0.018 0.027
[42]
liver ACMSD
Mean 32.8
Standard deviation 10
Values 19 32 35 44
[43]
ref_hepatocyte AFMID
Mean 27.8
Standard deviation 20
Values 4.8 35 51 41 7.6
[44]
HepG2 AFMID
Mean 39
Standard deviation 12
Values 47 31
[45]
HepG2.C3A AFMID
Mean 82.2
Standard deviation 14
Values 72 92
[46]
HuH.7 AFMID
Mean 24.5
Standard deviation 7.7
Values 32 17 25
[47]
SNU475 AFMID
Mean 2.9
Standard deviation 0.18
Values 2.8 3
[48]
THLE AFMID
Mean 4.73
Standard deviation 0.045
Values 4.7 4.8
[49]
liver AFMID
Mean 54.5
Standard deviation 41
Values 28 23 1.1e+02 54
[50]
ref_hepatocyte EIF2AK1
Mean 20.9
Standard deviation 7.3
Values 13 24 24 30 14
[51]
HepG2 EIF2AK1
Mean 118
Standard deviation 13
Values 1.3e+02 1.1e+02
[52]
HepG2.C3A EIF2AK1
Mean 124
Standard deviation 12
Values 1.2e+02 1.3e+02
[53]
HuH.7 EIF2AK1
Mean 117
Standard deviation 4.3
Values 1.2e+02 1.1e+02 1.2e+02
[54]
SNU475 EIF2AK1
Mean 50.9
Standard deviation 14
Values 41 61
[55]
THLE EIF2AK1
Mean 62.3
Standard deviation 7
Values 57 67
[56]
liver EIF2AK1
Mean 48.3
Standard deviation 17
Values 31 37 65 60
[57]
ref_hepatocyte AADAT
Mean 6.3
Standard deviation 9.1
Values 0.67 22 6.3 1.3 1.3
[58]
HepG2 AADAT
Mean 3.81
Standard deviation 2.5
Values 5.6 2
[59]
HepG2.C3A AADAT
Mean 3.96
Standard deviation 1.1
Values 4.7 3.2
[60]
HuH.7 AADAT
Mean 1.15
Standard deviation 0.46
Values 1.5 0.62 1.4
[61]
SNU475 AADAT
Mean 1.43
Standard deviation 0.11
Values 1.3 1.5
[62]
THLE AADAT
Mean 2.12
Standard deviation 0.11
Values 2 2.2
[63]
liver AADAT
Mean 10.5
Standard deviation 4.6
Values 6 7.2 16 13
[64]
ref_hepatocyte EIF2AK4
Mean 6.13
Standard deviation 3.2
Values 7.3 2.7 3.6 6.4 11
[65]
HepG2 EIF2AK4
Mean 42.9
Standard deviation 8.1
Values 49 37
[66]
HepG2.C3A EIF2AK4
Mean 49.3
Standard deviation 4
Values 52 46
[67]
HuH.7 EIF2AK4
Mean 10.2
Standard deviation 0.88
Values 9.4 10 11
[68]
SNU475 EIF2AK4
Mean 40.3
Standard deviation 5.3
Values 36 44
[69]
THLE EIF2AK4
Mean 38.3
Standard deviation 5.9
Values 34 42
[70]
liver EIF2AK4
Mean 21.9
Standard deviation 6.1
Values 20 31 19 18
[71]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 6.2 5.5 5.5 5.5 3.7
[72]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[73]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 25 23
[74]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 46 20 50
[75]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 19 28
[76]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[77]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 5.6 5 9 9.5
[78]
ref_hepatocyte IL1R2
Mean 5.23
Standard deviation 1.8
Values 8.1 3.1 5.6 4.7 4.7
[79]
HepG2 IL1R2
Mean 2.14
Standard deviation 0.65
Values 1.7 2.6
[80]
HepG2.C3A IL1R2
Mean 1.85
Standard deviation 0.42
Values 2.1 1.6
[81]
HuH.7 IL1R2
Mean 0.113
Standard deviation 0.041
Values 0.066 0.13 0.14
[82]
SNU475 IL1R2
Mean 0.199
Standard deviation 0.18
Values 0.32 0.074
[83]
THLE IL1R2
Mean 0.96
Standard deviation 0.27
Values 1.1 0.77
[84]
liver IL1R2
Mean 4.16
Standard deviation 2
Values 6.1 1.8 5.6 3.2
[85]
ref_hepatocyte AHR
Mean 4.68
Standard deviation 3.7
Values 2.7 11 2.8 1.7 5.3
[86]
HepG2 AHR
Mean 22.5
Standard deviation 5.4
Values 26 19
[87]
HepG2.C3A AHR
Mean 24.6
Standard deviation 3.3
Values 22 27
[88]
HuH.7 AHR
Mean 47.9
Standard deviation 14
Values 34 63 46
[89]
SNU475 AHR
Mean 12.5
Standard deviation 1.6
Values 14 11
[90]
THLE AHR
Mean 26.4
Standard deviation 1.2
Values 26 27
[91]
liver AHR
Mean 40.1
Standard deviation 20
Values 55 58 28 19
[92]
ref_hepatocyte KMO
Mean 3.63
Standard deviation 4.2
Values 0.79 8.8 7.5 0.026 0.95
[93]
HepG2 KMO
Mean 0.0165
Standard deviation 0.0071
Values 0.021 0.011
[94]
HepG2.C3A KMO
Mean 0.0452
Standard deviation 0.018
Values 0.032 0.058
[95]
HuH.7 KMO
Mean 0.212
Standard deviation 0.072
Values 0.17 0.3 0.17
[96]
SNU475 KMO
Mean 0.629
Standard deviation 0.51
Values 0.99 0.27
[97]
THLE KMO
Mean 0.0225
Standard deviation 0.0017
Values 0.024 0.021
[98]
liver KMO
Mean 16.3
Standard deviation 7.3
Values 9.6 14 27 15
[99]
ref_hepatocyte FOXO1
Mean 1.77
Standard deviation 0.68
Values 2 2.6 1.9 0.71 1.7
[100]
HepG2 FOXO1
Mean 12.6
Standard deviation 1.8
Values 14 11
[101]
HepG2.C3A FOXO1
Mean 8.92
Standard deviation 1.5
Values 7.9 10
[102]
HuH.7 FOXO1
Mean 9.41
Standard deviation 1.6
Values 7.6 10 10
[103]
SNU475 FOXO1
Mean 7.33
Standard deviation 1.8
Values 6 8.6
[104]
THLE FOXO1
Mean 33.2
Standard deviation 1.9
Values 32 35
[105]
liver FOXO1
Mean 21.4
Standard deviation 7
Values 29 19 25 13
[106]
ref_hepatocyte KLF5
Mean 1.27
Standard deviation 1.7
Values 4.1 0.065 0.13 0.52 1.6
[107]
HepG2 KLF5
Mean 8.63
Standard deviation 3
Values 6.5 11
[108]
HepG2.C3A KLF5
Mean 1.25
Standard deviation 0.14
Values 1.2 1.4
[109]
HuH.7 KLF5
Mean 34.7
Standard deviation 3.5
Values 36 31 38
[110]
SNU475 KLF5
Mean 4.81
Standard deviation 2.8
Values 6.8 2.8
[111]
THLE KLF5
Mean 7.33
Standard deviation 0.032
Values 7.3 7.4
[112]
liver KLF5
Mean 0.209
Standard deviation 0.13
Values 0.19 0.043 0.35 0.26
[113]
ref_hepatocyte TLR4
Mean 0.547
Standard deviation 0.41
Values 0.33 0.66 0.64 0 1.1
[114]
HepG2 TLR4
Mean 1.46
Standard deviation 0.9
Values 2.1 0.82
[115]
HepG2.C3A TLR4
Mean 0.0365
Standard deviation 0.024
Values 0.054 0.019
[116]
HuH.7 TLR4
Mean 0.0189
Standard deviation 0.019
Values 0.037 0.019 0
[117]
SNU475 TLR4
Mean 0.0293
Standard deviation 0.0087
Values 0.035 0.023
[118]
THLE TLR4
Mean 45
Standard deviation 10
Values 52 38
[119]
liver TLR4
Mean 17.2
Standard deviation 6.3
Values 25 19 13 11
[120]
ref_hepatocyte IDO1
Mean 0.512
Standard deviation 0.3
Values 0.35 0.33 0.22 0.8 0.86
[121]
HepG2 IDO1
Mean 0.438
Standard deviation 0.012
Values 0.45 0.43
[122]
HepG2.C3A IDO1
Mean 0.68
Standard deviation 0.23
Values 0.51 0.85
[123]
HuH.7 IDO1
Mean 0.343
Standard deviation 0.071
Values 0.26 0.4 0.37
[124]
SNU475 IDO1
Mean 3.13
Standard deviation 1.9
Values 1.8 4.4
[125]
THLE IDO1
Mean 0.339
Standard deviation 0.014
Values 0.35 0.33
[126]
liver IDO1
Mean 0.937
Standard deviation 0.19
Values 1.1 1.1 0.85 0.72
[127]
ref_hepatocyte IDO2
Mean 0.384
Standard deviation 0.62
Values 0 1.4 0.49 0 0
[128]
HepG2 IDO2
Mean 0
Standard deviation 0
Values 0 0
[129]
HepG2.C3A IDO2
Mean 0
Standard deviation 0
Values 0 0
[130]
HuH.7 IDO2
Mean 0
Standard deviation 0
Values 0 0 0
[131]
SNU475 IDO2
Mean 0.00485
Standard deviation 0.0003
Values 0.0051 0.0046
[132]
THLE IDO2
Mean 0
Standard deviation 0
Values 0 0
[133]
liver IDO2
Mean 0.511
Standard deviation 0.4
Values 0.25 0.7 0.12 0.98
[134]
ref_hepatocyte IFNG
Mean 0.182
Standard deviation 0.29
Values 0 0.67 0.23 0 0
[135]
HepG2 IFNG
Mean 0
Standard deviation 0
Values 0 0
[136]
HepG2.C3A IFNG
Mean 0
Standard deviation 0
Values 0 0
[137]
HuH.7 IFNG
Mean 0
Standard deviation 0
Values 0 0 0
[138]
SNU475 IFNG
Mean 0.206
Standard deviation 0.22
Values 0.051 0.36
[139]
THLE IFNG
Mean 0
Standard deviation 0
Values 0 0
[140]
liver IFNG
Mean 0.0524
Standard deviation 0.037
Values 0.026 0.057 0.024 0.1
[141]
ref_hepatocyte TNF
Mean 0.113
Standard deviation 0.17
Values 0 0.39 0.17 0 0
[142]
HepG2 TNF
Mean 0.533
Standard deviation 0.44
Values 0.22 0.84
[143]
HepG2.C3A TNF
Mean 0.108
Standard deviation 0.029
Values 0.13 0.087
[144]
HuH.7 TNF
Mean 0.00428
Standard deviation 0.0074
Values 0 0.013 0
[145]
SNU475 TNF
Mean 0.0443
Standard deviation 0.023
Values 0.061 0.028
[146]
THLE TNF
Mean 0.00532
Standard deviation 0.0075
Values 0 0.011
[147]
liver TNF
Mean 0.0431
Standard deviation 0.06
Values 0.13 0.014 0 0.026
[148]
ref_hepatocyte NOS1
Mean 0.0628
Standard deviation 0.06
Values 0.033 0.024 0.086 0.16 0.013
[149]
HepG2 NOS1
Mean 0.0472
Standard deviation 0.042
Values 0.077 0.017
[150]
HepG2.C3A NOS1
Mean 0.165
Standard deviation 0.04
Values 0.19 0.14
[151]
HuH.7 NOS1
Mean 0.0531
Standard deviation 0.054
Values 0.11 0.039 0.0082
[152]
SNU475 NOS1
Mean 0.0724
Standard deviation 0.07
Values 0.12 0.023
[153]
THLE NOS1
Mean 0.0754
Standard deviation 0.069
Values 0.12 0.027
[154]
liver NOS1
Mean 0.144
Standard deviation 0.1
Values 0.16 0.19 0 0.23
[155]
ref_hepatocyte IFNB1
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[156]
HepG2 IFNB1
Missing
[157]
HepG2.C3A IFNB1
Missing
[158]
HuH.7 IFNB1
Missing
[159]
SNU475 IFNB1
Missing
[160]
THLE IFNB1
Missing
[161]
liver IFNB1
Missing