WP_KIT_RECEPTOR_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | FOS | Proto-oncogene c-Fos | [8] | -5.03[9] | -3.65[10] | -4.48[11] | -5.41[12] | -4.13[13] | -0.54[14] |
3 | JUNB | Transcription factor jun-B | [15] | -0.97[16] | -1.72[17] | -1.17[18] | -1.41[19] | -0.36[20] | -0.62[21] |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | [22] | 1.06[23] | 0.95[24] | -0.29[25] | 0.70[26] | 0.94[27] | 0.52[28] |
5 | STAT3 | Signal transducer and activator of transcription 3 | [29] | 1.53[30] | 0.15[31] | 0.73[32] | 1.00[33] | 0.48[34] | 3.17[35] |
6 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [36] | 0.05[37] | -0.16[38] | 0.26[39] | 0.21[40] | 0.93[41] | -0.43[42] |
7 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [43] | 1.04[44] | 0.83[45] | 1.54[46] | -0.09[47] | 0.61[48] | -0.94[49] |
8 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [50] | 1.43[51] | 1.98[52] | 1.77[53] | 1.64[54] | 2.49[55] | 2.02[56] |
9 | GRB2 | Growth factor receptor-bound protein 2 | [57] | 2.18[58] | 2.13[59] | 2.09[60] | 1.31[61] | 1.44[62] | 1.06[63] |
10 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [64] | 0.91[65] | 0.11[66] | 1.05[67] | 3.28[68] | 1.23[69] | 1.72[70] |
11 | CRK | Adapter molecule crk | [71] | 0.78[72] | 0.83[73] | 0.73[74] | 0.51[75] | 1.13[76] | 1.61[77] |
12 | BAD | Bcl2-associated agonist of cell death | [78] | -0.69[79] | -0.44[80] | -1.55[81] | -0.31[82] | 0.30[83] | -0.65[84] |
13 | SHC1 | SHC-transforming protein 1 | [85] | 2.14[86] | 2.48[87] | 2.39[88] | 3.41[89] | 3.10[90] | 1.55[91] |
14 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [92] | 0.92[93] | 1.44[94] | 2.55[95] | 0.57[96] | 1.65[97] | 1.86[98] |
15 | HRAS | GTPase HRas | [99] | -0.03[100] | -0.61[101] | -1.57[102] | -0.19[103] | -0.20[104] | -1.90[105] |
16 | MAPK1 | Mitogen-activated protein kinase 1 | [106] | 2.69[107] | 2.95[108] | 2.61[109] | 2.60[110] | 2.46[111] | 2.54[112] |
17 | RPS6KA3 | Ribosomal protein S6 kinase alpha-3 | [113] | [114] | [115] | [116] | [117] | [118] | [119] |
18 | MAPK14 | Mitogen-activated protein kinase 14 | [120] | 2.45[121] | 2.64[122] | 2.06[123] | 2.44[124] | 2.12[125] | 2.05[126] |
19 | CRKL | Crk-like protein | [127] | 2.68[128] | 2.90[129] | 3.34[130] | 1.88[131] | 2.29[132] | 2.22[133] |
20 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [134] | 0.51[135] | 0.75[136] | 1.67[137] | 2.82[138] | 2.54[139] | 3.77[140] |
21 | MAPK8 | Mitogen-activated protein kinase 8 | [141] | -0.46[142] | 1.07[143] | -0.23[144] | -0.15[145] | -0.08[146] | 0.25[147] |
22 | SOS1 | Son of sevenless homolog 1 | [148] | 0.88[149] | 2.53[150] | 1.87[151] | 1.60[152] | 1.05[153] | 1.30[154] |
23 | LYN | Tyrosine-protein kinase Lyn | [155] | 0.12[156] | 0.06[157] | 0.43[158] | 1.81[159] | 0.78[160] | 0.78[161] |
24 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [162] | 0.52[163] | 0.83[164] | 1.24[165] | -6.39[166] | -1.15[167] | 0.59[168] |
25 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [169] | 2.85[170] | 3.20[171] | 3.64[172] | 1.46[173] | 2.23[174] | 0.48[175] |
26 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [176] | [177] | [178] | [179] | [180] | [181] | [182] |
27 | MAPK3 | Mitogen-activated protein kinase 3 | [183] | 2.83[184] | 3.00[185] | 2.87[186] | 1.18[187] | 1.41[188] | -0.27[189] |
28 | STAT5B | Signal transducer and activator of transcription 5B | [190] | 2.34[191] | 2.08[192] | 2.62[193] | 2.30[194] | 1.66[195] | 2.39[196] |
29 | SOCS6 | Suppressor of cytokine signaling 6 | [197] | 1.34[198] | 2.31[199] | 1.19[200] | 2.08[201] | 1.91[202] | 2.59[203] |
30 | GRB10 | Growth factor receptor-bound protein 10 | [204] | 3.49[205] | 0.53[206] | 2.74[207] | 1.44[208] | 2.52[209] | 2.71[210] |
31 | SRC | Proto-oncogene tyrosine-protein kinase Src | [211] | 4.00[212] | 4.11[213] | 2.94[214] | 3.15[215] | 2.54[216] | -0.08[217] |
32 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 4.47[218] | 4.21[219] | 3.38[220] | 3.58[221] | 3.28[222] | 1.11[223] | |
33 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [224] | [225] | [226] | [227] | [228] | [229] | [230] |
34 | FOXO3 | Forkhead box protein O3 | [231] | 1.43[232] | 1.64[233] | 2.12[234] | 1.15[235] | 2.61[236] | 3.10[237] |
35 | SNAI2 | Zinc finger protein SNAI2 | [238] | -4.23[239] | -5.08[240] | -6.95[241] | 0.85[242] | 4.08[243] | 0.16[244] |
36 | EP300 | Histone acetyltransferase p300 | [245] | 3.70[246] | 3.42[247] | 4.15[248] | 3.33[249] | 3.59[250] | 3.52[251] |
37 | PRKCA | Protein kinase C alpha type | [252] | 3.82[253] | 3.98[254] | 4.17[255] | 2.90[256] | 3.48[257] | 2.68[258] |
38 | STAT5A | Signal transducer and activator of transcription 5A | [259] | -0.97[260] | 0.33[261] | -0.77[262] | -0.09[263] | 0.88[264] | 1.00[265] |
39 | MITF | Microphthalmia-associated transcription factor | [266] | -3.36[267] | -4.15[268] | -6.19[269] | 2.03[270] | 0.50[271] | 0.01[272] |
40 | SOCS1 | Suppressor of cytokine signaling 1 | [273] | -0.47[274] | 0.52[275] | 0.62[276] | -1.04[277] | -2.21[278] | -0.70[279] |
41 | FYN | Tyrosine-protein kinase Fyn | [280] | 1.92[281] | -6.56[282] | 1.84[283] | 2.23[284] | 3.96[285] | 1.74[286] |
42 | GRB7 | Growth factor receptor-bound protein 7 | [287] | 3.39[288] | 3.83[289] | 0.83[290] | -1.90[291] | -0.95[292] | 0.44[293] |
43 | GAB2 | GRB2-associated-binding protein 2 | [294] | 2.54[295] | 2.45[296] | 2.53[297] | 1.68[298] | 1.98[299] | 1.31[300] |
44 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [301] | 4.83[302] | 5.34[303] | -5.01[304] | -4.91[305] | -1.75[306] | 2.05[307] |
45 | DOK1 | Docking protein 1 | [308] | -0.32[309] | -0.60[310] | 2.44[311] | 1.01[312] | 2.63[313] | 0.49[314] |
46 | JAK2 | Tyrosine-protein kinase JAK2 | [315] | 1.21[316] | 1.32[317] | 0.71[318] | 1.52[319] | 2.33[320] | 3.47[321] |
47 | TEC | Tyrosine-protein kinase Tec | [322] | -1.17[323] | -1.45[324] | -1.02[325] | 2.10[326] | 0.73[327] | 2.36[328] |
48 | TBX2 | T-box transcription factor TBX2 | [329] | 3.02[330] | 2.97[331] | 0.61[332] | 2.58[333] | 1.86[334] | 1.48[335] |
49 | CBL | E3 ubiquitin-protein ligase CBL | [336] | 5.43[337] | 4.49[338] | 4.55[339] | 5.89[340] | 5.58[341] | 4.52[342] |
50 | VAV1 | Proto-oncogene vav | [343] | -7.52[344] | -2.57[345] | -4.44[346] | -5.33[347] | -6.38[348] | 1.95[349] |
51 | MAPT | Microtubule-associated protein tau | [350] | 3.51[351] | 3.57[352] | 2.70[353] | 2.09[354] | -0.76[355] | 1.10[356] |
52 | SH2B2 | SH2B adapter protein 2 | [357] | 0.99[358] | 0.45[359] | 1.10[360] | 1.29[361] | 0.81[362] | -0.35[363] |
53 | PRKCB | Protein kinase C beta type | [364] | -5.83[365] | -4.52[366] | [367] | 3.24[368] | -1.86[369] | 4.30[370] |
54 | SNAI1 | Zinc finger protein SNAI1 | [371] | 4.05[372] | 2.49[373] | 4.39[374] | 3.77[375] | 3.27[376] | 1.81[377] |
55 | BTK | Tyrosine-protein kinase BTK | [378] | -6.40[379] | [380] | 0.40[381] | -2.26[382] | -4.27[383] | 2.59[384] |
56 | MATK | Megakaryocyte-associated tyrosine-protein kinase | [385] | 1.20[386] | [387] | [388] | -3.46[389] | -0.72[390] | 2.06[391] |
57 | KITLG | Kit ligand | [392] | 6.42[393] | 2.77[394] | 8.33[395] | 7.48[396] | 5.89[397] | 3.80[398] |
58 | BCL2 | Apoptosis regulator Bcl-2 | [399] | -1.87[400] | 3.65[401] | -3.92[402] | 2.53[403] | 2.45[404] | 4.00[405] |
59 | KIT | Mast/stem cell growth factor receptor Kit | [406] | -2.01[407] | -3.77[408] | [409] | 3.25[410] | -2.06[411] | 4.40[412] |
60 | MIR1281 | [413] | [414] | [415] | [416] | [417] | [418] | [419] |