WP_IRINOTECAN_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CES1 Liver carboxylesterase 1 [1] -0.94[2] -7.71[3] -7.29[4] -0.67[5] -6.47[6] -1.53[7]
2 CYP3A4 Cytochrome P450 3A4 [8] -9.13[9] -9.30[10] -9.70[11] -13.42[12] -9.82[13] 0.70[14]
3 CYP3A5 Cytochrome P450 3A5 [15] -4.20[16] -2.02[17] -3.45[18] -5.99[19] -6.16[20] 1.06[21]
4 UGT1A1 UDP-glucuronosyltransferase 1-1 [22] -3.75[23] -10.06[24] -3.58[25] 0.76[26] -7.19[27] -0.08[28]
5 CES2 Cocaine esterase [29] 1.60[30] 2.13[31] 1.24[32] 0.70[33] 2.37[34] 1.26[35]
6 SLCO1B1 Solute carrier organic anion transporter family member 1B1 [36] -12.56[37] -8.82[38] -2.28[39] -9.25[40] [41] 1.54[42]
7 ABCC2 Canalicular multispecific organic anion transporter 1 [43] 3.45[44] 4.97[45] 4.70[46] 2.85[47] -1.88[48] 1.92[49]
8 UGT1A9 UDP-glucuronosyltransferase 1-9 [50] -5.09[51] -10.02[52] -4.89[53] -3.58[54] -6.79[55] -0.67[56]
9 BCHE Cholinesterase [57] -9.72[58] -8.64[59] -5.78[60] 1.25[61] 4.55[62] 0.32[63]
10 NPC1 Niemann-Pick C1 protein [64] 4.57[65] 4.88[66] 6.17[67] 5.11[68] 6.65[69] 0.91[70]
11 ABCG2 ATP-binding cassette sub-family G member 2 [71] 2.67[72] 2.51[73] 4.96[74] 2.75[75] 3.69[76] 0.24[77]
12 ABCC1 Multidrug resistance-associated protein 1 [78] 7.86[79] 5.01[80] 5.41[81] 7.51[82] 8.00[83] 0.74[84]
13 UGT1A10 UDP-glucuronosyltransferase 1-10 [85] [86] [87] [88] [89] [90] [91]
[1]
ref_hepatocyte CES1
Mean 819
Standard deviation 9e+02
Values 1.5e+02 1.7e+03 1.9e+03 1.5e+02 1.8e+02
[2]
HepG2 CES1
Mean 154
Standard deviation 89
Values 91 2.2e+02
[3]
HepG2.C3A CES1
Mean 1.3
Standard deviation 0.53
Values 0.92 1.7
[4]
HuH.7 CES1
Mean 0.67
Standard deviation 0.32
Values 0.46 1 0.52
[5]
SNU475 CES1
Mean 111
Standard deviation 23
Values 94 1.3e+02
[6]
THLE CES1
Mean 0.535
Standard deviation 0.14
Values 0.63 0.44
[7]
liver CES1
Mean 411
Standard deviation 2.6e+02
Values 1.3e+02 3.2e+02 4.6e+02 7.4e+02
[8]
ref_hepatocyte CYP3A4
Mean 259
Standard deviation 4.1e+02
Values 11 9.6e+02 3.2e+02 0.24 11
[9]
HepG2 CYP3A4
Mean 0.167
Standard deviation 0.098
Values 0.24 0.097
[10]
HepG2.C3A CYP3A4
Mean 0.136
Standard deviation 0.096
Values 0.2 0.068
[11]
HuH.7 CYP3A4
Mean 0.0397
Standard deviation 0.029
Values 0.047 0.064 0.0082
[12]
SNU475 CYP3A4
Mean 0.00507
Standard deviation 0.0072
Values 0.01 0
[13]
THLE CYP3A4
Mean 0.0166
Standard deviation 0.0067
Values 0.012 0.021
[14]
liver CYP3A4
Mean 610
Standard deviation 5.3e+02
Values 49 6.4e+02 4.3e+02 1.3e+03
[15]
ref_hepatocyte CYP3A5
Mean 139
Standard deviation 1.6e+02
Values 35 3.9e+02 2e+02 22 55
[16]
HepG2 CYP3A5
Mean 2.75
Standard deviation 2.1
Values 4.2 1.3
[17]
HepG2.C3A CYP3A5
Mean 11.4
Standard deviation 3.8
Values 8.7 14
[18]
HuH.7 CYP3A5
Mean 1.63
Standard deviation 1.6
Values 0.83 3.5 0.58
[19]
SNU475 CYP3A5
Mean 0.471
Standard deviation 0.12
Values 0.39 0.56
[20]
THLE CYP3A5
Mean 0.113
Standard deviation 0.032
Values 0.14 0.09
[21]
liver CYP3A5
Mean 424
Standard deviation 3.2e+02
Values 2.8e+02 2.7e+02 9e+02 2.5e+02
[22]
ref_hepatocyte UGT1A1
Mean 67.2
Standard deviation 89
Values 15 96 2.1e+02 0.52 12
[23]
HepG2 UGT1A1
Mean 1.8
Standard deviation 0.2
Values 1.7 1.9
[24]
HepG2.C3A UGT1A1
Mean 0.0209
Standard deviation 0.016
Values 0.032 0.0097
[25]
HuH.7 UGT1A1
Mean 0.72
Standard deviation 0.5
Values 0.31 1.3 0.57
[26]
SNU475 UGT1A1
Mean 24.4
Standard deviation 21
Values 9.8 39
[27]
THLE UGT1A1
Mean 0.0266
Standard deviation 0.038
Values 0 0.053
[28]
liver UGT1A1
Mean 92.4
Standard deviation 46
Values 34 83 1.1e+02 1.4e+02
[29]
ref_hepatocyte CES2
Mean 49.3
Standard deviation 49
Values 11 1.1e+02 94 14 17
[30]
HepG2 CES2
Mean 54.1
Standard deviation 2.1
Values 56 53
[31]
HepG2.C3A CES2
Mean 71.8
Standard deviation 6.4
Values 67 76
[32]
HuH.7 CES2
Mean 14.9
Standard deviation 3.2
Values 16 11 17
[33]
SNU475 CES2
Mean 17.1
Standard deviation 1.6
Values 16 18
[34]
THLE CES2
Mean 14.8
Standard deviation 0.53
Values 14 15
[35]
liver CES2
Mean 171
Standard deviation 92
Values 95 89 2.4e+02 2.6e+02
[36]
ref_hepatocyte SLCO1B1
Mean 35.9
Standard deviation 41
Values 1.4 1e+02 37 0 40
[37]
HepG2 SLCO1B1
Mean 0.00214
Standard deviation 0.003
Values 0.0043 0
[38]
HepG2.C3A SLCO1B1
Mean 0.0263
Standard deviation 0.023
Values 0.043 0.0097
[39]
HuH.7 SLCO1B1
Mean 0.948
Standard deviation 1.4
Values 0.22 2.6 0.074
[40]
SNU475 SLCO1B1
Mean 0.0127
Standard deviation 0.018
Values 0.025 0
[41]
THLE SLCO1B1
Mean 0
Standard deviation 0
Values 0 0
[42]
liver SLCO1B1
Mean 152
Standard deviation 42
Values 95 1.8e+02 1.8e+02 1.5e+02
[43]
ref_hepatocyte ABCC2
Mean 31.6
Standard deviation 23
Values 16 17 17 68 40
[44]
HepG2 ABCC2
Mean 125
Standard deviation 1.3
Values 1.3e+02 1.2e+02
[45]
HepG2.C3A ABCC2
Mean 328
Standard deviation 1.2
Values 3.3e+02 3.3e+02
[46]
HuH.7 ABCC2
Mean 105
Standard deviation 48
Values 68 1.6e+02 88
[47]
SNU475 ABCC2
Mean 48.9
Standard deviation 12
Values 41 57
[48]
THLE ABCC2
Mean 0.497
Standard deviation 0.041
Values 0.53 0.47
[49]
liver ABCC2
Mean 174
Standard deviation 96
Values 1.9e+02 3e+02 89 1.1e+02
[50]
ref_hepatocyte UGT1A9
Mean 15.2
Standard deviation 13
Values 2.6 27 26 0 21
[51]
HepG2 UGT1A9
Mean 0.16
Standard deviation 0.057
Values 0.12 0.2
[52]
HepG2.C3A UGT1A9
Mean 0.00486
Standard deviation 0.0069
Values 0 0.0097
[53]
HuH.7 UGT1A9
Mean 0.0656
Standard deviation 0.056
Values 0.0094 0.12 0.066
[54]
SNU475 UGT1A9
Mean 0.273
Standard deviation 0.34
Values 0.03 0.51
[55]
THLE UGT1A9
Mean 0.00798
Standard deviation 0.011
Values 0 0.016
[56]
liver UGT1A9
Mean 13.9
Standard deviation 9.6
Values 3 22 8.7 22
[57]
ref_hepatocyte BCHE
Mean 11.7
Standard deviation 16
Values 1.6 39 12 0 5.4
[58]
HepG2 BCHE
Mean 0.00501
Standard deviation 0.001
Values 0.0043 0.0057
[59]
HepG2.C3A BCHE
Mean 0.00972
Standard deviation 0.014
Values 0 0.019
[60]
HuH.7 BCHE
Mean 0.0273
Standard deviation 0.032
Values 0.0094 0.064 0.0082
[61]
SNU475 BCHE
Mean 5.94
Standard deviation 0.44
Values 5.6 6.3
[62]
THLE BCHE
Mean 15.9
Standard deviation 2.8
Values 18 14
[63]
liver BCHE
Mean 21.2
Standard deviation 9.3
Values 16 17 35 17
[64]
ref_hepatocyte NPC1
Mean 4.23
Standard deviation 2.9
Values 9.1 1.7 2.5 4.8 3.1
[65]
HepG2 NPC1
Mean 36.4
Standard deviation 3.3
Values 34 39
[66]
HepG2.C3A NPC1
Mean 41.5
Standard deviation 19
Values 28 55
[67]
HuH.7 NPC1
Mean 39
Standard deviation 8.4
Values 31 47 39
[68]
SNU475 NPC1
Mean 31.4
Standard deviation 4.3
Values 34 28
[69]
THLE NPC1
Mean 24.7
Standard deviation 1.5
Values 24 26
[70]
liver NPC1
Mean 11.6
Standard deviation 4.1
Values 17 12 8.6 8.5
[71]
ref_hepatocyte ABCG2
Mean 3
Standard deviation 1.8
Values 2.9 4.4 1.5 1.1 5.2
[72]
HepG2 ABCG2
Mean 6.88
Standard deviation 0.34
Values 6.6 7.1
[73]
HepG2.C3A ABCG2
Mean 5.65
Standard deviation 0.97
Values 6.3 5
[74]
HuH.7 ABCG2
Mean 11.9
Standard deviation 1.2
Values 11 11 13
[75]
SNU475 ABCG2
Mean 4.32
Standard deviation 1
Values 5 3.6
[76]
THLE ABCG2
Mean 2.24
Standard deviation 1.1
Values 1.4 3
[77]
liver ABCG2
Mean 5.14
Standard deviation 1.6
Values 5 7.3 3.4 4.8
[78]
ref_hepatocyte ABCC1
Mean 1.64
Standard deviation 2.8
Values 0.55 0.21 0.18 6.7 0.55
[79]
HepG2 ABCC1
Mean 138
Standard deviation 32
Values 1.2e+02 1.6e+02
[80]
HepG2.C3A ABCC1
Mean 17.5
Standard deviation 0.7
Values 17 18
[81]
HuH.7 ABCC1
Mean 8.92
Standard deviation 1.5
Values 8.1 8.1 11
[82]
SNU475 ABCC1
Mean 64.4
Standard deviation 27
Values 45 83
[83]
THLE ABCC1
Mean 24.5
Standard deviation 8.1
Values 19 30
[84]
liver ABCC1
Mean 4
Standard deviation 2.2
Values 6.8 4.5 2.8 1.8
[85]
ref_hepatocyte UGT1A10
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[86]
HepG2 UGT1A10
Mean 0.00788
Standard deviation 0.0051
Values 0.0043 0.011
[87]
HepG2.C3A UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[88]
HuH.7 UGT1A10
Mean 0.115
Standard deviation 0.078
Values 0.075 0.21 0.066
[89]
SNU475 UGT1A10
Mean 0.012
Standard deviation 0.0027
Values 0.01 0.014
[90]
THLE UGT1A10
Mean 0
Standard deviation 0
Values 0 0
[91]
liver UGT1A10
Mean 0.0104
Standard deviation 0.014
Values 0.013 0.029 0 0