WP_INTERLEUKIN11_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | AKT1 | RAC-alpha serine/threonine-protein kinase | [8] | 1.05[9] | 0.79[10] | -0.33[11] | 0.78[12] | 0.61[13] | 0.19[14] |
3 | STAT3 | Signal transducer and activator of transcription 3 | [15] | 1.52[16] | 0.00[17] | 0.69[18] | 1.07[19] | 0.16[20] | 2.84[21] |
4 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [22] | 0.04[23] | -0.31[24] | 0.23[25] | 0.29[26] | 0.61[27] | -0.76[28] |
5 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [29] | 1.02[30] | 0.68[31] | 1.50[32] | -0.01[33] | 0.29[34] | -1.27[35] |
6 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [36] | 1.41[37] | 1.82[38] | 1.74[39] | 1.72[40] | 2.16[41] | 1.69[42] |
7 | GRB2 | Growth factor receptor-bound protein 2 | [43] | 2.16[44] | 1.98[45] | 2.06[46] | 1.39[47] | 1.11[48] | 0.73[49] |
8 | YES1 | Tyrosine-protein kinase Yes | [50] | 0.11[51] | 1.57[52] | 1.75[53] | 1.28[54] | 0.55[55] | 0.55[56] |
9 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [57] | 0.89[58] | -0.05[59] | 1.02[60] | 3.36[61] | 0.91[62] | 1.38[63] |
10 | IL6ST | Interleukin-6 receptor subunit beta | [64] | 1.23[65] | 2.45[66] | 1.93[67] | 2.56[68] | 3.54[69] | 4.21[70] |
11 | RELA | Transcription factor p65 | [71] | 1.10[72] | 0.57[73] | 0.67[74] | 0.78[75] | 0.49[76] | -0.45[77] |
12 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [78] | 0.90[79] | 1.29[80] | 2.51[81] | 0.65[82] | 1.32[83] | 1.53[84] |
13 | JAK1 | Tyrosine-protein kinase JAK1 | [85] | 1.48[86] | 0.94[87] | 1.08[88] | 1.46[89] | 1.91[90] | 1.96[91] |
14 | ICAM1 | Intercellular adhesion molecule 1 | [92] | 2.86[93] | 2.22[94] | 2.59[95] | 1.02[96] | 3.01[97] | 0.02[98] |
15 | HRAS | GTPase HRas | [99] | -0.04[100] | -0.77[101] | -1.60[102] | -0.12[103] | -0.52[104] | -2.23[105] |
16 | SOCS3 | Suppressor of cytokine signaling 3 | [106] | -3.17[107] | -3.61[108] | -1.93[109] | 0.03[110] | -1.23[111] | 0.56[112] |
17 | MAPK1 | Mitogen-activated protein kinase 1 | [113] | 2.67[114] | 2.79[115] | 2.58[116] | 2.68[117] | 2.14[118] | 2.21[119] |
18 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [120] | 0.49[121] | 0.59[122] | 1.64[123] | 2.90[124] | 2.21[125] | 3.43[126] |
19 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [127] | 2.54[128] | 2.97[129] | 2.89[130] | 1.51[131] | 2.15[132] | -1.88[133] |
20 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [134] | 2.84[135] | 3.04[136] | 3.61[137] | 1.54[138] | 1.91[139] | 0.14[140] |
21 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [141] | 2.10[142] | 2.44[143] | 2.53[144] | 1.58[145] | 2.31[146] | 2.42[147] |
22 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [148] | [149] | [150] | [151] | [152] | [153] | [154] |
23 | ATF1 | Cyclic AMP-dependent transcription factor ATF-1 | [155] | 0.34[156] | 1.58[157] | 1.26[158] | 0.99[159] | 0.68[160] | -0.05[161] |
24 | MAPK3 | Mitogen-activated protein kinase 3 | [162] | 2.82[163] | 2.84[164] | 2.84[165] | 1.26[166] | 1.09[167] | -0.61[168] |
25 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [169] | 1.87[170] | 3.07[171] | 2.99[172] | 1.48[173] | 2.11[174] | 1.95[175] |
26 | SRC | Proto-oncogene tyrosine-protein kinase Src | [176] | 3.99[177] | 3.95[178] | 2.91[179] | 3.23[180] | 2.22[181] | -0.42[182] |
27 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | [183] | 3.30[184] | 4.47[185] | 3.14[186] | 2.27[187] | 2.47[188] | 2.93[189] |
28 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [190] | 1.49[191] | 1.53[192] | 1.59[193] | 1.09[194] | 0.99[195] | 1.61[196] |
29 | FES | Tyrosine-protein kinase Fes/Fps | [197] | 1.74[198] | -0.27[199] | 0.04[200] | -5.78[201] | -1.69[202] | 1.61[203] |
30 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [204] | [205] | [206] | [207] | [208] | [209] | [210] |
31 | PIAS1 | E3 SUMO-protein ligase PIAS1 | [211] | 1.01[212] | 1.25[213] | 2.11[214] | 1.71[215] | 1.24[216] | 1.61[217] |
32 | TGFB1 | Transforming growth factor beta-1 | [218] | 4.44[219] | 3.38[220] | 0.59[221] | 4.67[222] | 3.71[223] | -0.80[224] |
33 | IL11RA | Interleukin-11 receptor subunit alpha | [225] | -1.01[226] | 1.25[227] | -0.18[228] | -0.71[229] | -1.01[230] | 1.58[231] |
34 | FYN | Tyrosine-protein kinase Fyn | [232] | 1.91[233] | -6.71[234] | 1.81[235] | 2.30[236] | 3.64[237] | 1.40[238] |
35 | CREB1 | Cyclic AMP-responsive element-binding protein 1 | [239] | 2.69[240] | 3.83[241] | 4.27[242] | 3.37[243] | 3.13[244] | 2.77[245] |
36 | ITGA2 | Integrin alpha-2 | [246] | 5.07[247] | 5.00[248] | 1.99[249] | 2.21[250] | 5.00[251] | -0.55[252] |
37 | PIAS3 | E3 SUMO-protein ligase PIAS3 | [253] | 2.27[254] | 1.44[255] | 2.69[256] | 3.55[257] | 3.06[258] | 1.20[259] |
38 | JAK2 | Tyrosine-protein kinase JAK2 | [260] | 1.19[261] | 1.17[262] | 0.68[263] | 1.60[264] | 2.00[265] | 3.14[266] |
39 | IL11 | Interleukin-11 | [267] | 7.46[268] | 3.80[269] | 1.25[270] | 4.01[271] | 3.75[272] | -1.21[273] |
40 | BCL2 | Apoptosis regulator Bcl-2 | [274] | -1.89[275] | 3.50[276] | -3.95[277] | 2.61[278] | 2.13[279] | 3.66[280] |
41 | RUNX2 | Runt-related transcription factor 2 | [281] | 0.12[282] | -0.26[283] | 4.77[284] | 7.96[285] | 9.72[286] | 4.05[287] |
42 | IBSP | Bone sialoprotein 2 | [288] | [289] | [290] | [291] | [292] | [293] | [294] |
43 | PTPA | Serine/threonine-protein phosphatase 2A activator | [295] | [296] | [297] | [298] | [299] | [300] | [301] |
44 | BGLAP | Osteocalcin | [302] | [303] | [304] | [305] | [306] | [307] | [308] |