WP_INTEGRATED_CANCER_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 CDKN1A Cyclin-dependent kinase inhibitor 1 [1] 0.20[2] -1.46[3] -3.70[4] -2.61[5] -0.28[6] -2.04[7]
2 AKT1 RAC-alpha serine/threonine-protein kinase [8] -0.56[9] -1.07[10] -1.69[11] -0.67[12] -0.88[13] -0.45[14]
3 MYC Myc proto-oncogene protein [15] -0.21[16] -0.82[17] -2.40[18] -3.41[19] -1.27[20] -2.20[21]
4 BAX Apoptosis regulator BAX [22] -0.31[23] -1.38[24] -1.39[25] -2.22[26] -2.06[27] -4.16[28]
5 STAT1 Signal transducer and activator of transcription 1-alpha/beta [29] -0.71[30] -1.91[31] -0.35[32] 1.91[33] -0.58[34] 0.75[35]
6 CDK4 Cyclin-dependent kinase 4 [36] 0.69[37] 1.00[38] 1.08[39] -0.44[40] -0.02[41] -1.04[42]
7 BAD Bcl2-associated agonist of cell death [43] -2.31[44] -2.45[45] -2.95[46] -1.69[47] -1.51[48] -1.63[49]
8 JAK1 Tyrosine-protein kinase JAK1 [50] -0.13[51] -0.92[52] -0.28[53] 0.01[54] 0.42[55] 1.33[56]
9 CDKN1B Cyclin-dependent kinase inhibitor 1B [57] -0.72[58] -0.56[59] 0.09[60] -1.73[61] -1.49[62] -1.11[63]
10 CASP3 Caspase-3 [64] -0.50[65] -0.10[66] -2.20[67] -1.52[68] -0.75[69] -1.01[70]
11 CDK2 Cyclin-dependent kinase 2 [71] -1.05[72] -1.16[73] -0.33[74] -0.64[75] -0.28[76] -2.39[77]
12 MSH6 DNA mismatch repair protein Msh6 [78] -0.33[79] -0.11[80] 0.55[81] 0.28[82] 0.47[83] 0.09[84]
13 MMP1 Interstitial collagenase [85] -5.80[86] -9.85[87] [88] -2.37[89] -3.05[90] -12.33[91]
14 CASP8 Caspase-8 [92] -0.62[93] -0.32[94] -0.70[95] -0.70[96] -1.67[97] -1.62[98]
15 PTEN Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN -1.18[99] -0.06[100] 0.59[101] -1.19[102] -0.16[103] 2.27[104]
16 MDM2 E3 ubiquitin-protein ligase Mdm2 [105] 1.47[106] 2.62[107] 0.30[108] -0.11[109] 0.54[110] 1.96[111]
17 SMAD3 Mothers against decapentaplegic homolog 3 [112] 1.29[113] 0.41[114] 1.09[115] 1.18[116] 1.83[117] 0.01[118]
18 CDK1 Cyclin-dependent kinase 1 [119] 0.61[120] 2.40[121] 1.59[122] 1.65[123] 2.24[124] -2.67[125]
19 CHEK2 Serine/threonine-protein kinase Chk2 [126] -0.54[127] -0.37[128] 0.48[129] -0.87[130] -1.47[131] -3.48[132]
20 TP53 Cellular tumor antigen p53 [133] 1.00[134] 0.29[135] 1.50[136] 0.67[137] 0.11[138] -0.25[139]
21 PLK1 Serine/threonine-protein kinase PLK1 [140] 1.85[141] 1.32[142] 1.63[143] 0.62[144] 1.44[145] -2.84[146]
22 ATF1 Cyclic AMP-dependent transcription factor ATF-1 [147] -1.26[148] -0.28[149] -0.11[150] -0.47[151] -0.81[152] -0.68[153]
23 BBC3 Bcl-2-binding component 3 [154] 0.10[155] -0.29[156] -0.34[157] -3.42[158] -2.89[159] -4.54[160]
24 MSH2 DNA mismatch repair protein Msh2 [161] 0.18[162] 1.20[163] 1.09[164] 1.51[165] 0.65[166] -0.90[167]
25 RAD50 DNA repair protein RAD50 [168] -0.49[169] 1.37[170] 0.97[171] 0.64[172] 0.91[173] 2.00[174]
26 CDC25B M-phase inducer phosphatase 2 [175] 1.23[176] 1.13[177] 0.96[178] 2.10[179] 2.04[180] 0.14[181]
27 BACH1 Transcription regulator protein BACH1 [182] 0.41[183] 0.46[184] 1.36[185] 1.50[186] 0.51[187] 2.42[188]
28 RB1 Retinoblastoma-associated protein [189] 0.58[190] 0.80[191] 1.82[192] 1.65[193] 1.75[194] 1.27[195]
29 CASP9 Caspase-9 [196] -0.48[197] 0.20[198] -0.23[199] -0.38[200] -1.29[201] -0.74[202]
30 SMAD2 Mothers against decapentaplegic homolog 2 [203] 1.38[204] 1.37[205] 1.32[206] 1.76[207] 1.73[208] 2.36[209]
31 E2F1 Transcription factor E2F1 [210] 1.31[211] 0.89[212] 1.47[213] 1.24[214] 1.46[215] -3.82[216]
32 CHEK1 Serine/threonine-protein kinase Chk1 [217] 0.90[218] 0.98[219] 1.00[220] 1.53[221] 1.53[222] -2.23[223]
33 CDKN2B Cyclin-dependent kinase 4 inhibitor B [224] -0.27[225] -5.02[226] -0.71[227] 0.54[228] 0.62[229] -2.29[230]
34 CDC25A M-phase inducer phosphatase 1 [231] 0.79[232] 1.15[233] 1.95[234] -0.28[235] 0.95[236] -2.86[237]
35 NOXA1 NADPH oxidase activator 1 [238] -3.00[239] -1.51[240] -2.10[241] -3.01[242] -4.45[243] -1.18[244]
36 BRCA1 Breast cancer type 1 susceptibility protein [245] 1.03[246] 2.00[247] 2.85[248] 1.52[249] 1.82[250] 1.47[251]
37 ATR Serine/threonine-protein kinase ATR [252] 0.45[253] 1.18[254] 1.71[255] 1.91[256] 1.65[257] 3.34[258]
38 MAP3K5 Mitogen-activated protein kinase kinase kinase 5 [259] -4.94[260] -8.14[261] -1.80[262] -2.49[263] 1.69[264] 2.85[265]
39 ATM Serine-protein kinase ATM [266] 2.39[267] 3.72[268] 3.90[269] 3.53[270] 2.79[271] 4.78[272]
40 POU2F1 POU domain, class 2, transcription factor 1 [273] 2.46[274] 2.99[275] 4.17[276] 3.50[277] 2.34[278] 3.91[279]
41 BLM Bloom syndrome protein [280] 0.90[281] 1.98[282] 3.24[283] 2.27[284] 2.13[285] -0.59[286]
42 BARD1 BRCA1-associated RING domain protein 1 [287] 0.67[288] 1.39[289] 1.86[290] 2.07[291] 1.93[292] 1.66[293]
43 BCL2 Apoptosis regulator Bcl-2 [294] -3.49[295] 1.64[296] -5.32[297] 1.15[298] 0.64[299] 3.03[300]
44 MRE11 Double-strand break repair protein MRE11 [301] [302] [303] [304] [305] [306] [307]
45 MIR3191 [308] [309] [310] [311] [312] [313] [314]
[1]
ref_hepatocyte CDKN1A
Mean 40.1
Standard deviation 28
Values 76 5.7 52 19 48
[2]
HepG2 CDKN1A
Mean 158
Standard deviation 49
Values 1.2e+02 1.9e+02
[3]
HepG2.C3A CDKN1A
Mean 53.9
Standard deviation 3.9
Values 57 51
[4]
HuH.7 CDKN1A
Mean 8
Standard deviation 1.9
Values 7.3 10 6.5
[5]
SNU475 CDKN1A
Mean 18.6
Standard deviation 7.8
Values 24 13
[6]
THLE CDKN1A
Mean 122
Standard deviation 11
Values 1.3e+02 1.1e+02
[7]
liver CDKN1A
Mean 16
Standard deviation 8.1
Values 16 6.2 16 26
[8]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[9]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[10]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[11]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[12]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[13]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[14]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[15]
ref_hepatocyte MYC
Mean 29.9
Standard deviation 34
Values 89 1.4 23 15 20
[16]
HepG2 MYC
Mean 88.8
Standard deviation 53
Values 52 1.3e+02
[17]
HepG2.C3A MYC
Mean 62.6
Standard deviation 15
Values 52 73
[18]
HuH.7 MYC
Mean 14.7
Standard deviation 2.6
Values 14 18 13
[19]
SNU475 MYC
Mean 7.93
Standard deviation 1.4
Values 8.9 6.9
[20]
THLE MYC
Mean 46
Standard deviation 10
Values 39 53
[21]
liver MYC
Mean 10.6
Standard deviation 6
Values 5.5 5.9 18 13
[22]
ref_hepatocyte BAX
Mean 24.8
Standard deviation 9.1
Values 34 11 27 30 21
[23]
HepG2 BAX
Mean 68.8
Standard deviation 16
Values 58 80
[24]
HepG2.C3A BAX
Mean 35.4
Standard deviation 3
Values 33 38
[25]
HuH.7 BAX
Mean 24.6
Standard deviation 9.8
Values 34 14 26
[26]
SNU475 BAX
Mean 15
Standard deviation 0.87
Values 16 14
[27]
THLE BAX
Mean 21.9
Standard deviation 0.028
Values 22 22
[28]
liver BAX
Mean 2.27
Standard deviation 0.64
Values 1.4 2.5 2.3 2.9
[29]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 19 18 12 17 35
[30]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 49 36
[31]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 25 15
[32]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 40 38 47
[33]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 1.1e+02 3.2e+02
[34]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[35]
liver STAT1
Mean 55.8
Standard deviation 15
Values 38 69 49 67
[36]
ref_hepatocyte CDK4
Mean 18.5
Standard deviation 5.3
Values 16 19 27 18 13
[37]
HepG2 CDK4
Mean 103
Standard deviation 10
Values 1.1e+02 96
[38]
HepG2.C3A CDK4
Mean 137
Standard deviation 38
Values 1.6e+02 1.1e+02
[39]
HuH.7 CDK4
Mean 102
Standard deviation 34
Values 1.3e+02 67 1.1e+02
[40]
SNU475 CDK4
Mean 38.6
Standard deviation 1.1
Values 39 38
[41]
THLE CDK4
Mean 67.8
Standard deviation 14
Values 58 78
[42]
liver CDK4
Mean 14.8
Standard deviation 9.3
Values 5.5 8.2 21 24
[43]
ref_hepatocyte BAD
Mean 16.7
Standard deviation 11
Values 6.7 27 28 5.4 16
[44]
HepG2 BAD
Mean 11.6
Standard deviation 0.78
Values 12 11
[45]
HepG2.C3A BAD
Mean 11.3
Standard deviation 1.1
Values 12 10
[46]
HuH.7 BAD
Mean 5.61
Standard deviation 0.7
Values 5.5 6.4 5
[47]
SNU475 BAD
Mean 14.6
Standard deviation 2.5
Values 13 16
[48]
THLE BAD
Mean 21.6
Standard deviation 1.3
Values 21 23
[49]
liver BAD
Mean 8.85
Standard deviation 6.2
Values 3.7 3.7 16 12
[50]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 18 10 14 6.8 27
[51]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 56 40
[52]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 29 31
[53]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 29 32 36
[54]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 39 47
[55]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[56]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 62 75 54 58
[57]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 7.5 15 10 23 13
[58]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 26 31
[59]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 36 34
[60]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 37 42 35
[61]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 9.7 14
[62]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[63]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 12 14 9.9 5.8
[64]
ref_hepatocyte CASP3
Mean 12.5
Standard deviation 12
Values 6.8 5.1 4.9 33 13
[65]
HepG2 CASP3
Mean 30.3
Standard deviation 8.2
Values 36 25
[66]
HepG2.C3A CASP3
Mean 43.1
Standard deviation 22
Values 59 27
[67]
HuH.7 CASP3
Mean 7.08
Standard deviation 1
Values 7.8 7.5 5.9
[68]
SNU475 CASP3
Mean 12.3
Standard deviation 0.36
Values 12 13
[69]
THLE CASP3
Mean 27.6
Standard deviation 0.68
Values 27 28
[70]
liver CASP3
Mean 10.2
Standard deviation 4.2
Values 6.1 9 9.5 16
[71]
ref_hepatocyte CDK2
Mean 12.1
Standard deviation 11
Values 3.3 4.6 5.7 19 28
[72]
HepG2 CDK2
Mean 20
Standard deviation 3.4
Values 22 18
[73]
HepG2.C3A CDK2
Mean 20
Standard deviation 9.1
Values 26 14
[74]
HuH.7 CDK2
Mean 24.9
Standard deviation 12
Values 33 11 30
[75]
SNU475 CDK2
Mean 21.8
Standard deviation 2.6
Values 24 20
[76]
THLE CDK2
Mean 36.9
Standard deviation 5.3
Values 33 41
[77]
liver CDK2
Mean 3.76
Standard deviation 1.3
Values 3.2 2.3 4.4 5.2
[78]
ref_hepatocyte MSH6
Mean 10.9
Standard deviation 9.5
Values 4.3 3.6 4.4 23 19
[79]
HepG2 MSH6
Mean 30
Standard deviation 7.4
Values 35 25
[80]
HepG2.C3A MSH6
Mean 37.5
Standard deviation 7.9
Values 43 32
[81]
HuH.7 MSH6
Mean 41.5
Standard deviation 12
Values 47 28 50
[82]
SNU475 MSH6
Mean 37.5
Standard deviation 5.6
Values 41 34
[83]
THLE MSH6
Mean 56
Standard deviation 3.5
Values 54 59
[84]
liver MSH6
Mean 19
Standard deviation 6.7
Values 20 28 11 17
[85]
ref_hepatocyte MMP1
Mean 10.4
Standard deviation 23
Values 52 0.12 0.078 0 0.4
[86]
HepG2 MMP1
Mean 0.642
Standard deviation 0.089
Values 0.58 0.7
[87]
HepG2.C3A MMP1
Mean 0.0419
Standard deviation 0.032
Values 0.064 0.019
[88]
HuH.7 MMP1
Mean 0
Standard deviation 0
Values 0 0 0
[89]
SNU475 MMP1
Mean 5.69
Standard deviation 7.7
Values 11 0.27
[90]
THLE MMP1
Mean 4.66
Standard deviation 3.3
Values 2.4 7
[91]
liver MMP1
Mean 0.00331
Standard deviation 0.0066
Values 0.013 0 0 0
[92]
ref_hepatocyte CASP8
Mean 8.88
Standard deviation 6.8
Values 8.9 2.8 1.9 18 13
[93]
HepG2 CASP8
Mean 19.9
Standard deviation 3.1
Values 18 22
[94]
HepG2.C3A CASP8
Mean 26.3
Standard deviation 13
Values 35 17
[95]
HuH.7 CASP8
Mean 14.2
Standard deviation 3.6
Values 18 11 14
[96]
SNU475 CASP8
Mean 15.4
Standard deviation 0.7
Values 15 16
[97]
THLE CASP8
Mean 10.3
Standard deviation 0.97
Values 9.6 11
[98]
liver CASP8
Mean 4.72
Standard deviation 0.87
Values 5 5.2 3.4 5.3
[99]
ref_hepatocyte PTEN
Mean 6.57
Standard deviation 2.4
Values 5.2 11 7 4.2 5.9
[100]
HepG2 PTEN
Mean 9.98
Standard deviation 2.3
Values 12 8.4
[101]
HepG2.C3A PTEN
Mean 23.3
Standard deviation 3.3
Values 21 26
[102]
HuH.7 PTEN
Mean 25.7
Standard deviation 12
Values 19 39 19
[103]
SNU475 PTEN
Mean 8.16
Standard deviation 1.8
Values 6.9 9.4
[104]
THLE PTEN
Mean 21.8
Standard deviation 0.98
Values 22 21
[105]
liver PTEN
Mean 52
Standard deviation 9.3
Values 53 55 61 39
[106]
ref_hepatocyte MDM2
Mean 6.36
Standard deviation 2.9
Values 5 4.8 3.6 11 7.6
[107]
HepG2 MDM2
Mean 60.6
Standard deviation 13
Values 70 51
[108]
HepG2.C3A MDM2
Mean 145
Standard deviation 52
Values 1.8e+02 1.1e+02
[109]
HuH.7 MDM2
Mean 20.4
Standard deviation 0.31
Values 20 20 21
[110]
SNU475 MDM2
Mean 16.7
Standard deviation 1.8
Values 15 18
[111]
THLE MDM2
Mean 34.2
Standard deviation 0.86
Values 35 34
[112]
liver MDM2
Mean 40.5
Standard deviation 11
Values 45 54 29 35
[113]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 13 2.2 1.9 4.8 8.4
[114]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 40 60
[115]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 22 37
[116]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 28 41 31
[117]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 36 40
[118]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[119]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 13 7.4 12 7.1
[120]
ref_hepatocyte CDK1
Mean 5.78
Standard deviation 6.9
Values 0.06 0.72 1.6 13 14
[121]
HepG2 CDK1
Mean 30.4
Standard deviation 14
Values 40 21
[122]
HepG2.C3A CDK1
Mean 113
Standard deviation 85
Values 1.7e+02 53
[123]
HuH.7 CDK1
Mean 45.1
Standard deviation 21
Values 60 21 55
[124]
SNU475 CDK1
Mean 51.1
Standard deviation 5
Values 55 48
[125]
THLE CDK1
Mean 101
Standard deviation 11
Values 93 1.1e+02
[126]
liver CDK1
Mean 1.48
Standard deviation 1.4
Values 0.013 1.4 1 3.4
[127]
ref_hepatocyte CHEK2
Mean 5.74
Standard deviation 6.1
Values 4.2 1.1 1.7 16 5.5
[128]
HepG2 CHEK2
Mean 13.6
Standard deviation 0.16
Values 14 13
[129]
HepG2.C3A CHEK2
Mean 16.4
Standard deviation 6.4
Values 21 12
[130]
HuH.7 CHEK2
Mean 20.8
Standard deviation 7.6
Values 28 13 22
[131]
SNU475 CHEK2
Mean 8.87
Standard deviation 0.55
Values 9.3 8.5
[132]
THLE CHEK2
Mean 7.68
Standard deviation 1.3
Values 6.8 8.6
[133]
liver CHEK2
Mean 0.84
Standard deviation 0.33
Values 0.4 0.88 0.87 1.2
[134]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 6.2 5.5 5.5 5.5 3.7
[135]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[136]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 25 23
[137]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 46 20 50
[138]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 19 28
[139]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[140]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 5.6 5 9 9.5
[141]
ref_hepatocyte PLK1
Mean 4.92
Standard deviation 5.9
Values 0.65 0.48 1.1 13 9.1
[142]
HepG2 PLK1
Mean 61.1
Standard deviation 5.4
Values 65 57
[143]
HepG2.C3A PLK1
Mean 45.5
Standard deviation 17
Values 58 33
[144]
HuH.7 PLK1
Mean 39.6
Standard deviation 20
Values 47 17 55
[145]
SNU475 PLK1
Mean 21.4
Standard deviation 1.4
Values 22 20
[146]
THLE PLK1
Mean 49.2
Standard deviation 23
Values 33 65
[147]
liver PLK1
Mean 1.13
Standard deviation 1.1
Values 0.093 0.53 1.2 2.7
[148]
ref_hepatocyte ATF1
Mean 4.77
Standard deviation 1.6
Values 3.9 3.9 3.1 6.7 6.4
[149]
HepG2 ATF1
Mean 6.84
Standard deviation 1.3
Values 7.8 5.9
[150]
HepG2.C3A ATF1
Mean 14.5
Standard deviation 3.5
Values 17 12
[151]
HuH.7 ATF1
Mean 11.5
Standard deviation 1.2
Values 10 12 13
[152]
SNU475 ATF1
Mean 9.76
Standard deviation 0.062
Values 9.7 9.8
[153]
THLE ATF1
Mean 10.1
Standard deviation 1.6
Values 8.9 11
[154]
liver ATF1
Mean 4.86
Standard deviation 1.2
Values 3.4 4.8 5.1 6.2
[155]
ref_hepatocyte BBC3
Mean 4.09
Standard deviation 4.3
Values 11 1.3 3.2 3.6 0.92
[156]
HepG2 BBC3
Mean 15.1
Standard deviation 11
Values 7 23
[157]
HepG2.C3A BBC3
Mean 12.4
Standard deviation 9.8
Values 5.5 19
[158]
HuH.7 BBC3
Mean 8.39
Standard deviation 3.1
Values 7.8 12 5.7
[159]
SNU475 BBC3
Mean 1.08
Standard deviation 0.44
Values 0.77 1.4
[160]
THLE BBC3
Mean 2.04
Standard deviation 0.082
Values 2.1 2
[161]
liver BBC3
Mean 0.288
Standard deviation 0.11
Values 0.44 0.3 0.24 0.18
[162]
ref_hepatocyte MSH2
Mean 3.98
Standard deviation 3.2
Values 2.4 1.5 1.3 8.5 6.1
[163]
HepG2 MSH2
Mean 15.5
Standard deviation 8
Values 21 9.9
[164]
HepG2.C3A MSH2
Mean 33.8
Standard deviation 15
Values 45 23
[165]
HuH.7 MSH2
Mean 22.1
Standard deviation 10
Values 28 10 28
[166]
SNU475 MSH2
Mean 32
Standard deviation 6.8
Values 37 27
[167]
THLE MSH2
Mean 23.1
Standard deviation 1.9
Values 22 24
[168]
liver MSH2
Mean 3.5
Standard deviation 1.1
Values 2.9 4.8 2.3 4
[169]
ref_hepatocyte RAD50
Mean 3.85
Standard deviation 2.1
Values 2.3 2.8 2.9 3.9 7.4
[170]
HepG2 RAD50
Mean 9.45
Standard deviation 2.3
Values 11 7.9
[171]
HepG2.C3A RAD50
Mean 36.9
Standard deviation 0.99
Values 36 38
[172]
HuH.7 RAD50
Mean 19.7
Standard deviation 4.1
Values 15 22 22
[173]
SNU475 RAD50
Mean 17
Standard deviation 2.2
Values 19 15
[174]
THLE RAD50
Mean 26.8
Standard deviation 8.4
Values 33 21
[175]
liver RAD50
Mean 25.2
Standard deviation 5.7
Values 18 26 32 25
[176]
ref_hepatocyte CDC25B
Mean 3.7
Standard deviation 1.9
Values 1.4 1.9 4.9 5.6 4.7
[177]
HepG2 CDC25B
Mean 29.8
Standard deviation 3.6
Values 27 32
[178]
HepG2.C3A CDC25B
Mean 30.1
Standard deviation 0.9
Values 31 29
[179]
HuH.7 CDC25B
Mean 18.7
Standard deviation 7.4
Values 22 10 24
[180]
SNU475 CDC25B
Mean 44.8
Standard deviation 0.23
Values 45 45
[181]
THLE CDC25B
Mean 56.1
Standard deviation 11
Values 48 64
[182]
liver CDC25B
Mean 6.65
Standard deviation 3.5
Values 2.6 4.9 9 10
[183]
ref_hepatocyte BACH1
Mean 3.37
Standard deviation 1.7
Values 2.2 2.4 2.2 4 6
[184]
HepG2 BACH1
Mean 15.4
Standard deviation 2
Values 17 14
[185]
HepG2.C3A BACH1
Mean 17.2
Standard deviation 0.92
Values 18 17
[186]
HuH.7 BACH1
Mean 22.6
Standard deviation 5.9
Values 16 27 24
[187]
SNU475 BACH1
Mean 26.9
Standard deviation 2.6
Values 25 29
[188]
THLE BACH1
Mean 17.7
Standard deviation 0.89
Values 18 17
[189]
liver BACH1
Mean 29.7
Standard deviation 14
Values 32 48 16 22
[190]
ref_hepatocyte RB1
Mean 3.07
Standard deviation 1.4
Values 3 2.2 1.4 5 3.8
[191]
HepG2 RB1
Mean 15.8
Standard deviation 7.9
Values 21 10
[192]
HepG2.C3A RB1
Mean 19.9
Standard deviation 6.1
Values 24 16
[193]
HuH.7 RB1
Mean 28.2
Standard deviation 3.3
Values 28 25 32
[194]
SNU475 RB1
Mean 27.3
Standard deviation 0.91
Values 27 28
[195]
THLE RB1
Mean 38.3
Standard deviation 1.7
Values 37 40
[196]
liver RB1
Mean 12.1
Standard deviation 2.2
Values 9 14 12 13
[197]
ref_hepatocyte CASP9
Mean 2.59
Standard deviation 1
Values 2 4.4 2.7 1.9 1.9
[198]
HepG2 CASP9
Mean 6.38
Standard deviation 0.81
Values 7 5.8
[199]
HepG2.C3A CASP9
Mean 11.1
Standard deviation 0.21
Values 11 11
[200]
HuH.7 CASP9
Mean 5.76
Standard deviation 1.5
Values 6.6 4.1 6.7
[201]
SNU475 CASP9
Mean 5.65
Standard deviation 0.92
Values 5 6.3
[202]
THLE CASP9
Mean 3.94
Standard deviation 0.43
Values 3.6 4.2
[203]
liver CASP9
Mean 2.54
Standard deviation 1.2
Values 1.6 1.9 2.4 4.2
[204]
ref_hepatocyte SMAD2
Mean 2.54
Standard deviation 1.2
Values 1.9 1.6 1.9 4.5 2.8
[205]
HepG2 SMAD2
Mean 22.7
Standard deviation 2.3
Values 24 21
[206]
HepG2.C3A SMAD2
Mean 24.2
Standard deviation 1.1
Values 23 25
[207]
HuH.7 SMAD2
Mean 16.4
Standard deviation 1.6
Values 15 18 17
[208]
SNU475 SMAD2
Mean 24.3
Standard deviation 3.3
Values 22 27
[209]
THLE SMAD2
Mean 31
Standard deviation 0.65
Values 31 32
[210]
liver SMAD2
Mean 21.4
Standard deviation 6.7
Values 25 29 17 15
[211]
ref_hepatocyte E2F1
Mean 2.5
Standard deviation 3.1
Values 0.64 0.54 1.2 7.9 2.2
[212]
HepG2 E2F1
Mean 21.3
Standard deviation 1.8
Values 23 20
[213]
HepG2.C3A E2F1
Mean 17.2
Standard deviation 4.9
Values 21 14
[214]
HuH.7 E2F1
Mean 18
Standard deviation 12
Values 28 5.1 21
[215]
SNU475 E2F1
Mean 16.7
Standard deviation 4.8
Values 20 13
[216]
THLE E2F1
Mean 25.4
Standard deviation 2.4
Values 24 27
[217]
liver E2F1
Mean 0.29
Standard deviation 0.19
Values 0.15 0.49 0.12 0.41
[218]
ref_hepatocyte CHEK1
Mean 2.44
Standard deviation 1.9
Values 1.9 0.99 0.69 3.2 5.4
[219]
HepG2 CHEK1
Mean 15.6
Standard deviation 7.2
Values 21 11
[220]
HepG2.C3A CHEK1
Mean 17.9
Standard deviation 12
Values 26 9.6
[221]
HuH.7 CHEK1
Mean 12.7
Standard deviation 5.1
Values 16 6.8 15
[222]
SNU475 CHEK1
Mean 19.9
Standard deviation 4.6
Values 23 17
[223]
THLE CHEK1
Mean 26.2
Standard deviation 4.4
Values 23 29
[224]
liver CHEK1
Mean 0.851
Standard deviation 0.2
Values 0.64 1 0.73 1
[225]
ref_hepatocyte CDKN2B
Mean 2.34
Standard deviation 3.2
Values 3.5 0.081 0.4 0.3 7.5
[226]
HepG2 CDKN2B
Mean 6.66
Standard deviation 0.64
Values 6.2 7.1
[227]
HepG2.C3A CDKN2B
Mean 0.268
Standard deviation 0.076
Values 0.32 0.21
[228]
HuH.7 CDKN2B
Mean 3.7
Standard deviation 0.34
Values 3.8 3.3 4
[229]
SNU475 CDKN2B
Mean 9.59
Standard deviation 3.2
Values 7.3 12
[230]
THLE CDKN2B
Mean 13.3
Standard deviation 2
Values 15 12
[231]
liver CDKN2B
Mean 0.784
Standard deviation 0.26
Values 0.83 0.66 0.52 1.1
[232]
ref_hepatocyte CDC25A
Mean 2.04
Standard deviation 2.5
Values 1 0.37 0.26 6.2 2.3
[233]
HepG2 CDC25A
Mean 12.1
Standard deviation 2.6
Values 14 10
[234]
HepG2.C3A CDC25A
Mean 16.8
Standard deviation 9.8
Values 24 9.8
[235]
HuH.7 CDC25A
Mean 20.5
Standard deviation 10
Values 27 8.6 26
[236]
SNU475 CDC25A
Mean 4.76
Standard deviation 2.1
Values 6.2 3.3
[237]
THLE CDC25A
Mean 14.6
Standard deviation 2.2
Values 13 16
[238]
liver CDC25A
Mean 0.459
Standard deviation 0.38
Values 0.2 1 0.33 0.28
[239]
ref_hepatocyte NOXA1
Mean 1.89
Standard deviation 1.8
Values 1.3 3.9 3.9 0.22 0.24
[240]
HepG2 NOXA1
Mean 0.811
Standard deviation 0.3
Values 0.6 1
[241]
HepG2.C3A NOXA1
Mean 2.46
Standard deviation 1.3
Values 1.5 3.4
[242]
HuH.7 NOXA1
Mean 1.15
Standard deviation 0.47
Values 0.98 1.7 0.78
[243]
SNU475 NOXA1
Mean 0.661
Standard deviation 0.38
Values 0.39 0.93
[244]
THLE NOXA1
Mean 0.319
Standard deviation 0.23
Values 0.48 0.16
[245]
liver NOXA1
Mean 1.37
Standard deviation 0.56
Values 0.98 0.98 2.2 1.3
[246]
ref_hepatocyte BRCA1
Mean 1.87
Standard deviation 0.88
Values 0.59 2 2.6 2.7 1.4
[247]
HepG2 BRCA1
Mean 13.1
Standard deviation 3
Values 15 11
[248]
HepG2.C3A BRCA1
Mean 27.8
Standard deviation 18
Values 40 15
[249]
HuH.7 BRCA1
Mean 35
Standard deviation 16
Values 39 17 49
[250]
SNU475 BRCA1
Mean 15.2
Standard deviation 6.4
Values 20 11
[251]
THLE BRCA1
Mean 24.5
Standard deviation 0.48
Values 25 24
[252]
liver BRCA1
Mean 8.47
Standard deviation 9.4
Values 4.5 4.3 22 2.5
[253]
ref_hepatocyte ATR
Mean 1.48
Standard deviation 0.93
Values 0.87 0.82 1.1 1.5 3.1
[254]
HepG2 ATR
Mean 6.99
Standard deviation 2.6
Values 8.9 5.1
[255]
HepG2.C3A ATR
Mean 12.4
Standard deviation 3
Values 15 10
[256]
HuH.7 ATR
Mean 12.6
Standard deviation 3.2
Values 11 10 16
[257]
SNU475 ATR
Mean 15.7
Standard deviation 0.082
Values 16 16
[258]
THLE ATR
Mean 17.2
Standard deviation 1.5
Values 18 16
[259]
liver ATR
Mean 24.7
Standard deviation 14
Values 28 43 13 15
[260]
ref_hepatocyte MAP3K5
Mean 1.19
Standard deviation 0.96
Values 0.68 2.2 2.2 0 0.9
[261]
HepG2 MAP3K5
Mean 0.133
Standard deviation 0.055
Values 0.094 0.17
[262]
HepG2.C3A MAP3K5
Mean 0.0156
Standard deviation 0.0083
Values 0.021 0.0097
[263]
HuH.7 MAP3K5
Mean 0.888
Standard deviation 0.21
Values 0.67 0.92 1.1
[264]
SNU475 MAP3K5
Mean 0.598
Standard deviation 0.29
Values 0.81 0.39
[265]
THLE MAP3K5
Mean 14.1
Standard deviation 0.49
Values 14 14
[266]
liver MAP3K5
Mean 14
Standard deviation 6.9
Values 20 20 7.3 8.7
[267]
ref_hepatocyte ATM
Mean 0.969
Standard deviation 0.7
Values 0.27 1.1 0.7 2.1 0.69
[268]
HepG2 ATM
Mean 17.5
Standard deviation 8.3
Values 23 12
[269]
HepG2.C3A ATM
Mean 47.4
Standard deviation 4.5
Values 51 44
[270]
HuH.7 ATM
Mean 37.5
Standard deviation 9.1
Values 27 44 41
[271]
SNU475 ATM
Mean 31.7
Standard deviation 8.2
Values 26 38
[272]
THLE ATM
Mean 24.9
Standard deviation 4.4
Values 28 22
[273]
liver ATM
Mean 43.7
Standard deviation 31
Values 64 76 17 17
[274]
ref_hepatocyte POU2F1
Mean 0.484
Standard deviation 0.32
Values 0.31 0.51 0.34 1 0.23
[275]
HepG2 POU2F1
Mean 9.18
Standard deviation 1.7
Values 10 8
[276]
HepG2.C3A POU2F1
Mean 14.3
Standard deviation 0.65
Values 14 15
[277]
HuH.7 POU2F1
Mean 22.6
Standard deviation 6.4
Values 16 24 28
[278]
SNU475 POU2F1
Mean 15.4
Standard deviation 3.3
Values 13 18
[279]
THLE POU2F1
Mean 9.09
Standard deviation 0.13
Values 9.2 9
[280]
liver POU2F1
Mean 11.9
Standard deviation 6.1
Values 17 17 9 4.7
[281]
ref_hepatocyte BLM
Mean 0.47
Standard deviation 0.48
Values 0.16 0.18 0.18 1.3 0.54
[282]
HepG2 BLM
Mean 3.02
Standard deviation 1.6
Values 4.1 1.9
[283]
HepG2.C3A BLM
Mean 6.88
Standard deviation 4.6
Values 10 3.6
[284]
HuH.7 BLM
Mean 11.6
Standard deviation 6.1
Values 14 4.6 16
[285]
SNU475 BLM
Mean 6.41
Standard deviation 2.4
Values 8.1 4.7
[286]
THLE BLM
Mean 7.59
Standard deviation 0.46
Values 7.3 7.9
[287]
liver BLM
Mean 0.512
Standard deviation 0.32
Values 0.13 0.87 0.38 0.67
[288]
ref_hepatocyte BARD1
Mean 0.427
Standard deviation 0.62
Values 0 0 0.1 0.59 1.4
[289]
HepG2 BARD1
Mean 2.35
Standard deviation 1.5
Values 3.4 1.3
[290]
HepG2.C3A BARD1
Mean 4.15
Standard deviation 3.3
Values 6.4 1.8
[291]
HuH.7 BARD1
Mean 4.04
Standard deviation 1.6
Values 3.3 3 5.9
[292]
SNU475 BARD1
Mean 5.09
Standard deviation 0.31
Values 5.3 4.9
[293]
THLE BARD1
Mean 6.04
Standard deviation 1.7
Values 4.8 7.3
[294]
liver BARD1
Mean 2.22
Standard deviation 0.7
Values 2.5 3 1.4 1.9
[295]
ref_hepatocyte BCL2
Mean 0.0984
Standard deviation 0.087
Values 0.15 0.2 0.12 0.019 0
[296]
HepG2 BCL2
Mean 0.0301
Standard deviation 0.0061
Values 0.026 0.034
[297]
HepG2.C3A BCL2
Mean 1.13
Standard deviation 0.21
Values 0.99 1.3
[298]
HuH.7 BCL2
Mean 0.00642
Standard deviation 0.011
Values 0 0.019 0
[299]
SNU475 BCL2
Mean 0.618
Standard deviation 0.094
Values 0.68 0.55
[300]
THLE BCL2
Mean 0.568
Standard deviation 0.0088
Values 0.56 0.57
[301]
liver BCL2
Mean 1.31
Standard deviation 1
Values 2.5 1.8 0.49 0.49
[302]
ref_hepatocyte MRE11
Missing
[303]
HepG2 MRE11
Missing
[304]
HepG2.C3A MRE11
Missing
[305]
HuH.7 MRE11
Missing
[306]
SNU475 MRE11
Missing
[307]
THLE MRE11
Missing
[308]
liver MRE11
Missing
[309]
ref_hepatocyte MIR3191
Missing
[310]
HepG2 MIR3191
Missing
[311]
HepG2.C3A MIR3191
Missing
[312]
HuH.7 MIR3191
Missing
[313]
SNU475 MIR3191
Missing
[314]
THLE MIR3191
Missing
[315]
liver MIR3191
Missing