WP_IL7_SIGNALING_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 AKT1 RAC-alpha serine/threonine-protein kinase [1] -0.94[2] -0.44[3] -1.94[4] -0.72[5] -0.34[6] -0.98[7]
2 STAT3 Signal transducer and activator of transcription 3 [8] -0.47[9] -1.24[10] -0.92[11] -0.43[12] -0.79[13] 1.67[14]
3 MYC Myc proto-oncogene protein [15] -0.59[16] -0.20[17] -2.64[18] -3.46[19] -0.73[20] -2.74[21]
4 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 [22] -1.95[23] -1.55[24] -1.39[25] -1.22[26] -0.35[27] -1.93[28]
5 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 [29] -0.97[30] -0.56[31] -0.11[32] -1.52[33] -0.67[34] -2.44[35]
6 BCL2L1 Bcl-2-like protein 1 [36] 1.12[37] 1.24[38] 1.78[39] -1.29[40] -0.54[41] -1.56[42]
7 CCND1 G1/S-specific cyclin-D1 [43] 2.03[44] 0.26[45] 0.67[46] 1.21[47] 0.09[48] 0.32[49]
8 STAT1 Signal transducer and activator of transcription 1-alpha/beta [50] -1.10[51] -1.28[52] -0.59[53] 1.86[54] -0.05[55] 0.21[56]
9 BAD Bcl2-associated agonist of cell death [57] -2.69[58] -1.83[59] -3.20[60] -1.74[61] -0.98[62] -2.16[63]
10 JAK1 Tyrosine-protein kinase JAK1 [64] -0.51[65] -0.29[66] -0.53[67] -0.05[68] 0.96[69] 0.79[70]
11 CDKN1B Cyclin-dependent kinase inhibitor 1B [71] -1.11[72] 0.07[73] -0.15[74] -1.78[75] -0.96[76] -1.65[77]
12 MAPK1 Mitogen-activated protein kinase 1 [78] 0.69[79] 1.56[80] 0.97[81] 1.18[82] 1.19[83] 1.04[84]
13 PIK3R1 Phosphatidylinositol 3-kinase regulatory subunit alpha [85] -1.49[86] -0.64[87] 0.03[88] 1.39[89] 1.26[90] 2.26[91]
14 PIK3R2 Phosphatidylinositol 3-kinase regulatory subunit beta [92] 0.85[93] 1.81[94] 2.00[95] 0.03[96] 0.96[97] -1.03[98]
15 MAPK3 Mitogen-activated protein kinase 3 [99] 0.83[100] 1.61[101] 1.23[102] -0.25[103] 0.13[104] -1.78[105]
16 GSK3B Glycogen synthase kinase-3 beta [106] 0.24[107] 0.61[108] 0.77[109] 1.14[110] 1.33[111] 0.42[112]
17 STAT5B Signal transducer and activator of transcription 5B [113] 0.34[114] 0.70[115] 0.98[116] 0.88[117] 0.38[118] 0.88[119]
18 STAT5A Signal transducer and activator of transcription 5A [120] -2.97[121] -1.06[122] -2.41[123] -1.52[124] -0.40[125] -0.50[126]
19 FYN Tyrosine-protein kinase Fyn [127] -0.08[128] -7.95[129] 0.20[130] 0.80[131] 2.69[132] 0.23[133]
20 PTK2B Protein-tyrosine kinase 2-beta [134] -1.83[135] 0.26[136] 0.81[137] -2.45[138] 0.54[139] 1.03[140]
21 IL7 Interleukin-7 [141] -3.68[142] -1.47[143] -7.50[144] -6.47[145] -2.48[146] 0.56[147]
22 IL2RG Cytokine receptor common subunit gamma [148] -2.67[149] -3.83[150] -3.60[151] -4.27[152] [153] -0.85[154]
23 IL7R Interleukin-7 receptor subunit alpha [155] -5.26[156] -5.12[157] -5.63[158] 4.57[159] 4.84[160] 1.48[161]
24 JAK3 Tyrosine-protein kinase JAK3 [162] 1.22[163] 4.23[164] -2.20[165] -1.31[166] -0.21[167] 2.36[168]
25 IL2RA Interleukin-2 receptor subunit alpha [169] [170] -5.88[171] [172] -5.28[173] -6.82[174] -0.20[175]
[1]
ref_hepatocyte AKT1
Mean 37.6
Standard deviation 15
Values 19 32 31 55 50
[2]
HepG2 AKT1
Mean 87.8
Standard deviation 2.3
Values 86 89
[3]
HepG2.C3A AKT1
Mean 66.6
Standard deviation 2.4
Values 68 65
[4]
HuH.7 AKT1
Mean 30.2
Standard deviation 6.6
Values 35 23 33
[5]
SNU475 AKT1
Mean 66.6
Standard deviation 14
Values 57 76
[6]
THLE AKT1
Mean 75.8
Standard deviation 6.1
Values 72 80
[7]
liver AKT1
Mean 45.1
Standard deviation 25
Values 79 48 34 20
[8]
ref_hepatocyte STAT3
Mean 30.1
Standard deviation 11
Values 18 36 46 26 25
[9]
HepG2 STAT3
Mean 97.5
Standard deviation 10
Values 1e+02 90
[10]
HepG2.C3A STAT3
Mean 30.7
Standard deviation 5.2
Values 27 34
[11]
HuH.7 STAT3
Mean 49.1
Standard deviation 15
Values 35 65 47
[12]
SNU475 STAT3
Mean 65.4
Standard deviation 12
Values 57 74
[13]
THLE STAT3
Mean 44.3
Standard deviation 6
Values 40 49
[14]
liver STAT3
Mean 227
Standard deviation 42
Values 2e+02 2.3e+02 1.9e+02 2.8e+02
[15]
ref_hepatocyte MYC
Mean 29.9
Standard deviation 34
Values 89 1.4 23 15 20
[16]
HepG2 MYC
Mean 88.8
Standard deviation 53
Values 52 1.3e+02
[17]
HepG2.C3A MYC
Mean 62.6
Standard deviation 15
Values 52 73
[18]
HuH.7 MYC
Mean 14.7
Standard deviation 2.6
Values 14 18 13
[19]
SNU475 MYC
Mean 7.93
Standard deviation 1.4
Values 8.9 6.9
[20]
THLE MYC
Mean 46
Standard deviation 10
Values 39 53
[21]
liver MYC
Mean 10.6
Standard deviation 6
Values 5.5 5.9 18 13
[22]
ref_hepatocyte MAP2K1
Mean 28.1
Standard deviation 8.6
Values 32 27 15 27 39
[23]
HepG2 MAP2K1
Mean 32.6
Standard deviation 3.7
Values 30 35
[24]
HepG2.C3A MAP2K1
Mean 23.1
Standard deviation 0.39
Values 23 23
[25]
HuH.7 MAP2K1
Mean 33.2
Standard deviation 6.4
Values 40 27 33
[26]
SNU475 MAP2K1
Mean 35.5
Standard deviation 5.2
Values 39 32
[27]
THLE MAP2K1
Mean 56.5
Standard deviation 3.6
Values 54 59
[28]
liver MAP2K1
Mean 17.5
Standard deviation 8
Values 12 11 28 18
[29]
ref_hepatocyte MAP2K2
Mean 27.7
Standard deviation 8.5
Values 28 26 42 22 20
[30]
HepG2 MAP2K2
Mean 63.6
Standard deviation 21
Values 48 79
[31]
HepG2.C3A MAP2K2
Mean 45.2
Standard deviation 14
Values 36 55
[32]
HuH.7 MAP2K2
Mean 79.3
Standard deviation 9.5
Values 69 82 87
[33]
SNU475 MAP2K2
Mean 28.4
Standard deviation 0.16
Values 28 28
[34]
THLE MAP2K2
Mean 44.5
Standard deviation 0.75
Values 44 45
[35]
liver MAP2K2
Mean 12.1
Standard deviation 3
Values 11 11 17 9.8
[36]
ref_hepatocyte BCL2L1
Mean 26.8
Standard deviation 12
Values 34 16 23 16 44
[37]
HepG2 BCL2L1
Mean 260
Standard deviation 56
Values 2.2e+02 3e+02
[38]
HepG2.C3A BCL2L1
Mean 152
Standard deviation 4.3
Values 1.5e+02 1.5e+02
[39]
HuH.7 BCL2L1
Mean 283
Standard deviation 60
Values 3.2e+02 2.1e+02 3.1e+02
[40]
SNU475 BCL2L1
Mean 32.1
Standard deviation 4.1
Values 35 29
[41]
THLE BCL2L1
Mean 47
Standard deviation 4.7
Values 44 50
[42]
liver BCL2L1
Mean 21.6
Standard deviation 11
Values 14 9.8 31 31
[43]
ref_hepatocyte CCND1
Mean 23
Standard deviation 14
Values 19 12 11 44 28
[44]
HepG2 CCND1
Mean 421
Standard deviation 48
Values 3.9e+02 4.5e+02
[45]
HepG2.C3A CCND1
Mean 66.1
Standard deviation 12
Values 74 58
[46]
HuH.7 CCND1
Mean 113
Standard deviation 31
Values 1.2e+02 79 1.4e+02
[47]
SNU475 CCND1
Mean 155
Standard deviation 66
Values 2e+02 1.1e+02
[48]
THLE CCND1
Mean 62.5
Standard deviation 6.4
Values 67 58
[49]
liver CCND1
Mean 67.8
Standard deviation 49
Values 25 1.1e+02 26 1.1e+02
[50]
ref_hepatocyte STAT1
Mean 20.3
Standard deviation 8.7
Values 19 18 12 17 35
[51]
HepG2 STAT1
Mean 42.7
Standard deviation 9.4
Values 49 36
[52]
HepG2.C3A STAT1
Mean 20.1
Standard deviation 7.2
Values 25 15
[53]
HuH.7 STAT1
Mean 41.6
Standard deviation 4.5
Values 40 38 47
[54]
SNU475 STAT1
Mean 216
Standard deviation 1.4e+02
Values 1.1e+02 3.2e+02
[55]
THLE STAT1
Mean 50.3
Standard deviation 2.1
Values 49 52
[56]
liver STAT1
Mean 55.8
Standard deviation 15
Values 38 69 49 67
[57]
ref_hepatocyte BAD
Mean 16.7
Standard deviation 11
Values 6.7 27 28 5.4 16
[58]
HepG2 BAD
Mean 11.6
Standard deviation 0.78
Values 12 11
[59]
HepG2.C3A BAD
Mean 11.3
Standard deviation 1.1
Values 12 10
[60]
HuH.7 BAD
Mean 5.61
Standard deviation 0.7
Values 5.5 6.4 5
[61]
SNU475 BAD
Mean 14.6
Standard deviation 2.5
Values 13 16
[62]
THLE BAD
Mean 21.6
Standard deviation 1.3
Values 21 23
[63]
liver BAD
Mean 8.85
Standard deviation 6.2
Values 3.7 3.7 16 12
[64]
ref_hepatocyte JAK1
Mean 15.2
Standard deviation 7.8
Values 18 10 14 6.8 27
[65]
HepG2 JAK1
Mean 47.8
Standard deviation 11
Values 56 40
[66]
HepG2.C3A JAK1
Mean 29.8
Standard deviation 1.3
Values 29 31
[67]
HuH.7 JAK1
Mean 32.5
Standard deviation 3.3
Values 29 32 36
[68]
SNU475 JAK1
Mean 43.1
Standard deviation 5.5
Values 39 47
[69]
THLE JAK1
Mean 75.4
Standard deviation 6.9
Values 70 80
[70]
liver JAK1
Mean 62.3
Standard deviation 9.1
Values 62 75 54 58
[71]
ref_hepatocyte CDKN1B
Mean 13.8
Standard deviation 6
Values 7.5 15 10 23 13
[72]
HepG2 CDKN1B
Mean 28.7
Standard deviation 3.4
Values 26 31
[73]
HepG2.C3A CDKN1B
Mean 34.7
Standard deviation 1.4
Values 36 34
[74]
HuH.7 CDKN1B
Mean 38.2
Standard deviation 3.7
Values 37 42 35
[75]
SNU475 CDKN1B
Mean 11.8
Standard deviation 2.9
Values 9.7 14
[76]
THLE CDKN1B
Mean 18.2
Standard deviation 3.4
Values 16 21
[77]
liver CDKN1B
Mean 10.5
Standard deviation 3.5
Values 12 14 9.9 5.8
[78]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[79]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[80]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[81]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[82]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[83]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[84]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[85]
ref_hepatocyte PIK3R1
Mean 7.45
Standard deviation 3.9
Values 4.2 14 8.1 4.1 7.4
[86]
HepG2 PIK3R1
Mean 11.9
Standard deviation 3
Values 14 9.8
[87]
HepG2.C3A PIK3R1
Mean 11.5
Standard deviation 2.6
Values 13 9.6
[88]
HuH.7 PIK3R1
Mean 23.4
Standard deviation 8.6
Values 15 32 23
[89]
SNU475 PIK3R1
Mean 57.3
Standard deviation 32
Values 35 80
[90]
THLE PIK3R1
Mean 45.5
Standard deviation 1.5
Values 44 47
[91]
liver PIK3R1
Mean 84.8
Standard deviation 47
Values 1.4e+02 1e+02 64 32
[92]
ref_hepatocyte PIK3R2
Mean 5.25
Standard deviation 3.4
Values 3.1 3.8 4.9 11 3.2
[93]
HepG2 PIK3R2
Mean 42.5
Standard deviation 2.8
Values 41 44
[94]
HepG2.C3A PIK3R2
Mean 44.2
Standard deviation 13
Values 35 53
[95]
HuH.7 PIK3R2
Mean 64.7
Standard deviation 10
Values 64 55 75
[96]
SNU475 PIK3R2
Mean 15.7
Standard deviation 3.3
Values 13 18
[97]
THLE PIK3R2
Mean 26
Standard deviation 2.8
Values 24 28
[98]
liver PIK3R2
Mean 6.1
Standard deviation 1.7
Values 6.9 6 7.6 3.8
[99]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[100]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[101]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[102]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[103]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[104]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[105]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[106]
ref_hepatocyte GSK3B
Mean 4.16
Standard deviation 1.7
Values 4.9 2.1 2.7 5.2 5.9
[107]
HepG2 GSK3B
Mean 22.1
Standard deviation 6
Values 26 18
[108]
HepG2.C3A GSK3B
Mean 15.3
Standard deviation 2.3
Values 17 14
[109]
HuH.7 GSK3B
Mean 21.8
Standard deviation 5.6
Values 15 26 24
[110]
SNU475 GSK3B
Mean 26.9
Standard deviation 2.6
Values 25 29
[111]
THLE GSK3B
Mean 26.7
Standard deviation 2.9
Values 25 29
[112]
liver GSK3B
Mean 13.2
Standard deviation 3.2
Values 16 15 14 8.6
[113]
ref_hepatocyte STAT5B
Mean 3.99
Standard deviation 1.3
Values 2.3 5.6 4.6 4.1 3.3
[114]
HepG2 STAT5B
Mean 22.6
Standard deviation 6.3
Values 18 27
[115]
HepG2.C3A STAT5B
Mean 15.5
Standard deviation 4
Values 13 18
[116]
HuH.7 STAT5B
Mean 24.2
Standard deviation 2.2
Values 26 22 25
[117]
SNU475 STAT5B
Mean 21.5
Standard deviation 4
Values 19 24
[118]
THLE STAT5B
Mean 13.3
Standard deviation 0.2
Values 13 13
[119]
liver STAT5B
Mean 17.5
Standard deviation 4.7
Values 22 21 13 14
[120]
ref_hepatocyte STAT5A
Mean 2.36
Standard deviation 1.6
Values 5 0.95 1.5 1.8 2.7
[121]
HepG2 STAT5A
Mean 1.35
Standard deviation 0.098
Values 1.3 1.4
[122]
HepG2.C3A STAT5A
Mean 2.72
Standard deviation 0.23
Values 2.9 2.6
[123]
HuH.7 STAT5A
Mean 1.37
Standard deviation 0.38
Values 1.2 1.8 1.1
[124]
SNU475 STAT5A
Mean 2.42
Standard deviation 0.13
Values 2.3 2.5
[125]
THLE STAT5A
Mean 4.58
Standard deviation 0.3
Values 4.8 4.4
[126]
liver STAT5A
Mean 3.96
Standard deviation 1.5
Values 6.2 3.5 3 3.3
[127]
ref_hepatocyte FYN
Mean 2.1
Standard deviation 2.2
Values 0.23 5.5 2.6 2.2 0.039
[128]
HepG2 FYN
Mean 8.91
Standard deviation 0.7
Values 8.4 9.4
[129]
HepG2.C3A FYN
Mean 0.0204
Standard deviation 0.0014
Values 0.021 0.019
[130]
HuH.7 FYN
Mean 7.43
Standard deviation 2.2
Values 8.5 4.8 8.9
[131]
SNU475 FYN
Mean 10.7
Standard deviation 2.5
Values 8.9 12
[132]
THLE FYN
Mean 34.5
Standard deviation 4.9
Values 38 31
[133]
liver FYN
Mean 5.84
Standard deviation 2.1
Values 5 4.4 8.9 5.1
[134]
ref_hepatocyte PTK2B
Mean 1.68
Standard deviation 1.2
Values 2.1 3.2 2.2 0.39 0.56
[135]
HepG2 PTK2B
Mean 2.13
Standard deviation 0.072
Values 2.1 2.2
[136]
HepG2.C3A PTK2B
Mean 4.85
Standard deviation 0.49
Values 4.5 5.2
[137]
HuH.7 PTK2B
Mean 9.07
Standard deviation 0.34
Values 8.8 8.9 9.5
[138]
SNU475 PTK2B
Mean 0.901
Standard deviation 0.46
Values 0.57 1.2
[139]
THLE PTK2B
Mean 6.23
Standard deviation 0.98
Values 6.9 5.5
[140]
liver PTK2B
Mean 8.17
Standard deviation 0.99
Values 9.4 7.3 8.5 7.4
[141]
ref_hepatocyte IL7
Mean 1.1
Standard deviation 0.7
Values 1.1 2.2 1.1 1 0.18
[142]
HepG2 IL7
Mean 0.386
Standard deviation 0.18
Values 0.51 0.26
[143]
HepG2.C3A IL7
Mean 0.954
Standard deviation 0.44
Values 1.3 0.64
[144]
HuH.7 IL7
Mean 0.0187
Standard deviation 0.017
Values 0.0094 0.039 0.0082
[145]
SNU475 IL7
Mean 0.0363
Standard deviation 0.0011
Values 0.035 0.037
[146]
THLE IL7
Mean 0.502
Standard deviation 0.13
Values 0.41 0.6
[147]
liver IL7
Mean 3.86
Standard deviation 1.5
Values 5.3 2.8 4.9 2.4
[148]
ref_hepatocyte IL2RG
Mean 1.04
Standard deviation 1.2
Values 0.89 3 1.3 0 0
[149]
HepG2 IL2RG
Mean 0.733
Standard deviation 0.88
Values 0.11 1.4
[150]
HepG2.C3A IL2RG
Mean 0.176
Standard deviation 0.067
Values 0.13 0.22
[151]
HuH.7 IL2RG
Mean 0.264
Standard deviation 0.039
Values 0.31 0.24 0.25
[152]
SNU475 IL2RG
Mean 0.158
Standard deviation 0.092
Values 0.22 0.093
[153]
THLE IL2RG
Mean 0
Standard deviation 0
Values 0 0
[154]
liver IL2RG
Mean 1.37
Standard deviation 1.1
Values 0.41 0.51 2.4 2.2
[155]
ref_hepatocyte IL7R
Mean 0.372
Standard deviation 0.35
Values 0.72 0.62 0 0 0.52
[156]
HepG2 IL7R
Mean 0.0437
Standard deviation 0.044
Values 0.013 0.074
[157]
HepG2.C3A IL7R
Mean 0.0258
Standard deviation 0.009
Values 0.032 0.019
[158]
HuH.7 IL7R
Mean 0.0232
Standard deviation 0.02
Values 0.037 0.032 0
[159]
SNU475 IL7R
Mean 25.9
Standard deviation 8
Values 32 20
[160]
THLE IL7R
Mean 27.3
Standard deviation 0.78
Values 27 28
[161]
liver IL7R
Mean 2.45
Standard deviation 1
Values 3.7 1.8 2.8 1.4
[162]
ref_hepatocyte JAK3
Mean 0.235
Standard deviation 0.23
Values 0.15 0.31 0.078 0.61 0.026
[163]
HepG2 JAK3
Mean 2.46
Standard deviation 0.35
Values 2.2 2.7
[164]
HepG2.C3A JAK3
Mean 10.6
Standard deviation 4.3
Values 7.6 14
[165]
HuH.7 JAK3
Mean 0.158
Standard deviation 0.069
Values 0.12 0.24 0.11
[166]
SNU475 JAK3
Mean 0.279
Standard deviation 0.0072
Values 0.28 0.27
[167]
THLE JAK3
Mean 0.519
Standard deviation 0.094
Values 0.59 0.45
[168]
liver JAK3
Mean 2.86
Standard deviation 0.73
Values 3.9 2.2 2.8 2.5
[169]
ref_hepatocyte IL2RA
Mean 0.131
Standard deviation 0.1
Values 0.19 0.057 0 0.15 0.26
[170]
HepG2 IL2RA
Mean 0
Standard deviation 0
Values 0 0
[171]
HepG2.C3A IL2RA
Mean 0.00536
Standard deviation 0.0076
Values 0.011 0
[172]
HuH.7 IL2RA
Mean 0
Standard deviation 0
Values 0 0 0
[173]
SNU475 IL2RA
Mean 0.00992
Standard deviation 0.0075
Values 0.015 0.0046
[174]
THLE IL2RA
Mean 0.00296
Standard deviation 0.0042
Values 0.0059 0
[175]
liver IL2RA
Mean 0.27
Standard deviation 0.33
Values 0.75 0.2 0.024 0.1