WP_IL5_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | JUN | Transcription factor AP-1 | [8] | 0.83[9] | -0.54[10] | -0.50[11] | -0.72[12] | 0.01[13] | -0.88[14] |
3 | FOS | Proto-oncogene c-Fos | [15] | -4.70[16] | -3.26[17] | -4.15[18] | -5.18[19] | -3.95[20] | -0.38[21] |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | [22] | 1.40[23] | 1.34[24] | 0.03[25] | 0.94[26] | 1.12[27] | 0.68[28] |
5 | STAT3 | Signal transducer and activator of transcription 3 | [29] | 1.87[30] | 0.54[31] | 1.05[32] | 1.23[33] | 0.66[34] | 3.33[35] |
6 | MYC | Myc proto-oncogene protein | [36] | 1.74[37] | 1.58[38] | -0.68[39] | -1.80[40] | 0.73[41] | -1.07[42] |
7 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [43] | 0.39[44] | 0.23[45] | 0.58[46] | 0.44[47] | 1.11[48] | -0.26[49] |
8 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [50] | 1.37[51] | 1.22[52] | 1.86[53] | 0.14[54] | 0.79[55] | -0.77[56] |
9 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [57] | 1.76[58] | 2.37[59] | 2.09[60] | 1.88[61] | 2.67[62] | 2.19[63] |
10 | GRB2 | Growth factor receptor-bound protein 2 | [64] | 2.51[65] | 2.52[66] | 2.41[67] | 1.54[68] | 1.62[69] | 1.23[70] |
11 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [71] | 1.24[72] | 0.50[73] | 1.38[74] | 3.52[75] | 1.41[76] | 1.88[77] |
12 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [78] | [79] | [80] | [81] | [82] | [83] | [84] |
13 | SHC1 | SHC-transforming protein 1 | [85] | 2.48[86] | 2.87[87] | 2.72[88] | 3.64[89] | 3.28[90] | 1.71[91] |
14 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [92] | 1.25[93] | 1.83[94] | 2.87[95] | 0.80[96] | 1.83[97] | 2.02[98] |
15 | JAK1 | Tyrosine-protein kinase JAK1 | [99] | 1.83[100] | 1.49[101] | 1.44[102] | 1.61[103] | 2.42[104] | 2.46[105] |
16 | MAPK1 | Mitogen-activated protein kinase 1 | [106] | 3.02[107] | 3.34[108] | 2.93[109] | 2.84[110] | 2.64[111] | 2.70[112] |
17 | GSK3A | Glycogen synthase kinase-3 alpha | [113] | 1.94[114] | 1.85[115] | 1.72[116] | 1.07[117] | 1.99[118] | -0.90[119] |
18 | KRAS | GTPase KRas | [120] | 0.80[121] | 0.96[122] | 2.32[123] | 1.79[124] | 1.61[125] | 1.60[126] |
19 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [127] | 0.84[128] | 1.14[129] | 2.00[130] | 3.05[131] | 2.72[132] | 3.93[133] |
20 | SOS1 | Son of sevenless homolog 1 | [134] | 1.21[135] | 2.92[136] | 2.20[137] | 1.83[138] | 1.23[139] | 1.47[140] |
21 | ELK1 | ETS domain-containing protein Elk-1 | [141] | 1.00[142] | -0.96[143] | 1.23[144] | 1.26[145] | 2.01[146] | 0.76[147] |
22 | LYN | Tyrosine-protein kinase Lyn | [148] | 0.45[149] | 0.45[150] | 0.75[151] | 2.04[152] | 0.96[153] | 0.94[154] |
23 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [155] | 3.19[156] | 3.59[157] | 3.97[158] | 1.69[159] | 2.41[160] | 0.64[161] |
24 | RPS6KA1 | Ribosomal protein S6 kinase alpha-1 | [162] | [163] | [164] | [165] | [166] | [167] | [168] |
25 | MAPK3 | Mitogen-activated protein kinase 3 | [169] | 3.16[170] | 3.39[171] | 3.20[172] | 1.41[173] | 1.59[174] | -0.11[175] |
26 | GSK3B | Glycogen synthase kinase-3 beta | [176] | 2.58[177] | 2.39[178] | 2.73[179] | 2.80[180] | 2.79[181] | 2.09[182] |
27 | STAT5B | Signal transducer and activator of transcription 5B | [183] | 2.67[184] | 2.47[185] | 2.94[186] | 2.54[187] | 1.84[188] | 2.55[189] |
28 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [190] | [191] | [192] | [193] | [194] | [195] | [196] |
29 | FOXO3 | Forkhead box protein O3 | [197] | 1.77[198] | 2.04[199] | 2.44[200] | 1.39[201] | 2.79[202] | 3.26[203] |
30 | STAT5A | Signal transducer and activator of transcription 5A | [204] | -0.63[205] | 0.72[206] | -0.45[207] | 0.14[208] | 1.06[209] | 1.16[210] |
31 | JAK2 | Tyrosine-protein kinase JAK2 | [211] | 1.54[212] | 1.71[213] | 1.04[214] | 1.75[215] | 2.51[216] | 3.63[217] |
32 | SPRED1 | Sprouty-related, EVH1 domain-containing protein 1 | [218] | 3.73[219] | 4.42[220] | 4.10[221] | 4.96[222] | 5.61[223] | 3.72[224] |
33 | MAPT | Microtubule-associated protein tau | [225] | 3.84[226] | 3.96[227] | 3.03[228] | 2.32[229] | -0.58[230] | 1.26[231] |
34 | SYK | Tyrosine-protein kinase SYK | [232] | -6.85[233] | -0.80[234] | -4.05[235] | 1.09[236] | -2.27[237] | 4.29[238] |
35 | BTK | Tyrosine-protein kinase BTK | [239] | -6.07[240] | [241] | 0.72[242] | -2.02[243] | -4.09[244] | 2.75[245] |
36 | CSF2RB | Cytokine receptor common subunit beta | [246] | [247] | [248] | [249] | -5.16[250] | -2.69[251] | 3.79[252] |
37 | BCL2 | Apoptosis regulator Bcl-2 | [253] | -1.54[254] | 4.04[255] | -3.60[256] | 2.76[257] | 2.64[258] | 4.16[259] |
38 | PIK3CG | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | [260] | [261] | [262] | 2.33[263] | -2.40[264] | 5.03[265] | |
39 | IL5RA | Interleukin-5 receptor subunit alpha | [266] | [267] | [268] | [269] | 0.40[270] | 0.65[271] | 3.26[272] |
40 | IL2 | Interleukin-2 | [273] | [274] | [275] | [276] | [277] | [278] | [279] |