WP_IL4_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | NFKBIA | NF-kappa-B inhibitor alpha | [1] | -1.76[2] | -3.18[3] | -3.53[4] | -4.82[5] | -2.34[6] | -1.80[7] |
2 | FOS | Proto-oncogene c-Fos | [8] | -6.71[9] | -5.08[10] | -5.71[11] | -7.47[12] | -5.80[13] | -1.97[14] |
3 | AKT1 | RAC-alpha serine/threonine-protein kinase | [15] | -0.62[16] | -0.48[17] | -1.53[18] | -1.35[19] | -0.73[20] | -0.91[21] |
4 | CEBPB | CCAAT/enhancer-binding protein beta | [22] | -1.87[23] | -2.14[24] | -2.08[25] | -2.71[26] | -1.18[27] | -2.34[28] |
5 | CEBPA | CCAAT/enhancer-binding protein alpha | [29] | -0.36[30] | -1.20[31] | 1.05[32] | -8.32[33] | -8.07[34] | -0.70[35] |
6 | STAT3 | Signal transducer and activator of transcription 3 | [36] | -0.15[37] | -1.28[38] | -0.51[39] | -1.06[40] | -1.19[41] | 1.74[42] |
7 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [43] | -0.25[44] | 0.54[45] | 0.53[46] | -0.41[47] | 0.82[48] | 0.59[49] |
8 | GRB2 | Growth factor receptor-bound protein 2 | [50] | 0.50[51] | 0.70[52] | 0.85[53] | -0.74[54] | -0.23[55] | -0.37[56] |
9 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [57] | -0.77[58] | -1.32[59] | -0.18[60] | 1.23[61] | -0.44[62] | 0.28[63] |
10 | NFIL3 | Nuclear factor interleukin-3-regulated protein | [64] | -1.21[65] | 0.00[66] | -0.26[67] | -3.56[68] | -2.13[69] | -2.80[70] |
11 | BAD | Bcl2-associated agonist of cell death | [71] | -2.37[72] | -1.87[73] | -2.79[74] | -2.36[75] | -1.37[76] | -2.09[77] |
12 | SHC1 | SHC-transforming protein 1 | [78] | 0.46[79] | 1.05[80] | 1.16[81] | 1.35[82] | 1.43[83] | 0.11[84] |
13 | RELA | Transcription factor p65 | [85] | -0.57[86] | -0.70[87] | -0.53[88] | -1.35[89] | -0.85[90] | -1.55[91] |
14 | STAT6 | Signal transducer and activator of transcription 6 | [92] | -0.35[93] | 0.26[94] | -0.80[95] | -0.45[96] | 0.04[97] | 0.03[98] |
15 | JAK1 | Tyrosine-protein kinase JAK1 | [99] | -0.19[100] | -0.33[101] | -0.12[102] | -0.67[103] | 0.57[104] | 0.86[105] |
16 | FLNA | Filamin-A | [106] | 3.43[107] | 2.26[108] | -0.66[109] | 4.25[110] | 3.48[111] | 1.49[112] |
17 | IL4R | Interleukin-4 receptor subunit alpha | [113] | -0.09[114] | -0.33[115] | -0.95[116] | -2.50[117] | -1.54[118] | -0.04[119] |
18 | SOCS3 | Suppressor of cytokine signaling 3 | [120] | -4.84[121] | -4.88[122] | -3.13[123] | -2.10[124] | -2.58[125] | -0.53[126] |
19 | MAPK1 | Mitogen-activated protein kinase 1 | [127] | 1.01[128] | 1.51[129] | 1.38[130] | 0.55[131] | 0.79[132] | 1.11[133] |
20 | MAPK14 | Mitogen-activated protein kinase 14 | [134] | 0.77[135] | 1.21[136] | 0.82[137] | 0.38[138] | 0.45[139] | 0.62[140] |
21 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [141] | -0.06[142] | 1.35[143] | 1.62[144] | -0.52[145] | -0.15[146] | 0.36[147] |
22 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [148] | -1.17[149] | -0.69[150] | 0.44[151] | 0.77[152] | 0.87[153] | 2.34[154] |
23 | BIRC5 | Baculoviral IAP repeat-containing protein 5 | [155] | 0.88[156] | 1.69[157] | 1.68[158] | -0.62[159] | 0.81[160] | -2.98[161] |
24 | SOS1 | Son of sevenless homolog 1 | [162] | -0.80[163] | 1.10[164] | 0.64[165] | -0.45[166] | -0.63[167] | -0.13[168] |
25 | ELK1 | ETS domain-containing protein Elk-1 | [169] | -1.01[170] | -2.78[171] | -0.33[172] | -1.02[173] | 0.16[174] | -0.83[175] |
26 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [176] | -0.03[177] | 0.01[178] | -0.16[179] | -1.55[180] | -0.04[181] | -0.22[182] |
27 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [183] | -1.16[184] | -0.60[185] | 0.01[186] | -8.44[187] | -2.82[188] | -0.85[189] |
28 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [190] | 1.17[191] | 1.76[192] | 2.41[193] | -0.59[194] | 0.56[195] | -0.96[196] |
29 | TYK2 | Non-receptor tyrosine-protein kinase TYK2 | [197] | 0.44[198] | 1.16[199] | 1.33[200] | -0.55[201] | 0.97[202] | 1.32[203] |
30 | MAPK3 | Mitogen-activated protein kinase 3 | [204] | 1.15[205] | 1.56[206] | 1.64[207] | -0.88[208] | -0.26[209] | -1.71[210] |
31 | STAT5B | Signal transducer and activator of transcription 5B | [211] | 0.66[212] | 0.65[213] | 1.38[214] | 0.25[215] | -0.01[216] | 0.96[217] |
32 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [218] | 0.20[219] | 1.79[220] | 1.78[221] | -0.65[222] | 0.76[223] | 0.85[224] |
33 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [225] | -0.18[226] | 0.25[227] | 0.38[228] | -1.04[229] | -0.35[230] | 0.52[231] |
34 | FES | Tyrosine-protein kinase Fes/Fps | [232] | 0.08[233] | -1.55[234] | -1.16[235] | -7.91[236] | -3.03[237] | 0.52[238] |
35 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [239] | [240] | [241] | [242] | [243] | [244] | [245] |
36 | IRS1 | Insulin receptor substrate 1 | [246] | 1.39[247] | 1.20[248] | 2.66[249] | 0.41[250] | 0.58[251] | 1.45[252] |
37 | EP300 | Histone acetyltransferase p300 | [253] | 2.02[254] | 1.98[255] | 2.91[256] | 1.27[257] | 1.92[258] | 2.09[259] |
38 | STAT5A | Signal transducer and activator of transcription 5A | [260] | -2.65[261] | -1.11[262] | -2.01[263] | -2.14[264] | -0.79[265] | -0.43[266] |
39 | SOCS5 | Suppressor of cytokine signaling 5 | [267] | 0.09[268] | 1.63[269] | 1.14[270] | 0.98[271] | 0.94[272] | 0.42[273] |
40 | IRS2 | Insulin receptor substrate 2 | [274] | -6.35[275] | [276] | -3.10[277] | -1.96[278] | 2.46[279] | 1.72[280] |
41 | SOCS1 | Suppressor of cytokine signaling 1 | [281] | -2.15[282] | -0.91[283] | -0.61[284] | -3.09[285] | -3.88[286] | -2.13[287] |
42 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | -1.08[288] | 0.93[289] | 1.15[290] | -0.17[291] | 0.63[292] | 1.25[293] | |
43 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.19[294] | 2.64[295] | -1.14[296] | -1.02[297] | 0.34[298] | -0.37[299] | |
44 | GAB2 | GRB2-associated-binding protein 2 | [300] | 0.86[301] | 1.02[302] | 1.30[303] | -0.38[304] | 0.31[305] | -0.12[306] |
45 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [307] | 3.15[308] | 3.91[309] | -6.25[310] | -6.96[311] | -3.42[312] | 0.61[313] |
46 | IL2RG | Cytokine receptor common subunit gamma | [314] | -2.35[315] | -3.87[316] | -3.19[317] | -4.89[318] | [319] | -0.77[320] |
47 | JAK2 | Tyrosine-protein kinase JAK2 | [321] | -0.47[322] | -0.11[323] | -0.52[324] | -0.54[325] | 0.66[326] | 2.04[327] |
48 | CBL | E3 ubiquitin-protein ligase CBL | [328] | 3.75[329] | 3.06[330] | 3.31[331] | 3.84[332] | 3.91[333] | 3.09[334] |
49 | DOK2 | Docking protein 2 | [335] | -5.55[336] | -5.79[337] | -6.59[338] | -8.77[339] | -9.21[340] | 0.97[341] |
50 | MAPK11 | Mitogen-activated protein kinase 11 | [342] | -0.87[343] | -0.61[344] | -1.47[345] | -0.94[346] | 1.65[347] | -0.50[348] |
51 | JAK3 | Tyrosine-protein kinase JAK3 | [349] | 1.55[350] | 4.19[351] | -1.79[352] | -1.93[353] | -0.60[354] | 2.43[355] |
52 | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3 | [356] | -4.89[357] | [358] | 2.41[359] | 0.01[360] | 0.73[361] | 0.55[362] |
53 | HRH1 | Histamine H1 receptor | [363] | -0.90[364] | -0.63[365] | -1.87[366] | 5.04[367] | 6.45[368] | 1.75[369] |
54 | MIR1281 | [370] | [371] | [372] | [373] | [374] | [375] | [376] | |
55 | IL4 | Interleukin-4 | [377] | [378] | [379] | [380] | [381] | [382] | [383] |