WP_IL3_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | YWHAQ | 14-3-3 protein theta | [1] | -0.37[2] | -0.39[3] | -0.72[4] | 0.67[5] | 0.19[6] | -1.07[7] |
2 | JUN | Transcription factor AP-1 | [8] | -1.13[9] | -2.50[10] | -2.26[11] | -2.39[12] | -1.62[13] | -2.28[14] |
3 | YWHAB | 14-3-3 protein beta/alpha | [15] | 0.40[16] | 0.28[17] | -0.47[18] | 0.62[19] | 0.25[20] | -0.56[21] |
4 | FOS | Proto-oncogene c-Fos | [22] | -6.65[23] | -5.22[24] | -5.92[25] | -6.85[26] | -5.59[27] | -1.77[28] |
5 | AKT1 | RAC-alpha serine/threonine-protein kinase | [29] | -0.56[30] | -0.62[31] | -1.73[32] | -0.73[33] | -0.52[34] | -0.71[35] |
6 | STAT3 | Signal transducer and activator of transcription 3 | [36] | -0.09[37] | -1.41[38] | -0.71[39] | -0.44[40] | -0.97[41] | 1.94[42] |
7 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [43] | -1.57[44] | -1.72[45] | -1.18[46] | -1.23[47] | -0.52[48] | -1.66[49] |
8 | BCL2L1 | Bcl-2-like protein 1 | [50] | 1.50[51] | 1.06[52] | 1.98[53] | -1.30[54] | -0.72[55] | -1.28[56] |
9 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [57] | -0.19[58] | 0.41[59] | 0.33[60] | 0.21[61] | 1.03[62] | 0.79[63] |
10 | GRB2 | Growth factor receptor-bound protein 2 | [64] | 0.56[65] | 0.57[66] | 0.65[67] | -0.13[68] | -0.02[69] | -0.17[70] |
11 | BAD | Bcl2-associated agonist of cell death | [71] | -2.31[72] | -2.01[73] | -2.99[74] | -1.75[75] | -1.15[76] | -1.89[77] |
12 | SHC1 | SHC-transforming protein 1 | [78] | 0.53[79] | 0.92[80] | 0.96[81] | 1.97[82] | 1.65[83] | 0.31[84] |
13 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [85] | -0.80[86] | -0.81[87] | -0.84[88] | -1.15[89] | -0.37[90] | -1.25[91] |
14 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [92] | -0.70[93] | -0.12[94] | 1.11[95] | -0.87[96] | 0.19[97] | 0.63[98] |
15 | JAK1 | Tyrosine-protein kinase JAK1 | [99] | -0.12[100] | -0.47[101] | -0.32[102] | -0.06[103] | 0.78[104] | 1.06[105] |
16 | HRAS | GTPase HRas | [106] | -1.65[107] | -2.18[108] | -3.01[109] | -1.63[110] | -1.65[111] | -3.13[112] |
17 | MAPK1 | Mitogen-activated protein kinase 1 | [113] | 1.07[114] | 1.38[115] | 1.17[116] | 1.17[117] | 1.01[118] | 1.31[119] |
18 | CRKL | Crk-like protein | [120] | 1.07[121] | 1.33[122] | 1.90[123] | 0.44[124] | 0.84[125] | 0.99[126] |
19 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [127] | -1.11[128] | -0.82[129] | 0.23[130] | 1.38[131] | 1.08[132] | 2.53[133] |
20 | MAPK8 | Mitogen-activated protein kinase 8 | [134] | -2.08[135] | -0.50[136] | -1.67[137] | -1.59[138] | -1.54[139] | -0.98[140] |
21 | SOS1 | Son of sevenless homolog 1 | [141] | -0.74[142] | 0.96[143] | 0.43[144] | 0.16[145] | -0.41[146] | 0.07[147] |
22 | LYN | Tyrosine-protein kinase Lyn | [148] | -1.50[149] | -1.51[150] | -1.01[151] | 0.37[152] | -0.68[153] | -0.45[154] |
23 | PTPN6 | Tyrosine-protein phosphatase non-receptor type 6 | [155] | -1.10[156] | -0.74[157] | -0.20[158] | -7.82[159] | -2.61[160] | -0.65[161] |
24 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [162] | 1.24[163] | 1.63[164] | 2.20[165] | 0.02[166] | 0.78[167] | -0.76[168] |
25 | RAPGEF1 | Rap guanine nucleotide exchange factor 1 | [169] | 1.45[170] | 1.45[171] | 1.13[172] | 0.57[173] | 0.44[174] | 0.71[175] |
26 | MAPK3 | Mitogen-activated protein kinase 3 | [176] | 1.21[177] | 1.43[178] | 1.43[179] | -0.26[180] | -0.05[181] | -1.51[182] |
27 | STAT5B | Signal transducer and activator of transcription 5B | [183] | 0.72[184] | 0.52[185] | 1.18[186] | 0.87[187] | 0.20[188] | 1.16[189] |
28 | SRC | Proto-oncogene tyrosine-protein kinase Src | [190] | 2.39[191] | 2.54[192] | 1.51[193] | 1.72[194] | 1.09[195] | -1.32[196] |
29 | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 | -0.57[197] | 1.72[198] | -3.69[199] | -4.75[200] | -6.69[201] | -2.45[202] | |
30 | STAT5A | Signal transducer and activator of transcription 5A | [203] | -2.59[204] | -1.24[205] | -2.21[206] | -1.53[207] | -0.58[208] | -0.23[209] |
31 | TGFB1 | Transforming growth factor beta-1 | [210] | 2.83[211] | 1.97[212] | -0.82[213] | 3.15[214] | 2.58[215] | -1.70[216] |
32 | FYN | Tyrosine-protein kinase Fyn | [217] | 0.31[218] | -8.12[219] | 0.41[220] | 0.79[221] | 2.51[222] | 0.50[223] |
33 | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1.25[224] | 2.51[225] | -1.34[226] | -0.40[227] | 0.56[228] | -0.17[229] | |
34 | GAB2 | GRB2-associated-binding protein 2 | [230] | 0.93[231] | 0.89[232] | 1.10[233] | 0.24[234] | 0.52[235] | 0.08[236] |
35 | HCK | Tyrosine-protein kinase HCK | [237] | -6.48[238] | -6.49[239] | [240] | -5.95[241] | -6.69[242] | 0.24[243] |
36 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | [244] | 3.21[245] | 3.77[246] | -6.45[247] | -6.35[248] | -3.20[249] | 0.81[250] |
37 | JAK2 | Tyrosine-protein kinase JAK2 | [251] | -0.41[252] | -0.25[253] | -0.72[254] | 0.08[255] | 0.87[256] | 2.24[257] |
38 | CD69 | Early activation antigen CD69 | [258] | -9.67[259] | [260] | -7.66[261] | -7.33[262] | [263] | -0.32[264] |
39 | CBL | E3 ubiquitin-protein ligase CBL | [265] | 3.81[266] | 2.93[267] | 3.11[268] | 4.45[269] | 4.13[270] | 3.29[271] |
40 | VAV1 | Proto-oncogene vav | [272] | -9.14[273] | -4.14[274] | -5.88[275] | -6.77[276] | -7.84[277] | 0.72[278] |
41 | CD86 | T-lymphocyte activation antigen CD86 | [279] | [280] | [281] | -5.21[282] | -4.78[283] | -6.61[284] | 0.88[285] |
42 | SYK | Tyrosine-protein kinase SYK | [286] | -8.80[287] | -2.76[288] | -5.81[289] | -0.58[290] | -3.90[291] | 2.89[292] |
43 | IL3RA | Interleukin-3 receptor subunit alpha | [293] | [294] | [295] | [296] | [297] | [298] | [299] |
44 | CSF2RB | Cytokine receptor common subunit beta | [300] | [301] | [302] | [303] | -6.83[304] | -4.33[305] | 2.40[306] |
45 | BCL2 | Apoptosis regulator Bcl-2 | [307] | -3.49[308] | 2.08[309] | -5.36[310] | 1.09[311] | 1.00[312] | 2.76[313] |
46 | IL5RA | Interleukin-5 receptor subunit alpha | [314] | [315] | [316] | [317] | -1.27[318] | -0.99[319] | 1.86[320] |
47 | IL3 | Interleukin-3 | [321] | [322] | [323] | [324] | [325] | [326] | [327] |
48 | CCR3 | C-C chemokine receptor type 3 | [328] | [329] | [330] | [331] | [332] | [333] | [334] |
49 | CXCL8 | Interleukin-8 | [335] | [336] | [337] | [338] | [339] | [340] | [341] |