WP_IL2_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RPS6 | 40S ribosomal protein S6 | [1] | [2] | [3] | [4] | [5] | [6] | [7] |
2 | JUN | Transcription factor AP-1 | [8] | 0.83[9] | -0.52[10] | -0.42[11] | -0.67[12] | 0.08[13] | -0.92[14] |
3 | FOS | Proto-oncogene c-Fos | [15] | -4.69[16] | -3.24[17] | -4.07[18] | -5.14[19] | -3.89[20] | -0.42[21] |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | [22] | 1.40[23] | 1.36[24] | 0.11[25] | 0.98[26] | 1.18[27] | 0.64[28] |
5 | STAT3 | Signal transducer and activator of transcription 3 | [29] | 1.87[30] | 0.56[31] | 1.13[32] | 1.27[33] | 0.73[34] | 3.29[35] |
6 | MYC | Myc proto-oncogene protein | [36] | 1.75[37] | 1.60[38] | -0.60[39] | -1.76[40] | 0.79[41] | -1.11[42] |
7 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [43] | 0.39[44] | 0.25[45] | 0.66[46] | 0.49[47] | 1.18[48] | -0.30[49] |
8 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [50] | 1.37[51] | 1.24[52] | 1.94[53] | 0.19[54] | 0.85[55] | -0.81[56] |
9 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [57] | 1.76[58] | 2.39[59] | 2.17[60] | 1.92[61] | 2.73[62] | 2.15[63] |
10 | GRB2 | Growth factor receptor-bound protein 2 | [64] | 2.51[65] | 2.54[66] | 2.49[67] | 1.58[68] | 1.68[69] | 1.19[70] |
11 | STAT1 | Signal transducer and activator of transcription 1-alpha/beta | [71] | 1.25[72] | 0.52[73] | 1.46[74] | 3.56[75] | 1.47[76] | 1.84[77] |
12 | RPS6KB2 | Ribosomal protein S6 kinase beta-2 | [78] | [79] | [80] | [81] | [82] | [83] | [84] |
13 | SHC1 | SHC-transforming protein 1 | [85] | 2.48[86] | 2.89[87] | 2.80[88] | 3.68[89] | 3.35[90] | 1.67[91] |
14 | RAF1 | RAF proto-oncogene serine/threonine-protein kinase | [92] | 1.26[93] | 1.85[94] | 2.95[95] | 0.84[96] | 1.89[97] | 1.99[98] |
15 | JAK1 | Tyrosine-protein kinase JAK1 | [99] | 1.83[100] | 1.51[101] | 1.52[102] | 1.66[103] | 2.48[104] | 2.42[105] |
16 | HRAS | GTPase HRas | [106] | 0.31[107] | -0.20[108] | -1.17[109] | 0.08[110] | 0.05[111] | -1.77[112] |
17 | SOCS3 | Suppressor of cytokine signaling 3 | [113] | -2.82[114] | -3.04[115] | -1.49[116] | 0.23[117] | -0.66[118] | 1.02[119] |
18 | MAPK1 | Mitogen-activated protein kinase 1 | [120] | 3.03[121] | 3.36[122] | 3.02[123] | 2.88[124] | 2.71[125] | 2.66[126] |
19 | NMI | N-myc-interactor | [127] | -2.73[128] | -3.42[129] | -1.82[130] | 0.77[131] | -0.31[132] | -0.02[133] |
20 | CRKL | Crk-like protein | [134] | 3.02[135] | 3.31[136] | 3.75[137] | 2.15[138] | 2.54[139] | 2.34[140] |
21 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [141] | 0.85[142] | 1.16[143] | 2.08[144] | 3.10[145] | 2.78[146] | 3.89[147] |
22 | SOS1 | Son of sevenless homolog 1 | [148] | 1.22[149] | 2.94[150] | 2.28[151] | 1.87[152] | 1.29[153] | 1.43[154] |
23 | CISH | Cytokine-inducible SH2-containing protein | [155] | -1.59[156] | -1.21[157] | -1.17[158] | -1.62[159] | -2.88[160] | 1.99[161] |
24 | MAPK3 | Mitogen-activated protein kinase 3 | [162] | 3.17[163] | 3.41[164] | 3.28[165] | 1.45[166] | 1.65[167] | -0.15[168] |
25 | STAT5B | Signal transducer and activator of transcription 5B | [169] | 2.68[170] | 2.49[171] | 3.02[172] | 2.58[173] | 1.90[174] | 2.51[175] |
26 | RPS6KB1 | Ribosomal protein S6 kinase beta-1 | [176] | [177] | [178] | [179] | [180] | [181] | [182] |
27 | FOXO3 | Forkhead box protein O3 | [183] | 1.77[184] | 2.06[185] | 2.52[186] | 1.43[187] | 2.85[188] | 3.22[189] |
28 | STAT5A | Signal transducer and activator of transcription 5A | [190] | -0.63[191] | 0.74[192] | -0.37[193] | 0.18[194] | 1.12[195] | 1.13[196] |
29 | FYN | Tyrosine-protein kinase Fyn | [197] | 2.26[198] | -6.15[199] | 2.25[200] | 2.50[201] | 4.21[202] | 1.86[203] |
30 | PTK2B | Protein-tyrosine kinase 2-beta | [204] | 0.51[205] | 2.06[206] | 2.85[207] | -0.75[208] | 2.06[209] | 2.66[210] |
31 | GAB2 | GRB2-associated-binding protein 2 | [211] | 2.88[212] | 2.86[213] | 2.94[214] | 1.95[215] | 2.22[216] | 1.43[217] |
32 | IL2RG | Cytokine receptor common subunit gamma | [218] | -0.33[219] | -2.03[220] | -1.55[221] | -2.57[222] | [223] | 0.78[224] |
33 | CCND2 | G1/S-specific cyclin-D2 | [225] | 4.46[226] | 3.24[227] | -3.14[228] | -3.42[229] | -0.33[230] | 2.74[231] |
34 | CBL | E3 ubiquitin-protein ligase CBL | [232] | 5.77[233] | 4.90[234] | 4.95[235] | 6.16[236] | 5.83[237] | 4.65[238] |
35 | IL2RB | Interleukin-2 receptor subunit beta | [239] | -3.45[240] | -3.82[241] | -4.96[242] | -1.79[243] | -4.03[244] | 2.43[245] |
36 | MAPT | Microtubule-associated protein tau | [246] | 3.85[247] | 3.98[248] | 3.11[249] | 2.36[250] | -0.51[251] | 1.22[252] |
37 | LCK | Tyrosine-protein kinase Lck | [253] | 4.10[254] | 4.37[255] | -5.80[256] | -4.05[257] | -4.07[258] | 2.12[259] |
38 | SYK | Tyrosine-protein kinase SYK | [260] | -6.85[261] | -0.78[262] | -3.97[263] | 1.13[264] | -2.20[265] | 4.25[266] |
39 | JAK3 | Tyrosine-protein kinase JAK3 | [267] | 3.56[268] | 6.03[269] | -0.15[270] | 0.40[271] | 1.31[272] | 3.99[273] |
40 | IL2RA | Interleukin-2 receptor subunit alpha | [274] | [275] | -4.08[276] | [277] | -3.57[278] | -5.30[279] | 1.42[280] |
41 | BCL2 | Apoptosis regulator Bcl-2 | [281] | -1.54[282] | 4.06[283] | -3.52[284] | 2.80[285] | 2.70[286] | 4.12[287] |
42 | IL2 | Interleukin-2 | [288] | [289] | [290] | [291] | [292] | [293] | [294] |