WP_IL1_SIGNALING_PATHWAY | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | SQSTM1 | Sequestosome-1 | [1] | -1.26[2] | -2.22[3] | -1.61[4] | -0.72[5] | -0.94[6] | -1.34[7] |
2 | NFKBIA | NF-kappa-B inhibitor alpha | [8] | -0.56[9] | -2.26[10] | -2.57[11] | -3.07[12] | -1.32[13] | -0.68[14] |
3 | JUN | Transcription factor AP-1 | [15] | 0.00[16] | -1.45[17] | -1.11[18] | -1.26[19] | -0.82[20] | -1.36[21] |
4 | AKT1 | RAC-alpha serine/threonine-protein kinase | [22] | 0.57[23] | 0.44[24] | -0.58[25] | 0.40[26] | 0.29[27] | 0.21[28] |
5 | MAP2K3 | Dual specificity mitogen-activated protein kinase kinase 3 | [29] | -0.73[30] | -0.33[31] | -1.37[32] | -1.38[33] | -1.64[34] | -0.98[35] |
6 | UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1 | [36] | -3.38[37] | -3.48[38] | -3.27[39] | -3.44[40] | -4.22[41] | -4.56[42] |
7 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | [43] | -0.44[44] | -0.67[45] | -0.03[46] | -0.10[47] | 0.28[48] | -0.74[49] |
8 | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 | [50] | 0.55[51] | 0.32[52] | 1.25[53] | -0.40[54] | -0.04[55] | -1.25[56] |
9 | IKBKG | NF-kappa-B essential modulator | [57] | -0.40[58] | -0.15[59] | -2.34[60] | -0.40[61] | -1.74[62] | -0.15[63] |
10 | PTPN11 | Tyrosine-protein phosphatase non-receptor type 11 | [64] | 0.94[65] | 1.46[66] | 1.48[67] | 1.33[68] | 1.84[69] | 1.71[70] |
11 | IRAK1 | Interleukin-1 receptor-associated kinase 1 | [71] | 1.91[72] | 1.40[73] | 0.44[74] | 1.24[75] | 1.48[76] | -0.23[77] |
12 | ECSIT | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial | -1.03[78] | -0.22[79] | 0.34[80] | -2.48[81] | -2.31[82] | -0.63[83] | |
13 | UBE2N | Ubiquitin-conjugating enzyme E2 N | [84] | 1.18[85] | 1.75[86] | 0.64[87] | 0.76[88] | 0.53[89] | -0.27[90] |
14 | TOLLIP | Toll-interacting protein | [91] | 0.22[92] | 0.21[93] | 0.27[94] | -0.58[95] | -1.55[96] | 1.60[97] |
15 | IL1R1 | Interleukin-1 receptor type 1 | [98] | -0.08[99] | -0.35[100] | -0.93[101] | -0.38[102] | 2.17[103] | 1.23[104] |
16 | RELA | Transcription factor p65 | [105] | 0.63[106] | 0.22[107] | 0.42[108] | 0.39[109] | 0.17[110] | -0.43[111] |
17 | NFKBIB | NF-kappa-B inhibitor beta | [112] | -0.67[113] | -0.75[114] | -0.36[115] | -1.37[116] | -1.15[117] | -1.27[118] |
18 | MAPKAPK | MAP kinase-activated protein kinase 2 | [119] | 0.95[120] | 0.08[121] | 0.56[122] | 1.84[123] | 0.92[124] | -0.49[125] |
19 | MYD88 | Myeloid differentiation primary response protein MyD88 | [126] | 0.31[127] | 0.46[128] | -0.04[129] | -0.59[130] | -0.42[131] | 1.25[132] |
20 | IL1RAP | Interleukin-1 receptor accessory protein | [133] | -1.00[134] | 1.31[135] | 1.02[136] | -1.02[137] | -0.06[138] | 2.64[139] |
21 | MAPK1 | Mitogen-activated protein kinase 1 | [140] | 2.20[141] | 2.43[142] | 2.33[143] | 2.30[144] | 1.82[145] | 2.23[146] |
22 | CCL2 | C-C motif chemokine 2 | [147] | -12.90[148] | [149] | -12.17[150] | -3.67[151] | -1.63[152] | -3.24[153] |
23 | TAB2 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 | [154] | 0.86[155] | 1.12[156] | 1.45[157] | 2.15[158] | 1.48[159] | 0.70[160] |
24 | MAPK14 | Mitogen-activated protein kinase 14 | [161] | 1.97[162] | 2.13[163] | 1.77[164] | 2.13[165] | 1.48[166] | 1.74[167] |
25 | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | [168] | 0.39[169] | 1.56[170] | 1.49[171] | 0.93[172] | 0.99[173] | 0.70[174] |
26 | IRAK2 | Interleukin-1 receptor-associated kinase-like 2 | [175] | 0.42[176] | 0.61[177] | 0.46[178] | -1.98[179] | -0.56[180] | -0.57[181] |
27 | PRKCZ | Protein kinase C zeta type | [182] | 0.97[183] | 1.44[184] | -0.50[185] | -1.85[186] | -4.18[187] | -1.19[188] |
28 | ATF2 | Cyclic AMP-dependent transcription factor ATF-2 | [189] | 1.13[190] | 2.27[191] | 2.57[192] | 1.23[193] | 0.87[194] | 1.47[195] |
29 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | [196] | 0.02[197] | 0.23[198] | 1.39[199] | 2.51[200] | 1.89[201] | 3.45[202] |
30 | MAPK8 | Mitogen-activated protein kinase 8 | [203] | -0.95[204] | 0.55[205] | -0.51[206] | -0.46[207] | -0.73[208] | -0.06[209] |
31 | TAB3 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 | [210] | 0.55[211] | 2.59[212] | 2.75[213] | 0.80[214] | 1.87[215] | 1.28[216] |
32 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | [217] | 1.16[218] | 0.93[219] | 0.79[220] | 0.20[221] | 0.98[222] | 0.90[223] |
33 | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta | [224] | 2.37[225] | 2.68[226] | 3.36[227] | 1.15[228] | 1.58[229] | 0.16[230] |
34 | MAP2K4 | Dual specificity mitogen-activated protein kinase kinase 4 | [231] | 1.20[232] | 1.92[233] | 1.19[234] | 1.65[235] | 0.92[236] | 1.52[237] |
35 | MAPK9 | Mitogen-activated protein kinase 9 | [238] | 1.72[239] | 2.04[240] | 2.16[241] | 2.16[242] | 1.49[243] | 0.96[244] |
36 | MAPK3 | Mitogen-activated protein kinase 3 | [245] | 2.34[246] | 2.48[247] | 2.59[248] | 0.87[249] | 0.76[250] | -0.59[251] |
37 | CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha | [252] | 1.40[253] | 2.71[254] | 2.74[255] | 1.10[256] | 1.78[257] | 1.97[258] |
38 | MAP2K7 | Dual specificity mitogen-activated protein kinase kinase 7 | [259] | 1.46[260] | 1.70[261] | 2.33[262] | 0.73[263] | 1.15[264] | -0.30[265] |
39 | TAB1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | [266] | 1.14[267] | 1.88[268] | 2.02[269] | 0.46[270] | 0.67[271] | 0.68[272] |
40 | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | 3.98[273] | 3.70[274] | 3.09[275] | 3.27[276] | 2.63[277] | 0.79[278] | |
41 | IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta | [279] | 1.01[280] | 1.17[281] | 1.34[282] | 0.70[283] | 0.67[284] | 1.63[285] |
42 | IL1B | Interleukin-1 beta | [286] | -8.20[287] | -7.98[288] | -3.59[289] | -3.14[290] | 2.32[291] | -4.75[292] |
43 | PELI1 | E3 ubiquitin-protein ligase pellino homolog 1 | [293] | 0.64[294] | 1.65[295] | 2.23[296] | 0.19[297] | 0.15[298] | 1.86[299] |
44 | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 | [300] | 1.93[301] | 3.23[302] | 3.02[303] | 3.52[304] | 2.67[305] | 4.27[306] |
45 | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 | [307] | 0.10[308] | 0.64[309] | -0.46[310] | 2.52[311] | 1.38[312] | 1.33[313] |
46 | MAP2K6 | Dual specificity mitogen-activated protein kinase kinase 6 | [314] | 0.78[315] | -2.34[316] | 2.58[317] | 1.46[318] | -2.71[319] | -1.17[320] |
47 | MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 | [321] | 2.11[322] | 2.69[323] | 2.04[324] | 2.53[325] | 2.66[326] | 2.60[327] |
48 | IRAK4 | Interleukin-1 receptor-associated kinase 4 | [328] | 0.75[329] | 2.21[330] | 2.55[331] | 1.86[332] | 1.49[333] | 2.23[334] |
49 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | [335] | 3.14[336] | 2.95[337] | 2.74[338] | 2.77[339] | 1.52[340] | 3.25[341] |
50 | TRAF6 | TNF receptor-associated factor 6 | [342] | 1.58[343] | 1.56[344] | 2.20[345] | 2.11[346] | 1.43[347] | 3.36[348] |
51 | REL | Proto-oncogene c-Rel | [349] | -0.02[350] | 1.84[351] | 1.83[352] | 0.59[353] | 0.62[354] | 2.80[355] |
52 | PELI2 | E3 ubiquitin-protein ligase pellino homolog 2 | [356] | -2.36[357] | -3.16[358] | -3.64[359] | 4.42[360] | 3.02[361] | 3.93[362] |
53 | IRAK3 | Interleukin-1 receptor-associated kinase 3 | [363] | -0.96[364] | 0.13[365] | 2.06[366] | 6.49[367] | 8.60[368] | 6.34[369] |
54 | IL1A | Interleukin-1 alpha | [370] | 0.07[371] | -0.24[372] | -1.35[373] | -0.19[374] | 6.43[375] | -1.13[376] |
55 | HSPB2 | Heat shock protein beta-2 | [377] | 1.59[378] | 2.43[379] | -2.45[380] | 3.39[381] | 2.55[382] | 3.93[383] |
56 | MIR718 | [384] | [385] | [386] | [387] | [388] | [389] | [390] | |
57 | MIR6502 | [391] | [392] | [393] | [394] | [395] | [396] | [397] |