WP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 SERPINE1 Plasminogen activator inhibitor 1 [1] -0.70[2] -0.27[3] -5.63[4] -6.06[5] 0.07[6] -4.59[7]
2 SHC1 SHC-transforming protein 1 [8] -0.67[9] -0.24[10] 1.21[11] 0.40[12] -0.66[13] 0.07[14]
3 FLNA Filamin-A [15] 2.29[16] 0.96[17] -0.60[18] 3.29[19] 1.38[20] 1.45[21]
4 TGFBR2 TGF-beta receptor type-2 [22] 0.98[23] 0.66[24] 1.69[25] -1.19[26] -0.02[27] 0.80[28]
5 MAPK1 Mitogen-activated protein kinase 1 [29] -0.13[30] 0.22[31] 1.43[32] -0.40[33] -1.30[34] 1.07[35]
6 MAPK14 Mitogen-activated protein kinase 14 [36] -0.36[37] -0.08[38] 0.87[39] -0.57[40] -1.64[41] 0.58[42]
7 MAPK8 Mitogen-activated protein kinase 8 [43] -3.28[44] -1.66[45] -1.41[46] -3.16[47] -3.84[48] -1.22[49]
8 AGTR1 Type-1 angiotensin II receptor [50] -9.19[51] -7.14[52] -0.25[53] -3.52[54] -8.47[55] 0.73[56]
9 SMAD3 Mothers against decapentaplegic homolog 3 [57] 0.09[58] -0.30[59] 1.31[60] -0.46[61] -0.12[62] -0.50[63]
10 TGFBR1 TGF-beta receptor type-1 [64] -1.51[65] -1.07[66] -0.19[67] -1.91[68] -1.35[69] 0.62[70]
11 MAPK3 Mitogen-activated protein kinase 3 [71] 0.01[72] 0.27[73] 1.69[74] -1.83[75] -2.35[76] -1.75[77]
12 SMAD4 Mothers against decapentaplegic homolog 4 [78] -0.44[79] 0.40[80] 1.74[81] -0.34[82] -0.52[83] 2.08[84]
13 SMAD2 Mothers against decapentaplegic homolog 2 [85] 0.18[86] 0.65[87] 1.53[88] 0.13[89] -0.23[90] 1.86[91]
14 TGFBR3 Transforming growth factor beta receptor type 3 [92] 0.45[93] 2.71[94] 2.66[95] -0.40[96] -2.62[97] 2.27[98]
15 LTBP1 Latent-transforming growth factor beta-binding protein 1 [99] -2.59[100] -8.44[101] -1.02[102] 0.01[103] -0.32[104] 1.68[105]
16 ENG Endoglin [106] -2.73[107] -0.72[108] -5.35[109] 0.80[110] -3.60[111] 3.20[112]
17 NR2C2 Nuclear receptor subfamily 2 group C member 2 [113] 1.40[114] 2.32[115] 4.16[116] 1.45[117] 1.27[118] 3.74[119]
18 FBN1 Fibrillin-1 [120] 1.22[121] -0.50[122] 3.42[123] 4.09[124] 6.50[125] 6.69[126]
19 LTBP2 Latent-transforming growth factor beta-binding protein 2 [127] 3.88[128] 1.77[129] 3.30[130] 4.42[131] 2.69[132] 3.11[133]
20 POSTN Periostin [134] -5.61[135] -4.29[136] -2.00[137] 5.75[138] 3.23[139] 2.73[140]
21 ANGPT2 Angiopoietin-2 [141] -3.56[142] -2.11[143] -0.17[144] -2.76[145] -3.28[146] 4.29[147]
22 FBN2 Fibrillin-2 [148] -0.67[149] [150] -3.07[151] 2.09[152] 4.37[153] 3.15[154]
23 RUNX2 Runt-related transcription factor 2 [155] -2.68[156] -2.83[157] 3.62[158] 4.87[159] 6.28[160] 2.91[161]
24 FBN3 Fibrillin-3 [162] 1.76[163] 5.00[164] 4.04[165] -5.29[166] [167] 0.02[168]
25 CCN2 [169] [170] [171] [172] [173] [174] [175]
[1]
ref_hepatocyte SERPINE1
Mean 117
Standard deviation 1.5e+02
Values 3.2e+02 2.1 27 3.2 2.4e+02
[2]
HepG2 SERPINE1
Mean 569
Standard deviation 1.9e+02
Values 4.3e+02 7.1e+02
[3]
HepG2.C3A SERPINE1
Mean 590
Standard deviation 4.9e+02
Values 2.5e+02 9.4e+02
[4]
HuH.7 SERPINE1
Mean 5.32
Standard deviation 1.3
Values 4.1 6.6 5.2
[5]
SNU475 SERPINE1
Mean 15.4
Standard deviation 11
Values 24 7.3
[6]
THLE SERPINE1
Mean 1.76e+03
Standard deviation 4.3e+02
Values 1.5e+03 2.1e+03
[7]
liver SERPINE1
Mean 11.3
Standard deviation 5.1
Values 6.6 11 9 18
[8]
ref_hepatocyte SHC1
Mean 16.6
Standard deviation 7.2
Values 19 16 26 5.8 17
[9]
HepG2 SHC1
Mean 82
Standard deviation 0.099
Values 82 82
[10]
HepG2.C3A SHC1
Mean 84.9
Standard deviation 11
Values 93 77
[11]
HuH.7 SHC1
Mean 85.9
Standard deviation 2.4
Values 85 84 89
[12]
SNU475 SHC1
Mean 191
Standard deviation 36
Values 1.7e+02 2.2e+02
[13]
THLE SHC1
Mean 150
Standard deviation 11
Values 1.4e+02 1.6e+02
[14]
liver SHC1
Mean 40.4
Standard deviation 11
Values 37 32 37 56
[15]
ref_hepatocyte FLNA
Mean 15.1
Standard deviation 16
Values 17 2.3 0.88 15 40
[16]
HepG2 FLNA
Mean 584
Standard deviation 2.4e+02
Values 4.1e+02 7.5e+02
[17]
HepG2.C3A FLNA
Mean 179
Standard deviation 17
Values 1.7e+02 1.9e+02
[18]
HuH.7 FLNA
Mean 22.3
Standard deviation 8.8
Values 16 18 32
[19]
SNU475 FLNA
Mean 1.29e+03
Standard deviation 6.6e+02
Values 8.3e+02 1.8e+03
[20]
THLE FLNA
Mean 565
Standard deviation 1.5e+02
Values 4.6e+02 6.7e+02
[21]
liver FLNA
Mean 95.8
Standard deviation 81
Values 1.9e+02 1.3e+02 16 44
[22]
ref_hepatocyte TGFBR2
Mean 11.1
Standard deviation 9.7
Values 6.4 3.5 4.2 26 15
[23]
HepG2 TGFBR2
Mean 172
Standard deviation 10
Values 1.8e+02 1.7e+02
[24]
HepG2.C3A TGFBR2
Mean 106
Standard deviation 5.8
Values 1e+02 1.1e+02
[25]
HuH.7 TGFBR2
Mean 80.1
Standard deviation 11
Values 77 71 92
[26]
SNU475 TGFBR2
Mean 42.5
Standard deviation 18
Values 55 29
[27]
THLE TGFBR2
Mean 157
Standard deviation 23
Values 1.4e+02 1.7e+02
[28]
liver TGFBR2
Mean 44.6
Standard deviation 11
Values 57 51 31 40
[29]
ref_hepatocyte MAPK1
Mean 10.7
Standard deviation 3.7
Values 13 7.4 6.1 14 13
[30]
HepG2 MAPK1
Mean 77.6
Standard deviation 22
Values 93 62
[31]
HepG2.C3A MAPK1
Mean 76.1
Standard deviation 7.2
Values 81 71
[32]
HuH.7 MAPK1
Mean 64.8
Standard deviation 7.4
Values 61 60 73
[33]
SNU475 MAPK1
Mean 71.1
Standard deviation 8
Values 65 77
[34]
THLE MAPK1
Mean 62.4
Standard deviation 14
Values 53 72
[35]
liver MAPK1
Mean 52.3
Standard deviation 14
Values 61 68 39 41
[36]
ref_hepatocyte MAPK14
Mean 8.71
Standard deviation 2
Values 7.2 8.3 7.5 12 8.5
[37]
HepG2 MAPK14
Mean 53.4
Standard deviation 8.7
Values 60 47
[38]
HepG2.C3A MAPK14
Mean 49.9
Standard deviation 0.11
Values 50 50
[39]
HuH.7 MAPK14
Mean 35.7
Standard deviation 1.3
Values 34 36 37
[40]
SNU475 MAPK14
Mean 51.3
Standard deviation 0.4
Values 51 52
[41]
THLE MAPK14
Mean 40
Standard deviation 3.6
Values 37 43
[42]
liver MAPK14
Mean 30.1
Standard deviation 8.3
Values 37 38 24 22
[43]
ref_hepatocyte MAPK8
Mean 7.1
Standard deviation 4.4
Values 15 4.7 3.8 6.5 5.6
[44]
HepG2 MAPK8
Mean 5.76
Standard deviation 1
Values 6.5 5.1
[45]
HepG2.C3A MAPK8
Mean 13.6
Standard deviation 4
Values 17 11
[46]
HuH.7 MAPK8
Mean 5.99
Standard deviation 0.68
Values 5.2 6.2 6.5
[47]
SNU475 MAPK8
Mean 6.98
Standard deviation 0.5
Values 6.6 7.3
[48]
THLE MAPK8
Mean 7.08
Standard deviation 1
Values 6.4 7.8
[49]
liver MAPK8
Mean 7.08
Standard deviation 1
Values 7.6 7.8 7.3 5.6
[50]
ref_hepatocyte AGTR1
Mean 6.51
Standard deviation 7
Values 1.6 11 17 1.1 2
[51]
HepG2 AGTR1
Mean 0.088
Standard deviation 0.0029
Values 0.09 0.086
[52]
HepG2.C3A AGTR1
Mean 0.28
Standard deviation 0.17
Values 0.16 0.4
[53]
HuH.7 AGTR1
Mean 12.2
Standard deviation 6.8
Values 9.2 20 7.4
[54]
SNU475 AGTR1
Mean 4.95
Standard deviation 0.26
Values 4.8 5.1
[55]
THLE AGTR1
Mean 0.263
Standard deviation 0.079
Values 0.21 0.32
[56]
liver AGTR1
Mean 24.9
Standard deviation 11
Values 18 15 39 28
[57]
ref_hepatocyte SMAD3
Mean 5.99
Standard deviation 4.6
Values 13 2.2 1.9 4.8 8.4
[58]
HepG2 SMAD3
Mean 50.4
Standard deviation 14
Values 40 60
[59]
HepG2.C3A SMAD3
Mean 29.5
Standard deviation 11
Values 22 37
[60]
HuH.7 SMAD3
Mean 33.2
Standard deviation 6.9
Values 28 41 31
[61]
SNU475 SMAD3
Mean 38.2
Standard deviation 2.7
Values 36 40
[62]
THLE SMAD3
Mean 78.9
Standard deviation 8.4
Values 73 85
[63]
liver SMAD3
Mean 9.85
Standard deviation 3
Values 13 7.4 12 7.1
[64]
ref_hepatocyte TGFBR1
Mean 4.72
Standard deviation 3.6
Values 3.6 3.1 1.8 4.2 11
[65]
HepG2 TGFBR1
Mean 13.1
Standard deviation 3.3
Values 15 11
[66]
HepG2.C3A TGFBR1
Mean 13.6
Standard deviation 0.22
Values 14 13
[67]
HuH.7 TGFBR1
Mean 9.25
Standard deviation 2.6
Values 7.2 12 8.3
[68]
SNU475 TGFBR1
Mean 11
Standard deviation 1.8
Values 12 9.7
[69]
THLE TGFBR1
Mean 26.5
Standard deviation 5.3
Values 30 23
[70]
liver TGFBR1
Mean 16.9
Standard deviation 7.4
Values 20 25 8.6 13
[71]
ref_hepatocyte MAPK3
Mean 4.16
Standard deviation 1.3
Values 3.6 3.3 6 5.1 2.8
[72]
HepG2 MAPK3
Mean 33.1
Standard deviation 5.2
Values 29 37
[73]
HepG2.C3A MAPK3
Mean 30.4
Standard deviation 12
Values 22 39
[74]
HuH.7 MAPK3
Mean 30
Standard deviation 4.8
Values 32 25 34
[75]
SNU475 MAPK3
Mean 10.2
Standard deviation 2.4
Values 8.5 12
[76]
THLE MAPK3
Mean 11.6
Standard deviation 1.1
Values 11 12
[77]
liver MAPK3
Mean 2.87
Standard deviation 2.4
Values 0.82 0.81 5 4.8
[78]
ref_hepatocyte SMAD4
Mean 3.16
Standard deviation 0.71
Values 4.2 3.4 2.4 2.9 2.8
[79]
HepG2 SMAD4
Mean 18.3
Standard deviation 3.2
Values 21 16
[80]
HepG2.C3A SMAD4
Mean 25.2
Standard deviation 3
Values 23 27
[81]
HuH.7 SMAD4
Mean 23.6
Standard deviation 3.4
Values 20 27 24
[82]
SNU475 SMAD4
Mean 21.8
Standard deviation 2.7
Values 20 24
[83]
THLE SMAD4
Mean 31.4
Standard deviation 1.4
Values 30 32
[84]
liver SMAD4
Mean 31
Standard deviation 13
Values 44 40 23 16
[85]
ref_hepatocyte SMAD2
Mean 2.54
Standard deviation 1.2
Values 1.9 1.6 1.9 4.5 2.8
[86]
HepG2 SMAD2
Mean 22.7
Standard deviation 2.3
Values 24 21
[87]
HepG2.C3A SMAD2
Mean 24.2
Standard deviation 1.1
Values 23 25
[88]
HuH.7 SMAD2
Mean 16.4
Standard deviation 1.6
Values 15 18 17
[89]
SNU475 SMAD2
Mean 24.3
Standard deviation 3.3
Values 22 27
[90]
THLE SMAD2
Mean 31
Standard deviation 0.65
Values 31 32
[91]
liver SMAD2
Mean 21.4
Standard deviation 6.7
Values 25 29 17 15
[92]
ref_hepatocyte TGFBR3
Mean 1.93
Standard deviation 2.1
Values 0.09 2.2 1.8 5.3 0.2
[93]
HepG2 TGFBR3
Mean 20.9
Standard deviation 5.1
Values 25 17
[94]
HepG2.C3A TGFBR3
Mean 77
Standard deviation 7.3
Values 72 82
[95]
HuH.7 TGFBR3
Mean 27.4
Standard deviation 4.9
Values 25 24 33
[96]
SNU475 TGFBR3
Mean 12.9
Standard deviation 0.55
Values 13 12
[97]
THLE TGFBR3
Mean 4.52
Standard deviation 0.6
Values 4.9 4.1
[98]
liver TGFBR3
Mean 21.6
Standard deviation 5.7
Values 22 28 15 22
[99]
ref_hepatocyte LTBP1
Mean 1.78
Standard deviation 2.2
Values 1.6 0.98 0.64 0.094 5.6
[100]
HepG2 LTBP1
Mean 2.33
Standard deviation 0.23
Values 2.2 2.5
[101]
HepG2.C3A LTBP1
Mean 0.0312
Standard deviation 0.017
Values 0.043 0.019
[102]
HuH.7 LTBP1
Mean 1.96
Standard deviation 0.39
Values 1.5 2.1 2.3
[103]
SNU475 LTBP1
Mean 15.6
Standard deviation 3.7
Values 13 18
[104]
THLE LTBP1
Mean 20.4
Standard deviation 0.27
Values 20 21
[105]
liver LTBP1
Mean 13.2
Standard deviation 3.2
Values 16 16 12 9.4
[106]
ref_hepatocyte ENG
Mean 1.52
Standard deviation 1.6
Values 1 2.9 3.5 0.19 0
[107]
HepG2 ENG
Mean 1.81
Standard deviation 1.4
Values 0.82 2.8
[108]
HepG2.C3A ENG
Mean 5.61
Standard deviation 2.3
Values 4 7.2
[109]
HuH.7 ENG
Mean 0.0838
Standard deviation 0.057
Values 0.028 0.14 0.082
[110]
SNU475 ENG
Mean 23.1
Standard deviation 15
Values 34 12
[111]
THLE ENG
Mean 1.79
Standard deviation 0.46
Values 1.5 2.1
[112]
liver ENG
Mean 32.5
Standard deviation 25
Values 14 15 33 68
[113]
ref_hepatocyte NR2C2
Mean 0.825
Standard deviation 0.42
Values 1.2 0.49 0.33 1.2 0.84
[114]
HepG2 NR2C2
Mean 17.2
Standard deviation 3.4
Values 20 15
[115]
HepG2.C3A NR2C2
Mean 25.1
Standard deviation 0.87
Values 24 26
[116]
HuH.7 NR2C2
Mean 32.9
Standard deviation 3.6
Values 29 35 35
[117]
SNU475 NR2C2
Mean 19.8
Standard deviation 0.2
Values 20 20
[118]
THLE NR2C2
Mean 28.4
Standard deviation 0.12
Values 28 28
[119]
liver NR2C2
Mean 25.5
Standard deviation 13
Values 39 34 16 12
[120]
ref_hepatocyte FBN1
Mean 0.0913
Standard deviation 0.079
Values 0.043 0.081 0.052 0.23 0.049
[121]
HepG2 FBN1
Mean 1.68
Standard deviation 0.54
Values 2.1 1.3
[122]
HepG2.C3A FBN1
Mean 0.392
Standard deviation 0.0088
Values 0.39 0.4
[123]
HuH.7 FBN1
Mean 2.19
Standard deviation 0.46
Values 1.7 2.3 2.6
[124]
SNU475 FBN1
Mean 13.6
Standard deviation 5
Values 17 10
[125]
THLE FBN1
Mean 119
Standard deviation 48
Values 85 1.5e+02
[126]
liver FBN1
Mean 21.8
Standard deviation 19
Values 34 42 3.5 8.1
[127]
ref_hepatocyte LTBP2
Mean 0.0813
Standard deviation 0.044
Values 0.1 0.13 0.095 0.068 0.013
[128]
HepG2 LTBP2
Mean 9.45
Standard deviation 0.2
Values 9.6 9.3
[129]
HepG2.C3A LTBP2
Mean 1.68
Standard deviation 0.51
Values 1.3 2
[130]
HuH.7 LTBP2
Mean 1.79
Standard deviation 0.83
Values 1.2 2.7 1.4
[131]
SNU475 LTBP2
Mean 15.2
Standard deviation 3.4
Values 13 18
[132]
THLE LTBP2
Mean 7.52
Standard deviation 3.9
Values 4.8 10
[133]
liver LTBP2
Mean 1.63
Standard deviation 0.73
Values 2.5 1.9 0.94 1.2
[134]
ref_hepatocyte POSTN
Mean 0.0798
Standard deviation 0.1
Values 0 0.024 0.22 0 0.15
[135]
HepG2 POSTN
Mean 0.0129
Standard deviation 0.0061
Values 0.0086 0.017
[136]
HepG2.C3A POSTN
Mean 0.0248
Standard deviation 0.02
Values 0.011 0.039
[137]
HuH.7 POSTN
Mean 0.0446
Standard deviation 0.037
Values 0.0094 0.083 0.041
[138]
SNU475 POSTN
Mean 37.6
Standard deviation 2.7
Values 36 40
[139]
THLE POSTN
Mean 10.7
Standard deviation 6.2
Values 6.3 15
[140]
liver POSTN
Mean 1.23
Standard deviation 0.56
Values 0.64 1.2 1.1 2
[141]
ref_hepatocyte ANGPT2
Mean 0.0772
Standard deviation 0.055
Values 0.019 0.081 0.14 0.024 0.12
[142]
HepG2 ANGPT2
Mean 0.0515
Standard deviation 6.9e-05
Values 0.051 0.052
[143]
HepG2.C3A ANGPT2
Mean 0.109
Standard deviation 0.044
Values 0.14 0.078
[144]
HuH.7 ANGPT2
Mean 0.154
Standard deviation 0.071
Values 0.14 0.23 0.09
[145]
SNU475 ANGPT2
Mean 0.0996
Standard deviation 0.0097
Values 0.11 0.093
[146]
THLE ANGPT2
Mean 0.114
Standard deviation 0.12
Values 0.2 0.032
[147]
liver ANGPT2
Mean 3.49
Standard deviation 1.7
Values 3.6 5.7 1.6 3.1
[148]
ref_hepatocyte FBN2
Mean 0.0445
Standard deviation 0.062
Values 0.092 0.13 0 0 0
[149]
HepG2 FBN2
Mean 0.22
Standard deviation 0.13
Values 0.12 0.32
[150]
HepG2.C3A FBN2
Mean 0
Standard deviation 0
Values 0 0
[151]
HuH.7 FBN2
Mean 0.0119
Standard deviation 0.01
Values 0 0.019 0.016
[152]
SNU475 FBN2
Mean 1.66
Standard deviation 0.29
Values 1.9 1.5
[153]
THLE FBN2
Mean 13.2
Standard deviation 5.2
Values 9.5 17
[154]
liver FBN2
Mean 0.917
Standard deviation 0.78
Values 1.5 1.7 0.24 0.26
[155]
ref_hepatocyte RUNX2
Mean 0.0228
Standard deviation 0.051
Values 0 0.11 0 0 0
[156]
HepG2 RUNX2
Mean 0.0279
Standard deviation 0.033
Values 0.0043 0.052
[157]
HepG2.C3A RUNX2
Mean 0.0194
Standard deviation 0.027
Values 0 0.039
[158]
HuH.7 RUNX2
Mean 0.624
Standard deviation 0.22
Values 0.46 0.87 0.54
[159]
SNU475 RUNX2
Mean 5.82
Standard deviation 3.1
Values 8 3.6
[160]
THLE RUNX2
Mean 25.4
Standard deviation 0.45
Values 26 25
[161]
liver RUNX2
Mean 0.398
Standard deviation 0.22
Values 0.4 0.29 0.71 0.21
[162]
ref_hepatocyte FBN3
Mean 0.0216
Standard deviation 0.029
Values 0.0054 0.065 0 0.038 0
[163]
HepG2 FBN3
Mean 0.578
Standard deviation 0.45
Values 0.26 0.89
[164]
HepG2.C3A FBN3
Mean 4.21
Standard deviation 0.52
Values 3.8 4.6
[165]
HuH.7 FBN3
Mean 0.797
Standard deviation 0.41
Values 1.2 0.42 0.73
[166]
SNU475 FBN3
Mean 0.00485
Standard deviation 0.0003
Values 0.0051 0.0046
[167]
THLE FBN3
Mean 0
Standard deviation 0
Values 0 0
[168]
liver FBN3
Mean 0.0509
Standard deviation 0.046
Values 0.026 0.1 0 0.077
[169]
ref_hepatocyte CCN2
Missing
[170]
HepG2 CCN2
Missing
[171]
HepG2.C3A CCN2
Missing
[172]
HuH.7 CCN2
Missing
[173]
SNU475 CCN2
Missing
[174]
THLE CCN2
Missing
[175]
liver CCN2
Missing