WP_HIPPO_SIGNALING_REGULATION_PATHWAYS | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | RHOA | Transforming protein RhoA | [1] | -1.15[2] | -1.75[3] | -1.70[4] | -1.48[5] | -0.86[6] | -1.63[7] |
2 | CDC42 | Cell division control protein 42 homolog | [8] | -1.04[9] | -0.42[10] | -1.60[11] | -0.79[12] | -1.35[13] | -2.39[14] |
3 | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas | 0.22[15] | 0.15[16] | -0.37[17] | 0.59[18] | -0.01[19] | -1.64[20] | |
4 | MST1 | Hepatocyte growth factor-like protein | [21] | -4.37[22] | -1.23[23] | -3.50[24] | -9.14[25] | -8.17[26] | 0.03[27] |
5 | RAC1 | Ras-related C3 botulinum toxin substrate 1 | [28] | -0.61[29] | -1.04[30] | -0.50[31] | -0.25[32] | -0.10[33] | -1.27[34] |
6 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [35] | -0.14[36] | -0.12[37] | -0.14[38] | -0.35[39] | -0.29[40] | 0.29[41] |
7 | CTNNB1 | Catenin beta-1 | [42] | 1.41[43] | 0.80[44] | 1.52[45] | 0.49[46] | 0.89[47] | 0.80[48] |
8 | GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 | [49] | -0.15[50] | -1.31[51] | -1.32[52] | -0.43[53] | 0.80[54] | -0.50[55] |
9 | CDH2 | Cadherin-2 | [56] | -0.07[57] | -2.11[58] | -1.47[59] | 1.53[60] | 0.07[61] | -0.34[62] |
10 | PRKAG1 | 5'-AMP-activated protein kinase subunit gamma-1 | [63] | -1.63[64] | -1.20[65] | -1.25[66] | -0.60[67] | -0.73[68] | -1.95[69] |
11 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [70] | -0.38[71] | -0.65[72] | -0.83[73] | -0.73[74] | 0.02[75] | -1.09[76] |
12 | GNAI3 | Guanine nucleotide-binding protein G(k) subunit alpha | [77] | -0.09[78] | 0.35[79] | 0.28[80] | 0.84[81] | 0.64[82] | -0.07[83] |
13 | FGFR4 | Fibroblast growth factor receptor 4 | [84] | 1.74[85] | 1.98[86] | 2.39[87] | -4.49[88] | -4.46[89] | 0.19[90] |
14 | PRKAG2 | 5'-AMP-activated protein kinase subunit gamma-2 | [91] | -4.27[92] | -9.47[93] | -3.21[94] | -2.00[95] | -1.69[96] | -0.78[97] |
15 | MET | Hepatocyte growth factor receptor | [98] | -0.13[99] | -0.20[100] | 0.26[101] | 1.27[102] | 0.16[103] | 0.66[104] |
16 | CDH1 | Cadherin-1 | [105] | 0.91[106] | 1.29[107] | 1.64[108] | -3.43[109] | -7.52[110] | 1.26[111] |
17 | GNA11 | Guanine nucleotide-binding protein subunit alpha-11 | [112] | -0.88[113] | -1.06[114] | -1.28[115] | -1.44[116] | -0.48[117] | -1.56[118] |
18 | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | [119] | -0.30[120] | 0.88[121] | 2.23[122] | 1.20[123] | 1.64[124] | 1.75[125] |
19 | PRKCZ | Protein kinase C zeta type | [126] | 0.26[127] | 0.54[128] | -1.64[129] | -2.56[130] | -4.59[131] | -1.94[132] |
20 | YY1AP1 | YY1-associated protein 1 | [133] | -0.36[134] | -0.67[135] | -0.10[136] | 0.51[137] | 0.19[138] | -0.16[139] |
21 | PRKAB2 | 5'-AMP-activated protein kinase subunit beta-2 | [140] | 0.67[141] | 1.76[142] | 1.70[143] | 0.77[144] | -0.10[145] | 1.10[146] |
22 | EPHA2 | Ephrin type-A receptor 2 | [147] | 2.04[148] | 2.15[149] | -0.20[150] | 0.68[151] | 1.40[152] | -1.08[153] |
23 | FGFR3 | Fibroblast growth factor receptor 3 | [154] | 2.51[155] | 2.33[156] | 2.48[157] | -3.55[158] | -2.04[159] | 0.14[160] |
24 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [161] | -0.16[162] | -0.58[163] | 0.35[164] | -0.55[165] | -0.52[166] | -0.16[167] |
25 | NF2 | Merlin | [168] | -0.24[169] | -0.70[170] | 0.50[171] | 0.17[172] | 0.09[173] | 0.83[174] |
26 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [175] | 0.76[176] | 0.11[177] | -1.85[178] | -4.36[179] | -1.40[180] | -0.48[181] |
27 | SMAD3 | Mothers against decapentaplegic homolog 3 | [182] | 1.72[183] | 1.01[184] | 1.07[185] | 1.54[186] | 2.58[187] | -0.09[188] |
28 | INSR | Insulin receptor | [189] | 0.25[190] | 0.80[191] | 2.05[192] | -3.34[193] | -0.58[194] | 3.70[195] |
29 | EGFR | Epidermal growth factor receptor | [196] | -0.91[197] | -1.38[198] | 1.32[199] | 0.17[200] | 0.96[201] | 2.35[202] |
30 | PRKAB1 | 5'-AMP-activated protein kinase subunit beta-1 | [203] | 0.50[204] | 0.93[205] | -0.09[206] | -0.33[207] | -0.05[208] | -0.30[209] |
31 | PRKCI | Protein kinase C iota type | [210] | 0.84[211] | 1.42[212] | 2.85[213] | 0.89[214] | 1.47[215] | -0.05[216] |
32 | PRKCD | Protein kinase C delta type | [217] | 0.89[218] | 1.03[219] | 0.34[220] | -0.76[221] | 0.56[222] | -1.37[223] |
33 | MTOR | Serine/threonine-protein kinase mTOR | [224] | 2.32[225] | 3.23[226] | 2.63[227] | 2.42[228] | 2.67[229] | 3.14[230] |
34 | STK3 | Serine/threonine-protein kinase 3 | [231] | -1.30[232] | -0.54[233] | -0.50[234] | 1.06[235] | -0.11[236] | 0.88[237] |
35 | TEAD2 | Transcriptional enhancer factor TEF-4 | [238] | 0.83[239] | -0.33[240] | 1.04[241] | 1.75[242] | 0.77[243] | -0.71[244] |
36 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [245] | -1.05[246] | -0.37[247] | 0.74[248] | 1.97[249] | 1.00[250] | 1.40[251] |
37 | TEAD4 | Transcriptional enhancer factor TEF-3 | [252] | 2.07[253] | 1.38[254] | 0.24[255] | -0.62[256] | -0.15[257] | -2.83[258] |
38 | TEAD3 | Transcriptional enhancer factor TEF-5 | [259] | 1.65[260] | 1.58[261] | -0.24[262] | 0.73[263] | 0.92[264] | -0.47[265] |
39 | SMAD2 | Mothers against decapentaplegic homolog 2 | [266] | 1.81[267] | 1.96[268] | 1.29[269] | 2.12[270] | 2.48[271] | 2.26[272] |
40 | PRKCA | Protein kinase C alpha type | [273] | 2.62[274] | 2.56[275] | 2.75[276] | 1.89[277] | 2.41[278] | 1.61[279] |
41 | TEAD1 | Transcriptional enhancer factor TEF-1 | [280] | 1.52[281] | 1.75[282] | 1.88[283] | 4.21[284] | 3.30[285] | 2.92[286] |
42 | TCF7L2 | Transcription factor 7-like 2 | [287] | 0.65[288] | 1.32[289] | 1.35[290] | 0.43[291] | 0.58[292] | 1.42[293] |
43 | LATS2 | Serine/threonine-protein kinase LATS2 | [294] | 0.75[295] | 0.86[296] | 1.32[297] | 1.93[298] | 1.64[299] | 0.66[300] |
44 | PRKD3 | Serine/threonine-protein kinase D3 | [301] | 1.58[302] | 2.01[303] | 1.68[304] | 2.92[305] | 2.77[306] | 1.93[307] |
45 | GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha | [308] | -0.14[309] | 0.54[310] | 0.88[311] | 1.33[312] | 1.71[313] | 1.13[314] |
46 | TCF7L1 | Transcription factor 7-like 1 | [315] | -3.27[316] | -1.56[317] | 0.46[318] | -2.08[319] | -1.79[320] | -0.01[321] |
47 | TCF7 | Transcription factor 7 | [322] | 2.22[323] | 0.78[324] | -0.34[325] | -0.10[326] | -0.24[327] | -0.67[328] |
48 | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 | [329] | 1.79[330] | 1.17[331] | 1.46[332] | 2.45[333] | 2.26[334] | 0.42[335] |
49 | LATS1 | Serine/threonine-protein kinase LATS1 | [336] | 1.16[337] | 1.61[338] | 2.13[339] | 2.43[340] | 2.17[341] | 1.95[342] |
50 | CSF1R | Macrophage colony-stimulating factor 1 receptor | [343] | -6.52[344] | -9.55[345] | -8.37[346] | -0.50[347] | -4.96[348] | 2.39[349] |
51 | FGFR2 | Fibroblast growth factor receptor 2 | [350] | -2.72[351] | -1.62[352] | 2.15[353] | 1.20[354] | -3.48[355] | 3.12[356] |
52 | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 | [357] | 2.58[358] | 4.10[359] | 3.35[360] | 0.52[361] | 1.17[362] | 2.19[363] |
53 | FGFR1 | Fibroblast growth factor receptor 1 | [364] | 4.36[365] | 2.58[366] | 4.06[367] | 4.80[368] | 4.23[369] | 1.36[370] |
54 | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | [371] | 2.82[372] | 3.17[373] | 3.02[374] | 2.78[375] | 0.99[376] | 1.55[377] |
55 | IGF1R | Insulin-like growth factor 1 receptor | [378] | 4.53[379] | 3.74[380] | 2.24[381] | 4.21[382] | 3.92[383] | 1.79[384] |
56 | PRKCE | Protein kinase C epsilon type | [385] | 0.43[386] | -1.19[387] | 1.13[388] | 0.72[389] | 1.25[390] | 3.26[391] |
57 | PRKCH | Protein kinase C eta type | [392] | -0.58[393] | -4.49[394] | -3.01[395] | 2.01[396] | 3.81[397] | 2.80[398] |
58 | CDH16 | Cadherin-16 | [399] | 0.93[400] | 3.73[401] | -6.78[402] | -2.56[403] | -8.83[404] | -7.37[405] |
59 | PDGFRA | Platelet-derived growth factor receptor alpha | [406] | -3.83[407] | -4.91[408] | 2.55[409] | 0.27[410] | 5.10[411] | 5.02[412] |
60 | PDGFRB | Platelet-derived growth factor receptor beta | [413] | 1.09[414] | 1.38[415] | -1.25[416] | 1.59[417] | 2.32[418] | 3.11[419] |
61 | CDH5 | Cadherin-5 | [420] | -1.79[421] | -4.04[422] | [423] | -5.17[424] | -5.56[425] | 4.23[426] |
62 | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | [427] | -1.83[428] | -6.72[429] | -8.73[430] | -2.20[431] | -2.74[432] | 1.93[433] |
63 | KDR | Vascular endothelial growth factor receptor 2 | [434] | -5.84[435] | -7.60[436] | -7.06[437] | -2.00[438] | 4.63[439] | 5.99[440] |
64 | FLT4 | Vascular endothelial growth factor receptor 3 | [441] | -1.58[442] | -0.44[443] | -1.83[444] | -1.50[445] | -1.43[446] | 4.22[447] |
65 | CDH3 | Cadherin-3 | [448] | -1.60[449] | -4.01[450] | -4.62[451] | -2.55[452] | -2.56[453] | -3.02[454] |
66 | PRKCB | Protein kinase C beta type | [455] | -7.03[456] | -5.93[457] | [458] | 2.22[459] | -2.92[460] | 3.23[461] |
67 | FLT1 | Vascular endothelial growth factor receptor 1 | [462] | -1.72[463] | -1.46[464] | -2.07[465] | -0.55[466] | -1.32[467] | 5.79[468] |
68 | CDH15 | Cadherin-15 | [469] | 1.93[470] | 2.68[471] | -1.45[472] | -0.10[473] | -3.45[474] | -1.34[475] |
69 | CDH6 | Cadherin-6 | [476] | -3.77[477] | -3.19[478] | -1.57[479] | 5.77[480] | -2.60[481] | 2.18[482] |
70 | GNAL | Guanine nucleotide-binding protein G(olf) subunit alpha | [483] | 1.63[484] | 2.33[485] | 2.43[486] | 1.84[487] | 1.98[488] | 2.23[489] |
71 | TEK | Angiopoietin-1 receptor | [490] | -4.76[491] | -6.37[492] | -5.51[493] | 4.06[494] | 1.83[495] | 5.12[496] |
72 | CDH24 | Cadherin-24 | [497] | 3.20[498] | 0.25[499] | 3.20[500] | 4.01[501] | 5.12[502] | -0.55[503] |
73 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [504] | -2.55[505] | -0.83[506] | 3.28[507] | 4.82[508] | 3.50[509] | 3.01[510] |
74 | KIT | Mast/stem cell growth factor receptor Kit | [511] | -3.20[512] | -5.19[513] | [514] | 2.24[515] | -3.13[516] | 3.33[517] |
75 | CDH11 | Cadherin-11 | [518] | -2.57[519] | [520] | -2.49[521] | 1.56[522] | 8.51[523] | 3.08[524] |
76 | PRKCQ | Protein kinase C theta type | [525] | 0.69[526] | -2.97[527] | [528] | 1.87[529] | 3.53[530] | 1.78[531] |
77 | CDH13 | Cadherin-13 | [532] | -4.45[533] | -3.94[534] | -5.05[535] | -0.12[536] | 7.36[537] | 3.43[538] |
78 | LEF1 | Lymphoid enhancer-binding factor 1 | [539] | 2.44[540] | -4.59[541] | 3.16[542] | 0.82[543] | -0.72[544] | 0.78[545] |
79 | CDH12 | Cadherin-12 | [546] | -0.07[547] | 1.75[548] | 4.59[549] | 1.28[550] | 0.03[551] | 2.74[552] |
80 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | [553] | [554] | [555] | -3.98[556] | -3.05[557] | [558] | 2.62[559] |
81 | PRKCG | Protein kinase C gamma type | [560] | -1.04[561] | -0.46[562] | -3.01[563] | -1.32[564] | -1.25[565] | [566] |
82 | NGFR | Tumor necrosis factor receptor superfamily member 16 | [567] | 8.25[568] | 1.30[569] | -2.87[570] | 1.49[571] | 2.60[572] | 7.30[573] |
83 | CDH17 | Cadherin-17 | [574] | 2.84[575] | 1.49[576] | 10.06[577] | 4.60[578] | 0.86[579] | -0.39[580] |
84 | PRKAG3 | 5'-AMP-activated protein kinase subunit gamma-3 | [581] | -1.95[582] | [583] | -2.55[584] | -1.28[585] | [586] | 2.82[587] |
85 | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 | [588] | 0.04[589] | -0.22[590] | 0.62[591] | 9.37[592] | 7.25[593] | 3.49[594] |
86 | CDH4 | Cadherin-4 | [595] | 4.94[596] | 4.80[597] | 4.25[598] | 4.95[599] | 5.32[600] | 3.53[601] |
87 | CDH20 | Cadherin-20 | [602] | [603] | -1.71[604] | [605] | [606] | 1.97[607] | 2.24[608] |
88 | TAFAZZIN | [609] | [610] | [611] | [612] | [613] | [614] | [615] | |
89 | CDH10 | Cadherin-10 | [616] | [617] | [618] | [619] | [620] | [621] | [622] |
90 | CDH9 | Cadherin-9 | [623] | [624] | [625] | [626] | [627] | [628] | [629] |
91 | CDH22 | Cadherin-22 | [630] | [631] | [632] | [633] | [634] | [635] | [636] |
92 | CDH18 | Cadherin-18 | [637] | [638] | [639] | [640] | [641] | [642] | [643] |
93 | NTRK2 | BDNF/NT-3 growth factors receptor | [644] | [645] | [646] | [647] | [648] | [649] | [650] |
94 | CDH19 | Cadherin-19 | [651] | [652] | [653] | [654] | [655] | [656] | [657] |
95 | NTRK1 | High affinity nerve growth factor receptor | [658] | [659] | [660] | [661] | [662] | [663] | [664] |
96 | MIR197 | [665] | [666] | [667] | [668] | [669] | [670] | [671] | |
97 | CDH7 | Cadherin-7 | [672] | [673] | [674] | [675] | [676] | [677] | [678] |
98 | CDH8 | Cadherin-8 | [679] | [680] | [681] | [682] | [683] | [684] | [685] |
99 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [686] | [687] | [688] | [689] | [690] | [691] | [692] |