WP_HIPPOMERLIN_SIGNALING_DYSREGULATION | Return to index | ||||||||
Order | Gene | Description | ref_hepatocyte | HepG2 | HepG2.C3A | HuH.7 | SNU475 | THLE | liver |
1 | ITGB1 | Integrin beta-1 | [1] | -0.52[2] | -0.32[3] | -0.49[4] | 0.50[5] | 0.75[6] | -0.49[7] |
2 | MST1 | Hepatocyte growth factor-like protein | [8] | -4.91[9] | -1.50[10] | -3.89[11] | -9.83[12] | -8.86[13] | -0.32[14] |
3 | RBX1 | E3 ubiquitin-protein ligase RBX1 | [15] | -2.81[16] | -2.20[17] | -2.62[18] | -3.67[19] | -3.07[20] | -2.75[21] |
4 | PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit | [22] | -0.67[23] | -0.38[24] | -0.53[25] | -1.05[26] | -0.98[27] | -0.06[28] |
5 | PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit | [29] | -0.77[30] | -0.88[31] | 0.04[32] | 0.57[33] | -1.65[34] | -1.61[35] |
6 | CTNNB1 | Catenin beta-1 | [36] | 0.87[37] | 0.53[38] | 1.13[39] | -0.21[40] | 0.19[41] | 0.45[42] |
7 | CTNNA1 | Catenin alpha-1 | [43] | 0.70[44] | 0.36[45] | -0.39[46] | 0.39[47] | 0.20[48] | -0.03[49] |
8 | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit | [50] | -0.99[51] | -0.25[52] | -0.46[53] | -0.20[54] | -0.21[55] | -0.16[56] |
9 | DDB1 | DNA damage-binding protein 1 | [57] | 0.87[58] | 0.40[59] | 1.23[60] | -0.12[61] | 0.08[62] | -0.06[63] |
10 | MYC | Myc proto-oncogene protein | [64] | -0.32[65] | -0.49[66] | -2.81[67] | -3.75[68] | -1.21[69] | -2.65[70] |
11 | PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | -0.07[71] | 0.89[72] | 0.81[73] | -0.72[74] | -0.45[75] | -1.73[76] | |
12 | CCND1 | G1/S-specific cyclin-D1 | [77] | 2.30[78] | -0.03[79] | 0.50[80] | 0.92[81] | -0.39[82] | 0.40[83] |
13 | CDH2 | Cadherin-2 | [84] | -0.61[85] | -2.37[86] | -1.86[87] | 0.83[88] | -0.62[89] | -0.69[90] |
14 | CUL4A | Cullin-4A | [91] | -0.51[92] | -0.06[93] | -1.06[94] | -1.03[95] | -1.05[96] | -0.08[97] |
15 | PRKACA | cAMP-dependent protein kinase catalytic subunit alpha | [98] | -0.91[99] | -0.92[100] | -1.22[101] | -1.43[102] | -0.67[103] | -1.44[104] |
16 | ITGAV | Integrin alpha-V | [105] | 0.79[106] | 0.76[107] | -0.19[108] | 1.32[109] | 1.37[110] | -0.22[111] |
17 | ITGA6 | Integrin alpha-6 | [112] | -0.40[113] | 0.16[114] | -0.05[115] | -2.11[116] | -3.57[117] | -1.18[118] |
18 | FGFR4 | Fibroblast growth factor receptor 4 | [119] | 1.21[120] | 1.72[121] | 2.00[122] | -5.19[123] | -5.15[124] | -0.16[125] |
19 | ITGB5 | Integrin beta-5 | [126] | 0.77[127] | 1.04[128] | -0.29[129] | 0.11[130] | 0.43[131] | -0.43[132] |
20 | NRAS | GTPase NRas | [133] | -0.12[134] | 0.48[135] | 0.60[136] | 0.04[137] | -0.22[138] | -0.91[139] |
21 | MET | Hepatocyte growth factor receptor | [140] | -0.66[141] | -0.46[142] | -0.13[143] | 0.57[144] | -0.53[145] | 0.31[146] |
22 | CD44 | CD44 antigen | [147] | -7.81[148] | -9.14[149] | -3.02[150] | 0.80[151] | 1.43[152] | -1.94[153] |
23 | CDH1 | Cadherin-1 | [154] | 0.37[155] | 1.02[156] | 1.25[157] | -4.13[158] | -8.21[159] | 0.91[160] |
24 | HRAS | GTPase HRas | [161] | -1.76[162] | -2.29[163] | -3.38[164] | -1.91[165] | -1.95[166] | -3.32[167] |
25 | ITGA5 | Integrin alpha-5 | [168] | -1.97[169] | -8.22[170] | -1.33[171] | 1.77[172] | 2.57[173] | 0.48[174] |
26 | PAK2 | Serine/threonine-protein kinase PAK 2 | [175] | 0.70[176] | 0.61[177] | 0.61[178] | -0.21[179] | 0.51[180] | 0.71[181] |
27 | AJUBA | LIM domain-containing protein ajuba | [182] | 1.78[183] | 0.44[184] | 2.09[185] | 0.27[186] | -0.49[187] | -0.10[188] |
28 | KRAS | GTPase KRas | [189] | -1.26[190] | -1.11[191] | 0.19[192] | -0.16[193] | -0.33[194] | 0.02[195] |
29 | PTK2 | Focal adhesion kinase 1 | [196] | -0.01[197] | 0.64[198] | 0.73[199] | 0.99[200] | 0.36[201] | 0.11[202] |
30 | YY1AP1 | YY1-associated protein 1 | [203] | -0.90[204] | -0.93[205] | -0.49[206] | -0.19[207] | -0.51[208] | -0.51[209] |
31 | EPHA2 | Ephrin type-A receptor 2 | [210] | 1.51[211] | 1.88[212] | -0.59[213] | -0.02[214] | 0.70[215] | -1.43[216] |
32 | FGFR3 | Fibroblast growth factor receptor 3 | [217] | 1.98[218] | 2.06[219] | 2.09[220] | -4.25[221] | -2.73[222] | -0.21[223] |
33 | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit | [224] | -0.70[225] | -0.84[226] | -0.04[227] | -1.25[228] | -1.22[229] | -0.51[230] |
34 | VGLL4 | Transcription cofactor vestigial-like protein 4 | [231] | -0.72[232] | -0.51[233] | -0.93[234] | -0.71[235] | -0.85[236] | -1.95[237] |
35 | NF2 | Merlin | [238] | -0.78[239] | -0.96[240] | 0.11[241] | -0.53[242] | -0.60[243] | 0.48[244] |
36 | PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | [245] | 0.23[246] | -0.15[247] | -2.24[248] | -5.06[249] | -2.09[250] | -0.83[251] |
37 | INSR | Insulin receptor | [252] | -0.29[253] | 0.53[254] | 1.66[255] | -4.04[256] | -1.27[257] | 3.35[258] |
38 | ITGA1 | Integrin alpha-1 | [259] | -1.59[260] | -0.31[261] | -0.62[262] | -1.98[263] | -0.46[264] | 2.98[265] |
39 | EGFR | Epidermal growth factor receptor | [266] | -1.45[267] | -1.65[268] | 0.93[269] | -0.53[270] | 0.26[271] | 2.00[272] |
40 | PAK4 | Serine/threonine-protein kinase PAK 4 | [273] | 0.14[274] | 0.36[275] | 0.75[276] | 0.06[277] | -0.04[278] | -0.99[279] |
41 | PPP1R12A | Protein phosphatase 1 regulatory subunit 12A | [280] | -0.59[281] | 1.31[282] | 0.74[283] | 1.77[284] | 0.86[285] | 1.09[286] |
42 | ITGB2 | Integrin beta-2 | [287] | 0.55[288] | 2.10[289] | -6.48[290] | -6.15[291] | -7.96[292] | 0.66[293] |
43 | STK3 | Serine/threonine-protein kinase 3 | [294] | -1.83[295] | -0.80[296] | -0.89[297] | 0.36[298] | -0.80[299] | 0.53[300] |
44 | SAV1 | Protein salvador homolog 1 | [301] | -0.57[302] | -0.16[303] | -1.51[304] | -0.30[305] | 0.08[306] | -0.31[307] |
45 | ITGA3 | Integrin alpha-3 | [308] | 1.21[309] | -3.33[310] | -4.61[311] | 3.42[312] | 3.28[313] | -2.14[314] |
46 | TEAD2 | Transcriptional enhancer factor TEF-4 | [315] | 0.29[316] | -0.60[317] | 0.65[318] | 1.05[319] | 0.08[320] | -1.06[321] |
47 | PRKACB | cAMP-dependent protein kinase catalytic subunit beta | [322] | -1.58[323] | -0.64[324] | 0.35[325] | 1.27[326] | 0.30[327] | 1.05[328] |
48 | TEAD4 | Transcriptional enhancer factor TEF-3 | [329] | 1.53[330] | 1.12[331] | -0.15[332] | -1.32[333] | -0.85[334] | -3.18[335] |
49 | TEAD3 | Transcriptional enhancer factor TEF-5 | [336] | 1.12[337] | 1.31[338] | -0.63[339] | 0.03[340] | 0.23[341] | -0.82[342] |
50 | TEAD1 | Transcriptional enhancer factor TEF-1 | [343] | 0.98[344] | 1.48[345] | 1.49[346] | 3.51[347] | 2.61[348] | 2.57[349] |
51 | PAK1 | Serine/threonine-protein kinase PAK 1 | [350] | -0.76[351] | -1.35[352] | 0.76[353] | -2.82[354] | 1.13[355] | -0.39[356] |
52 | LATS2 | Serine/threonine-protein kinase LATS2 | [357] | 0.22[358] | 0.59[359] | 0.93[360] | 1.23[361] | 0.95[362] | 0.31[363] |
53 | ITGA7 | Integrin alpha-7 | [364] | -3.41[365] | -2.87[366] | -2.45[367] | -0.92[368] | 0.80[369] | -0.10[370] |
54 | LIN28B | Protein lin-28 homolog B | [371] | 1.64[372] | 2.48[373] | 2.81[374] | 0.93[375] | -6.07[376] | -9.05[377] |
55 | ITGA2 | Integrin alpha-2 | [378] | 3.36[379] | 3.47[380] | 0.21[381] | 0.42[382] | 3.57[383] | -1.64[384] |
56 | LATS1 | Serine/threonine-protein kinase LATS1 | [385] | 0.63[386] | 1.35[387] | 1.74[388] | 1.73[389] | 1.48[390] | 1.60[391] |
57 | CSF1R | Macrophage colony-stimulating factor 1 receptor | [392] | -7.05[393] | -9.81[394] | -8.76[395] | -1.20[396] | -5.66[397] | 2.04[398] |
58 | CXCL10 | C-X-C motif chemokine 10 | [399] | -9.89[400] | -7.41[401] | -2.60[402] | -2.52[403] | -9.94[404] | -3.04[405] |
59 | FOXM1 | Forkhead box protein M1 | [406] | 2.48[407] | 2.54[408] | 3.04[409] | 1.95[410] | 3.63[411] | -1.27[412] |
60 | ITGB7 | Integrin beta-7 | [413] | -3.83[414] | -0.65[415] | -6.33[416] | -4.43[417] | -4.72[418] | -0.83[419] |
61 | FGFR2 | Fibroblast growth factor receptor 2 | [420] | -3.26[421] | -1.88[422] | 1.76[423] | 0.50[424] | -4.17[425] | 2.77[426] |
62 | ITGB3 | Integrin beta-3 | [427] | -2.38[428] | -4.92[429] | -1.70[430] | 1.89[431] | 1.73[432] | 0.67[433] |
63 | ITGAL | Integrin alpha-L | [434] | -1.37[435] | 0.65[436] | 2.03[437] | -5.25[438] | -4.98[439] | 1.49[440] |
64 | FGFR1 | Fibroblast growth factor receptor 1 | [441] | 3.83[442] | 2.31[443] | 3.67[444] | 4.10[445] | 3.53[446] | 1.01[447] |
65 | IGF1R | Insulin-like growth factor 1 receptor | [448] | 3.99[449] | 3.47[450] | 1.85[451] | 3.51[452] | 3.23[453] | 1.43[454] |
66 | ITGAE | Integrin alpha-E | [455] | 1.19[456] | 1.98[457] | 0.73[458] | 1.19[459] | 1.61[460] | 0.56[461] |
67 | CDH16 | Cadherin-16 | [462] | 0.39[463] | 3.47[464] | -7.17[465] | -3.26[466] | -9.53[467] | -7.72[468] |
68 | PDGFRA | Platelet-derived growth factor receptor alpha | [469] | -4.37[470] | -5.18[471] | 2.16[472] | -0.43[473] | 4.41[474] | 4.66[475] |
69 | PDGFRB | Platelet-derived growth factor receptor beta | [476] | 0.55[477] | 1.12[478] | -1.64[479] | 0.89[480] | 1.62[481] | 2.76[482] |
70 | CDH5 | Cadherin-5 | [483] | -2.32[484] | -4.31[485] | [486] | -5.87[487] | -6.26[488] | 3.87[489] |
71 | PPP1R14A | Protein phosphatase 1 regulatory subunit 14A | [490] | -6.25[491] | -7.06[492] | 1.22[493] | -0.85[494] | -4.34[495] | 0.95[496] |
72 | ITGAM | Integrin alpha-M | [497] | -3.14[498] | -5.53[499] | -4.61[500] | -3.55[501] | -5.80[502] | 2.26[503] |
73 | KDR | Vascular endothelial growth factor receptor 2 | [504] | -6.37[505] | -7.86[506] | -7.45[507] | -2.70[508] | 3.93[509] | 5.64[510] |
74 | AMOT | Angiomotin | [511] | 0.66[512] | -6.65[513] | -0.91[514] | 3.00[515] | 1.27[516] | 1.60[517] |
75 | ITGAX | Integrin alpha-X | [518] | -1.22[519] | -0.41[520] | -2.73[521] | -2.21[522] | -1.66[523] | 1.65[524] |
76 | FLT4 | Vascular endothelial growth factor receptor 3 | [525] | -2.12[526] | -0.70[527] | -2.22[528] | -2.20[529] | -2.12[530] | 3.87[531] |
77 | CDH3 | Cadherin-3 | [532] | -2.13[533] | -4.28[534] | -5.01[535] | -3.25[536] | -3.25[537] | -3.37[538] |
78 | FLT1 | Vascular endothelial growth factor receptor 1 | [539] | -2.26[540] | -1.72[541] | -2.46[542] | -1.25[543] | -2.02[544] | 5.44[545] |
79 | ITGA4 | Integrin alpha-4 | [546] | -4.40[547] | [548] | -2.04[549] | 6.63[550] | 3.45[551] | 2.78[552] |
80 | CDH15 | Cadherin-15 | [553] | 1.39[554] | 2.41[555] | -1.84[556] | -0.80[557] | -4.15[558] | -1.69[559] |
81 | ITGB6 | Integrin beta-6 | [560] | [561] | [562] | [563] | -2.06[564] | -4.69[565] | -3.42[566] |
82 | CDH6 | Cadherin-6 | [567] | -4.30[568] | -3.45[569] | -1.96[570] | 5.07[571] | -3.30[572] | 1.83[573] |
83 | TEK | Angiopoietin-1 receptor | [574] | -5.29[575] | -6.64[576] | -5.90[577] | 3.36[578] | 1.14[579] | 4.77[580] |
84 | CDH24 | Cadherin-24 | [581] | 2.67[582] | -0.02[583] | 2.81[584] | 3.31[585] | 4.42[586] | -0.90[587] |
85 | PRKAR2B | cAMP-dependent protein kinase type II-beta regulatory subunit | [588] | -3.09[589] | -1.09[590] | 2.89[591] | 4.13[592] | 2.81[593] | 2.66[594] |
86 | ITGAD | Integrin alpha-D | [595] | -5.93[596] | [597] | [598] | -5.88[599] | [600] | 2.81[601] |
87 | ITGB4 | Integrin beta-4 | [602] | 4.97[603] | 5.21[604] | 1.36[605] | 3.20[606] | 1.23[607] | 2.15[608] |
88 | PAK3 | Serine/threonine-protein kinase PAK 3 | [609] | -7.16[610] | [611] | [612] | -2.56[613] | -0.67[614] | 0.13[615] |
89 | ITGA9 | Integrin alpha-9 | [616] | -3.46[617] | -0.90[618] | -1.03[619] | -2.37[620] | -4.34[621] | 6.53[622] |
90 | KIT | Mast/stem cell growth factor receptor Kit | [623] | -3.74[624] | -5.45[625] | [626] | 1.54[627] | -3.82[628] | 2.98[629] |
91 | PAK6 | Serine/threonine-protein kinase PAK 6 | [630] | -2.42[631] | [632] | 0.18[633] | 1.24[634] | 0.52[635] | -1.73[636] |
92 | CDH11 | Cadherin-11 | [637] | -3.10[638] | [639] | -2.88[640] | 0.86[641] | 7.81[642] | 2.73[643] |
93 | ITGA10 | Integrin alpha-10 | [644] | 2.06[645] | 2.73[646] | -2.05[647] | 1.04[648] | 3.34[649] | 2.67[650] |
94 | CDH13 | Cadherin-13 | [651] | -4.98[652] | -4.20[653] | -5.44[654] | -0.82[655] | 6.67[656] | 3.08[657] |
95 | CDH12 | Cadherin-12 | [658] | -0.61[659] | 1.49[660] | 4.20[661] | 0.58[662] | -0.67[663] | 2.39[664] |
96 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | [665] | [666] | [667] | -4.38[668] | -3.75[669] | [670] | 2.26[671] |
97 | ITGA2B | Integrin alpha-IIb | [672] | 2.86[673] | 3.31[674] | 3.01[675] | 2.06[676] | 0.59[677] | 1.96[678] |
98 | NGFR | Tumor necrosis factor receptor superfamily member 16 | [679] | 7.72[680] | 1.04[681] | -3.26[682] | 0.79[683] | 1.90[684] | 6.95[685] |
99 | ITGA8 | Integrin alpha-8 | [686] | [687] | -3.42[688] | -4.63[689] | 2.87[690] | [691] | 3.80[692] |
100 | CDH17 | Cadherin-17 | [693] | 2.30[694] | 1.22[695] | 9.67[696] | 3.90[697] | 0.16[698] | -0.74[699] |
101 | ITGB8 | Integrin beta-8 | [700] | 1.52[701] | 1.19[702] | 5.00[703] | 4.59[704] | 5.66[705] | 6.09[706] |
102 | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 | [707] | -0.49[708] | -0.48[709] | 0.23[710] | 8.67[711] | 6.56[712] | 3.14[713] |
103 | CDH4 | Cadherin-4 | [714] | 4.40[715] | 4.53[716] | 3.86[717] | 4.25[718] | 4.63[719] | 3.18[720] |
104 | CDH20 | Cadherin-20 | [721] | [722] | -1.97[723] | [724] | [725] | 1.27[726] | 1.89[727] |
105 | CDH8 | Cadherin-8 | [728] | [729] | [730] | [731] | [732] | [733] | [734] |
106 | CDH7 | Cadherin-7 | [735] | [736] | [737] | [738] | [739] | [740] | [741] |
107 | MIR4329 | [742] | [743] | [744] | [745] | [746] | [747] | [748] | |
108 | ITGA11 | Integrin alpha-11 | [749] | [750] | [751] | [752] | [753] | [754] | [755] |
109 | PAK5 | Serine/threonine-protein kinase PAK 5 | [756] | [757] | [758] | [759] | [760] | [761] | [762] |
110 | BUB1B-PA | BUB1B-PAK6 readthrough (Fragment) | [763] | [764] | [765] | [766] | [767] | [768] | [769] |
111 | MIR98 | [770] | [771] | [772] | [773] | [774] | [775] | [776] | |
112 | DCAF1 | DDB1- and CUL4-associated factor 1 | [777] | [778] | [779] | [780] | [781] | [782] | [783] |
113 | PRKACG | cAMP-dependent protein kinase catalytic subunit gamma | [784] | [785] | [786] | [787] | [788] | [789] | [790] |
114 | LINC02478 | [791] | [792] | [793] | [794] | [795] | [796] | [797] | |
115 | CDH22 | Cadherin-22 | [798] | [799] | [800] | [801] | [802] | [803] | [804] |
116 | CDH18 | Cadherin-18 | [805] | [806] | [807] | [808] | [809] | [810] | [811] |
117 | CDH10 | Cadherin-10 | [812] | [813] | [814] | [815] | [816] | [817] | [818] |
118 | CDH9 | Cadherin-9 | [819] | [820] | [821] | [822] | [823] | [824] | [825] |
119 | TAFAZZIN | [826] | [827] | [828] | [829] | [830] | [831] | [832] | |
120 | NTRK1 | High affinity nerve growth factor receptor | [833] | [834] | [835] | [836] | [837] | [838] | [839] |
121 | CCN2 | [840] | [841] | [842] | [843] | [844] | [845] | [846] | |
122 | CDH19 | Cadherin-19 | [847] | [848] | [849] | [850] | [851] | [852] | [853] |
123 | NTRK2 | BDNF/NT-3 growth factors receptor | [854] | [855] | [856] | [857] | [858] | [859] | [860] |