WP_HEREDITARY_LEIOMYOMATOSIS_AND_RENAL_CELL_CARCINOMA_PATHWAY Return to index
Order Gene Description ref_hepatocyte HepG2 HepG2.C3A HuH.7 SNU475 THLE liver
1 RPS6 40S ribosomal protein S6 [1] [2] [3] [4] [5] [6] [7]
2 LDHA L-lactate dehydrogenase A chain [8] 0.98[9] 1.08[10] 1.26[11] 1.02[12] 0.54[13] 1.13[14]
3 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial [15] -1.17[16] -0.18[17] -1.08[18] -1.18[19] -0.53[20] -0.10[21]
4 HIF1A Hypoxia-inducible factor 1-alpha [22] 0.51[23] 0.33[24] 1.16[25] 3.32[26] 3.82[27] 0.08[28]
5 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial -0.11[29] 0.02[30] 1.08[31] 0.49[32] 0.16[33] 1.03[34]
6 PRKAG1 5'-AMP-activated protein kinase subunit gamma-1 [35] -0.75[36] -0.07[37] 0.08[38] 0.69[39] 0.52[40] -0.76[41]
7 NFE2L2 Nuclear factor erythroid 2-related factor 2 [42] 1.43[43] 2.52[44] 2.15[45] 1.50[46] 1.86[47] 1.06[48]
8 VEGFA Vascular endothelial growth factor A [49] 1.89[50] 3.37[51] 2.00[52] 1.47[53] 2.31[54] 1.67[55]
9 KEAP1 Kelch-like ECH-associated protein 1 [56] 0.88[57] 0.93[58] 0.69[59] 0.22[60] 1.33[61] 1.44[62]
10 EGLN1 Egl nine homolog 1 [63] 2.00[64] 1.80[65] 1.31[66] 2.51[67] 2.59[68] 2.39[69]
11 PRKAA1 5'-AMP-activated protein kinase catalytic subunit alpha-1 [70] 0.59[71] 2.02[72] 3.56[73] 2.50[74] 2.89[75] 2.95[76]
12 SLC11A2 Natural resistance-associated macrophage protein 2 [77] 2.33[78] 3.28[79] 1.46[80] 1.04[81] 1.91[82] 2.57[83]
13 CUL3 Cullin-3 [84] 1.28[85] 2.35[86] 2.09[87] 2.50[88] 2.71[89] 1.83[90]
14 ACACB Acetyl-CoA carboxylase 2 [91] -0.20[92] 0.92[93] 1.07[94] -0.73[95] -0.32[96] 5.07[97]
15 TP53 Cellular tumor antigen p53 [98] 2.31[99] 2.02[100] 2.81[101] 2.33[102] 2.11[103] 0.85[104]
16 PRKAB1 5'-AMP-activated protein kinase subunit beta-1 [105] 1.38[106] 2.06[107] 1.24[108] 0.97[109] 1.20[110] 0.89[111]
17 ACACA Acetyl-CoA carboxylase 1 [112] 3.12[113] 3.61[114] 4.56[115] 3.62[116] 2.93[117] 4.24[118]
18 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 [119] 7.31[120] 4.48[121] 3.57[122] 4.48[123] 3.73[124] -0.46[125]
19 PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 3.04[126] 3.90[127] 3.54[128] 3.65[129] 2.00[130] 2.95[131]
20 PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [132] [133] [134] [135] [136]
[1]
ref_hepatocyte RPS6
Mean 819
Standard deviation 2.5e+02
Values 9e+02 7.2e+02 1.2e+03 6.5e+02 6.1e+02
[2]
HepG2 RPS6
Missing
[3]
HepG2.C3A RPS6
Missing
[4]
HuH.7 RPS6
Missing
[5]
SNU475 RPS6
Missing
[6]
THLE RPS6
Missing
[7]
liver RPS6
Missing
[8]
ref_hepatocyte LDHA
Mean 277
Standard deviation 1.5e+02
Values 1.4e+02 2.5e+02 5.4e+02 2e+02 2.5e+02
[9]
HepG2 LDHA
Mean 762
Standard deviation 74
Values 8.1e+02 7.1e+02
[10]
HepG2.C3A LDHA
Mean 652
Standard deviation 1.7e+02
Values 7.7e+02 5.3e+02
[11]
HuH.7 LDHA
Mean 696
Standard deviation 62
Values 6.9e+02 6.3e+02 7.6e+02
[12]
SNU475 LDHA
Mean 505
Standard deviation 20
Values 5.2e+02 4.9e+02
[13]
THLE LDHA
Mean 372
Standard deviation 35
Values 3.5e+02 4e+02
[14]
liver LDHA
Mean 467
Standard deviation 2.8e+02
Values 2.1e+02 2.5e+02 7.3e+02 6.8e+02
[15]
ref_hepatocyte PDHB
Mean 48.5
Standard deviation 30
Values 15 33 35 75 85
[16]
HepG2 PDHB
Mean 30
Standard deviation 6.5
Values 35 25
[17]
HepG2.C3A PDHB
Mean 47.6
Standard deviation 2.1
Values 46 49
[18]
HuH.7 PDHB
Mean 24.2
Standard deviation 4.2
Values 28 20 24
[19]
SNU475 PDHB
Mean 19.1
Standard deviation 2.2
Values 18 21
[20]
THLE PDHB
Mean 30.9
Standard deviation 4.1
Values 28 34
[21]
liver PDHB
Mean 34.7
Standard deviation 25
Values 12 15 62 50
[22]
ref_hepatocyte HIF1A
Mean 26.5
Standard deviation 22
Values 30 5.8 8.1 27 61
[23]
HepG2 HIF1A
Mean 52.5
Standard deviation 22
Values 68 37
[24]
HepG2.C3A HIF1A
Mean 37.2
Standard deviation 10
Values 44 30
[25]
HuH.7 HIF1A
Mean 62
Standard deviation 17
Values 49 55 81
[26]
SNU475 HIF1A
Mean 237
Standard deviation 65
Values 1.9e+02 2.8e+02
[27]
THLE HIF1A
Mean 346
Standard deviation 60
Values 3.9e+02 3e+02
[28]
liver HIF1A
Mean 21.5
Standard deviation 8.5
Values 31 25 12 18
[29]
ref_hepatocyte PDHA1
Mean 24.9
Standard deviation 8.4
Values 16 20 25 25 38
[30]
HepG2 PDHA1
Mean 32
Standard deviation 3.7
Values 35 29
[31]
HepG2.C3A PDHA1
Mean 28.2
Standard deviation 0.42
Values 28 28
[32]
HuH.7 PDHA1
Mean 55
Standard deviation 18
Values 67 34 64
[33]
SNU475 PDHA1
Mean 31.4
Standard deviation 0.34
Values 31 32
[34]
THLE PDHA1
Mean 25.6
Standard deviation 3
Values 24 28
[35]
liver PDHA1
Mean 39.1
Standard deviation 23
Values 17 22 54 63
[36]
ref_hepatocyte PRKAG1
Mean 18.2
Standard deviation 5.6
Values 21 14 20 11 25
[37]
HepG2 PRKAG1
Mean 15.1
Standard deviation 4.3
Values 18 12
[38]
HepG2.C3A PRKAG1
Mean 19.4
Standard deviation 1.6
Values 21 18
[39]
HuH.7 PRKAG1
Mean 20.2
Standard deviation 3.3
Values 19 24 18
[40]
SNU475 PRKAG1
Mean 26.4
Standard deviation 2
Values 25 28
[41]
THLE PRKAG1
Mean 24.2
Standard deviation 2.7
Values 22 26
[42]
liver PRKAG1
Mean 8.25
Standard deviation 1.9
Values 5.8 9 7.9 10
[43]
ref_hepatocyte NFE2L2
Mean 15.6
Standard deviation 4.9
Values 11 19 21 18 9.4
[44]
HepG2 NFE2L2
Mean 58.6
Standard deviation 25
Values 76 41
[45]
HepG2.C3A NFE2L2
Mean 99.8
Standard deviation 19
Values 1.1e+02 86
[46]
HuH.7 NFE2L2
Mean 72.7
Standard deviation 3
Values 74 75 69
[47]
SNU475 NFE2L2
Mean 39.6
Standard deviation 2.1
Values 41 38
[48]
THLE NFE2L2
Mean 52.3
Standard deviation 3.2
Values 55 50
[49]
liver NFE2L2
Mean 25
Standard deviation 9.2
Values 15 21 28 36
[50]
ref_hepatocyte VEGFA
Mean 15.4
Standard deviation 8.3
Values 12 25 22 12 5.2
[51]
HepG2 VEGFA
Mean 78.9
Standard deviation 39
Values 51 1.1e+02
[52]
HepG2.C3A VEGFA
Mean 178
Standard deviation 91
Values 1.1e+02 2.4e+02
[53]
HuH.7 VEGFA
Mean 64.6
Standard deviation 7.4
Values 73 62 59
[54]
SNU475 VEGFA
Mean 38.2
Standard deviation 17
Values 50 26
[55]
THLE VEGFA
Mean 70.1
Standard deviation 17
Values 82 58
[56]
liver VEGFA
Mean 37.5
Standard deviation 27
Values 48 70 18 14
[57]
ref_hepatocyte KEAP1
Mean 14.9
Standard deviation 4.1
Values 17 15 20 11 11
[58]
HepG2 KEAP1
Mean 38
Standard deviation 2.6
Values 36 40
[59]
HepG2.C3A KEAP1
Mean 31.6
Standard deviation 0.82
Values 32 31
[60]
HuH.7 KEAP1
Mean 25.2
Standard deviation 5.2
Values 30 20 26
[61]
SNU475 KEAP1
Mean 15.5
Standard deviation 1.8
Values 17 14
[62]
THLE KEAP1
Mean 34.5
Standard deviation 4.9
Values 31 38
[63]
liver KEAP1
Mean 30.9
Standard deviation 7.7
Values 29 23 31 41
[64]
ref_hepatocyte EGLN1
Mean 8.8
Standard deviation 6.1
Values 5.7 6.2 4.6 8 19
[65]
HepG2 EGLN1
Mean 48.7
Standard deviation 24
Values 66 32
[66]
HepG2.C3A EGLN1
Mean 34.1
Standard deviation 2.9
Values 36 32
[67]
HuH.7 EGLN1
Mean 22.9
Standard deviation 3.7
Values 20 27 22
[68]
SNU475 EGLN1
Mean 44.8
Standard deviation 1.6
Values 44 46
[69]
THLE EGLN1
Mean 48.9
Standard deviation 6.8
Values 54 44
[70]
liver EGLN1
Mean 35.3
Standard deviation 14
Values 45 50 24 22
[71]
ref_hepatocyte PRKAA1
Mean 8.04
Standard deviation 3.4
Values 6.1 14 7.2 5.4 7.6
[72]
HepG2 PRKAA1
Mean 16.8
Standard deviation 2.1
Values 18 15
[73]
HepG2.C3A PRKAA1
Mean 36.3
Standard deviation 5.5
Values 40 32
[74]
HuH.7 PRKAA1
Mean 99.5
Standard deviation 14
Values 84 1e+02 1.1e+02
[75]
SNU475 PRKAA1
Mean 40.7
Standard deviation 4.8
Values 37 44
[76]
THLE PRKAA1
Mean 55.1
Standard deviation 6.9
Values 60 50
[77]
liver PRKAA1
Mean 47.6
Standard deviation 7.3
Values 47 58 40 45
[78]
ref_hepatocyte SLC11A2
Mean 7.42
Standard deviation 2.2
Values 9.1 9.8 6.4 7.3 4.4
[79]
HepG2 SLC11A2
Mean 51.9
Standard deviation 3
Values 50 54
[80]
HepG2.C3A SLC11A2
Mean 80.2
Standard deviation 5.6
Values 84 76
[81]
HuH.7 SLC11A2
Mean 21.4
Standard deviation 1.3
Values 21 23 21
[82]
SNU475 SLC11A2
Mean 13.6
Standard deviation 0.2
Values 13 14
[83]
THLE SLC11A2
Mean 25.8
Standard deviation 1.4
Values 25 27
[84]
liver SLC11A2
Mean 33.8
Standard deviation 8
Values 45 34 31 26
[85]
ref_hepatocyte CUL3
Mean 5.91
Standard deviation 1.6
Values 3.5 6 5.4 7.2 7.4
[86]
HepG2 CUL3
Mean 20
Standard deviation 5.9
Values 24 16
[87]
HepG2.C3A CUL3
Mean 33.5
Standard deviation 2.3
Values 35 32
[88]
HuH.7 CUL3
Mean 26.4
Standard deviation 3
Values 27 23 29
[89]
SNU475 CUL3
Mean 29.9
Standard deviation 0.9
Values 31 29
[90]
THLE CUL3
Mean 35.6
Standard deviation 0.55
Values 35 36
[91]
liver CUL3
Mean 16.1
Standard deviation 5.2
Values 20 20 15 9.1
[92]
ref_hepatocyte ACACB
Mean 5.46
Standard deviation 5.5
Values 1.1 13 9.6 1.7 1.8
[93]
HepG2 ACACB
Mean 6.6
Standard deviation 0.54
Values 7 6.2
[94]
HepG2.C3A ACACB
Mean 11.5
Standard deviation 0.088
Values 12 11
[95]
HuH.7 ACACB
Mean 12.1
Standard deviation 1.9
Values 9.8 13 13
[96]
SNU475 ACACB
Mean 2.94
Standard deviation 0.034
Values 2.9 3
[97]
THLE ACACB
Mean 4.04
Standard deviation 0.24
Values 4.2 3.9
[98]
liver ACACB
Mean 141
Standard deviation 89
Values 2.6e+02 1.6e+02 90 59
[99]
ref_hepatocyte TP53
Mean 5.28
Standard deviation 0.94
Values 6.2 5.5 5.5 5.5 3.7
[100]
HepG2 TP53
Mean 36.3
Standard deviation 0.12
Values 36 36
[101]
HepG2.C3A TP53
Mean 23.9
Standard deviation 1.8
Values 25 23
[102]
HuH.7 TP53
Mean 38.7
Standard deviation 16
Values 46 20 50
[103]
SNU475 TP53
Mean 23.7
Standard deviation 6.7
Values 19 28
[104]
THLE TP53
Mean 21.1
Standard deviation 6.6
Values 16 26
[105]
liver TP53
Mean 7.29
Standard deviation 2.3
Values 5.6 5 9 9.5
[106]
ref_hepatocyte PRKAB1
Mean 4.81
Standard deviation 1.6
Values 4.2 6.9 5.3 2.5 5.1
[107]
HepG2 PRKAB1
Mean 17.4
Standard deviation 1
Values 17 18
[108]
HepG2.C3A PRKAB1
Mean 22.4
Standard deviation 1.5
Values 21 23
[109]
HuH.7 PRKAB1
Mean 11.9
Standard deviation 0.19
Values 12 12 12
[110]
SNU475 PRKAB1
Mean 8.43
Standard deviation 1.5
Values 7.4 9.5
[111]
THLE PRKAB1
Mean 10.2
Standard deviation 0.44
Values 9.9 10
[112]
liver PRKAB1
Mean 6.83
Standard deviation 3.2
Values 4 4.5 7.9 11
[113]
ref_hepatocyte ACACA
Mean 3.02
Standard deviation 0.95
Values 1.7 2.7 3.2 4.3 3.2
[114]
HepG2 ACACA
Mean 36.5
Standard deviation 4.8
Values 40 33
[115]
HepG2.C3A ACACA
Mean 41.2
Standard deviation 13
Values 32 50
[116]
HuH.7 ACACA
Mean 74.7
Standard deviation 16
Values 57 78 89
[117]
SNU475 ACACA
Mean 33.2
Standard deviation 14
Values 23 43
[118]
THLE ACACA
Mean 21.2
Standard deviation 5
Values 18 25
[119]
liver ACACA
Mean 44
Standard deviation 21
Values 50 70 21 35
[120]
ref_hepatocyte SLC2A1
Mean 2.27
Standard deviation 1.4
Values 2.3 1 0.99 4.2 2.9
[121]
HepG2 SLC2A1
Mean 502
Standard deviation 1.7e+02
Values 3.8e+02 6.3e+02
[122]
HepG2.C3A SLC2A1
Mean 56.3
Standard deviation 15
Values 67 46
[123]
HuH.7 SLC2A1
Mean 28.3
Standard deviation 3.1
Values 26 27 32
[124]
SNU475 SLC2A1
Mean 45.4
Standard deviation 2.9
Values 43 47
[125]
THLE SLC2A1
Mean 27.9
Standard deviation 3.1
Values 26 30
[126]
liver SLC2A1
Mean 1.26
Standard deviation 0.55
Values 0.77 1.2 1.1 2.1
[127]
ref_hepatocyte PDK1
Mean 1.82
Standard deviation 1.1
Values 0.89 2.1 1.1 3.7 1.3
[128]
HepG2 PDK1
Mean 20.7
Standard deviation 5.2
Values 24 17
[129]
HepG2.C3A PDK1
Mean 30.3
Standard deviation 3.9
Values 33 28
[130]
HuH.7 PDK1
Mean 22.3
Standard deviation 0.9
Values 21 22 23
[131]
SNU475 PDK1
Mean 20.4
Standard deviation 4.6
Values 17 24
[132]
THLE PDK1
Mean 6.71
Standard deviation 0.29
Values 6.5 6.9
[133]
liver PDK1
Mean 10.8
Standard deviation 3
Values 7.1 12 10 14
[134]
ref_hepatocyte PDHA2
Mean 0
Standard deviation 0
Values 0 0 0 0 0
[135]
HepG2 PDHA2
Missing
[136]
HepG2.C3A PDHA2
Missing
[137]
HuH.7 PDHA2
Missing
[138]
SNU475 PDHA2
Missing
[139]
THLE PDHA2
Missing
[140]
liver PDHA2
Missing